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The map label for this gene is hisS [H]

Identifier: 159041236

GI number: 159041236

Start: 694033

End: 695316

Strand: Reverse

Name: hisS [H]

Synonym: Cmaq_0658

Alternate gene names: 159041236

Gene position: 695316-694033 (Counterclockwise)

Preceding gene: 159041238

Following gene: 159041235

Centisome position: 33.47

GC content: 47.2

Gene sequence:

>1284_bases
ATGCGTGCATCTAAGAGGCATGTGGAGGATTGGTTGCTTCAACCACCAAGGGGTATGAATGATTGGACACCGGATAAGTA
TTACTCACTAATCACTGTAGCCTCTAAGTTATCCAGGGTTGCTGAGTCCTTCGGATACAGCGCCATTGAGACCCCTGCCC
TCGAGCACTTTGAGGTTTTGAAGGCTAAGGCGGGTGAGGAGGTGATTAACGAGATATATTACCTTAAGGATAAGGCAGGT
AGGGAATTAGGCCTCAGATTCGACATGACTGTGCCCGTGGCTAGGGTCCTATCATATAGGCGTGACTTCCCAAGGCCCAT
TAGACTATACTATGTCTCAAAGGTTTGGAGGTATGATGAACCACAGTTCGGTAGGTTTAGGGAGTTTTACCAATTTGGGG
TTGAGCACGTAGGCTCACCCACTGTTCAATCCGATGCGGAGGTGCTGGCCTTAGCGGTGAAGTCCCTTGAGTCAGTTAAC
TTACCTCAATTAACTGTGAAGGTTAGTGATAGGAGGATCATGGATCAACTACTGGATAAGATGAGTATTAGTACTGCTAG
GGAATCAGTGTTAAGGATACTTGACAAGAGGGGTAAGGTTACTGATGACGAGTTAATTAAGCTACTTATTAGGGAGGGTA
TTGATAAGACTAAGGCAGAGTCCCTAGTGGCAATAGCCAGCACCAGGACTCCGATAGTTAACTCGACGGGTGAATTAAGG
GAATTAGGTGTGGGTGATGATTTAATTAACTATGTTGAATCCCTCGTCAACGCCTTAACGGATTATGGTGTGTTGGATAG
GGTTTACCTGGATTTAAGCATAGTGAGAGGATTAGACTACTACACGGGCTTCGTCTTCGAACTCTACACCGATAAGATTA
AGCTAGCCGTGGGGGGTGGTGGGAGGTATGATGAGTTACTTAAGGTTTATTCAGGGGAGGATGTGCCAGCCGTTGGATTC
GCCATAGGTATTGAGAGGGTGATGCTGGCTCTAAGTGAGGAACAGGGTGGTGTTCCCCCAGTGGATTACTACGTGTACCC
CATGGAGAGTAGTTACTACGGCATGGGTGTTAGGATTGCTGAGAAGTTGAGGGAAATTGGGTTAAGGGTTATTGTTGACG
TGGGTAAACCAAGCCTAAGGTCAGCCCTGGAGTACGCCGCTAGGATTAAGGCGAGGAAGTTCATAATAATTGGCCGGAGG
GAGGTTGAGAAGGGTGTTGTTAGGGTTAGGGATCTTGAGACCTGGAGTGAGGAGGACGTGCCCTTAGATAAGATCCTTAA
GTAA

Upstream 100 bases:

>100_bases
CATTGGGTGTAATTAGGCTTCATAATTTAAGGTAATAGTAAGCACACTCAATGACCCTAGTCCAGAGGGAAGGGTATTAC
TATTAAGGTTATGTTTTTTA

Downstream 100 bases:

>100_bases
TCCTTATAAGGCTAATCCAAGACTCCTTAGTTAATAATGAGTAGGGCAAGGGGATTCAGAAGCATTAGGAGCAAGGAATT
AGTGTGCTTCTTCTGTCTCA

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MRASKRHVEDWLLQPPRGMNDWTPDKYYSLITVASKLSRVAESFGYSAIETPALEHFEVLKAKAGEEVINEIYYLKDKAG
RELGLRFDMTVPVARVLSYRRDFPRPIRLYYVSKVWRYDEPQFGRFREFYQFGVEHVGSPTVQSDAEVLALAVKSLESVN
LPQLTVKVSDRRIMDQLLDKMSISTARESVLRILDKRGKVTDDELIKLLIREGIDKTKAESLVAIASTRTPIVNSTGELR
ELGVGDDLINYVESLVNALTDYGVLDRVYLDLSIVRGLDYYTGFVFELYTDKIKLAVGGGGRYDELLKVYSGEDVPAVGF
AIGIERVMLALSEEQGGVPPVDYYVYPMESSYYGMGVRIAEKLREIGLRVIVDVGKPSLRSALEYAARIKARKFIIIGRR
EVEKGVVRVRDLETWSEEDVPLDKILK

Sequences:

>Translated_427_residues
MRASKRHVEDWLLQPPRGMNDWTPDKYYSLITVASKLSRVAESFGYSAIETPALEHFEVLKAKAGEEVINEIYYLKDKAG
RELGLRFDMTVPVARVLSYRRDFPRPIRLYYVSKVWRYDEPQFGRFREFYQFGVEHVGSPTVQSDAEVLALAVKSLESVN
LPQLTVKVSDRRIMDQLLDKMSISTARESVLRILDKRGKVTDDELIKLLIREGIDKTKAESLVAIASTRTPIVNSTGELR
ELGVGDDLINYVESLVNALTDYGVLDRVYLDLSIVRGLDYYTGFVFELYTDKIKLAVGGGGRYDELLKVYSGEDVPAVGF
AIGIERVMLALSEEQGGVPPVDYYVYPMESSYYGMGVRIAEKLREIGLRVIVDVGKPSLRSALEYAARIKARKFIIIGRR
EVEKGVVRVRDLETWSEEDVPLDKILK
>Mature_427_residues
MRASKRHVEDWLLQPPRGMNDWTPDKYYSLITVASKLSRVAESFGYSAIETPALEHFEVLKAKAGEEVINEIYYLKDKAG
RELGLRFDMTVPVARVLSYRRDFPRPIRLYYVSKVWRYDEPQFGRFREFYQFGVEHVGSPTVQSDAEVLALAVKSLESVN
LPQLTVKVSDRRIMDQLLDKMSISTARESVLRILDKRGKVTDDELIKLLIREGIDKTKAESLVAIASTRTPIVNSTGELR
ELGVGDDLINYVESLVNALTDYGVLDRVYLDLSIVRGLDYYTGFVFELYTDKIKLAVGGGGRYDELLKVYSGEDVPAVGF
AIGIERVMLALSEEQGGVPPVDYYVYPMESSYYGMGVRIAEKLREIGLRVIVDVGKPSLRSALEYAARIKARKFIIIGRR
EVEKGVVRVRDLETWSEEDVPLDKILK

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI6996014, Length=448, Percent_Identity=29.2410714285714, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI15029520, Length=451, Percent_Identity=26.8292682926829, Blast_Score=155, Evalue=5e-38,
Organism=Escherichia coli, GI1788861, Length=428, Percent_Identity=26.1682242990654, Blast_Score=139, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71993693, Length=457, Percent_Identity=26.9146608315098, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI71993686, Length=457, Percent_Identity=26.9146608315098, Blast_Score=135, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6325290, Length=468, Percent_Identity=26.0683760683761, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24643061, Length=465, Percent_Identity=26.6666666666667, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24643059, Length=484, Percent_Identity=25.6198347107438, Blast_Score=141, Evalue=8e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 48460; Mature: 48460

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRASKRHVEDWLLQPPRGMNDWTPDKYYSLITVASKLSRVAESFGYSAIETPALEHFEVL
CCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHH
KAKAGEEVINEIYYLKDKAGRELGLRFDMTVPVARVLSYRRDFPRPIRLYYVSKVWRYDE
HHHHHHHHHHHHHHHHHCCCCEECCEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
PQFGRFREFYQFGVEHVGSPTVQSDAEVLALAVKSLESVNLPQLTVKVSDRRIMDQLLDK
CCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHH
MSISTARESVLRILDKRGKVTDDELIKLLIREGIDKTKAESLVAIASTRTPIVNSTGELR
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHEEEEECCCCCCCCCCCHHH
ELGVGDDLINYVESLVNALTDYGVLDRVYLDLSIVRGLDYYTGFVFELYTDKIKLAVGGG
HCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEEEECEEEEEECCC
GRYDELLKVYSGEDVPAVGFAIGIERVMLALSEEQGGVPPVDYYVYPMESSYYGMGVRIA
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHH
EKLREIGLRVIVDVGKPSLRSALEYAARIKARKFIIIGRREVEKGVVRVRDLETWSEEDV
HHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCEEEEEEHHHHHHHHHEEECCCCCCCCCC
PLDKILK
CHHHHCC
>Mature Secondary Structure
MRASKRHVEDWLLQPPRGMNDWTPDKYYSLITVASKLSRVAESFGYSAIETPALEHFEVL
CCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHH
KAKAGEEVINEIYYLKDKAGRELGLRFDMTVPVARVLSYRRDFPRPIRLYYVSKVWRYDE
HHHHHHHHHHHHHHHHHCCCCEECCEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
PQFGRFREFYQFGVEHVGSPTVQSDAEVLALAVKSLESVNLPQLTVKVSDRRIMDQLLDK
CCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHH
MSISTARESVLRILDKRGKVTDDELIKLLIREGIDKTKAESLVAIASTRTPIVNSTGELR
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHEEEEECCCCCCCCCCCHHH
ELGVGDDLINYVESLVNALTDYGVLDRVYLDLSIVRGLDYYTGFVFELYTDKIKLAVGGG
HCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEEEECEEEEEECCC
GRYDELLKVYSGEDVPAVGFAIGIERVMLALSEEQGGVPPVDYYVYPMESSYYGMGVRIA
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHH
EKLREIGLRVIVDVGKPSLRSALEYAARIKARKFIIIGRREVEKGVVRVRDLETWSEEDV
HHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCEEEEEEHHHHHHHHHEEECCCCCCCCCC
PLDKILK
CHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA