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The map label for this gene is mprA [H]

Identifier: 159896739

GI number: 159896739

Start: 241105

End: 241476

Strand: Reverse

Name: mprA [H]

Synonym: Haur_0206

Alternate gene names: 159896739

Gene position: 241476-241105 (Counterclockwise)

Preceding gene: 159896740

Following gene: 159896738

Centisome position: 3.8

GC content: 47.58

Gene sequence:

>372_bases
ATGCACATTTTATTGGTTGATGACAATCAAGATATTATTCGTTTAGTTCAACAGGTTTTAGCACTGGAAGGCCATCGGGT
TTCGATTGCGCGTGACGGATTGGAAGCATTGCAAAAAGTTGCTAGCCAACGCCCCGATGCAGTGATTCTTGATGTGAATA
TGCCCATGCTCGAAGGCACCGAAGTTTGCCGCCGGATCAAAATGAGCTATAGCATTCCAGTGATGATGCTGACCGTGCGC
TCTGAACAGGTTGATTTTCAACGTGGAGCCGATGCTGGCGCAGATGCCTACCTCTCCAAACCCTTTGACATCCCCGTTTT
CATCGAATACCTCAATGCTATGCTGCGTTTGCGCTATGGCAAAACCCACTAA

Upstream 100 bases:

>100_bases
CCTGTGTCACAGCCAAAAACAGGACTTTTGGGGGATACTTCATCACCATCGTGGGGGACATGCTGAGTATAATGGCTCCA
TTGCACTTTTTGGAGGCCGT

Downstream 100 bases:

>100_bases
CCAAGGCTATGGGCTGGCTGGCGCTCAGGATTTAGACTGAGCTTAGGTCAACATTCGGCCTGATGCTTGAGCATGCCGCT
TTTCAGTATAGTGGTTGTAG

Product: response regulator receiver protein

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 123; Mature: 123

Protein sequence:

>123_residues
MHILLVDDNQDIIRLVQQVLALEGHRVSIARDGLEALQKVASQRPDAVILDVNMPMLEGTEVCRRIKMSYSIPVMMLTVR
SEQVDFQRGADAGADAYLSKPFDIPVFIEYLNAMLRLRYGKTH

Sequences:

>Translated_123_residues
MHILLVDDNQDIIRLVQQVLALEGHRVSIARDGLEALQKVASQRPDAVILDVNMPMLEGTEVCRRIKMSYSIPVMMLTVR
SEQVDFQRGADAGADAYLSKPFDIPVFIEYLNAMLRLRYGKTH
>Mature_123_residues
MHILLVDDNQDIIRLVQQVLALEGHRVSIARDGLEALQKVASQRPDAVILDVNMPMLEGTEVCRRIKMSYSIPVMMLTVR
SEQVDFQRGADAGADAYLSKPFDIPVFIEYLNAMLRLRYGKTH

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786911, Length=121, Percent_Identity=37.1900826446281, Blast_Score=79, Evalue=1e-16,
Organism=Escherichia coli, GI1790860, Length=101, Percent_Identity=41.5841584158416, Blast_Score=78, Evalue=1e-16,
Organism=Escherichia coli, GI2367329, Length=114, Percent_Identity=36.8421052631579, Blast_Score=69, Evalue=1e-13,
Organism=Escherichia coli, GI87082012, Length=116, Percent_Identity=32.7586206896552, Blast_Score=68, Evalue=2e-13,
Organism=Escherichia coli, GI1786599, Length=117, Percent_Identity=34.1880341880342, Blast_Score=66, Evalue=6e-13,
Organism=Escherichia coli, GI1788191, Length=120, Percent_Identity=32.5, Blast_Score=64, Evalue=3e-12,
Organism=Escherichia coli, GI1790863, Length=102, Percent_Identity=33.3333333333333, Blast_Score=63, Evalue=6e-12,
Organism=Escherichia coli, GI145693157, Length=112, Percent_Identity=33.9285714285714, Blast_Score=63, Evalue=6e-12,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=33.0434782608696, Blast_Score=62, Evalue=1e-11,
Organism=Escherichia coli, GI1787375, Length=121, Percent_Identity=31.404958677686, Blast_Score=61, Evalue=2e-11,
Organism=Escherichia coli, GI1788394, Length=114, Percent_Identity=28.9473684210526, Blast_Score=60, Evalue=3e-11,
Organism=Escherichia coli, GI1788550, Length=103, Percent_Identity=31.0679611650485, Blast_Score=60, Evalue=4e-11,
Organism=Escherichia coli, GI1790299, Length=103, Percent_Identity=32.0388349514563, Blast_Score=60, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 13942; Mature: 13942

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHILLVDDNQDIIRLVQQVLALEGHRVSIARDGLEALQKVASQRPDAVILDVNMPMLEGT
CEEEEEECCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHH
EVCRRIKMSYSIPVMMLTVRSEQVDFQRGADAGADAYLSKPFDIPVFIEYLNAMLRLRYG
HHHHHHHHCCCCCEEEEEECCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
KTH
CCC
>Mature Secondary Structure
MHILLVDDNQDIIRLVQQVLALEGHRVSIARDGLEALQKVASQRPDAVILDVNMPMLEGT
CEEEEEECCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHH
EVCRRIKMSYSIPVMMLTVRSEQVDFQRGADAGADAYLSKPFDIPVFIEYLNAMLRLRYG
HHHHHHHHCCCCCEEEEEECCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
KTH
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA