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The map label for this gene is irlR [H]

Identifier: 158425609

GI number: 158425609

Start: 4551545

End: 4552219

Strand: Direct

Name: irlR [H]

Synonym: AZC_3985

Alternate gene names: 158425609

Gene position: 4551545-4552219 (Clockwise)

Preceding gene: 158425608

Following gene: 158425610

Centisome position: 84.76

GC content: 68.3

Gene sequence:

>675_bases
GTGCGGCTGCTCGTCATCGAGGACGATCCGGAGCTGGGTTCCTGGCTTCGCACCACGCTGGAAGACGCCTTTGGCGGGGC
CGATCTCGTGACCTCGCTCGACGAGGCACAAGCGGCCGTCAAGGTCCGGGAGTTCGACCTCATCGTCATGGACCGGCGGC
TGCCGGACGGGGACTCCATCGAGCTCATCGGCGCGTTCCAGCGGCTGCGCCCGCGGCCAAGCCTTCTGGTGCTCACCGCC
CTGGACGATCCGAACCACATCGCCAAGGCGCTCGATGCGGGCGCGGACGACTATCTCGCCAAGCCCTTCGAGCCGGTGGA
ACTCATCGCCCGTGTGCGGGCCGTGATGCGCCGCGCCCAGCTCGACCAGAGCGACGGCGTCGTGACGGTCGCGAACCTGC
GCTTCTGCACCGCGGCCCGCACCGCCTATATCGAGGACACCTCCCTCATCCTGCCGCGACGGGAGCTGGCGCTGCTGGAA
GCGCTGATCCGGCGCGTGGGGCAGGTGGTGCTGCGGGAGACGCTGGAAAACGCCGCCTACGGTTTTGACGACGAGATCCA
GTCCAACGCCATCGACGCCCATCTCTCGCGCCTGCGCAAGCGCCTGCGCGAGCACAACTGCCAGGCCCAGATCCGCCCCC
TGCGCGGTCTGGGCTACATGCTGTCCGAACATTGA

Upstream 100 bases:

>100_bases
CCAGTTCCGCCATCATTCTGCTCGACTGCCGGATATGTTGAGCAAAATCTTAAGCTGCGCGTTCGGGGGACCGAGCGCCG
GTGGGGGCTGGAGACACGAC

Downstream 100 bases:

>100_bases
AACGGTTTCTGCCCGGCTCCATCGCCGCGTCGGGGGCGCTGTTTCTGGGGTTCTGCCTCACGGTCGTGCTGCTGTTCTCC
TGGGTCACCTTCGCCGCCCT

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MRLLVIEDDPELGSWLRTTLEDAFGGADLVTSLDEAQAAVKVREFDLIVMDRRLPDGDSIELIGAFQRLRPRPSLLVLTA
LDDPNHIAKALDAGADDYLAKPFEPVELIARVRAVMRRAQLDQSDGVVTVANLRFCTAARTAYIEDTSLILPRRELALLE
ALIRRVGQVVLRETLENAAYGFDDEIQSNAIDAHLSRLRKRLREHNCQAQIRPLRGLGYMLSEH

Sequences:

>Translated_224_residues
MRLLVIEDDPELGSWLRTTLEDAFGGADLVTSLDEAQAAVKVREFDLIVMDRRLPDGDSIELIGAFQRLRPRPSLLVLTA
LDDPNHIAKALDAGADDYLAKPFEPVELIARVRAVMRRAQLDQSDGVVTVANLRFCTAARTAYIEDTSLILPRRELALLE
ALIRRVGQVVLRETLENAAYGFDDEIQSNAIDAHLSRLRKRLREHNCQAQIRPLRGLGYMLSEH
>Mature_224_residues
MRLLVIEDDPELGSWLRTTLEDAFGGADLVTSLDEAQAAVKVREFDLIVMDRRLPDGDSIELIGAFQRLRPRPSLLVLTA
LDDPNHIAKALDAGADDYLAKPFEPVELIARVRAVMRRAQLDQSDGVVTVANLRFCTAARTAYIEDTSLILPRRELALLE
ALIRRVGQVVLRETLENAAYGFDDEIQSNAIDAHLSRLRKRLREHNCQAQIRPLRGLGYMLSEH

Specific function: Member of the two-component regulatory system irlR/irlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=34.841628959276, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=33.6322869955157, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=32.1266968325792, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=28.7671232876712, Blast_Score=102, Evalue=1e-23,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=32.1266968325792, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786599, Length=226, Percent_Identity=30.9734513274336, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=30.6666666666667, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=29.8701298701299, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=32.7354260089686, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1786911, Length=207, Percent_Identity=33.3333333333333, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=30.1310043668122, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25136; Mature: 25136

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLVIEDDPELGSWLRTTLEDAFGGADLVTSLDEAQAAVKVREFDLIVMDRRLPDGDSI
CEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCH
ELIGAFQRLRPRPSLLVLTALDDPNHIAKALDAGADDYLAKPFEPVELIARVRAVMRRAQ
HHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHH
LDQSDGVVTVANLRFCTAARTAYIEDTSLILPRRELALLEALIRRVGQVVLRETLENAAY
CCCCCCEEEEECHHHHHHHHHHEECCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GFDDEIQSNAIDAHLSRLRKRLREHNCQAQIRPLRGLGYMLSEH
CCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHCCC
>Mature Secondary Structure
MRLLVIEDDPELGSWLRTTLEDAFGGADLVTSLDEAQAAVKVREFDLIVMDRRLPDGDSI
CEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCH
ELIGAFQRLRPRPSLLVLTALDDPNHIAKALDAGADDYLAKPFEPVELIARVRAVMRRAQ
HHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHH
LDQSDGVVTVANLRFCTAARTAYIEDTSLILPRRELALLEALIRRVGQVVLRETLENAAY
CCCCCCEEEEECHHHHHHHHHHEECCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GFDDEIQSNAIDAHLSRLRKRLREHNCQAQIRPLRGLGYMLSEH
CCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9393784 [H]