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The map label for this gene is Hgd [H]

Identifier: 159041450

GI number: 159041450

Start: 921482

End: 922336

Strand: Reverse

Name: Hgd [H]

Synonym: Cmaq_0877

Alternate gene names: 159041450

Gene position: 922336-921482 (Counterclockwise)

Preceding gene: 159041452

Following gene: 159041447

Centisome position: 44.4

GC content: 43.63

Gene sequence:

>855_bases
ATGCGAATCTGCGTCATAGGATTAGGTAGAATGGGTAGGGGTATTGCAGTGAACTTATCAAGGAAGGGGCATGAGGTCCT
GGGCTTCGATATTGACCCAAACGCCGCAGGTAGGCTTAGCGGTAGTAATGTAGTGGTGGTTAATGATATGGTTAAGTGCA
CTGATGGTGTTGATTACGTAATCATAGCTGTTCCAACGGGTAGAGAATCAATCAGCGTTATTAGTAATATAGCCAATGCG
GCTAAGGGCATTATACTGGATACAACCACAATGAGCCTTAGTGAATTAAGTAACGTGCTTAAGATTATTGAGGAGAAGAG
GTTAAGGTACCTATCAGTTAGGCTTGAGAAGGGGCCTAGGGAGGCTGAGAGGGGTGAACTCGTACTATACGTGGGTGGTG
ATGAGGGATTGTTTAAGGAGGCGAACAGTATACTAAGCCAAATAGGTACACCGATATACGTTGGTAACCATGAACAAGCC
ACCGCACTTAAACTGATAAGTAACGTAATATTAACCGCCAATACAGTGGTGTTAGCTGAGGTATCAGTTTTAATTCGTAA
ACTGGGGATGGATCCAGATACTGTGGTTAAGGCATTATCCATGGGTGGTTCTGATTCAGCACAATTAAGAACTAGGTTGC
CGTGGATGCTTAAGGGTAATTACGGTGAATCCTTCTCACTAAGATTAGCCAGGGACGTTATAGATAAGGCCCTTGAGTAC
GCACAATCCATCGGTATTCAACTACCCATGACAACCCTGATAGATGAATTACTCAGAATAGCAGAAACCACAGGATACGG
CTCAAAAGACTTCTCAGAAATAGCCGAGGTGCTTAAGGTTAATGAAAAGAAGTGA

Upstream 100 bases:

>100_bases
ATTTAACCATTAGGGAGCCACTGGAGCTTACCTTTAATTGCATTAACGGTCAGGGAATTGACTTGAAAAAATATTAAATA
ATAAAGCCTAATCCGGATCC

Downstream 100 bases:

>100_bases
AATACTTGAAACCATGAGAAAACATTACTGGAAGAATCATGCCTTTTGGATCAATACTTAATCCGTATTTCAAGTACCCT
CCTGAAGTATAATCCAGTAA

Product: NAD-binding 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MRICVIGLGRMGRGIAVNLSRKGHEVLGFDIDPNAAGRLSGSNVVVVNDMVKCTDGVDYVIIAVPTGRESISVISNIANA
AKGIILDTTTMSLSELSNVLKIIEEKRLRYLSVRLEKGPREAERGELVLYVGGDEGLFKEANSILSQIGTPIYVGNHEQA
TALKLISNVILTANTVVLAEVSVLIRKLGMDPDTVVKALSMGGSDSAQLRTRLPWMLKGNYGESFSLRLARDVIDKALEY
AQSIGIQLPMTTLIDELLRIAETTGYGSKDFSEIAEVLKVNEKK

Sequences:

>Translated_284_residues
MRICVIGLGRMGRGIAVNLSRKGHEVLGFDIDPNAAGRLSGSNVVVVNDMVKCTDGVDYVIIAVPTGRESISVISNIANA
AKGIILDTTTMSLSELSNVLKIIEEKRLRYLSVRLEKGPREAERGELVLYVGGDEGLFKEANSILSQIGTPIYVGNHEQA
TALKLISNVILTANTVVLAEVSVLIRKLGMDPDTVVKALSMGGSDSAQLRTRLPWMLKGNYGESFSLRLARDVIDKALEY
AQSIGIQLPMTTLIDELLRIAETTGYGSKDFSEIAEVLKVNEKK
>Mature_284_residues
MRICVIGLGRMGRGIAVNLSRKGHEVLGFDIDPNAAGRLSGSNVVVVNDMVKCTDGVDYVIIAVPTGRESISVISNIANA
AKGIILDTTTMSLSELSNVLKIIEEKRLRYLSVRLEKGPREAERGELVLYVGGDEGLFKEANSILSQIGTPIYVGNHEQA
TALKLISNVILTANTVVLAEVSVLIRKLGMDPDTVVKALSMGGSDSAQLRTRLPWMLKGNYGESFSLRLARDVIDKALEY
AQSIGIQLPMTTLIDELLRIAETTGYGSKDFSEIAEVLKVNEKK

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=291, Percent_Identity=26.1168384879725, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI40556376, Length=286, Percent_Identity=22.027972027972, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI1786719, Length=286, Percent_Identity=26.9230769230769, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI145693186, Length=281, Percent_Identity=24.1992882562278, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1790315, Length=286, Percent_Identity=24.8251748251748, Blast_Score=89, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24655230, Length=291, Percent_Identity=24.7422680412371, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19922568, Length=291, Percent_Identity=24.7422680412371, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28574115, Length=280, Percent_Identity=23.2142857142857, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 30746; Mature: 30746

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRICVIGLGRMGRGIAVNLSRKGHEVLGFDIDPNAAGRLSGSNVVVVNDMVKCTDGVDYV
CEEEEEECCCCCCCEEEEECCCCCEEEEEECCCCCCCCCCCCCEEEEECCCHHCCCCCEE
IIAVPTGRESISVISNIANAAKGIILDTTTMSLSELSNVLKIIEEKRLRYLSVRLEKGPR
EEEECCCCHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHHEEEEEECCCCC
EAERGELVLYVGGDEGLFKEANSILSQIGTPIYVGNHEQATALKLISNVILTANTVVLAE
CCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCCHHHHHH
VSVLIRKLGMDPDTVVKALSMGGSDSAQLRTRLPWMLKGNYGESFSLRLARDVIDKALEY
HHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHH
AQSIGIQLPMTTLIDELLRIAETTGYGSKDFSEIAEVLKVNEKK
HHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MRICVIGLGRMGRGIAVNLSRKGHEVLGFDIDPNAAGRLSGSNVVVVNDMVKCTDGVDYV
CEEEEEECCCCCCCEEEEECCCCCEEEEEECCCCCCCCCCCCCEEEEECCCHHCCCCCEE
IIAVPTGRESISVISNIANAAKGIILDTTTMSLSELSNVLKIIEEKRLRYLSVRLEKGPR
EEEECCCCHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHHEEEEEECCCCC
EAERGELVLYVGGDEGLFKEANSILSQIGTPIYVGNHEQATALKLISNVILTANTVVLAE
CCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCCHHHHHH
VSVLIRKLGMDPDTVVKALSMGGSDSAQLRTRLPWMLKGNYGESFSLRLARDVIDKALEY
HHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHH
AQSIGIQLPMTTLIDELLRIAETTGYGSKDFSEIAEVLKVNEKK
HHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA