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The map label for this gene is pyrG

Identifier: 159898267

GI number: 159898267

Start: 2028567

End: 2030171

Strand: Direct

Name: pyrG

Synonym: Haur_1743

Alternate gene names: 159898267

Gene position: 2028567-2030171 (Clockwise)

Preceding gene: 159898266

Following gene: 159898274

Centisome position: 31.96

GC content: 49.66

Gene sequence:

>1605_bases
ATGACGAAGTATATTTTCGTGACGGGCGGCGTAGCTTCATCGGTGGGCAAGGGAATCACCGTGGCCTCGCTGGGCCGTTT
GCTGAAAAGTCGTGGCATTAGCGTTTCAATTCAAAAACTTGATCCATATATCAATGTTGACCCTGGTACGATGTCGCCTT
ACCAACATGGCGAGGTCTTTGTGACCGAAGATGGGGCTGAAACCGACCTCGATTTGGGCCACTACGAACGCTTTATTGAT
GAAAATTTGTCCCGCGTTAACAACATTACAACCGGCCAAATTTATTCTTCAGTGATTCAAAAAGAGCGCCGTGGCGATTT
CCTCGGCGGCACGATTCAAGTAATTCCGCATATCACCAACGAAATTAAAAGCCGCGTCGCTTTGGTAGCCAAGAATACCA
ATGCTGATGTGGTGATTGTCGAAATTGGCGGCACGGTTGGCGATATCGAAAGTTTACCCTTCCTCGAAGCCATTCGACAA
ATGAAAAAAGATGTGGGCCGCGATAACGTGATGTATATTCACGTGACCTTGTTGCCTTATCTCCAAGCCAGTGGCGAACT
CAAAACCAAGCCGACCCAACACTCAATCGCCGAATTACGCCGCGTCGGTATCTCGCCAGCCGTGGTGTTGTGTCGCTCCG
ATTTGCCAGTTGATGATGATATGCGTGAGAAAATCGCTCTGTTTGCTGATTTACCCAACGAGGCTGTGGTAGCTCTGCCT
ACCGTTGATTCGATTTATGAAGTGCCGTTGGTGCTTGAGGAAGCAGGCTTAGGCGATTTAATTATCGAACGCTTGGCTTT
GGCTGCTCAGCCAGTCCAGCTCGATGAATGGCGCTCACTCGTTGCACGTATCAAACAACCCAAACGCCATACCACGGTGG
CGATTGTTGGCAAATATGTTGAACTGCGCGATGCCTATATGAGTGTGGCTGAATCGGTGCGCCACGCTGGTTGGGCCCAA
GATATTCAAGTTGATATCAAATGGGTCTCTTCAGAAGAGCTTGAAGTGGCTGATCCTGTAACCATGCTTGGCGATGTCCA
AGGGATTATCGTGCCTGGCGGCTTTGGCTATCGTGGGGTCGAGGGCAAAATTCGGGCTGTGCGCTATGCTCGCGAAAACA
AAATTCCCTTCTTGGGGCTTTGTTTAGGCATGCAATGTGCCACGATTGAATTTGCTCGCTTTGCCTTGAATGCGCCCGAT
GCCAACTCAACCGAGTTTAACCCGAACACCAAACTGCCAGTGATCGACTTTATGCCCGATCAATTGGATATTAGTGATAA
GGGTGGGACGATGCGCTTGGGGGTTTACCCATGTATTTTAGCCCCCGATACTAAGGCTGCCAAAGCCTATGGCCGTGAAT
TAGCCTTGGAACGCCATCGCCATCGCTTTGAGTTTAACAACAAATATCGTAAAGCCATGGAAGCCGCTGGTTTTGTGATT
AGTGGCCACTCGCCTGATGGCCGTTTGGTCGAGATTGTCGAGTTGCGCGACCATCCATGGTTTGTGGCTTCGCAGTTCCA
CCCTGAATTCAAATCGCGTCCAAACAACCCACATCCATTGTTCCGCGATTTTGTGCAGGCTGCCTTGGAACAAATTGCTG
AATAA

Upstream 100 bases:

>100_bases
TAAATTCAACTGTCCCTACGATCAAACCATCTATGGTATAATCAAGGCCCGTACTGATGATATTCAGTGCGGATTTTTTA
TTTAACGCGGAGCACAGTAA

Downstream 100 bases:

>100_bases
TACCTTTTATGGTTCAGCAGCCCACTCCCACCTTGCTAGTGAGAGTGGGCTGCTGAAGGAATGACGACGATTGCTAGACT
AGCGGCTTTTGACTTGCGTC

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 534; Mature: 533

Protein sequence:

>534_residues
MTKYIFVTGGVASSVGKGITVASLGRLLKSRGISVSIQKLDPYINVDPGTMSPYQHGEVFVTEDGAETDLDLGHYERFID
ENLSRVNNITTGQIYSSVIQKERRGDFLGGTIQVIPHITNEIKSRVALVAKNTNADVVIVEIGGTVGDIESLPFLEAIRQ
MKKDVGRDNVMYIHVTLLPYLQASGELKTKPTQHSIAELRRVGISPAVVLCRSDLPVDDDMREKIALFADLPNEAVVALP
TVDSIYEVPLVLEEAGLGDLIIERLALAAQPVQLDEWRSLVARIKQPKRHTTVAIVGKYVELRDAYMSVAESVRHAGWAQ
DIQVDIKWVSSEELEVADPVTMLGDVQGIIVPGGFGYRGVEGKIRAVRYARENKIPFLGLCLGMQCATIEFARFALNAPD
ANSTEFNPNTKLPVIDFMPDQLDISDKGGTMRLGVYPCILAPDTKAAKAYGRELALERHRHRFEFNNKYRKAMEAAGFVI
SGHSPDGRLVEIVELRDHPWFVASQFHPEFKSRPNNPHPLFRDFVQAALEQIAE

Sequences:

>Translated_534_residues
MTKYIFVTGGVASSVGKGITVASLGRLLKSRGISVSIQKLDPYINVDPGTMSPYQHGEVFVTEDGAETDLDLGHYERFID
ENLSRVNNITTGQIYSSVIQKERRGDFLGGTIQVIPHITNEIKSRVALVAKNTNADVVIVEIGGTVGDIESLPFLEAIRQ
MKKDVGRDNVMYIHVTLLPYLQASGELKTKPTQHSIAELRRVGISPAVVLCRSDLPVDDDMREKIALFADLPNEAVVALP
TVDSIYEVPLVLEEAGLGDLIIERLALAAQPVQLDEWRSLVARIKQPKRHTTVAIVGKYVELRDAYMSVAESVRHAGWAQ
DIQVDIKWVSSEELEVADPVTMLGDVQGIIVPGGFGYRGVEGKIRAVRYARENKIPFLGLCLGMQCATIEFARFALNAPD
ANSTEFNPNTKLPVIDFMPDQLDISDKGGTMRLGVYPCILAPDTKAAKAYGRELALERHRHRFEFNNKYRKAMEAAGFVI
SGHSPDGRLVEIVELRDHPWFVASQFHPEFKSRPNNPHPLFRDFVQAALEQIAE
>Mature_533_residues
TKYIFVTGGVASSVGKGITVASLGRLLKSRGISVSIQKLDPYINVDPGTMSPYQHGEVFVTEDGAETDLDLGHYERFIDE
NLSRVNNITTGQIYSSVIQKERRGDFLGGTIQVIPHITNEIKSRVALVAKNTNADVVIVEIGGTVGDIESLPFLEAIRQM
KKDVGRDNVMYIHVTLLPYLQASGELKTKPTQHSIAELRRVGISPAVVLCRSDLPVDDDMREKIALFADLPNEAVVALPT
VDSIYEVPLVLEEAGLGDLIIERLALAAQPVQLDEWRSLVARIKQPKRHTTVAIVGKYVELRDAYMSVAESVRHAGWAQD
IQVDIKWVSSEELEVADPVTMLGDVQGIIVPGGFGYRGVEGKIRAVRYARENKIPFLGLCLGMQCATIEFARFALNAPDA
NSTEFNPNTKLPVIDFMPDQLDISDKGGTMRLGVYPCILAPDTKAAKAYGRELALERHRHRFEFNNKYRKAMEAAGFVIS
GHSPDGRLVEIVELRDHPWFVASQFHPEFKSRPNNPHPLFRDFVQAALEQIAE

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=552, Percent_Identity=46.9202898550725, Blast_Score=494, Evalue=1e-140,
Organism=Homo sapiens, GI28559085, Length=547, Percent_Identity=46.4351005484461, Blast_Score=490, Evalue=1e-138,
Organism=Homo sapiens, GI28559083, Length=547, Percent_Identity=46.4351005484461, Blast_Score=490, Evalue=1e-138,
Organism=Homo sapiens, GI221316689, Length=547, Percent_Identity=46.4351005484461, Blast_Score=490, Evalue=1e-138,
Organism=Escherichia coli, GI1789142, Length=539, Percent_Identity=55.4730983302412, Blast_Score=596, Evalue=1e-171,
Organism=Caenorhabditis elegans, GI25148299, Length=607, Percent_Identity=39.5387149917628, Blast_Score=419, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6322563, Length=560, Percent_Identity=43.9285714285714, Blast_Score=466, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6319432, Length=558, Percent_Identity=43.010752688172, Blast_Score=459, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24664469, Length=553, Percent_Identity=45.750452079566, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI21357815, Length=498, Percent_Identity=43.7751004016064, Blast_Score=414, Evalue=1e-116,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_HERA2 (A9B6S7)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001544514.1
- ProteinModelPortal:   A9B6S7
- SMR:   A9B6S7
- GeneID:   5733630
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_1743
- HOGENOM:   HBG597806
- OMA:   RVTMQKL
- ProtClustDB:   PRK05380
- BioCyc:   HAUR316274:HAUR_1743-MONOMER
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 59137; Mature: 59005

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 381-381 ACT_SITE 507-507 ACT_SITE 509-509

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKYIFVTGGVASSVGKGITVASLGRLLKSRGISVSIQKLDPYINVDPGTMSPYQHGEVF
CCEEEEEECCHHHHHCCCCCHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCCCCCEEE
VTEDGAETDLDLGHYERFIDENLSRVNNITTGQIYSSVIQKERRGDFLGGTIQVIPHITN
EECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHEEHHHHHH
EIKSRVALVAKNTNADVVIVEIGGTVGDIESLPFLEAIRQMKKDVGRDNVMYIHVTLLPY
HHHHHEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEEHH
LQASGELKTKPTQHSIAELRRVGISPAVVLCRSDLPVDDDMREKIALFADLPNEAVVALP
HHCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEC
TVDSIYEVPLVLEEAGLGDLIIERLALAAQPVQLDEWRSLVARIKQPKRHTTVAIVGKYV
CHHHHHHCCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEHHHH
ELRDAYMSVAESVRHAGWAQDIQVDIKWVSSEELEVADPVTMLGDVQGIIVPGGFGYRGV
HHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCHHHHCCCCEEEEECCCCCCCC
EGKIRAVRYARENKIPFLGLCLGMQCATIEFARFALNAPDANSTEFNPNTKLPVIDFMPD
CCHHHEEEEHHHCCCCEEEHHHCCCHHHHHHHHHEECCCCCCCCCCCCCCCCCEEECCCC
QLDISDKGGTMRLGVYPCILAPDTKAAKAYGRELALERHRHRFEFNNKYRKAMEAAGFVI
CEEECCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEE
SGHSPDGRLVEIVELRDHPWFVASQFHPEFKSRPNNPHPLFRDFVQAALEQIAE
ECCCCCCCEEEEEEECCCCEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TKYIFVTGGVASSVGKGITVASLGRLLKSRGISVSIQKLDPYINVDPGTMSPYQHGEVF
CEEEEEECCHHHHHCCCCCHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCCCCCEEE
VTEDGAETDLDLGHYERFIDENLSRVNNITTGQIYSSVIQKERRGDFLGGTIQVIPHITN
EECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHEEHHHHHH
EIKSRVALVAKNTNADVVIVEIGGTVGDIESLPFLEAIRQMKKDVGRDNVMYIHVTLLPY
HHHHHEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEEHH
LQASGELKTKPTQHSIAELRRVGISPAVVLCRSDLPVDDDMREKIALFADLPNEAVVALP
HHCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEC
TVDSIYEVPLVLEEAGLGDLIIERLALAAQPVQLDEWRSLVARIKQPKRHTTVAIVGKYV
CHHHHHHCCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEHHHH
ELRDAYMSVAESVRHAGWAQDIQVDIKWVSSEELEVADPVTMLGDVQGIIVPGGFGYRGV
HHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCHHHHCCCCEEEEECCCCCCCC
EGKIRAVRYARENKIPFLGLCLGMQCATIEFARFALNAPDANSTEFNPNTKLPVIDFMPD
CCHHHEEEEHHHCCCCEEEHHHCCCHHHHHHHHHEECCCCCCCCCCCCCCCCCEEECCCC
QLDISDKGGTMRLGVYPCILAPDTKAAKAYGRELALERHRHRFEFNNKYRKAMEAAGFVI
CEEECCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEE
SGHSPDGRLVEIVELRDHPWFVASQFHPEFKSRPNNPHPLFRDFVQAALEQIAE
ECCCCCCCEEEEEEECCCCEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA