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The map label for this gene is ubiB [H]

Identifier: 158425542

GI number: 158425542

Start: 4478811

End: 4480379

Strand: Reverse

Name: ubiB [H]

Synonym: AZC_3918

Alternate gene names: 158425542

Gene position: 4480379-4478811 (Counterclockwise)

Preceding gene: 158425543

Following gene: 158425541

Centisome position: 83.44

GC content: 70.55

Gene sequence:

>1569_bases
GTGATTCTCGTTCTCATCGACGCCGCGCGCCTCGCGCGCGCCGGCTATGTGCTTGCCCGCGAGGGCGTGCTGAGCCTCGT
GAGCCCGGCCATGGTGCCGCCGCTCGCACGGCCCGGCCTGCGCCTTGCGCGCCTCATCGCCCGCCCCGATGCCGGCACGC
GGGCGGCGCGCCTCTCCGCCGCGCTGAGCCGCCTCGGCCCCTCCTATGTGAAGCTCGGCCAGTTCCTCGCCACCCGGCCG
GACGTGGTGGGCGCGTCCGTCGCCCGCGACCTGGAGGTTCTGCAGGACCGCATGCCCGCCTTCGGGCAGACGGTGGCGGA
GCAGACGGTGGTGGACGCCTTCGAGCGGCCGCTCTCCGAGGTCTATGCGGAATTCGGCCCGCCCGTGGCCGCCGCCTCCA
TCGCCGAGGTGCACAAGGCGGTGGTGGTGGAGCGCGACGGCACCCGCCGCACCGTGGCGGTGAAGATCCTGCGCCCCGGC
ATCGAGCGGCGCTTCTCCGCCGACGTCGCCACCTTCCGTCGCATCGCCGCTTTCGCCGAGAAGATCTCCGCCGAGGCCCG
GCGCCTGCGGCTCACCACGGTGGTGGATACGCTCGGCCGATCCGTCACCATGGAGATGGACCTGCGCCTCGAGGCCGCGG
CCTATGCGGAGCTGGCCGAGAATGTGAAGGACGATCCGGACGTCCACGTGCCGGCAGTGGACTGGGACCGTTCCGCCCGC
GAGGTGCTGACCACCGAGTGGATCGACGGCATCAAGCTCTCCGACCGTGCCGGGCTTGAGGCGGCGGGGCACGATCTCCA
GAACCTCGCCCGCATCGTCATGCAGTCCTTCCTGCGGCAGGCCATGCGCGACGGCTTCTTCCATGCCGACATGCACCCCG
GCAATCTGTTCGTGGATGCGGAAGGCCGTCTCGTGGTGGTGGACTGCGGCATCATGGGCCGCCTCGGCCTCAAGGAGCGG
CGCTTCCTCGCCGAAATCCTCTACGGCTTCATCACCCGCAACTGGCGGCGCACGGCGGAAGTGCATTTCGAGGCGGGCTA
TGTGCCCTCCCACCATTCGGTGGAGGACTTTGCCCTCGCCATCCGCGCCATCGGCGAGCCGATCCATTCCCGCAGCGCCG
ACCAGATTTCCATGGCCCGGCTGCTCTCGCTGCTGCTGGAAGTGACCGGCCTCTTCGACATGAAGACCCGGCCCGAACTG
CTGCTGCTGCAGAAGACCATGGTGGTGGTGGAGGGCGTGGCGCGCGGCCTTGATCCGCAGCTCAACATGTGGACCACCGC
CGCCCCGGTGGTGGAGGACTGGATCGCCCAGAACCTCGGCCCTGTCGGTCGCCTCCAGCAGGCGGGCTCCGGCATCGGCG
AGGTGGGCCGCTTCGTCCTCGACGCGCCGGTCCTGCTCACCCGCGCCGGCCGCGTGGTGAGCCAGCTCGACGAAGCAACC
CGCAACGGCCTCCACCTCTCCCCCGAGACGCTGGAGGGCATCGGCGCCGCCGAAGCCCGCCGCGCCTTCTGGGGCAATGC
GGCCCTCTGGGTGATCGCCATCGCGCTGCTGCTGCTGGCGCTGAAATGA

Upstream 100 bases:

