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The map label for this gene is msrA [H]

Identifier: 159898274

GI number: 159898274

Start: 2037276

End: 2037818

Strand: Direct

Name: msrA [H]

Synonym: Haur_1750

Alternate gene names: 159898274

Gene position: 2037276-2037818 (Clockwise)

Preceding gene: 159898267

Following gene: 159898275

Centisome position: 32.1

GC content: 46.96

Gene sequence:

>543_bases
ATGACTCAACAATATGCTTTGGCGACCCTCGGTGGTGGCTGTTTTTGGTGCTTAGAAGCGGTTTTTGATGATCTACAAGG
AATCATCAGGGTTGAATCGGGCTATGCTGGTGGCCATGTTGCCAACCCAACCTACGAAGAAATTTGCGGCAAAAAAACTG
GGCATGCCGAAGTTGTGCGCTTAACCTATGATCCCAGCGTGATCAATTTCAGCCAAATTTTGGATGTCTTTTTCACCATC
CACGATCCAACCACGCTGAATCGGCAAGGCTACGATGTTGGGCCACAATATCGCTCGGCGATCTTTTATCACGATGCTGA
GCAAAAAGCCGTGGCTGAGCAAACGATTGCGGCATTAAATGCCAGCGGTCAGTGGCCCGACCCAATTGTGACCGAAGTAA
CACCAATTAACAATTACTATGAAGCCGAAGATTATCACCAAGAATATTTTGCCCACAATCCCTTCCAACCCTATTGTATG
GCGGTCGTCTCGCCCAAAGTCCAGAAGTTTCGCAAAGAATTTAGCAAGCAGCGAAAATCTTAA

Upstream 100 bases:

>100_bases
ACGGATGAGTTCAACGGGCGATTTAGCCCATTCTAATGGTCAATTTTAATTTGCCTAGCTCTCTAGCTAGCAACGATAGC
AATCAAGGATAGTTAACTAA

Downstream 100 bases:

>100_bases
CCCAACCCCGATTGGATTGGCACAGTCGAGTTATGGTATACTAGCTATAATTATGACACATTGTGTGTTATATAGCTAGA
TAGTAGTTTGATTTACATGG

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 180; Mature: 179

Protein sequence:

>180_residues
MTQQYALATLGGGCFWCLEAVFDDLQGIIRVESGYAGGHVANPTYEEICGKKTGHAEVVRLTYDPSVINFSQILDVFFTI
HDPTTLNRQGYDVGPQYRSAIFYHDAEQKAVAEQTIAALNASGQWPDPIVTEVTPINNYYEAEDYHQEYFAHNPFQPYCM
AVVSPKVQKFRKEFSKQRKS

Sequences:

>Translated_180_residues
MTQQYALATLGGGCFWCLEAVFDDLQGIIRVESGYAGGHVANPTYEEICGKKTGHAEVVRLTYDPSVINFSQILDVFFTI
HDPTTLNRQGYDVGPQYRSAIFYHDAEQKAVAEQTIAALNASGQWPDPIVTEVTPINNYYEAEDYHQEYFAHNPFQPYCM
AVVSPKVQKFRKEFSKQRKS
>Mature_179_residues
TQQYALATLGGGCFWCLEAVFDDLQGIIRVESGYAGGHVANPTYEEICGKKTGHAEVVRLTYDPSVINFSQILDVFFTIH
DPTTLNRQGYDVGPQYRSAIFYHDAEQKAVAEQTIAALNASGQWPDPIVTEVTPINNYYEAEDYHQEYFAHNPFQPYCMA
VVSPKVQKFRKEFSKQRKS

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=157, Percent_Identity=45.2229299363057, Blast_Score=134, Evalue=4e-32,
Organism=Homo sapiens, GI208609995, Length=157, Percent_Identity=45.2229299363057, Blast_Score=134, Evalue=4e-32,
Organism=Homo sapiens, GI208609993, Length=113, Percent_Identity=45.1327433628319, Blast_Score=87, Evalue=7e-18,
Organism=Escherichia coli, GI1790665, Length=151, Percent_Identity=45.0331125827815, Blast_Score=132, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17533973, Length=144, Percent_Identity=37.5, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320881, Length=157, Percent_Identity=40.1273885350318, Blast_Score=116, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24664627, Length=165, Percent_Identity=37.5757575757576, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24664631, Length=165, Percent_Identity=36.3636363636364, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI45553131, Length=158, Percent_Identity=36.7088607594937, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 20357; Mature: 20226

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQYALATLGGGCFWCLEAVFDDLQGIIRVESGYAGGHVANPTYEEICGKKTGHAEVVR
CCCCEEHHHHCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCHHHHCCCCCCCCEEEE
LTYDPSVINFSQILDVFFTIHDPTTLNRQGYDVGPQYRSAIFYHDAEQKAVAEQTIAALN
EEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHEEEEECCHHHHHHHHHHHHHC
ASGQWPDPIVTEVTPINNYYEAEDYHQEYFAHNPFQPYCMAVVSPKVQKFRKEFSKQRKS
CCCCCCCCCCEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQQYALATLGGGCFWCLEAVFDDLQGIIRVESGYAGGHVANPTYEEICGKKTGHAEVVR
CCCEEHHHHCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCHHHHCCCCCCCCEEEE
LTYDPSVINFSQILDVFFTIHDPTTLNRQGYDVGPQYRSAIFYHDAEQKAVAEQTIAALN
EEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHEEEEECCHHHHHHHHHHHHHC
ASGQWPDPIVTEVTPINNYYEAEDYHQEYFAHNPFQPYCMAVVSPKVQKFRKEFSKQRKS
CCCCCCCCCCEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA