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The map label for this gene is pepIP [H]

Identifier: 158425397

GI number: 158425397

Start: 4327815

End: 4328615

Strand: Direct

Name: pepIP [H]

Synonym: AZC_3773

Alternate gene names: 158425397

Gene position: 4327815-4328615 (Clockwise)

Preceding gene: 158425396

Following gene: 158425398

Centisome position: 80.6

GC content: 66.92

Gene sequence:

>801_bases
GTGGCGGGAGAGGGCCACGACGAGACCATCGTCGTGCTCCATGGCGGACGCGGCATCGGCGACCACCGGGCCGATTTCCA
GGCCTTCCTGCCCCTTACCGACTGCTATCGGCTGCTCGCTTATGACCAGCGTGGCTGCGGACTCTCCTCGCTGACGCCGC
CCTATACCTTCGGCCAGTTCGCGGATGATCTCGAAGCCATCCGGCAGGAGCTGTGCGGCGGCGGCCGCATCATCCTGATC
GGCGGCTCCTTCGGCGGCATGATCGCCCTCACCTATGCGGTGAAATATGGCGCGAACGGCCTCTCCCGCCTCATCCTGCG
CGGCACGGCGCCGAGCCACCACCATGAGGCGGAGGCCATCGCCAATTTCAAGGCGCGCCTGCACAAGGCGCCCAGTGCCT
CCCTGCGCATGGTGGAGAAGATGTTCTCGGACGTCATCGACGACACCGAGCTGCGCCTCATCTGGCTGGCCCTCCAGCCG
CTCTATTTCGAGACCTTCGATCCCGACGCCGCGCTGGAGCGCACCCGCACGCTGAGCCTGCACGCGGAGACGCATAACGC
CCTCTTCGCCGTGAAGGACTATGACCTGCGCGACCAGTTGCCCGGCATCGCGGTGCCGACACAGGTGATCGTGGGCGGCG
AGGACTGGATCTGCCCGCCTTCCCAGTCGCGCCTCATCGCCGAGCGCGTGCCCGGCGCGGAGCTTCTGGAAATTCCGGGC
GCGAACCATTCCGTCCATATCGAGGCCAACGCACAGGTGCTCGCCGGCATCCGCTCCTTCCTCGAAAGGACGGCCCCGTG
A

Upstream 100 bases:

>100_bases
GACGAATGGACGGATGCGGACGCGCCGCCACGGGAGGGCACCCATGCCGCCGAGTGAGCCGCGCAGCATCACGCTCAATG
GGGCGCGCTTCGTCTATGAC

Downstream 100 bases:

>100_bases
CGCGCTATATGGCGGCGAAATTCGGCGAGGCGCTCATCGCCATCTGGGGCGTGGTGACGATCGTCTTCTTCGTCACGCGC
CTTGTGGGCGACCCGGTGGC

Product: prolyl aminopeptidase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MAGEGHDETIVVLHGGRGIGDHRADFQAFLPLTDCYRLLAYDQRGCGLSSLTPPYTFGQFADDLEAIRQELCGGGRIILI
GGSFGGMIALTYAVKYGANGLSRLILRGTAPSHHHEAEAIANFKARLHKAPSASLRMVEKMFSDVIDDTELRLIWLALQP
LYFETFDPDAALERTRTLSLHAETHNALFAVKDYDLRDQLPGIAVPTQVIVGGEDWICPPSQSRLIAERVPGAELLEIPG
ANHSVHIEANAQVLAGIRSFLERTAP

Sequences:

>Translated_266_residues
MAGEGHDETIVVLHGGRGIGDHRADFQAFLPLTDCYRLLAYDQRGCGLSSLTPPYTFGQFADDLEAIRQELCGGGRIILI
GGSFGGMIALTYAVKYGANGLSRLILRGTAPSHHHEAEAIANFKARLHKAPSASLRMVEKMFSDVIDDTELRLIWLALQP
LYFETFDPDAALERTRTLSLHAETHNALFAVKDYDLRDQLPGIAVPTQVIVGGEDWICPPSQSRLIAERVPGAELLEIPG
ANHSVHIEANAQVLAGIRSFLERTAP
>Mature_265_residues
AGEGHDETIVVLHGGRGIGDHRADFQAFLPLTDCYRLLAYDQRGCGLSSLTPPYTFGQFADDLEAIRQELCGGGRIILIG
GSFGGMIALTYAVKYGANGLSRLILRGTAPSHHHEAEAIANFKARLHKAPSASLRMVEKMFSDVIDDTELRLIWLALQPL
YFETFDPDAALERTRTLSLHAETHNALFAVKDYDLRDQLPGIAVPTQVIVGGEDWICPPSQSRLIAERVPGAELLEIPGA
NHSVHIEANAQVLAGIRSFLERTAP

Specific function: Characterized by a high specificity towards di- or tripeptides with proline at the NH(2)-terminal position, but is not able to hydrolyze longer peptides, or peptides with hydroxyproline at the NH(2)-end [H]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cell envelope [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005945
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 29022; Mature: 28891

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGEGHDETIVVLHGGRGIGDHRADFQAFLPLTDCYRLLAYDQRGCGLSSLTPPYTFGQF
CCCCCCCCEEEEEECCCCCCCCCCCHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
ADDLEAIRQELCGGGRIILIGGSFGGMIALTYAVKYGANGLSRLILRGTAPSHHHEAEAI
HHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCHHHHHEEECCCCCCCHHHHHH
ANFKARLHKAPSASLRMVEKMFSDVIDDTELRLIWLALQPLYFETFDPDAALERTRTLSL
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEECCCCHHHHHHHEEEEE
HAETHNALFAVKDYDLRDQLPGIAVPTQVIVGGEDWICPPSQSRLIAERVPGAELLEIPG
EECCCCEEEEEECCCHHHCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHCCCCCEEECCC
ANHSVHIEANAQVLAGIRSFLERTAP
CCCEEEEECCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AGEGHDETIVVLHGGRGIGDHRADFQAFLPLTDCYRLLAYDQRGCGLSSLTPPYTFGQF
CCCCCCCEEEEEECCCCCCCCCCCHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
ADDLEAIRQELCGGGRIILIGGSFGGMIALTYAVKYGANGLSRLILRGTAPSHHHEAEAI
HHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCHHHHHEEECCCCCCCHHHHHH
ANFKARLHKAPSASLRMVEKMFSDVIDDTELRLIWLALQPLYFETFDPDAALERTRTLSL
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEECCCCHHHHHHHEEEEE
HAETHNALFAVKDYDLRDQLPGIAVPTQVIVGGEDWICPPSQSRLIAERVPGAELLEIPG
EECCCCEEEEEECCCHHHCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHCCCCCEEECCC
ANHSVHIEANAQVLAGIRSFLERTAP
CCCEEEEECCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8012575; 8012576 [H]