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The map label for this gene is tyrS1 [H]

Identifier: 159041466

GI number: 159041466

Start: 935179

End: 936303

Strand: Reverse

Name: tyrS1 [H]

Synonym: Cmaq_0894

Alternate gene names: 159041466

Gene position: 936303-935179 (Counterclockwise)

Preceding gene: 159041472

Following gene: 159041464

Centisome position: 45.07

GC content: 44.98

Gene sequence:

>1125_bases
GTGATGGATGTTGAGGATAAGGTTAACCTAGCCCTAAAGTACCCCACTGAGGAGTTATTGACAGTGGAGGAGTTGAGGAG
TTACTTTGAGACCGGTGAAACCCTTAAGCATTACATAGGCTTTGAGATATCAGGCTACATTCACATAGGCACTGGGGTGG
TGAGTATGTATAAGTTGGTTGACTTACAGAAGGCTGGGGTTAAGGTATCCATCCTACTGGCTGATTTACATTCCTGGCTG
AACCATAAACTGGGCGGTGACCTAGAGGTTATTAGGAAAGTGGCTGTGACTTACTTTAAGGAGACGTTGAGGAAGTCCAT
TAGTGTACTTGGCGGTGACCCGGATTCAGTGGACTTCATACTTGCATCTAATCTTACTGAGGAGAAGCGTGAATACTGGG
TTCAGGTCCTTGACCTGGCTAGGCAAGTATCATTATCTGACGTTAGGCATAGTTTAACCATAATGGGTAGGACATTCACT
AATTCAGCTAAGATGTCTTGGTTAATATACCCGTTAATGCAGGTTATTGATGTATACGCCTTGGGAACCCACATTGCGCA
TGGTGGTGTGGATCAAAGGAAGGTCTATGTCCTAGCTAGGGATGTTTACGACAAGGTTAAATTAATGCCACTGACCCTTG
GGGGAAGGGTTGTGAAACCCATAATTCTACTGCATCACTTAATACCTTCATTAACCATGACTGGTAAGGAGAGTAGGCTT
GATTTATCGGAGACTAAGATGAGTAAGTCGAGGCCTGAAACCGCCATATTCCTACACGATTCACCTGATGATGTAGCCCG
GAAGATTAAGAACGCCTACTGCCCACCTAAGATGACTGAGAATAATCCCGTGATTGAACTAGCTAAGTTATTCTCCTTCA
GGGAACCTAGGAGAAGCCCATTCACTGTAAAAAGACCCAGTGAGTACGGTGGCCCAGTGGAGTATTGGACATTCGATGAG
TTAACCAAGGATTACGTCGAGGGGAAGATTCACCCACTGGATCTTAAGAACGCGGTTATTGAGGAGGCTGTTAAATTCCT
GGAGCCTTATTGGAAATGGTTCAGTAATGGTGAAGGAGCCAAGTTGCTCAGCGATATGAGCAGTATGATTAAAGTAACGC
GCTGA

Upstream 100 bases:

>100_bases
AATCCTGGAATTAAACGCCTCACCTGGTTTATTCCACCGTGATGAAGGGGTGCATCATGGTTACGACTAAAATCCTTATT
AAGCTTAGGTTGGTTACTTG

Downstream 100 bases:

>100_bases
TTACATCACGTAGAGTGAACCCACCCATGTTGATTAATGGGGCATACTTAATAACCTTTAAGCCTATTTTAGGATTAGTC
ATGAGGAGTCTAATTAACGC

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase 1; TyrRS 1 [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MMDVEDKVNLALKYPTEELLTVEELRSYFETGETLKHYIGFEISGYIHIGTGVVSMYKLVDLQKAGVKVSILLADLHSWL
NHKLGGDLEVIRKVAVTYFKETLRKSISVLGGDPDSVDFILASNLTEEKREYWVQVLDLARQVSLSDVRHSLTIMGRTFT
NSAKMSWLIYPLMQVIDVYALGTHIAHGGVDQRKVYVLARDVYDKVKLMPLTLGGRVVKPIILLHHLIPSLTMTGKESRL
DLSETKMSKSRPETAIFLHDSPDDVARKIKNAYCPPKMTENNPVIELAKLFSFREPRRSPFTVKRPSEYGGPVEYWTFDE
LTKDYVEGKIHPLDLKNAVIEEAVKFLEPYWKWFSNGEGAKLLSDMSSMIKVTR

Sequences:

>Translated_374_residues
MMDVEDKVNLALKYPTEELLTVEELRSYFETGETLKHYIGFEISGYIHIGTGVVSMYKLVDLQKAGVKVSILLADLHSWL
NHKLGGDLEVIRKVAVTYFKETLRKSISVLGGDPDSVDFILASNLTEEKREYWVQVLDLARQVSLSDVRHSLTIMGRTFT
NSAKMSWLIYPLMQVIDVYALGTHIAHGGVDQRKVYVLARDVYDKVKLMPLTLGGRVVKPIILLHHLIPSLTMTGKESRL
DLSETKMSKSRPETAIFLHDSPDDVARKIKNAYCPPKMTENNPVIELAKLFSFREPRRSPFTVKRPSEYGGPVEYWTFDE
LTKDYVEGKIHPLDLKNAVIEEAVKFLEPYWKWFSNGEGAKLLSDMSSMIKVTR
>Mature_374_residues
MMDVEDKVNLALKYPTEELLTVEELRSYFETGETLKHYIGFEISGYIHIGTGVVSMYKLVDLQKAGVKVSILLADLHSWL
NHKLGGDLEVIRKVAVTYFKETLRKSISVLGGDPDSVDFILASNLTEEKREYWVQVLDLARQVSLSDVRHSLTIMGRTFT
NSAKMSWLIYPLMQVIDVYALGTHIAHGGVDQRKVYVLARDVYDKVKLMPLTLGGRVVKPIILLHHLIPSLTMTGKESRL
DLSETKMSKSRPETAIFLHDSPDDVARKIKNAYCPPKMTENNPVIELAKLFSFREPRRSPFTVKRPSEYGGPVEYWTFDE
LTKDYVEGKIHPLDLKNAVIEEAVKFLEPYWKWFSNGEGAKLLSDMSSMIKVTR

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507947, Length=349, Percent_Identity=31.2320916905444, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI71992775, Length=333, Percent_Identity=29.7297297297297, Blast_Score=91, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6321624, Length=355, Percent_Identity=30.7042253521127, Blast_Score=140, Evalue=4e-34,
Organism=Drosophila melanogaster, GI21357223, Length=335, Percent_Identity=31.9402985074627, Blast_Score=129, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002307
- InterPro:   IPR015624 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 42585; Mature: 42585

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDVEDKVNLALKYPTEELLTVEELRSYFETGETLKHYIGFEISGYIHIGTGVVSMYKLV
CCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEECHHHHHHHHHH
DLQKAGVKVSILLADLHSWLNHKLGGDLEVIRKVAVTYFKETLRKSISVLGGDPDSVDFI
HHHHCCCEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
LASNLTEEKREYWVQVLDLARQVSLSDVRHSLTIMGRTFTNSAKMSWLIYPLMQVIDVYA
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHH
LGTHIAHGGVDQRKVYVLARDVYDKVKLMPLTLGGRVVKPIILLHHLIPSLTMTGKESRL
HHHHHHCCCCCCCEEEEEEHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHCEECCCCCCC
DLSETKMSKSRPETAIFLHDSPDDVARKIKNAYCPPKMTENNPVIELAKLFSFREPRRSP
CHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCC
FTVKRPSEYGGPVEYWTFDELTKDYVEGKIHPLDLKNAVIEEAVKFLEPYWKWFSNGEGA
CEEECCCCCCCCCCEEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCH
KLLSDMSSMIKVTR
HHHHHHHHHHHCCC
>Mature Secondary Structure
MMDVEDKVNLALKYPTEELLTVEELRSYFETGETLKHYIGFEISGYIHIGTGVVSMYKLV
CCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEECHHHHHHHHHH
DLQKAGVKVSILLADLHSWLNHKLGGDLEVIRKVAVTYFKETLRKSISVLGGDPDSVDFI
HHHHCCCEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
LASNLTEEKREYWVQVLDLARQVSLSDVRHSLTIMGRTFTNSAKMSWLIYPLMQVIDVYA
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHH
LGTHIAHGGVDQRKVYVLARDVYDKVKLMPLTLGGRVVKPIILLHHLIPSLTMTGKESRL
HHHHHHCCCCCCCEEEEEEHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHCEECCCCCCC
DLSETKMSKSRPETAIFLHDSPDDVARKIKNAYCPPKMTENNPVIELAKLFSFREPRRSP
CHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCC
FTVKRPSEYGGPVEYWTFDELTKDYVEGKIHPLDLKNAVIEEAVKFLEPYWKWFSNGEGA
CEEECCCCCCCCCCEEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCH
KLLSDMSSMIKVTR
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11792869 [H]