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The map label for this gene is 159041956

Identifier: 159041956

GI number: 159041956

Start: 1469888

End: 1471861

Strand: Reverse

Name: 159041956

Synonym: Cmaq_1392

Alternate gene names: NA

Gene position: 1471861-1469888 (Counterclockwise)

Preceding gene: 159041958

Following gene: 159041955

Centisome position: 70.85

GC content: 49.19

Gene sequence:

>1974_bases
ATGGGTTGTATGGTTATTGTTGCTGTTGATGTTGGTGGTACTTTTACGGATTTCGTTACTTTAAGTGATGACGGTTCAAT
AGAATCCTTTAAGGTTCTTAGTACACCTAGGAATCCTGAGGCAGCAGTATTAGGGGGTCTTAGGAGGATTAATGCCCGTA
TTGATGAGGTCCTGCATGCAACCACAATTGGGACAAATGCCCTATTGGGTCAGGTGGGTCTTGAGTTGCCTAAGGTTGCC
TTATTCACCACTAAGGGTTTTAGGGATGTTATTGAGATTGGGCGTCAGAATAGGCCTAGGCTCTATGACTTATTCTTCGA
GAAGCCTAAGCCCCTTGTACCCAGGGAGCTTAGGTTTGAGATTGAGGAGAGGACGTTAGCTAACGGTGAGGTGGTTAAGG
AGGTTAACCCACGTGAGGTTGAGGAGTATGCTGTTAAGGCTAAGTCCCTTGGCGTAAACTCAGTTGCAGTATCTTACCTG
CACTCATACATTAATCCACGTAATGAGGAGATTACAGGCAGTGTATTAGGCAGGTACTTTAACTACGTAGCCTTATCAAG
TAAAATTGCCCCAGAGCCTAGGGAGTATGAAAGAACCTCCACAGCGGTCGTTAATGCTGCCTTAATGCCCATTGTTAGCC
AGTACATTAATGAGTTTTCCAAGGGCCTTAGGGAGCTGGGTATTGATAAGTTCTTCATAATGTCCAGTTCAGGAGGCCTA
GTGGATAGTGATGAAGCCACTCAGAGGCCTGTTCAATTAATTGAATCAGGCCCAGCAGCCGGCGCCGTGGCCGCTGCGGA
ATTCTCAAGGATTATTAGTGTTAGGAATGTTATTGGATTCGACATGGGTGGGACCACGGCGAAGGCATCATCCATAGTTA
ACCATGAACCCGAGGTAACCACGGAGTATGAGGTCGGCGGTGAGGTTCACCATGGGAGACTAGTTAAGGGCAGCGGTTAC
CCGGTGAGATTCCCATTCATAGACCTTGCTGAAGTATCCTCAGGTGGTGGTACAATTATTTGGCGTGATGAAGCCGGCGC
CTTAAGGGTTGGGCCATTGAGCGCGGGTGCTGATCCTGGGCCAATATGCTACGATAAGGGTGGTGTGGAGCCAACGCTCA
CTGATGCTAACCTAGCCCTAGGTAGAATTGGGGATTACCTCCTTGGTGGTGAAATGAAGCTGAATAAGGAAGGCGCCATC
AAAGGGCTGCGTAGACTGGGTGATCCAATTGATGTTGCTCTCAACGCCATTAAACTCGCTAATATTGAGATGGCCAGGGC
AGTGAGGCTTGTTACAGTGGAGAGGGGGCTTAATCCAGGGGATTTTGCATTAATGGCATTCGGTGGTGCTGGTCCCCAGC
ACTCTGCTGAGATTGCTGAGGAATTAGGGGTAAGCACCATTATTGTGCCACCGGAGCCTGGTGCTTTTTCCGCTCTTGGT
TTATTAATGGCTGATGAGAAGTTTGAGGTGAGGATGTCGTATCCAAGGGATTTAGAGGAGGGTTTTATGAAGCTGGAGGA
TGAGTTAAGCCAGAGGCTTGGCAAGGTGTCTTACTTCCTCAGGTACGCTGACGTTAGGTACAGGGGGCAGGGCTGGGAAT
TAACCATACCAGTGAATAGGCCTGCTAGGATTGAGGACGTGGAGAGGACCTTTAATGATAAGCACCAGGCAACCTACGGG
TTTAGGTTGAGTAAGCCTATTGAGGTTGTTACCATAAGGGTCTTCGCGGTGGTAACAAGGTTGAAGCCTAGGTTCAAGGT
GAAGAACCTGGGGGGTGAGGCTAAGCCAAGGGGCTTTAGGAGAGTCTTCTTTAATGAGTGGGTTGAAGCACCCGTTTACT
GGCGTGGCGACATACCCATGGGGCAGGTGATTGAGGGACCAGCCGTAATTGAGGAGTATGGTTCAACAATAGTGGTGCCG
CCTAGGTGGAGGGCTGAGGTTGGTGGGAATGCGGAGGTGATTATGAGGAGGTGA

Upstream 100 bases:

>100_bases
GAAACCCATGTTAGTATATAACGGTACTCCTGGTGATAGTACTTCCCACTTATGCATTTTATTGATGTGAGGGAAAAAGA
TATAAACTTATTGCGTCTCC

Downstream 100 bases:

>100_bases
CGCCATGGTATCCTGGGAAATAATCTACAGGGCATCAGTATTCATAGCTGAGGAAATGGGTGTGGCATTGAAGCGCTCGG
CCTTTTCCCCAAATATCCGT

Product: 5-oxoprolinase

Products: ADP; phosphate; N-carbamoylsarcosine

Alternate protein names: NA

Number of amino acids: Translated: 657; Mature: 656

Protein sequence:

>657_residues
MGCMVIVAVDVGGTFTDFVTLSDDGSIESFKVLSTPRNPEAAVLGGLRRINARIDEVLHATTIGTNALLGQVGLELPKVA
LFTTKGFRDVIEIGRQNRPRLYDLFFEKPKPLVPRELRFEIEERTLANGEVVKEVNPREVEEYAVKAKSLGVNSVAVSYL
HSYINPRNEEITGSVLGRYFNYVALSSKIAPEPREYERTSTAVVNAALMPIVSQYINEFSKGLRELGIDKFFIMSSSGGL
VDSDEATQRPVQLIESGPAAGAVAAAEFSRIISVRNVIGFDMGGTTAKASSIVNHEPEVTTEYEVGGEVHHGRLVKGSGY
PVRFPFIDLAEVSSGGGTIIWRDEAGALRVGPLSAGADPGPICYDKGGVEPTLTDANLALGRIGDYLLGGEMKLNKEGAI
KGLRRLGDPIDVALNAIKLANIEMARAVRLVTVERGLNPGDFALMAFGGAGPQHSAEIAEELGVSTIIVPPEPGAFSALG
LLMADEKFEVRMSYPRDLEEGFMKLEDELSQRLGKVSYFLRYADVRYRGQGWELTIPVNRPARIEDVERTFNDKHQATYG
FRLSKPIEVVTIRVFAVVTRLKPRFKVKNLGGEAKPRGFRRVFFNEWVEAPVYWRGDIPMGQVIEGPAVIEEYGSTIVVP
PRWRAEVGGNAEVIMRR

Sequences:

