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The map label for this gene is sucD [H]

Identifier: 158425638

GI number: 158425638

Start: 4581727

End: 4582614

Strand: Reverse

Name: sucD [H]

Synonym: AZC_4014

Alternate gene names: 158425638

Gene position: 4582614-4581727 (Counterclockwise)

Preceding gene: 158425639

Following gene: 158425637

Centisome position: 85.34

GC content: 68.13

Gene sequence:

>888_bases
GTGATGTCCGTGCTTATTGACGCCAATACCAAGGTCATCACCCAGGGCTTCACGGGCAAGAACGGCACGTTCCACTCCGA
GCAGGCCATCGCCTACGGCACCAAGGTCGTCGGCGGCACCTCGCCCGGCAAGGGCGGCTCCACCCACCTCGGCCTGCCGG
TGTTCGACACCGTGATCGAGGCCCGCGAGAAGACCGGCGCCGACGCCTCCGTGATCTACGTGCCGCCTCCGGGCGCCGCC
GACGCGATCCTGGAAGCCATCGACGCGGAGATCCCGCTCATCGTCTGCATCACCGAGGGCATCCCGGTGCTCGACATGGT
GAAGGTGAAGCGCGCCCTCTCCGGCTCCAAGTCGCGCCTCATCGGCCCGAACTGCCCGGGCGTGGTGACCGCCGGCCAGT
CGAAGATCGGCATCATGCCGGCCAACATCTTCAAGACCGGCTCGGTCGGCATCGTGTCGCGCTCCGGCACGCTGACCTAT
GAAGCGGTGTTCCAGACCTCGCAGGAAGGCCTCGGCCAGACCTCGGCGGTCGGCATCGGCGGCGACCCGGTGAAGGGTAC
CGAGTTCATCGACGTGCTCGAGCTGTTCCTTGCCGATCCCAAGACCGAGTCGATCGTCATGATCGGCGAGATCGGTGGCT
CGGCCGAGGAAGACGCGGCCCAGTTCCTCAAGGACGAGGCCAAGCGCGGCCGCAAGAAGCCGATGGTCGGCTTCATCGCC
GGCCGCACGGCGCCTCCCGGCCGCCGCATGGGCCACGCCGGCGCGATCATCTCCGGCGGCAAGGGCGGCGCGGAAGACAA
GATCGCCGCCATGGAAGAGGCCGGCATCCGGGTCTCTCCCTCCCCGGCGCGCCTCGGCAAGACCCTGGTGGAAGTGCTGA
AGGGCTGA

Upstream 100 bases:

>100_bases
GCAAGCAGATCATCCGCGACAGCGGCCTGAACGTGATCCCTGCCGATGACCTGGACGATGCGGCGCAGAAGATCGTCGCG
GCCGTGAAGAAGGAAGCTGC

Downstream 100 bases:

>100_bases
TGAAAAGGACGGCAATCCGGCGGGAGACCATCGGGTTGCCGTCTTTGCATTGGACGAGTGTCACCGCGTGCCACGCTGGG
GAAAGCCTCCAGCAGTACGC

Product: succinyl-CoA ligase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MMSVLIDANTKVITQGFTGKNGTFHSEQAIAYGTKVVGGTSPGKGGSTHLGLPVFDTVIEAREKTGADASVIYVPPPGAA
DAILEAIDAEIPLIVCITEGIPVLDMVKVKRALSGSKSRLIGPNCPGVVTAGQSKIGIMPANIFKTGSVGIVSRSGTLTY
EAVFQTSQEGLGQTSAVGIGGDPVKGTEFIDVLELFLADPKTESIVMIGEIGGSAEEDAAQFLKDEAKRGRKKPMVGFIA
GRTAPPGRRMGHAGAIISGGKGGAEDKIAAMEEAGIRVSPSPARLGKTLVEVLKG

Sequences:

>Translated_295_residues
MMSVLIDANTKVITQGFTGKNGTFHSEQAIAYGTKVVGGTSPGKGGSTHLGLPVFDTVIEAREKTGADASVIYVPPPGAA
DAILEAIDAEIPLIVCITEGIPVLDMVKVKRALSGSKSRLIGPNCPGVVTAGQSKIGIMPANIFKTGSVGIVSRSGTLTY
EAVFQTSQEGLGQTSAVGIGGDPVKGTEFIDVLELFLADPKTESIVMIGEIGGSAEEDAAQFLKDEAKRGRKKPMVGFIA
GRTAPPGRRMGHAGAIISGGKGGAEDKIAAMEEAGIRVSPSPARLGKTLVEVLKG
>Mature_295_residues
MMSVLIDANTKVITQGFTGKNGTFHSEQAIAYGTKVVGGTSPGKGGSTHLGLPVFDTVIEAREKTGADASVIYVPPPGAA
DAILEAIDAEIPLIVCITEGIPVLDMVKVKRALSGSKSRLIGPNCPGVVTAGQSKIGIMPANIFKTGSVGIVSRSGTLTY
EAVFQTSQEGLGQTSAVGIGGDPVKGTEFIDVLELFLADPKTESIVMIGEIGGSAEEDAAQFLKDEAKRGRKKPMVGFIA
GRTAPPGRRMGHAGAIISGGKGGAEDKIAAMEEAGIRVSPSPARLGKTLVEVLKG

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=289, Percent_Identity=68.8581314878893, Blast_Score=339, Evalue=2e-93,
Organism=Homo sapiens, GI38569421, Length=263, Percent_Identity=30.4182509505703, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI38569423, Length=263, Percent_Identity=30.4182509505703, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI1786949, Length=293, Percent_Identity=66.2116040955631, Blast_Score=377, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17550194, Length=294, Percent_Identity=64.6258503401361, Blast_Score=367, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17553126, Length=294, Percent_Identity=63.265306122449, Blast_Score=353, Evalue=4e-98,
Organism=Caenorhabditis elegans, GI17557344, Length=285, Percent_Identity=28.4210526315789, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17551266, Length=276, Percent_Identity=28.2608695652174, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324716, Length=294, Percent_Identity=54.421768707483, Blast_Score=299, Evalue=3e-82,
Organism=Drosophila melanogaster, GI21356559, Length=292, Percent_Identity=61.6438356164384, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI28574296, Length=293, Percent_Identity=65.1877133105802, Blast_Score=347, Evalue=4e-96,
Organism=Drosophila melanogaster, GI281363477, Length=263, Percent_Identity=30.7984790874525, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI281363475, Length=263, Percent_Identity=30.7984790874525, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI281363473, Length=263, Percent_Identity=30.7984790874525, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30226; Mature: 30226

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSVLIDANTKVITQGFTGKNGTFHSEQAIAYGTKVVGGTSPGKGGSTHLGLPVFDTVIE
CEEEEEECCCEEEEECCCCCCCCCCCCCHHHHCCEEECCCCCCCCCCCCCCCHHHHHHHH
AREKTGADASVIYVPPPGAADAILEAIDAEIPLIVCITEGIPVLDMVKVKRALSGSKSRL
HHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCC
IGPNCPGVVTAGQSKIGIMPANIFKTGSVGIVSRSGTLTYEAVFQTSQEGLGQTSAVGIG
CCCCCCCEEECCCCEEEEEEHHHCCCCCEEEEECCCCEEEHHHHHHHHHCCCCCEEECCC
GDPVKGTEFIDVLELFLADPKTESIVMIGEIGGSAEEDAAQFLKDEAKRGRKKPMVGFIA
CCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEE
GRTAPPGRRMGHAGAIISGGKGGAEDKIAAMEEAGIRVSPSPARLGKTLVEVLKG
CCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHCCCEECCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MMSVLIDANTKVITQGFTGKNGTFHSEQAIAYGTKVVGGTSPGKGGSTHLGLPVFDTVIE
CEEEEEECCCEEEEECCCCCCCCCCCCCHHHHCCEEECCCCCCCCCCCCCCCHHHHHHHH
AREKTGADASVIYVPPPGAADAILEAIDAEIPLIVCITEGIPVLDMVKVKRALSGSKSRL
HHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCC
IGPNCPGVVTAGQSKIGIMPANIFKTGSVGIVSRSGTLTYEAVFQTSQEGLGQTSAVGIG
CCCCCCCEEECCCCEEEEEEHHHCCCCCEEEEECCCCEEEHHHHHHHHHCCCCCEEECCC
GDPVKGTEFIDVLELFLADPKTESIVMIGEIGGSAEEDAAQFLKDEAKRGRKKPMVGFIA
CCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEE
GRTAPPGRRMGHAGAIISGGKGGAEDKIAAMEEAGIRVSPSPARLGKTLVEVLKG
CCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHCCCEECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]