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The map label for this gene is tycC [H]

Identifier: 159898405

GI number: 159898405

Start: 2248321

End: 2253390

Strand: Direct

Name: tycC [H]

Synonym: Haur_1881

Alternate gene names: 159898405

Gene position: 2248321-2253390 (Clockwise)

Preceding gene: 159898404

Following gene: 159898406

Centisome position: 35.43

GC content: 53.45

Gene sequence:

>5070_bases
ATGTCTGAGCATTCAGATGATTCGTTGCGCAACCAGACTGATCCTGCATCTCGGCGAGTTCCGCTTTCGGCGGCCAAAAA
AGCGCGGCTCGAAAAACGCCTGCGCGGTGATAGCGACAATCAGCAGGCTGAATCAAGCATTCCTCGCCTCGCGACCTATG
ATCAGGTGCCATTATCGTTTGCGCAAGAACGGCTGTGGTTTCTCAGCCAATACGAACCAACGAGCAGCAACGCCTATATT
ATTCCCTTGGCCGTGCGGATCGATGGCCCCATTGATCCATCGCTGTTGGAGCAGGCTTTGCAATTGGTGGTGGATCGCCA
TGCCAGCTTCCGCACCACGTTTCATGCGCAGAATGGGGTGCCGTTTCAACGGGTTGCCCCACAGCTGCCGCTCAGGTTGC
CCGTGCTTGGGCTGGACGTGGCTGATGCGAGCGATGAGGCGGCGGTGTTGCAGGTCGTGCTGGATCAGCTTGTACCGCTG
TTGCAGCTACCGTTTGATCTTGAGCATGGGCCGTTGTTGCGAGCGACCTTACTGCGTTTAGCTGCCGAATCGCATGTGCT
GCTGCTGATTTGCCATCATATTATTAGTGATGGCTGGTCGATGGGGGTGCTGCTGCGCGATTTTGCCAGCTTTTTAGGCG
CGTTACGCACCAATACTGCGCCGGATGTACCGCCGTTGGTGGTGCAAGCCCCGGATGTCGCGGTGTGGCAACGGCAACGC
TTGCAAGGCCACTATCTGACGACACTCCAAGATTTTTGGAAGCAGCAGTTGGCGGATCTCGAACCATTGAATGTGCCTAC
CGATTTTGTCCGACCGGCCCAGCAATCCTATCGTGGGGCGACATTGAGTTTTCAGCTCCCCGCTGCGCTCAGCACCCAGC
TTCAGCGTATGGCGCAACAGCATGATGTGACCCCATTTATGCTGCTGCTTGCCGCATTTCAGGCTTTTTTGGCGCGACTG
AGTGGGCAACAGGATCTGGCGATTGGTTCCGTGCTAGCGAGTCGGGCCGATGCTGACCTTGATCCGGTGATTGGTTTTTT
GGTGAATACCTGGACGTTGCGGAACAACATAGATGTAGCGCAGCCATTGGCGCAGCTCTTGCCCACGGTGCGACGTACCG
TCCTGGCAGCGTTTGAGCACCGCGATTTACCGTTTGAGCAGGTGGTGCAACTGGTGCAACCGGAGCGTGATCTGAGCCGT
TCGCCCGTGTTTCAGGTGATGATGACCTATCAAAACGTGCCGCAACGGCAGATGGAATGGGGGGATGTTCGGTTGACCCC
GATTAGCCTGCCCAGCACGGTGGCGAAATTCGACCTAACTCTGGCGCTGAGCGAAACCCCCGAGGGTTTTCGTGGGGTGA
TGGAATATCGGAGCGATTTATTTCGGCGCAGCACGATTGCCACGATGGTTGCGCGTTGGGAAATGTTTTTACACGGGATT
GTGGCAGACTTTACCACGTCCATTGCCCGATTGCCGTTGGTCTTGCCTGCGGAACGCAGCTTATTGCTTGATACGTTGAA
TGCGACCACAACCGCCTACCCACACGATCAAAGCGTAGCAAGTTTGTTTGCCGAACAAGCCCGCCTGTGGCCGGAGCGGA
TTGCGCTTCGTTTTGGTGAGCACAGCCTCAGCTATCACGCGCTTGAGCAACGGGCCAACCAGCTAGCGCACCATCTGCAA
CTGCTGGGTGTTGGGCCAGAGCATGTGGTTGGTTTGTGTGTTGAGCGCTCGTTGGACTTAGTGGTGGCGATTCTGGCGAT
TCTCAAGGCTGGCGCAGCCTATGCCCCGGTCGATCCGAGTTATCCCGTTGAGCGTTTGGCCTGGATGCTGAGTGATTTAC
AGCCAACGGTGGTGATTGCACAGCACGGCGTGCTCGACCGCTTACCGTCGGTTGCGTGTTCCGTGGTTGTGCTTGAAACC
ATAGCCGCGCACCTCGCAGCGTATCCCACGACTGCGCCAACCGTGGACATCAGCCCCGAAAATTTGGCCTATGTGATGTA
TACCTCTGGTTCAACAGGCCGACCCAAAGGGATTATGATCAATCAGCGGAACATTGTGCGATTGGTCCGCAACACCACGT
ATGCGGCATTTGGGCCAGACCAGGTTGGGTTATTGCTGGCAACAGTGGCATTTGATGCTTCGACGTTCGAACTTTGGGGG
TGTTTGCTGAATGGTGGACGCTTAGTGATCGCCCCACCGCAGCAACTCAGCCTTGCCGAATTGGGCCACTTGGTGGAGCG
CGAACAGATTACGACGCTCTGGTTGACCGCCGGATTGTTCCATCAAATGGTGGATCATGCGCTGGATCGATTGGGTTCGT
TGCGTCAATTACTGGCCGGTGGCGATCGACTGTCGCCCGTGCATGTACACAAAGTGCTGGAACGCTGGCCGCAGTGTCGC
CTGATTAATGGGTATGGCCCAACGGAAAACACCACATTTAGCTGTTGTCAGCAGCTTAGTGCAACCACTGACCTGGCGCA
GGGCGTGCCGATTGGGCAGCCGATTGCGAACAGCACGGCCTATATTCTTGACCGGTTGTTGCAACTGGTTCCCATAGGGG
TTGTAGGCGAACTGTATTTGGGTGGCGCAGGCTTAGCGCGAGGGTATTTAGCGCGTCCAGACCAGACGGCGGCGGCATTT
ATCCCGAACCCCATGAGCCAAACGGCGGGCGAACGCCTGTATCGCTCGGGGGATCTGGCGCGGTATCGCGATGATGGGAC
GATCGAATTTATTGGACGACGGGATCAGCAAGTCAAGGTACGCGGGTATCGGATTGAGCTGGAAGAAATCGTTGGCGTGT
TGCTGGCACAACCACAGGTGGATGATGCGGTGGTGGTGGTGCGGGAGGATCGGGTTGGTGATCAGCGCTTGGTGGCCTAT
CTGGTGGGTGACAATCCGGCGATTGAGCTGATTGAACAAGCGGTGCAAGGCCAGGTCCCGAGCTATATGCTCCCGAGTGC
CTATGTTGTGCTTGATGCCTTGCCGTTGACGGCGAATGGCAAGGTTGATCGGCGGCGGTTGCCAGCGCCGAGCTATGCCG
CCATCGCGAACGATGATCCGCCACAAACCGATTTAGAGCAGGCGATAGCGGCGATTTGGGCCGAGGTCTTGGCGGTGCCG
AGCATTCAACGCCAGACCAACTTTTTCCAAGTAGGTGGACATTCGTTGAGTGCAACTCAGTTGATTGTGCGGTTACGCCA
AATGCTGAATCGCGATCTGCCCTTGCAATTATTGTTCGATTATCCTTATTTATATCAGCTTGCCGAGCAGCTTGAGCAGC
AACCAACAGCCCTGCCAACCGCGATTCAACCAATTCCACGTCATCAGCGCCTGCCGTTAACGTCTGCCCAGCAACGGGTT
TGGTTTTTTGAGCAATTAGTGCCCAATACGGCGATGTATACGATTGCTTTGCAACTACGATTAAGTGGCAAGCTTGAGCC
AGCCTTGTTGCAACAGGCGATTAATCTGCTGATTGCTCGCCATGAGATCTTGCGAGCGTCGTTTCATGGGCAGGCTGGGC
AGCCTTGGCTACACATTGCTAACCACTTAACGCTTGATCTAGAGTTGATTGATCTTCGGAAAATAGATATTGAACAGCAA
TCGATCGATGTTCAGAAAATATGCCAACGTTTAGCATATGCCAGCTATCAACTTGAGTATGCGCCCTTGCTGCGTTTTTG
CTTAATCCAGCTTGGCGTACAAAGCGCGATACTATTATTCACTATTCAGCATAGTATTACCGATGCTTGGTCGATTGATC
TGCTTTTGCAGGAGTTATGGCAAATCTATGCTGATTTAATCCACCAGCGCCCGCTGAGCCTTGCTGAATTATCAGTGCAA
TATGTTGATTTTGCTGCTTGGCAAGCTGCTTGGTTGGCTACGCCCGCAGCGCAACGCCAGTTAAGCTACTGGCTTGAACA
GCTCGCCGAAGCTCCACGCTTGTTGGCCTTACCAACCGATTATCCCCGCCCCGACAACCAAACCTTTGCTGGCTCGGTGG
TGAGCCTTGAATTACCTCAGCCTTTGACCCACGAGTTGCGTAGTTTGAGTCAACATCAGCATGTAACCTTGTTTATGTTG
TTGTTGGCGGCTTTCAAGAGCTTGCTTTATCGCTACACTGGGCAAACTGATCTCTGCGTTGGTTCGCCGATTGCCAATCG
TGGCCAGCCTGAGCTGCAAACAATGCTTGGCTTTTTTATCAATACCTTGGTGCTGCGTAGTCGCATTCAGCCAGCTTGGT
CTTTTCTTGAGCTCTTGGCTACGGTGCGAGCCACAACCTTGGCTGCCTATGCCCAGCAAGATCTCCCCTTAGAAAAGATT
ATTGAACAGCTCAAACTAGAGCGCGATTTGAGTTATAACCCATTGTTTCAGGTGATGTTTAATTTTCGTCACGATTTTGC
GATCAATCGCCAGCATTATGAGCTAGCGATTGAGGCTGAAATGTTGGCGAATGGTACATCAAAATTTGATTTAACTTTAG
ATGTAGCCGATCGTGGCTCCACGTTATTGCTATGGGTCGAATATAACTCGGCCTTGTTTGCCCCAGCGACGATTGAGCGG
ATGCTGGCACAATTTCAGGTCTTACTGAATAGCATTTGTGCGCATCCTGGGCAACAATTAAGTACACTGGAGCTGCGAAC
ACCCAATCAAATTGCTCAGTTAGAACAAGCGCGAGTTGCGCTATTACAGCAACTTGAGCAGCATCCAGCGATTAGCCAAG
CAGTTGTATTGGTTCGGCCCGATTTGCCGCAAGCCAACTGGGTCGTTGGCTATGTTGTCAAACAGCCAAATCAGCAGCTT
GAGCTTGGTCAATTGCAGGCAAGTATCCAAACAACCTACCCATTGGTACAGTTGGCACTTTATGAAGTGCCCGATATGCC
CTTGGATGCGGCTGGCACGGTTGACCACGCTGGATTAAGCAAGTATGGTCAGCCATTGCTTAACCAGCAATTACAGCAGC
CCGCCGTGCAATCCCCGACTGAAGCAATGCTTGCCGAAAAACGGGCTAAACTTTCCGCAGATAAACGGTCACTCCTAGAG
AAGCGTTTGAAACAATTACGAGGTGAATAA