>Translated_657_residues
MGCMVIVAVDVGGTFTDFVTLSDDGSIESFKVLSTPRNPEAAVLGGLRRINARIDEVLHATTIGTNALLGQVGLELPKVA
LFTTKGFRDVIEIGRQNRPRLYDLFFEKPKPLVPRELRFEIEERTLANGEVVKEVNPREVEEYAVKAKSLGVNSVAVSYL
HSYINPRNEEITGSVLGRYFNYVALSSKIAPEPREYERTSTAVVNAALMPIVSQYINEFSKGLRELGIDKFFIMSSSGGL
VDSDEATQRPVQLIESGPAAGAVAAAEFSRIISVRNVIGFDMGGTTAKASSIVNHEPEVTTEYEVGGEVHHGRLVKGSGY
PVRFPFIDLAEVSSGGGTIIWRDEAGALRVGPLSAGADPGPICYDKGGVEPTLTDANLALGRIGDYLLGGEMKLNKEGAI
KGLRRLGDPIDVALNAIKLANIEMARAVRLVTVERGLNPGDFALMAFGGAGPQHSAEIAEELGVSTIIVPPEPGAFSALG
LLMADEKFEVRMSYPRDLEEGFMKLEDELSQRLGKVSYFLRYADVRYRGQGWELTIPVNRPARIEDVERTFNDKHQATYG
FRLSKPIEVVTIRVFAVVTRLKPRFKVKNLGGEAKPRGFRRVFFNEWVEAPVYWRGDIPMGQVIEGPAVIEEYGSTIVVP
PRWRAEVGGNAEVIMRR
>Mature_656_residues
GCMVIVAVDVGGTFTDFVTLSDDGSIESFKVLSTPRNPEAAVLGGLRRINARIDEVLHATTIGTNALLGQVGLELPKVAL
FTTKGFRDVIEIGRQNRPRLYDLFFEKPKPLVPRELRFEIEERTLANGEVVKEVNPREVEEYAVKAKSLGVNSVAVSYLH
SYINPRNEEITGSVLGRYFNYVALSSKIAPEPREYERTSTAVVNAALMPIVSQYINEFSKGLRELGIDKFFIMSSSGGLV
DSDEATQRPVQLIESGPAAGAVAAAEFSRIISVRNVIGFDMGGTTAKASSIVNHEPEVTTEYEVGGEVHHGRLVKGSGYP
VRFPFIDLAEVSSGGGTIIWRDEAGALRVGPLSAGADPGPICYDKGGVEPTLTDANLALGRIGDYLLGGEMKLNKEGAIK
GLRRLGDPIDVALNAIKLANIEMARAVRLVTVERGLNPGDFALMAFGGAGPQHSAEIAEELGVSTIIVPPEPGAFSALGL
LMADEKFEVRMSYPRDLEEGFMKLEDELSQRLGKVSYFLRYADVRYRGQGWELTIPVNRPARIEDVERTFNDKHQATYGF
RLSKPIEVVTIRVFAVVTRLKPRFKVKNLGGEAKPRGFRRVFFNEWVEAPVYWRGDIPMGQVIEGPAVIEEYGSTIVVPP
RWRAEVGGNAEVIMRR

Specific function: Unknown

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=734, Percent_Identity=30.1089918256131, Blast_Score=221, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI133901900, Length=726, Percent_Identity=28.9256198347107, Blast_Score=218, Evalue=6e-57,
Organism=Saccharomyces cerevisiae, GI6322634, Length=750, Percent_Identity=29.0666666666667, Blast_Score=239, Evalue=8e-64,
Organism=Drosophila melanogaster, GI45550492, Length=748, Percent_Identity=31.0160427807487, Blast_Score=243, Evalue=4e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: 3.5.2.14

Molecular weight: Translated: 71957; Mature: 71826

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGCMVIVAVDVGGTFTDFVTLSDDGSIESFKVLSTPRNPEAAVLGGLRRINARIDEVLHA
CCEEEEEEEECCCCEEEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
TTIGTNALLGQVGLELPKVALFTTKGFRDVIEIGRQNRPRLYDLFFEKPKPLVPRELRFE
HHCCCHHHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCCEEEEHHHCCCCCCCCHHHHEE
IEERTLANGEVVKEVNPREVEEYAVKAKSLGVNSVAVSYLHSYINPRNEEITGSVLGRYF
EHHHCCCCCCEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
NYVALSSKIAPEPREYERTSTAVVNAALMPIVSQYINEFSKGLRELGIDKFFIMSSSGGL
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
VDSDEATQRPVQLIESGPAAGAVAAAEFSRIISVRNVIGFDMGGTTAKASSIVNHEPEVT
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHCCCCCCE
TEYEVGGEVHHGRLVKGSGYPVRFPFIDLAEVSSGGGTIIWRDEAGALRVGPLSAGADPG
EEEECCCEEECCEEEECCCCEEEECCEEHHHCCCCCCEEEEECCCCEEEECCCCCCCCCC
PICYDKGGVEPTLTDANLALGRIGDYLLGGEMKLNKEGAIKGLRRLGDPIDVALNAIKLA
CEEECCCCCCCEECCCCHHHHHHCCCCCCCCEEECCHHHHHHHHHCCCHHHHHHHHHHEE
NIEMARAVRLVTVERGLNPGDFALMAFGGAGPQHSAEIAEELGVSTIIVPPEPGAFSALG
CHHHHHHEEEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHCCCEEEEECCCCCCHHHHH
LLMADEKFEVRMSYPRDLEEGFMKLEDELSQRLGKVSYFLRYADVRYRGQGWELTIPVNR
HHEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCEEEEEECCC
PARIEDVERTFNDKHQATYGFRLSKPIEVVTIRVFAVVTRLKPRFKVKNLGGEAKPRGFR
CCCHHHHHHHHCCCCCEEECEEECCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHH
RVFFNEWVEAPVYWRGDIPMGQVIEGPAVIEEYGSTIVVPPRWRAEVGGNAEVIMRR
HHHHHHHHCCCEEEECCCCCCCEECCCHHHHHCCCEEEECCCCCCCCCCCCEEEEEC
>Mature Secondary Structure 
GCMVIVAVDVGGTFTDFVTLSDDGSIESFKVLSTPRNPEAAVLGGLRRINARIDEVLHA
CEEEEEEEECCCCEEEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
TTIGTNALLGQVGLELPKVALFTTKGFRDVIEIGRQNRPRLYDLFFEKPKPLVPRELRFE
HHCCCHHHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCCEEEEHHHCCCCCCCCHHHHEE
IEERTLANGEVVKEVNPREVEEYAVKAKSLGVNSVAVSYLHSYINPRNEEITGSVLGRYF
EHHHCCCCCCEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
NYVALSSKIAPEPREYERTSTAVVNAALMPIVSQYINEFSKGLRELGIDKFFIMSSSGGL
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
VDSDEATQRPVQLIESGPAAGAVAAAEFSRIISVRNVIGFDMGGTTAKASSIVNHEPEVT
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHCCCCCCE
TEYEVGGEVHHGRLVKGSGYPVRFPFIDLAEVSSGGGTIIWRDEAGALRVGPLSAGADPG
EEEECCCEEECCEEEECCCCEEEECCEEHHHCCCCCCEEEEECCCCEEEECCCCCCCCCC
PICYDKGGVEPTLTDANLALGRIGDYLLGGEMKLNKEGAIKGLRRLGDPIDVALNAIKLA
CEEECCCCCCCEECCCCHHHHHHCCCCCCCCEEECCHHHHHHHHHCCCHHHHHHHHHHEE
NIEMARAVRLVTVERGLNPGDFALMAFGGAGPQHSAEIAEELGVSTIIVPPEPGAFSALG
CHHHHHHEEEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHCCCEEEEECCCCCCHHHHH
LLMADEKFEVRMSYPRDLEEGFMKLEDELSQRLGKVSYFLRYADVRYRGQGWELTIPVNR
HHEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCEEEEEECCC
PARIEDVERTFNDKHQATYGFRLSKPIEVVTIRVFAVVTRLKPRFKVKNLGGEAKPRGFR
CCCHHHHHHHHCCCCCEEECEEECCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHH
RVFFNEWVEAPVYWRGDIPMGQVIEGPAVIEEYGSTIVVPPRWRAEVGGNAEVIMRR
HHHHHHHHCCCEEEECCCCCCCEECCCHHHHHCCCEEEECCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; N-methylimidazolidine-2,4-dione; H2O

Specific reaction: ATP + N-methylimidazolidine-2,4-dione + 2 H2O = ADP + phosphate + N-carbamoylsarcosine

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]