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The map label for this gene is guaAB [H]

Identifier: 159041767

GI number: 159041767

Start: 1266861

End: 1267994

Strand: Reverse

Name: guaAB [H]

Synonym: Cmaq_1202

Alternate gene names: 159041767

Gene position: 1267994-1266861 (Counterclockwise)

Preceding gene: 159041768

Following gene: 159041766

Centisome position: 61.03

GC content: 44.36

Gene sequence:

>1134_bases
ATGTTCACCCCCGAGGAATTCATAAGAACCATTACAGGAGAGGTACGGAAACTTGAGGTTAAGTGCGCCGTCGCCGCGGT
GAGCGGCGGTGTGGATAGCACCACCAGTGCCGTGGTTGCTAGATTAGCCCTTGGTGATAGGTTAATACCAGTGTTGTTTG
ATACAGGATTCATGAGGCTTAATGAAACCAGTGAAATAATTAACAGTTTAACTGAATTACTACCTATTAGGCTTATTGAT
GTTAAGGATGAGTTCTATAGGGCAATGATTAATTTAAGTGATGCCGAGGAGAAGAGGCTTACCTTCAGGAACGTTTTCTA
CAATGCATTATCAAGGGTGGTTAAGGATAATGACTGTGACTGGGTTGTACAGGGAACAATAGCCCCTGATTGGATTGAAA
CCACAGGGGGCATTAAGACTCAACATAATGTACTTGCCCAATTGGGTATTGAGACCGATAAGGTTTACGGATTCAAGCTA
CTGGAGCCTCTGAAGGATCTTTATAAGGATCAAGTGAGGGCACTTGCAAGATACTTGAAGATACCCAGTGCAATAACTGA
GAGGCAGCCCTTCCCTGGCCCTGGCTTAAGCATAAGGGCTGTGGGTAAGTTAACCATGGAGAAGCTTGAGGTCACCAGGT
GGTCAACCAGGGTTGTTGAGGAGGGGCTTAGTGGCTTAGGTTTAAGTCAATGGTTTGCAGCCGTCTGGGAGGATGATAGG
GTTACTGATGAAGAGTTAAGCAGTGTGATTAGGGGAATGGGTGAGAACTTAACGGTTGACGTGTTCAGCGTTAAGGGTAC
TGGAGTTAAAGGTGATTCAAGGGAATACGGTAGAGTGGTGTTGGTTAGGGGTAAGTTAAGTAACTGGAGTAATGCCTTTA
CCCTATACAGTAAATTAACCTACGGCACCAACGTAACCCACGTGATTTATGAATTAGCCAGGAGGAGGCCTAGCGGTGGA
TACTTCGTTGCAGTAAGGGCTGTGGTAACTGATGACTACATGACGGCTAATGTACCTACACTTAATGAGCAATTATTAAG
GAATATAGCTAATGAATTAATGAGAAGTGAATTAATTAGCGCCGTAGGAATTGATGTAACCCCAAAACCACCAGCAACAA
TAGAATTTGAGTAA

Upstream 100 bases:

>100_bases
AGGTGTTGCTCCTTAATTATTATTGTGTTTATTTAAATAAATTAAGAAAATACCGGGTACTTTAACGCAATGTTTAAATC
ACGGTAAGCAAAGTAGGCTT

Downstream 100 bases:

>100_bases
GCAATATTAATTAATAATTCATTAACACTTCTATGGTCTGAATCTAGTTAGGGAGGGATATTGGTGAATTCGCAGTATTA
ATTAAGTGATAATGGGAGGC

Product: GMP synthase domain-containing protein

Products: NA

Alternate protein names: GMP synthetase [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MFTPEEFIRTITGEVRKLEVKCAVAAVSGGVDSTTSAVVARLALGDRLIPVLFDTGFMRLNETSEIINSLTELLPIRLID
VKDEFYRAMINLSDAEEKRLTFRNVFYNALSRVVKDNDCDWVVQGTIAPDWIETTGGIKTQHNVLAQLGIETDKVYGFKL
LEPLKDLYKDQVRALARYLKIPSAITERQPFPGPGLSIRAVGKLTMEKLEVTRWSTRVVEEGLSGLGLSQWFAAVWEDDR
VTDEELSSVIRGMGENLTVDVFSVKGTGVKGDSREYGRVVLVRGKLSNWSNAFTLYSKLTYGTNVTHVIYELARRRPSGG
YFVAVRAVVTDDYMTANVPTLNEQLLRNIANELMRSELISAVGIDVTPKPPATIEFE

Sequences:

>Translated_377_residues
MFTPEEFIRTITGEVRKLEVKCAVAAVSGGVDSTTSAVVARLALGDRLIPVLFDTGFMRLNETSEIINSLTELLPIRLID
VKDEFYRAMINLSDAEEKRLTFRNVFYNALSRVVKDNDCDWVVQGTIAPDWIETTGGIKTQHNVLAQLGIETDKVYGFKL
LEPLKDLYKDQVRALARYLKIPSAITERQPFPGPGLSIRAVGKLTMEKLEVTRWSTRVVEEGLSGLGLSQWFAAVWEDDR
VTDEELSSVIRGMGENLTVDVFSVKGTGVKGDSREYGRVVLVRGKLSNWSNAFTLYSKLTYGTNVTHVIYELARRRPSGG
YFVAVRAVVTDDYMTANVPTLNEQLLRNIANELMRSELISAVGIDVTPKPPATIEFE
>Mature_377_residues
MFTPEEFIRTITGEVRKLEVKCAVAAVSGGVDSTTSAVVARLALGDRLIPVLFDTGFMRLNETSEIINSLTELLPIRLID
VKDEFYRAMINLSDAEEKRLTFRNVFYNALSRVVKDNDCDWVVQGTIAPDWIETTGGIKTQHNVLAQLGIETDKVYGFKL
LEPLKDLYKDQVRALARYLKIPSAITERQPFPGPGLSIRAVGKLTMEKLEVTRWSTRVVEEGLSGLGLSQWFAAVWEDDR
VTDEELSSVIRGMGENLTVDVFSVKGTGVKGDSREYGRVVLVRGKLSNWSNAFTLYSKLTYGTNVTHVIYELARRRPSGG
YFVAVRAVVTDDYMTANVPTLNEQLLRNIANELMRSELISAVGIDVTPKPPATIEFE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=331, Percent_Identity=27.190332326284, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1788854, Length=389, Percent_Identity=28.7917737789203, Blast_Score=137, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI71992717, Length=348, Percent_Identity=30.1724137931034, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71992710, Length=348, Percent_Identity=30.1724137931034, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI133901714, Length=348, Percent_Identity=30.1724137931034, Blast_Score=112, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6323873, Length=397, Percent_Identity=31.7380352644836, Blast_Score=166, Evalue=4e-42,
Organism=Drosophila melanogaster, GI281365319, Length=399, Percent_Identity=29.3233082706767, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001674
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 42065; Mature: 42065

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTPEEFIRTITGEVRKLEVKCAVAAVSGGVDSTTSAVVARLALGDRLIPVLFDTGFMRL
CCCHHHHHHHHHCHHHEEEEEEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHCCCCEEE
NETSEIINSLTELLPIRLIDVKDEFYRAMINLSDAEEKRLTFRNVFYNALSRVVKDNDCD
CCHHHHHHHHHHHHCEEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
WVVQGTIAPDWIETTGGIKTQHNVLAQLGIETDKVYGFKLLEPLKDLYKDQVRALARYLK
EEEECCCCCCHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IPSAITERQPFPGPGLSIRAVGKLTMEKLEVTRWSTRVVEEGLSGLGLSQWFAAVWEDDR
CCHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
VTDEELSSVIRGMGENLTVDVFSVKGTGVKGDSREYGRVVLVRGKLSNWSNAFTLYSKLT
CCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHH
YGTNVTHVIYELARRRPSGGYFVAVRAVVTDDYMTANVPTLNEQLLRNIANELMRSELIS
CCCCHHHHHHHHHHCCCCCCEEEEEEEEEECCCEECCCCCHHHHHHHHHHHHHHHHHHHH
AVGIDVTPKPPATIEFE
HHCCCCCCCCCCEEECC
>Mature Secondary Structure
MFTPEEFIRTITGEVRKLEVKCAVAAVSGGVDSTTSAVVARLALGDRLIPVLFDTGFMRL
CCCHHHHHHHHHCHHHEEEEEEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHCCCCEEE
NETSEIINSLTELLPIRLIDVKDEFYRAMINLSDAEEKRLTFRNVFYNALSRVVKDNDCD
CCHHHHHHHHHHHHCEEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
WVVQGTIAPDWIETTGGIKTQHNVLAQLGIETDKVYGFKLLEPLKDLYKDQVRALARYLK
EEEECCCCCCHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IPSAITERQPFPGPGLSIRAVGKLTMEKLEVTRWSTRVVEEGLSGLGLSQWFAAVWEDDR
CCHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
VTDEELSSVIRGMGENLTVDVFSVKGTGVKGDSREYGRVVLVRGKLSNWSNAFTLYSKLT
CCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHH
YGTNVTHVIYELARRRPSGGYFVAVRAVVTDDYMTANVPTLNEQLLRNIANELMRSELIS
CCCCHHHHHHHHHHCCCCCCEEEEEEEEEECCCEECCCCCHHHHHHHHHHHHHHHHHHHH
AVGIDVTPKPPATIEFE
HHCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]