Upstream 100 bases:

>100_bases
TGACTGGTTATACGCAGCATCAGCCTGAATTGCTCGCAATTGCAACCGAACATAAACGGTCACTCCTAGAGAAGCGTTTG
AAACAATTACGAGGTGAATA

Downstream 100 bases:

>100_bases
TGTCTGAGCATTCAGATGATTCGTTGCGCAACCAGACTGATCCTGCATCTCGGCGAGCTCCGCTTTCGGCGGCCAAAAAA
GCGTGGCTCGAAAAACGCCT

Product: amino acid adenylation domain-containing protein

Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]

Alternate protein names: Tyrocidine synthase III; ATP-dependent asparagine adenylase; AsnA; Asparagine activase; ATP-dependent glutamine adenylase; GlnA; Glutamine activase; ATP-dependent tyrosine adenylase; TyrA; Tyrosine activase; ATP-dependent valine adenylase; ValA; Valine activase; ATP-dependent ornithine adenylase; OrnA; Ornithine activase; ATP-dependent leucine adenylase; LeuA; Leucine activase [H]

Number of amino acids: Translated: 1689; Mature: 1688

Protein sequence:

>1689_residues
MSEHSDDSLRNQTDPASRRVPLSAAKKARLEKRLRGDSDNQQAESSIPRLATYDQVPLSFAQERLWFLSQYEPTSSNAYI
IPLAVRIDGPIDPSLLEQALQLVVDRHASFRTTFHAQNGVPFQRVAPQLPLRLPVLGLDVADASDEAAVLQVVLDQLVPL
LQLPFDLEHGPLLRATLLRLAAESHVLLLICHHIISDGWSMGVLLRDFASFLGALRTNTAPDVPPLVVQAPDVAVWQRQR
LQGHYLTTLQDFWKQQLADLEPLNVPTDFVRPAQQSYRGATLSFQLPAALSTQLQRMAQQHDVTPFMLLLAAFQAFLARL
SGQQDLAIGSVLASRADADLDPVIGFLVNTWTLRNNIDVAQPLAQLLPTVRRTVLAAFEHRDLPFEQVVQLVQPERDLSR
SPVFQVMMTYQNVPQRQMEWGDVRLTPISLPSTVAKFDLTLALSETPEGFRGVMEYRSDLFRRSTIATMVARWEMFLHGI
VADFTTSIARLPLVLPAERSLLLDTLNATTTAYPHDQSVASLFAEQARLWPERIALRFGEHSLSYHALEQRANQLAHHLQ
LLGVGPEHVVGLCVERSLDLVVAILAILKAGAAYAPVDPSYPVERLAWMLSDLQPTVVIAQHGVLDRLPSVACSVVVLET
IAAHLAAYPTTAPTVDISPENLAYVMYTSGSTGRPKGIMINQRNIVRLVRNTTYAAFGPDQVGLLLATVAFDASTFELWG
CLLNGGRLVIAPPQQLSLAELGHLVEREQITTLWLTAGLFHQMVDHALDRLGSLRQLLAGGDRLSPVHVHKVLERWPQCR
LINGYGPTENTTFSCCQQLSATTDLAQGVPIGQPIANSTAYILDRLLQLVPIGVVGELYLGGAGLARGYLARPDQTAAAF
IPNPMSQTAGERLYRSGDLARYRDDGTIEFIGRRDQQVKVRGYRIELEEIVGVLLAQPQVDDAVVVVREDRVGDQRLVAY
LVGDNPAIELIEQAVQGQVPSYMLPSAYVVLDALPLTANGKVDRRRLPAPSYAAIANDDPPQTDLEQAIAAIWAEVLAVP
SIQRQTNFFQVGGHSLSATQLIVRLRQMLNRDLPLQLLFDYPYLYQLAEQLEQQPTALPTAIQPIPRHQRLPLTSAQQRV
WFFEQLVPNTAMYTIALQLRLSGKLEPALLQQAINLLIARHEILRASFHGQAGQPWLHIANHLTLDLELIDLRKIDIEQQ
SIDVQKICQRLAYASYQLEYAPLLRFCLIQLGVQSAILLFTIQHSITDAWSIDLLLQELWQIYADLIHQRPLSLAELSVQ
YVDFAAWQAAWLATPAAQRQLSYWLEQLAEAPRLLALPTDYPRPDNQTFAGSVVSLELPQPLTHELRSLSQHQHVTLFML
LLAAFKSLLYRYTGQTDLCVGSPIANRGQPELQTMLGFFINTLVLRSRIQPAWSFLELLATVRATTLAAYAQQDLPLEKI
IEQLKLERDLSYNPLFQVMFNFRHDFAINRQHYELAIEAEMLANGTSKFDLTLDVADRGSTLLLWVEYNSALFAPATIER
MLAQFQVLLNSICAHPGQQLSTLELRTPNQIAQLEQARVALLQQLEQHPAISQAVVLVRPDLPQANWVVGYVVKQPNQQL
ELGQLQASIQTTYPLVQLALYEVPDMPLDAAGTVDHAGLSKYGQPLLNQQLQQPAVQSPTEAMLAEKRAKLSADKRSLLE
KRLKQLRGE

Sequences:

>Translated_1689_residues
MSEHSDDSLRNQTDPASRRVPLSAAKKARLEKRLRGDSDNQQAESSIPRLATYDQVPLSFAQERLWFLSQYEPTSSNAYI
IPLAVRIDGPIDPSLLEQALQLVVDRHASFRTTFHAQNGVPFQRVAPQLPLRLPVLGLDVADASDEAAVLQVVLDQLVPL
LQLPFDLEHGPLLRATLLRLAAESHVLLLICHHIISDGWSMGVLLRDFASFLGALRTNTAPDVPPLVVQAPDVAVWQRQR
LQGHYLTTLQDFWKQQLADLEPLNVPTDFVRPAQQSYRGATLSFQLPAALSTQLQRMAQQHDVTPFMLLLAAFQAFLARL
SGQQDLAIGSVLASRADADLDPVIGFLVNTWTLRNNIDVAQPLAQLLPTVRRTVLAAFEHRDLPFEQVVQLVQPERDLSR
SPVFQVMMTYQNVPQRQMEWGDVRLTPISLPSTVAKFDLTLALSETPEGFRGVMEYRSDLFRRSTIATMVARWEMFLHGI
VADFTTSIARLPLVLPAERSLLLDTLNATTTAYPHDQSVASLFAEQARLWPERIALRFGEHSLSYHALEQRANQLAHHLQ
LLGVGPEHVVGLCVERSLDLVVAILAILKAGAAYAPVDPSYPVERLAWMLSDLQPTVVIAQHGVLDRLPSVACSVVVLET
IAAHLAAYPTTAPTVDISPENLAYVMYTSGSTGRPKGIMINQRNIVRLVRNTTYAAFGPDQVGLLLATVAFDASTFELWG
CLLNGGRLVIAPPQQLSLAELGHLVEREQITTLWLTAGLFHQMVDHALDRLGSLRQLLAGGDRLSPVHVHKVLERWPQCR
LINGYGPTENTTFSCCQQLSATTDLAQGVPIGQPIANSTAYILDRLLQLVPIGVVGELYLGGAGLARGYLARPDQTAAAF
IPNPMSQTAGERLYRSGDLARYRDDGTIEFIGRRDQQVKVRGYRIELEEIVGVLLAQPQVDDAVVVVREDRVGDQRLVAY
LVGDNPAIELIEQAVQGQVPSYMLPSAYVVLDALPLTANGKVDRRRLPAPSYAAIANDDPPQTDLEQAIAAIWAEVLAVP
SIQRQTNFFQVGGHSLSATQLIVRLRQMLNRDLPLQLLFDYPYLYQLAEQLEQQPTALPTAIQPIPRHQRLPLTSAQQRV
WFFEQLVPNTAMYTIALQLRLSGKLEPALLQQAINLLIARHEILRASFHGQAGQPWLHIANHLTLDLELIDLRKIDIEQQ
SIDVQKICQRLAYASYQLEYAPLLRFCLIQLGVQSAILLFTIQHSITDAWSIDLLLQELWQIYADLIHQRPLSLAELSVQ
YVDFAAWQAAWLATPAAQRQLSYWLEQLAEAPRLLALPTDYPRPDNQTFAGSVVSLELPQPLTHELRSLSQHQHVTLFML
LLAAFKSLLYRYTGQTDLCVGSPIANRGQPELQTMLGFFINTLVLRSRIQPAWSFLELLATVRATTLAAYAQQDLPLEKI
IEQLKLERDLSYNPLFQVMFNFRHDFAINRQHYELAIEAEMLANGTSKFDLTLDVADRGSTLLLWVEYNSALFAPATIER
MLAQFQVLLNSICAHPGQQLSTLELRTPNQIAQLEQARVALLQQLEQHPAISQAVVLVRPDLPQANWVVGYVVKQPNQQL
ELGQLQASIQTTYPLVQLALYEVPDMPLDAAGTVDHAGLSKYGQPLLNQQLQQPAVQSPTEAMLAEKRAKLSADKRSLLE
KRLKQLRGE
>Mature_1688_residues
SEHSDDSLRNQTDPASRRVPLSAAKKARLEKRLRGDSDNQQAESSIPRLATYDQVPLSFAQERLWFLSQYEPTSSNAYII
PLAVRIDGPIDPSLLEQALQLVVDRHASFRTTFHAQNGVPFQRVAPQLPLRLPVLGLDVADASDEAAVLQVVLDQLVPLL
QLPFDLEHGPLLRATLLRLAAESHVLLLICHHIISDGWSMGVLLRDFASFLGALRTNTAPDVPPLVVQAPDVAVWQRQRL
QGHYLTTLQDFWKQQLADLEPLNVPTDFVRPAQQSYRGATLSFQLPAALSTQLQRMAQQHDVTPFMLLLAAFQAFLARLS
GQQDLAIGSVLASRADADLDPVIGFLVNTWTLRNNIDVAQPLAQLLPTVRRTVLAAFEHRDLPFEQVVQLVQPERDLSRS
PVFQVMMTYQNVPQRQMEWGDVRLTPISLPSTVAKFDLTLALSETPEGFRGVMEYRSDLFRRSTIATMVARWEMFLHGIV
ADFTTSIARLPLVLPAERSLLLDTLNATTTAYPHDQSVASLFAEQARLWPERIALRFGEHSLSYHALEQRANQLAHHLQL
LGVGPEHVVGLCVERSLDLVVAILAILKAGAAYAPVDPSYPVERLAWMLSDLQPTVVIAQHGVLDRLPSVACSVVVLETI
AAHLAAYPTTAPTVDISPENLAYVMYTSGSTGRPKGIMINQRNIVRLVRNTTYAAFGPDQVGLLLATVAFDASTFELWGC
LLNGGRLVIAPPQQLSLAELGHLVEREQITTLWLTAGLFHQMVDHALDRLGSLRQLLAGGDRLSPVHVHKVLERWPQCRL
INGYGPTENTTFSCCQQLSATTDLAQGVPIGQPIANSTAYILDRLLQLVPIGVVGELYLGGAGLARGYLARPDQTAAAFI
PNPMSQTAGERLYRSGDLARYRDDGTIEFIGRRDQQVKVRGYRIELEEIVGVLLAQPQVDDAVVVVREDRVGDQRLVAYL
VGDNPAIELIEQAVQGQVPSYMLPSAYVVLDALPLTANGKVDRRRLPAPSYAAIANDDPPQTDLEQAIAAIWAEVLAVPS
IQRQTNFFQVGGHSLSATQLIVRLRQMLNRDLPLQLLFDYPYLYQLAEQLEQQPTALPTAIQPIPRHQRLPLTSAQQRVW
FFEQLVPNTAMYTIALQLRLSGKLEPALLQQAINLLIARHEILRASFHGQAGQPWLHIANHLTLDLELIDLRKIDIEQQS
IDVQKICQRLAYASYQLEYAPLLRFCLIQLGVQSAILLFTIQHSITDAWSIDLLLQELWQIYADLIHQRPLSLAELSVQY
VDFAAWQAAWLATPAAQRQLSYWLEQLAEAPRLLALPTDYPRPDNQTFAGSVVSLELPQPLTHELRSLSQHQHVTLFMLL
LAAFKSLLYRYTGQTDLCVGSPIANRGQPELQTMLGFFINTLVLRSRIQPAWSFLELLATVRATTLAAYAQQDLPLEKII
EQLKLERDLSYNPLFQVMFNFRHDFAINRQHYELAIEAEMLANGTSKFDLTLDVADRGSTLLLWVEYNSALFAPATIERM
LAQFQVLLNSICAHPGQQLSTLELRTPNQIAQLEQARVALLQQLEQHPAISQAVVLVRPDLPQANWVVGYVVKQPNQQLE
LGQLQASIQTTYPLVQLALYEVPDMPLDAAGTVDHAGLSKYGQPLLNQQLQQPAVQSPTEAMLAEKRAKLSADKRSLLEK
RLKQLRGE