>100_bases
GCGCGGGTGACCGCGACCCCGCTCACCGGCGGTATTGTCTGCCTCCATTCGGGTTACCGCATCTGATGGCCGTGCGCGGC
CATCGCGGAAAGGGACCGGC

Downstream 100 bases:

>100_bases
GGGCTCGGCTGCTGGTCTGATGGATCCCAAAAGGGAGCTCGGCCGTTGTCGGAGACGTCAACCGGCCAAGCTTCGAAGGG
AAACTGTCTTGACCAGTCCA

Product: 2-polyprenylphenol 6-hydroxylase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 522; Mature: 522

Protein sequence:

>522_residues
MILVLIDAARLARAGYVLAREGVLSLVSPAMVPPLARPGLRLARLIARPDAGTRAARLSAALSRLGPSYVKLGQFLATRP
DVVGASVARDLEVLQDRMPAFGQTVAEQTVVDAFERPLSEVYAEFGPPVAAASIAEVHKAVVVERDGTRRTVAVKILRPG
IERRFSADVATFRRIAAFAEKISAEARRLRLTTVVDTLGRSVTMEMDLRLEAAAYAELAENVKDDPDVHVPAVDWDRSAR
EVLTTEWIDGIKLSDRAGLEAAGHDLQNLARIVMQSFLRQAMRDGFFHADMHPGNLFVDAEGRLVVVDCGIMGRLGLKER
RFLAEILYGFITRNWRRTAEVHFEAGYVPSHHSVEDFALAIRAIGEPIHSRSADQISMARLLSLLLEVTGLFDMKTRPEL
LLLQKTMVVVEGVARGLDPQLNMWTTAAPVVEDWIAQNLGPVGRLQQAGSGIGEVGRFVLDAPVLLTRAGRVVSQLDEAT
RNGLHLSPETLEGIGAAEARRAFWGNAALWVIAIALLLLALK

Sequences:

>Translated_522_residues
MILVLIDAARLARAGYVLAREGVLSLVSPAMVPPLARPGLRLARLIARPDAGTRAARLSAALSRLGPSYVKLGQFLATRP
DVVGASVARDLEVLQDRMPAFGQTVAEQTVVDAFERPLSEVYAEFGPPVAAASIAEVHKAVVVERDGTRRTVAVKILRPG
IERRFSADVATFRRIAAFAEKISAEARRLRLTTVVDTLGRSVTMEMDLRLEAAAYAELAENVKDDPDVHVPAVDWDRSAR
EVLTTEWIDGIKLSDRAGLEAAGHDLQNLARIVMQSFLRQAMRDGFFHADMHPGNLFVDAEGRLVVVDCGIMGRLGLKER
RFLAEILYGFITRNWRRTAEVHFEAGYVPSHHSVEDFALAIRAIGEPIHSRSADQISMARLLSLLLEVTGLFDMKTRPEL
LLLQKTMVVVEGVARGLDPQLNMWTTAAPVVEDWIAQNLGPVGRLQQAGSGIGEVGRFVLDAPVLLTRAGRVVSQLDEAT
RNGLHLSPETLEGIGAAEARRAFWGNAALWVIAIALLLLALK
>Mature_522_residues
MILVLIDAARLARAGYVLAREGVLSLVSPAMVPPLARPGLRLARLIARPDAGTRAARLSAALSRLGPSYVKLGQFLATRP
DVVGASVARDLEVLQDRMPAFGQTVAEQTVVDAFERPLSEVYAEFGPPVAAASIAEVHKAVVVERDGTRRTVAVKILRPG
IERRFSADVATFRRIAAFAEKISAEARRLRLTTVVDTLGRSVTMEMDLRLEAAAYAELAENVKDDPDVHVPAVDWDRSAR
EVLTTEWIDGIKLSDRAGLEAAGHDLQNLARIVMQSFLRQAMRDGFFHADMHPGNLFVDAEGRLVVVDCGIMGRLGLKER
RFLAEILYGFITRNWRRTAEVHFEAGYVPSHHSVEDFALAIRAIGEPIHSRSADQISMARLLSLLLEVTGLFDMKTRPEL
LLLQKTMVVVEGVARGLDPQLNMWTTAAPVVEDWIAQNLGPVGRLQQAGSGIGEVGRFVLDAPVLLTRAGRVVSQLDEAT
RNGLHLSPETLEGIGAAEARRAFWGNAALWVIAIALLLLALK

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=274, Percent_Identity=30.6569343065693, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI40254938, Length=338, Percent_Identity=24.8520710059172, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI217035081, Length=312, Percent_Identity=24.0384615384615, Blast_Score=90, Evalue=7e-18,
Organism=Escherichia coli, GI2367309, Length=390, Percent_Identity=38.2051282051282, Blast_Score=275, Evalue=7e-75,
Organism=Caenorhabditis elegans, GI17559152, Length=266, Percent_Identity=24.0601503759398, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI32565180, Length=358, Percent_Identity=25.9776536312849, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6325148, Length=436, Percent_Identity=22.2477064220184, Blast_Score=97, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24662575, Length=289, Percent_Identity=29.0657439446367, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI22024280, Length=257, Percent_Identity=23.7354085603113, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 57000; Mature: 57000

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILVLIDAARLARAGYVLAREGVLSLVSPAMVPPLARPGLRLARLIARPDAGTRAARLSA
CEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHH
ALSRLGPSYVKLGQFLATRPDVVGASVARDLEVLQDRMPAFGQTVAEQTVVDAFERPLSE
HHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
VYAEFGPPVAAASIAEVHKAVVVERDGTRRTVAVKILRPGIERRFSADVATFRRIAAFAE
HHHHHCCCHHHHHHHHHHHHHEEECCCCCEEEEEEEHHCCHHHHHHHHHHHHHHHHHHHH
KISAEARRLRLTTVVDTLGRSVTMEMDLRLEAAAYAELAENVKDDPDVHVPAVDWDRSAR
HHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHH
EVLTTEWIDGIKLSDRAGLEAAGHDLQNLARIVMQSFLRQAMRDGFFHADMHPGNLFVDA
HHHHHHHHCCCEECCCCCCCHHCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEEC
EGRLVVVDCGIMGRLGLKERRFLAEILYGFITRNWRRTAEVHFEAGYVPSHHSVEDFALA
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHEEEEEECCCCCCCCCHHHHHHH
IRAIGEPIHSRSADQISMARLLSLLLEVTGLFDMKTRPELLLLQKTMVVVEGVARGLDPQ
HHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCC
LNMWTTAAPVVEDWIAQNLGPVGRLQQAGSGIGEVGRFVLDAPVLLTRAGRVVSQLDEAT
CCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
RNGLHLSPETLEGIGAAEARRAFWGNAALWVIAIALLLLALK
HCCCCCCHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MILVLIDAARLARAGYVLAREGVLSLVSPAMVPPLARPGLRLARLIARPDAGTRAARLSA
CEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHH
ALSRLGPSYVKLGQFLATRPDVVGASVARDLEVLQDRMPAFGQTVAEQTVVDAFERPLSE
HHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
VYAEFGPPVAAASIAEVHKAVVVERDGTRRTVAVKILRPGIERRFSADVATFRRIAAFAE
HHHHHCCCHHHHHHHHHHHHHEEECCCCCEEEEEEEHHCCHHHHHHHHHHHHHHHHHHHH
KISAEARRLRLTTVVDTLGRSVTMEMDLRLEAAAYAELAENVKDDPDVHVPAVDWDRSAR
HHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHH
EVLTTEWIDGIKLSDRAGLEAAGHDLQNLARIVMQSFLRQAMRDGFFHADMHPGNLFVDA
HHHHHHHHCCCEECCCCCCCHHCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEEC
EGRLVVVDCGIMGRLGLKERRFLAEILYGFITRNWRRTAEVHFEAGYVPSHHSVEDFALA
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHEEEEEECCCCCCCCCHHHHHHH
IRAIGEPIHSRSADQISMARLLSLLLEVTGLFDMKTRPELLLLQKTMVVVEGVARGLDPQ
HHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCC
LNMWTTAAPVVEDWIAQNLGPVGRLQQAGSGIGEVGRFVLDAPVLLTRAGRVVSQLDEAT
CCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
RNGLHLSPETLEGIGAAEARRAFWGNAALWVIAIALLLLALK
HCCCCCCHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA