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The map label for this gene is tmk

Identifier: 159897030

GI number: 159897030

Start: 578865

End: 579575

Strand: Reverse

Name: tmk

Synonym: Haur_0498

Alternate gene names: 159897030

Gene position: 579575-578865 (Counterclockwise)

Preceding gene: 159897031

Following gene: 159897029

Centisome position: 9.13

GC content: 53.73

Gene sequence:

>711_bases
ATGAGCTTGTTCATTACCTTTGAAGGCCCAGAAGGTAGCGGGAAGAGCACCCAAGCCCGCTACCTCAAGGATTATCTACA
ACAGGCTGGCTATCCAGTCATCTTAACTCGTGAGCCAGGCGGAACGCCAATTAGCGATGCTGTGCGGCGGCTTGTGCTCG
ATGGTCAATGGACGGCGATGGAGCCGACAACTGAAACGCTTTTGTTTGCTGCCGCTCGAGCTCAGTTAGTTGGCGAGGTG
ATCTTGCCCTATCTGAAACTGGGCGGCATTGTTTTGTGCGATCGCTACGCCGATTCGACCTTTGCCCACCAAGGCTATGG
CTTGGGCCGTAACTTAACCGAGCTACGCGAAATCACCCGCTTTGCAACGGGCGGCTTACAACCTGATCTGACCTTCTTTT
TGGATTTGCCCGTTGAGCAAGGCTTGCAGCGCAAACGTAAACAGCGCGACGATTTTCGTGAATCAAGCCAATTAGCCTTG
CCCTTGCCCCACCTGCCCCAACCAAGCCCCAGCCAAAACGAACATTGGAATCGGCTTGATGCCCGCGAAATTGCCTACCA
TGAACGAGTGCGCAGTGGCTACCTTGAGATGATCGCCGCTGATCCACAACGTTGGCAGGTGTTTGATGCAGGAATTGAGC
GCGAAAGCCTCACCGAGCAACTGCTTTTGGCAGTCCAGCCACATCTCACCACGATTAAAACCTTGAGCTAA

Upstream 100 bases:

>100_bases
TCTACAATCAGAAAGTACTGGCAAAGAACCACGTCGCCGCATTCGGATCTTTCGCTAAAATCGGCAACGTGGCCTCAACT
TGTTGGACTGTAGGGGAACC

Downstream 100 bases:

>100_bases
AACCCGCCGTATAAGCTGCATCTCAGTCGAGCATCAGGCTGAGATGCGCTTAGGCGTTGGTTTGATATGGTACAATATCC
CAATCGTGGCAAATTAATTG

Product: dTMP kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MSLFITFEGPEGSGKSTQARYLKDYLQQAGYPVILTREPGGTPISDAVRRLVLDGQWTAMEPTTETLLFAAARAQLVGEV
ILPYLKLGGIVLCDRYADSTFAHQGYGLGRNLTELREITRFATGGLQPDLTFFLDLPVEQGLQRKRKQRDDFRESSQLAL
PLPHLPQPSPSQNEHWNRLDAREIAYHERVRSGYLEMIAADPQRWQVFDAGIERESLTEQLLLAVQPHLTTIKTLS

Sequences:

>Translated_236_residues
MSLFITFEGPEGSGKSTQARYLKDYLQQAGYPVILTREPGGTPISDAVRRLVLDGQWTAMEPTTETLLFAAARAQLVGEV
ILPYLKLGGIVLCDRYADSTFAHQGYGLGRNLTELREITRFATGGLQPDLTFFLDLPVEQGLQRKRKQRDDFRESSQLAL
PLPHLPQPSPSQNEHWNRLDAREIAYHERVRSGYLEMIAADPQRWQVFDAGIERESLTEQLLLAVQPHLTTIKTLS
>Mature_235_residues
SLFITFEGPEGSGKSTQARYLKDYLQQAGYPVILTREPGGTPISDAVRRLVLDGQWTAMEPTTETLLFAAARAQLVGEVI
LPYLKLGGIVLCDRYADSTFAHQGYGLGRNLTELREITRFATGGLQPDLTFFLDLPVEQGLQRKRKQRDDFRESSQLALP
LPHLPQPSPSQNEHWNRLDAREIAYHERVRSGYLEMIAADPQRWQVFDAGIERESLTEQLLLAVQPHLTTIKTLS

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=205, Percent_Identity=34.6341463414634, Blast_Score=99, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_HERA2 (A9AV71)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001543277.1
- ProteinModelPortal:   A9AV71
- SMR:   A9AV71
- GeneID:   5732412
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_0498
- HOGENOM:   HBG626009
- OMA:   EIAYHER
- ProtClustDB:   CLSK974630
- BioCyc:   HAUR316274:HAUR_0498-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 26607; Mature: 26475

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLFITFEGPEGSGKSTQARYLKDYLQQAGYPVILTREPGGTPISDAVRRLVLDGQWTAM
CEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCC
EPTTETLLFAAARAQLVGEVILPYLKLGGIVLCDRYADSTFAHQGYGLGRNLTELREITR
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHCCCCCCCCHHHHHHHHH
FATGGLQPDLTFFLDLPVEQGLQRKRKQRDDFRESSQLALPLPHLPQPSPSQNEHWNRLD
HHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCH
AREIAYHERVRSGYLEMIAADPQRWQVFDAGIERESLTEQLLLAVQPHLTTIKTLS
HHHHHHHHHHHHHHHHHHHCCCCCEEHHHCCCCHHHHHHHHHHHHCCCHHEHCCCC
>Mature Secondary Structure 
SLFITFEGPEGSGKSTQARYLKDYLQQAGYPVILTREPGGTPISDAVRRLVLDGQWTAM
EEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCC
EPTTETLLFAAARAQLVGEVILPYLKLGGIVLCDRYADSTFAHQGYGLGRNLTELREITR
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHCCCCCCCCHHHHHHHHH
FATGGLQPDLTFFLDLPVEQGLQRKRKQRDDFRESSQLALPLPHLPQPSPSQNEHWNRLD
HHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCH
AREIAYHERVRSGYLEMIAADPQRWQVFDAGIERESLTEQLLLAVQPHLTTIKTLS
HHHHHHHHHHHHHHHHHHHCCCCCEEHHHCCCCHHHHHHHHHHHHCCCHHEHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA