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The map label for this gene is cobM [H]

Identifier: 158425568

GI number: 158425568

Start: 4508680

End: 4509441

Strand: Direct

Name: cobM [H]

Synonym: AZC_3944

Alternate gene names: 158425568

Gene position: 4508680-4509441 (Clockwise)

Preceding gene: 158425567

Following gene: 158425570

Centisome position: 83.96

GC content: 71.92

Gene sequence:

>762_bases
ATGACCGTGCATTTCATCGGCGCCGGCCCCGGCGCCGCCGACCTCATCACCGTGCGCGGGCGCGATCTCATCGCCCGCTG
CCCCGTCTGCCTCTATGCCGGCTCCATCGTGGCGCCGGACCTGCTGGCCTATTGTCCGCCCGGCGCGCGCATCGTGGACA
CCGCGCCCCTCGATCTCGACCGGATCGAGCAAGAATATGTGGCGGCCCATGCGGCCGGACAGGACGTGGCACGACTGCAT
TCGGGCGACCTCTCGGTCTATAGCGCGGTCGCCGAGCAGGTGCGCCGGCTGGAGCGGAGGGGCATCCCCTATACGCTGAC
GCCCGGCGTGCCCGCCTTCGCGGCGGCGGCGGCGGCGCTGCGGGCGGAACTCACCGTGCCGGAAGTGGCGCAAAGCGTGG
TGCTGACCCGCGTCTCCGGCCGCGCCTCCGCCATGCCGGAGCGCGAAAAGCTCGCCACCTTTGCCGAGAGCGGCGCGACG
CTCGCCATCCACCTCGCCATCCATGCGCTGGACCGCGTGGTGGCGGAGCTCACCCCCTTCTATGGGGCGGAGTGCCCGGT
GGCGGTGGTGGTGAAGGCGAGTTGGCCGGACGAGCGCATCCTGCGCGGCACGCTCGCCACCATCGCCGCGCAGGTGGCGG
ACGATCCCATCGCCCGCACGGCGCTCATCCTCGTCGGCCCCGCCCTCGCCCCCGCCGATTTCCGCGAGAGCGCCCTCTAC
AATGTGGATTACGTCCGCCGCTTCCGGGGGATGGCGGAGTGA

Upstream 100 bases:

>100_bases
TGCGGCCTCAATGCCCATCTGCTGGGCCCGCGCCTCGCGCTCGGCTCGGTCACCTGCGCGCTCGCCCGCAGCGGCGCGCT
GCCATGAGTTCCCGTTTCCC

Downstream 100 bases:

>100_bases
GTGCCGGGCTGCGAGGAGAAAGCCCCTGCTTTGCGCCCGACCGGGCACAAGCGGAGAGCGTCTTACCCCCCTCCCCGCCC
TCCCCCTCAAGGGGGGAGGG

Product: precorrin-4 C11-methyltransferase region

Products: NA

Alternate protein names: Precorrin-3 methylase [H]

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MTVHFIGAGPGAADLITVRGRDLIARCPVCLYAGSIVAPDLLAYCPPGARIVDTAPLDLDRIEQEYVAAHAAGQDVARLH
SGDLSVYSAVAEQVRRLERRGIPYTLTPGVPAFAAAAAALRAELTVPEVAQSVVLTRVSGRASAMPEREKLATFAESGAT
LAIHLAIHALDRVVAELTPFYGAECPVAVVVKASWPDERILRGTLATIAAQVADDPIARTALILVGPALAPADFRESALY
NVDYVRRFRGMAE

Sequences:

>Translated_253_residues
MTVHFIGAGPGAADLITVRGRDLIARCPVCLYAGSIVAPDLLAYCPPGARIVDTAPLDLDRIEQEYVAAHAAGQDVARLH
SGDLSVYSAVAEQVRRLERRGIPYTLTPGVPAFAAAAAALRAELTVPEVAQSVVLTRVSGRASAMPEREKLATFAESGAT
LAIHLAIHALDRVVAELTPFYGAECPVAVVVKASWPDERILRGTLATIAAQVADDPIARTALILVGPALAPADFRESALY
NVDYVRRFRGMAE
>Mature_252_residues
TVHFIGAGPGAADLITVRGRDLIARCPVCLYAGSIVAPDLLAYCPPGARIVDTAPLDLDRIEQEYVAAHAAGQDVARLHS
GDLSVYSAVAEQVRRLERRGIPYTLTPGVPAFAAAAAALRAELTVPEVAQSVVLTRVSGRASAMPEREKLATFAESGATL
AIHLAIHALDRVVAELTPFYGAECPVAVVVKASWPDERILRGTLATIAAQVADDPIARTALILVGPALAPADFRESALYN
VDYVRRFRGMAE

Specific function: Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5 [H]

COG id: COG2875

COG function: function code H; Precorrin-4 methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=241, Percent_Identity=26.5560165975104, Blast_Score=66, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322922, Length=254, Percent_Identity=25.1968503937008, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006362
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.133 [H]

Molecular weight: Translated: 26789; Mature: 26658

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVHFIGAGPGAADLITVRGRDLIARCPVCLYAGSIVAPDLLAYCPPGARIVDTAPLDLD
CEEEEEECCCCCCCEEEECCCHHHHHCCHHHHCCCHHHHHHHHHCCCCCEEEECCCCCHH
RIEQEYVAAHAAGQDVARLHSGDLSVYSAVAEQVRRLERRGIPYTLTPGVPAFAAAAAAL
HHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHH
RAELTVPEVAQSVVLTRVSGRASAMPEREKLATFAESGATLAIHLAIHALDRVVAELTPF
HHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHCCC
YGAECPVAVVVKASWPDERILRGTLATIAAQVADDPIARTALILVGPALAPADFRESALY
CCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHEEECCCCCCCHHHHHHHC
NVDYVRRFRGMAE
CHHHHHHHCCCCC
>Mature Secondary Structure 
TVHFIGAGPGAADLITVRGRDLIARCPVCLYAGSIVAPDLLAYCPPGARIVDTAPLDLD
EEEEEECCCCCCCEEEECCCHHHHHCCHHHHCCCHHHHHHHHHCCCCCEEEECCCCCHH
RIEQEYVAAHAAGQDVARLHSGDLSVYSAVAEQVRRLERRGIPYTLTPGVPAFAAAAAAL
HHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHH
RAELTVPEVAQSVVLTRVSGRASAMPEREKLATFAESGATLAIHLAIHALDRVVAELTPF
HHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHCCC
YGAECPVAVVVKASWPDERILRGTLATIAAQVADDPIARTALILVGPALAPADFRESALY
CCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHEEECCCCCCCHHHHHHHC
NVDYVRRFRGMAE
CHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2211521; 8226690 [H]