Specific function: Incorporates six amino acids (for tyrocidine A, Asn, Gln, Tyr, Val, Orn, and Leu) in their L-configuration into the peptide product [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 6 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=637, Percent_Identity=22.1350078492936, Blast_Score=114, Evalue=1e-24,
Organism=Homo sapiens, GI156151445, Length=560, Percent_Identity=22.3214285714286, Blast_Score=96, Evalue=3e-19,
Organism=Homo sapiens, GI38505220, Length=366, Percent_Identity=25.1366120218579, Blast_Score=81, Evalue=1e-14,
Organism=Homo sapiens, GI122937307, Length=368, Percent_Identity=26.3586956521739, Blast_Score=80, Evalue=1e-14,
Organism=Homo sapiens, GI28416953, Length=547, Percent_Identity=23.5831809872029, Blast_Score=72, Evalue=4e-12,
Organism=Escherichia coli, GI1786801, Length=1052, Percent_Identity=30.1330798479087, Blast_Score=304, Evalue=3e-83,
Organism=Escherichia coli, GI1786810, Length=507, Percent_Identity=27.4161735700197, Blast_Score=119, Evalue=2e-27,
Organism=Escherichia coli, GI145693145, Length=532, Percent_Identity=26.6917293233083, Blast_Score=115, Evalue=3e-26,
Organism=Escherichia coli, GI1788107, Length=562, Percent_Identity=25.6227758007117, Blast_Score=101, Evalue=5e-22,
Organism=Escherichia coli, GI1790505, Length=521, Percent_Identity=23.0326295585413, Blast_Score=83, Evalue=1e-16,
Organism=Escherichia coli, GI1789201, Length=353, Percent_Identity=24.929178470255, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17550940, Length=1034, Percent_Identity=22.4371373307544, Blast_Score=197, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17556356, Length=551, Percent_Identity=26.497277676951, Blast_Score=150, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17538037, Length=504, Percent_Identity=23.015873015873, Blast_Score=104, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17560308, Length=372, Percent_Identity=25.5376344086022, Blast_Score=87, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71994690, Length=370, Percent_Identity=23.5135135135135, Blast_Score=80, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71994694, Length=370, Percent_Identity=23.5135135135135, Blast_Score=80, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17559526, Length=454, Percent_Identity=23.7885462555066, Blast_Score=79, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71994703, Length=370, Percent_Identity=23.5135135135135, Blast_Score=79, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17560140, Length=507, Percent_Identity=22.4852071005917, Blast_Score=70, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6319591, Length=961, Percent_Identity=24.6618106139438, Blast_Score=246, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6319699, Length=486, Percent_Identity=22.8395061728395, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24648676, Length=581, Percent_Identity=28.9156626506024, Blast_Score=195, Evalue=3e-49,
Organism=Drosophila melanogaster, GI21355181, Length=507, Percent_Identity=24.2603550295858, Blast_Score=110, Evalue=6e-24,
Organism=Drosophila melanogaster, GI19922652, Length=509, Percent_Identity=23.9685658153242, Blast_Score=99, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24581924, Length=520, Percent_Identity=22.3076923076923, Blast_Score=80, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24582852, Length=383, Percent_Identity=26.8929503916449, Blast_Score=77, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24648260, Length=480, Percent_Identity=21.25, Blast_Score=72, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR006163
- InterPro:   IPR020806
- InterPro:   IPR006162
- InterPro:   IPR001031 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00550 PP-binding; PF00975 Thioesterase [H]

EC number: 2.7.7.- [C]

Molecular weight: Translated: 188331; Mature: 188200

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHSDDSLRNQTDPASRRVPLSAAKKARLEKRLRGDSDNQQAESSIPRLATYDQVPLSF
CCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCHHHH
AQERLWFLSQYEPTSSNAYIIPLAVRIDGPIDPSLLEQALQLVVDRHASFRTTFHAQNGV
HHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHCCCHHEEEEECCCCC
PFQRVAPQLPLRLPVLGLDVADASDEAAVLQVVLDQLVPLLQLPFDLEHGPLLRATLLRL
CHHHHCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
AAESHVLLLICHHIISDGWSMGVLLRDFASFLGALRTNTAPDVPPLVVQAPDVAVWQRQR
HHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHH
LQGHYLTTLQDFWKQQLADLEPLNVPTDFVRPAQQSYRGATLSFQLPAALSTQLQRMAQQ
HCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCHHHHHCCCCEEEEECCHHHHHHHHHHHHH
HDVTPFMLLLAAFQAFLARLSGQQDLAIGSVLASRADADLDPVIGFLVNTWTLRNNIDVA
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHEECCCCCHH
QPLAQLLPTVRRTVLAAFEHRDLPFEQVVQLVQPERDLSRSPVFQVMMTYQNVPQRQMEW
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHCCC
GDVRLTPISLPSTVAKFDLTLALSETPEGFRGVMEYRSDLFRRSTIATMVARWEMFLHGI
CCEEEEEECCCHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VADFTTSIARLPLVLPAERSLLLDTLNATTTAYPHDQSVASLFAEQARLWPERIALRFGE
HHHHHHHHHHCCEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHCC
HSLSYHALEQRANQLAHHLQLLGVGPEHVVGLCVERSLDLVVAILAILKAGAAYAPVDPS
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
YPVERLAWMLSDLQPTVVIAQHGVLDRLPSVACSVVVLETIAAHLAAYPTTAPTVDISPE
CCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCC
NLAYVMYTSGSTGRPKGIMINQRNIVRLVRNTTYAAFGPDQVGLLLATVAFDASTFELWG
CEEEEEEECCCCCCCCCEEECCHHHHHHHHCCCEEECCCCHHHHHHHHHHCCCHHHHHHH
CLLNGGRLVIAPPQQLSLAELGHLVEREQITTLWLTAGLFHQMVDHALDRLGSLRQLLAG
HHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GDRLSPVHVHKVLERWPQCRLINGYGPTENTTFSCCQQLSATTDLAQGVPIGQPIANSTA
CCCCCHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
YILDRLLQLVPIGVVGELYLGGAGLARGYLARPDQTAAAFIPNPMSQTAGERLYRSGDLA
HHHHHHHHHHCCCHHHHHHCCCHHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHCCCCC
RYRDDGTIEFIGRRDQQVKVRGYRIELEEIVGVLLAQPQVDDAVVVVREDRVGDQRLVAY
EECCCCCEEEECCCCCEEEEEEEEEEHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEE
LVGDNPAIELIEQAVQGQVPSYMLPSAYVVLDALPLTANGKVDRRRLPAPSYAAIANDDP
EECCCHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEECCCCCC
PQTDLEQAIAAIWAEVLAVPSIQRQTNFFQVGGHSLSATQLIVRLRQMLNRDLPLQLLFD
CHHHHHHHHHHHHHHHHHCCCHHHHCCEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEC
YPYLYQLAEQLEQQPTALPTAIQPIPRHQRLPLTSAQQRVWFFEQLVPNTAMYTIALQLR
CHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEEE
LSGKLEPALLQQAINLLIARHEILRASFHGQAGQPWLHIANHLTLDLELIDLRKIDIEQQ
ECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCEEEEEEEEEEEEECCHHH
SIDVQKICQRLAYASYQLEYAPLLRFCLIQLGVQSAILLFTIQHSITDAWSIDLLLQELW
CCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEHHHHHCCHHHHHHHHHHHH
QIYADLIHQRPLSLAELSVQYVDFAAWQAAWLATPAAQRQLSYWLEQLAEAPRLLALPTD
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEECCCC
YPRPDNQTFAGSVVSLELPQPLTHELRSLSQHQHVTLFMLLLAAFKSLLYRYTGQTDLCV
CCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEE
GSPIANRGQPELQTMLGFFINTLVLRSRIQPAWSFLELLATVRATTLAAYAQQDLPLEKI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
IEQLKLERDLSYNPLFQVMFNFRHDFAINRQHYELAIEAEMLANGTSKFDLTLDVADRGS
HHHHHHHCCCCCCHHHHHHHHHHHHHEECCCCEEEEEEHHHHHCCCCEEEEEEEECCCCC
TLLLWVEYNSALFAPATIERMLAQFQVLLNSICAHPGQQLSTLELRTPNQIAQLEQARVA
EEEEEEECCCCEECHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHH
LLQQLEQHPAISQAVVLVRPDLPQANWVVGYVVKQPNQQLELGQLQASIQTTYPLVQLAL
HHHHHHHCCCHHHEEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
YEVPDMPLDAAGTVDHAGLSKYGQPLLNQQLQQPAVQSPTEAMLAEKRAKLSADKRSLLE
HHCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
KRLKQLRGE
HHHHHHCCC
>Mature Secondary Structure 
SEHSDDSLRNQTDPASRRVPLSAAKKARLEKRLRGDSDNQQAESSIPRLATYDQVPLSF
CCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCHHHH
AQERLWFLSQYEPTSSNAYIIPLAVRIDGPIDPSLLEQALQLVVDRHASFRTTFHAQNGV
HHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHCCCHHEEEEECCCCC
PFQRVAPQLPLRLPVLGLDVADASDEAAVLQVVLDQLVPLLQLPFDLEHGPLLRATLLRL
CHHHHCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
AAESHVLLLICHHIISDGWSMGVLLRDFASFLGALRTNTAPDVPPLVVQAPDVAVWQRQR
HHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHH
LQGHYLTTLQDFWKQQLADLEPLNVPTDFVRPAQQSYRGATLSFQLPAALSTQLQRMAQQ
HCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCHHHHHCCCCEEEEECCHHHHHHHHHHHHH
HDVTPFMLLLAAFQAFLARLSGQQDLAIGSVLASRADADLDPVIGFLVNTWTLRNNIDVA
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHEECCCCCHH
QPLAQLLPTVRRTVLAAFEHRDLPFEQVVQLVQPERDLSRSPVFQVMMTYQNVPQRQMEW
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHCCC
GDVRLTPISLPSTVAKFDLTLALSETPEGFRGVMEYRSDLFRRSTIATMVARWEMFLHGI
CCEEEEEECCCHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VADFTTSIARLPLVLPAERSLLLDTLNATTTAYPHDQSVASLFAEQARLWPERIALRFGE
HHHHHHHHHHCCEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHCC
HSLSYHALEQRANQLAHHLQLLGVGPEHVVGLCVERSLDLVVAILAILKAGAAYAPVDPS
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
YPVERLAWMLSDLQPTVVIAQHGVLDRLPSVACSVVVLETIAAHLAAYPTTAPTVDISPE
CCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCC
NLAYVMYTSGSTGRPKGIMINQRNIVRLVRNTTYAAFGPDQVGLLLATVAFDASTFELWG
CEEEEEEECCCCCCCCCEEECCHHHHHHHHCCCEEECCCCHHHHHHHHHHCCCHHHHHHH
CLLNGGRLVIAPPQQLSLAELGHLVEREQITTLWLTAGLFHQMVDHALDRLGSLRQLLAG
HHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GDRLSPVHVHKVLERWPQCRLINGYGPTENTTFSCCQQLSATTDLAQGVPIGQPIANSTA
CCCCCHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
YILDRLLQLVPIGVVGELYLGGAGLARGYLARPDQTAAAFIPNPMSQTAGERLYRSGDLA
HHHHHHHHHHCCCHHHHHHCCCHHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHCCCCC
RYRDDGTIEFIGRRDQQVKVRGYRIELEEIVGVLLAQPQVDDAVVVVREDRVGDQRLVAY
EECCCCCEEEECCCCCEEEEEEEEEEHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEE
LVGDNPAIELIEQAVQGQVPSYMLPSAYVVLDALPLTANGKVDRRRLPAPSYAAIANDDP
EECCCHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEECCCCCC
PQTDLEQAIAAIWAEVLAVPSIQRQTNFFQVGGHSLSATQLIVRLRQMLNRDLPLQLLFD
CHHHHHHHHHHHHHHHHHCCCHHHHCCEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEC
YPYLYQLAEQLEQQPTALPTAIQPIPRHQRLPLTSAQQRVWFFEQLVPNTAMYTIALQLR
CHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEEE
LSGKLEPALLQQAINLLIARHEILRASFHGQAGQPWLHIANHLTLDLELIDLRKIDIEQQ
ECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCEEEEEEEEEEEEECCHHH
SIDVQKICQRLAYASYQLEYAPLLRFCLIQLGVQSAILLFTIQHSITDAWSIDLLLQELW
CCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEHHHHHCCHHHHHHHHHHHH
QIYADLIHQRPLSLAELSVQYVDFAAWQAAWLATPAAQRQLSYWLEQLAEAPRLLALPTD
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEECCCC
YPRPDNQTFAGSVVSLELPQPLTHELRSLSQHQHVTLFMLLLAAFKSLLYRYTGQTDLCV
CCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEE
GSPIANRGQPELQTMLGFFINTLVLRSRIQPAWSFLELLATVRATTLAAYAQQDLPLEKI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
IEQLKLERDLSYNPLFQVMFNFRHDFAINRQHYELAIEAEMLANGTSKFDLTLDVADRGS
HHHHHHHCCCCCCHHHHHHHHHHHHHEECCCCEEEEEEHHHHHCCCCEEEEEEEECCCCC
TLLLWVEYNSALFAPATIERMLAQFQVLLNSICAHPGQQLSTLELRTPNQIAQLEQARVA
EEEEEEECCCCEECHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHH
LLQQLEQHPAISQAVVLVRPDLPQANWVVGYVVKQPNQQLELGQLQASIQTTYPLVQLAL
HHHHHHHCCCHHHEEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
YEVPDMPLDAAGTVDHAGLSKYGQPLLNQQLQQPAVQSPTEAMLAEKRAKLSADKRSLLE
HHCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
KRLKQLRGE
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Phosphopantetheine. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]

Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9352938; 10801488 [H]