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The map label for this gene is liaR [H]

Identifier: 159896628

GI number: 159896628

Start: 121695

End: 122441

Strand: Direct

Name: liaR [H]

Synonym: Haur_0095

Alternate gene names: 159896628

Gene position: 121695-122441 (Clockwise)

Preceding gene: 159896626

Following gene: 159896629

Centisome position: 1.92

GC content: 51.67

Gene sequence:

>747_bases
ATGCAGACAATCCAAACATTGGTGGTTGAAGATCATCCGGCATTGCGGGCGGCGATGGTTGCTGGGTTGCAGGCTACCAA
AGAGATAACCGTGATTGGCGAGGCTGGTAGCGGCGAGGATGCAATTGAATGGTGTGCTCAACATACGCCGCAAGCTATTT
TGATGGATGTGGCCTTGGCCAGTGAACTTAATGGCATTCAAGCAGCAGTGATTATTCGCCGTGAGCATCCGCGGATTCCA
GTGGTGTTTTATTCGATCCAAGATGATGATGCCTATTATCGCGATTTCCAGCGTTCGGGCATTCTAAGTCACTATGCGTA
TGTGCGCAAAAGCAATTATTTACTACCAGCGATGGTTGCCCCACTGCTGCGCGATGCCTTTCAAGGTCGGGCTTTTATCG
ACCCCGATATTGCTAGTCGGGTGCAAGAAGTTCGCCACCGTGATGAGCAATCGGCGCTTGATTTGCTTGAGCCTGCCGAG
CGCGAAGTGATGACCTTGGTGGCCCATGGCTTTACCAACGATCAAATTGCCCAGCGCTTGGGTTTTCGTGATGCCCGTGC
AGTCAGCCGCATCAATGGCCAAATTTACACGGCCTGGGGTTTGAATGAAAATACAACCGATGAAAAAGTAGCGCGTACTC
GGGCAACGATTATTTTTCACGAGCGCCAACTGATTGTCTGGGATGAAGAAGGACGCGGGCGGGCCTATATGCCCGATGGT
CAGTGGCAAGCACGCTGGAACGATTAA

Upstream 100 bases:

>100_bases
CCCCAATAATTAAAAGATTAACATGGCTTTGCACTTAATTGCTTGACACAAAGATTAAGGTTGAGCATATATTTGATGAT
AATTGGCTAAGGATTCTCCC

Downstream 100 bases:

>100_bases
GCAAATTGCCAATTTGTTGCATATAATGTGCTATACATACGAGTTTACCCATGTGATGGGAGATTAAGATGCTTGATCAA
TCTGTTGTTGAAGAGCAGCC

Product: response regulator receiver protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MQTIQTLVVEDHPALRAAMVAGLQATKEITVIGEAGSGEDAIEWCAQHTPQAILMDVALASELNGIQAAVIIRREHPRIP
VVFYSIQDDDAYYRDFQRSGILSHYAYVRKSNYLLPAMVAPLLRDAFQGRAFIDPDIASRVQEVRHRDEQSALDLLEPAE
REVMTLVAHGFTNDQIAQRLGFRDARAVSRINGQIYTAWGLNENTTDEKVARTRATIIFHERQLIVWDEEGRGRAYMPDG
QWQARWND

Sequences:

>Translated_248_residues
MQTIQTLVVEDHPALRAAMVAGLQATKEITVIGEAGSGEDAIEWCAQHTPQAILMDVALASELNGIQAAVIIRREHPRIP
VVFYSIQDDDAYYRDFQRSGILSHYAYVRKSNYLLPAMVAPLLRDAFQGRAFIDPDIASRVQEVRHRDEQSALDLLEPAE
REVMTLVAHGFTNDQIAQRLGFRDARAVSRINGQIYTAWGLNENTTDEKVARTRATIIFHERQLIVWDEEGRGRAYMPDG
QWQARWND
>Mature_248_residues
MQTIQTLVVEDHPALRAAMVAGLQATKEITVIGEAGSGEDAIEWCAQHTPQAILMDVALASELNGIQAAVIIRREHPRIP
VVFYSIQDDDAYYRDFQRSGILSHYAYVRKSNYLLPAMVAPLLRDAFQGRAFIDPDIASRVQEVRHRDEQSALDLLEPAE
REVMTLVAHGFTNDQIAQRLGFRDARAVSRINGQIYTAWGLNENTTDEKVARTRATIIFHERQLIVWDEEGRGRAYMPDG
QWQARWND

Specific function: Member of the two-component regulatory system liaS/liaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=181, Percent_Identity=24.8618784530387, Blast_Score=72, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 28101; Mature: 28101

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTIQTLVVEDHPALRAAMVAGLQATKEITVIGEAGSGEDAIEWCAQHTPQAILMDVALA
CCCHHEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHH
SELNGIQAAVIIRREHPRIPVVFYSIQDDDAYYRDFQRSGILSHYAYVRKSNYLLPAMVA
HHCCCCEEEEEEECCCCCCCEEEEEECCCCHHHHHHHHCCHHHHHHHHHCCCCCHHHHHH
PLLRDAFQGRAFIDPDIASRVQEVRHRDEQSALDLLEPAEREVMTLVAHGFTNDQIAQRL
HHHHHHHCCCCEECHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHHHHHCCCCCHHHHHHH
GFRDARAVSRINGQIYTAWGLNENTTDEKVARTRATIIFHERQLIVWDEEGRGRAYMPDG
CCHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHEEEEEECCEEEEECCCCCCCEECCCC
QWQARWND
CEECCCCC
>Mature Secondary Structure
MQTIQTLVVEDHPALRAAMVAGLQATKEITVIGEAGSGEDAIEWCAQHTPQAILMDVALA
CCCHHEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHH
SELNGIQAAVIIRREHPRIPVVFYSIQDDDAYYRDFQRSGILSHYAYVRKSNYLLPAMVA
HHCCCCEEEEEEECCCCCCCEEEEEECCCCHHHHHHHHCCHHHHHHHHHCCCCCHHHHHH
PLLRDAFQGRAFIDPDIASRVQEVRHRDEQSALDLLEPAEREVMTLVAHGFTNDQIAQRL
HHHHHHHCCCCEECHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHHHHHCCCCCHHHHHHH
GFRDARAVSRINGQIYTAWGLNENTTDEKVARTRATIIFHERQLIVWDEEGRGRAYMPDG
CCHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHEEEEEECCEEEEECCCCCCCEECCCC
QWQARWND
CEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]