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The map label for this gene is cobS [H]

Identifier: 158425303

GI number: 158425303

Start: 4225379

End: 4226362

Strand: Direct

Name: cobS [H]

Synonym: AZC_3679

Alternate gene names: 158425303

Gene position: 4225379-4226362 (Clockwise)

Preceding gene: 158425302

Following gene: 158425304

Centisome position: 78.69

GC content: 63.72

Gene sequence:

>984_bases
ATGATGAGCACCGAGACCGTGGCACCTACCCCCGACATGAAGGTTTCGGTGAGGCAGGTGTTTGGCATCGACATCGACAT
GGAAGTGCCGGCCTATTCCGAGCCGGATCCGCACGTTCCCGATCTCGATCCCGATTATCTGTTCGATCGTCAGACCACCC
TCGCGATCCTTGCGGGCTTTGCCTACAACCGCCGCGTGATGGTCACCGGCTATCACGGCACCGGCAAGTCCACCCACATC
GAGCAGGTCGCCGCCCGCCTCAACTGGCCGTGCGTGCGCGTGAACCTCGACAGCCACATCTCGCGTATCGACCTCATCGG
CAAGGATGCCATCGTGGTGCGCGACGGCATGCAGGTGACCGAGTTCCGCGACGGCATCCTGCCGTGGGCGCTCCAGAACA
ACGTCGCCATGGTGTTCGACGAATATGACGCCGGCCGTCCGGACGTGATGTTCGTGATCCAGCGCGTGCTCGAAGTCTCC
GGCCGCCTGACCCTGCTCGACCAGAACCGGGTGATCCGCCCCCACCCCGCCTTCCGCCTGTTCTCCACCGCGAACACGGT
CGGCCTCGGCGACACCACGGGCCTCTATCACGGCACGCAGCAGATCAATCAGGGCCAGATGGACCGCTGGTCCATCGTGA
CCACCCTCAACTACCTGCCCCACGACAAGGAAGTGGAGATCGTGCTCGCCAAGTCGAAGCACTATCAGAACCCGCAGGGA
CGCGAGACGGTGGCCCGCATGGTGCGCCTCGCCGATCTGACCCGTTCGGCCTTCATCAATGGCGACCTATCCACCGTGAT
GAGCCCGCGCACCGTGCTCACCTGGGCCGAGAATGCCGAGATCTTCAAGGACATCGGCTTCGCCCTGCGCGTCACCTTCC
TGAACAAGTGCGACGAGCTGGAGCGTCCGCTGGTGGCGGAGTTCTATCAGCGCTGCTTCGGGCAGGAGCTCCAGGAGAGC
GCGGTCAACCTCGTCCTCTCCTGA

Upstream 100 bases:

>100_bases
TGCGCGCACGAAGGCTGTTTTTGCACGTGCGGAAAACCTTTAAGGTGCCGCGAGCATGAATGCGGAAGAGTGAAGCGCGG
CGGGCCGCGCAAACGGAGGC

Downstream 100 bases:

>100_bases
CGTCCCATGATGTGCGGCCCCTCCCATGCGGAGGGGCCATTCCGCCCGCGCCGGCGTCCGTGACAGGCTGAGCTATGGCT
GCCCCGACCAACAAGACCGT

Product: cobalt chelatase

Products: NA

Alternate protein names: Hydrogenobyrinic acid a,c-diamide cobaltochelatase subunit CobS [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MMSTETVAPTPDMKVSVRQVFGIDIDMEVPAYSEPDPHVPDLDPDYLFDRQTTLAILAGFAYNRRVMVTGYHGTGKSTHI
EQVAARLNWPCVRVNLDSHISRIDLIGKDAIVVRDGMQVTEFRDGILPWALQNNVAMVFDEYDAGRPDVMFVIQRVLEVS
GRLTLLDQNRVIRPHPAFRLFSTANTVGLGDTTGLYHGTQQINQGQMDRWSIVTTLNYLPHDKEVEIVLAKSKHYQNPQG
RETVARMVRLADLTRSAFINGDLSTVMSPRTVLTWAENAEIFKDIGFALRVTFLNKCDELERPLVAEFYQRCFGQELQES
AVNLVLS

Sequences:

>Translated_327_residues
MMSTETVAPTPDMKVSVRQVFGIDIDMEVPAYSEPDPHVPDLDPDYLFDRQTTLAILAGFAYNRRVMVTGYHGTGKSTHI
EQVAARLNWPCVRVNLDSHISRIDLIGKDAIVVRDGMQVTEFRDGILPWALQNNVAMVFDEYDAGRPDVMFVIQRVLEVS
GRLTLLDQNRVIRPHPAFRLFSTANTVGLGDTTGLYHGTQQINQGQMDRWSIVTTLNYLPHDKEVEIVLAKSKHYQNPQG
RETVARMVRLADLTRSAFINGDLSTVMSPRTVLTWAENAEIFKDIGFALRVTFLNKCDELERPLVAEFYQRCFGQELQES
AVNLVLS
>Mature_327_residues
MMSTETVAPTPDMKVSVRQVFGIDIDMEVPAYSEPDPHVPDLDPDYLFDRQTTLAILAGFAYNRRVMVTGYHGTGKSTHI
EQVAARLNWPCVRVNLDSHISRIDLIGKDAIVVRDGMQVTEFRDGILPWALQNNVAMVFDEYDAGRPDVMFVIQRVLEVS
GRLTLLDQNRVIRPHPAFRLFSTANTVGLGDTTGLYHGTQQINQGQMDRWSIVTTLNYLPHDKEVEIVLAKSKHYQNPQG
RETVARMVRLADLTRSAFINGDLSTVMSPRTVLTWAENAEIFKDIGFALRVTFLNKCDELERPLVAEFYQRCFGQELQES
AVNLVLS

Specific function: Catalyzes cobalt insertion in the corrin ring [H]

COG id: COG0714

COG function: function code R; MoxR-like ATPases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI24415404, Length=212, Percent_Identity=25.4716981132075, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323135, Length=192, Percent_Identity=26.0416666666667, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI161076560, Length=185, Percent_Identity=27.027027027027, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI161076562, Length=185, Percent_Identity=27.027027027027, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011704
- InterPro:   IPR006537 [H]

Pfam domain/function: PF07728 AAA_5 [H]

EC number: =6.6.1.2 [H]

Molecular weight: Translated: 36944; Mature: 36944

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSTETVAPTPDMKVSVRQVFGIDIDMEVPAYSEPDPHVPDLDPDYLFDRQTTLAILAGF
CCCCCCCCCCCCCEEEEEHHHCCEEEECCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHH
AYNRRVMVTGYHGTGKSTHIEQVAARLNWPCVRVNLDSHISRIDLIGKDAIVVRDGMQVT
HCCCEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEHHHCCCEEEECCCCEEEEECCCCHH
EFRDGILPWALQNNVAMVFDEYDAGRPDVMFVIQRVLEVSGRLTLLDQNRVIRPHPAFRL
HHHCCCCCEEECCCEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECCCEECCCCCEEE
FSTANTVGLGDTTGLYHGTQQINQGQMDRWSIVTTLNYLPHDKEVEIVLAKSKHYQNPQG
EECCCCCCCCCCCCCCCCHHHHCCCCCCCEEEEEEHHCCCCCCCEEEEEECCCCCCCCCH
RETVARMVRLADLTRSAFINGDLSTVMSPRTVLTWAENAEIFKDIGFALRVTFLNKCDEL
HHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
ERPLVAEFYQRCFGQELQESAVNLVLS
CCCHHHHHHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure
MMSTETVAPTPDMKVSVRQVFGIDIDMEVPAYSEPDPHVPDLDPDYLFDRQTTLAILAGF
CCCCCCCCCCCCCEEEEEHHHCCEEEECCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHH
AYNRRVMVTGYHGTGKSTHIEQVAARLNWPCVRVNLDSHISRIDLIGKDAIVVRDGMQVT
HCCCEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEHHHCCCEEEECCCCEEEEECCCCHH
EFRDGILPWALQNNVAMVFDEYDAGRPDVMFVIQRVLEVSGRLTLLDQNRVIRPHPAFRL
HHHCCCCCEEECCCEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECCCEECCCCCEEE
FSTANTVGLGDTTGLYHGTQQINQGQMDRWSIVTTLNYLPHDKEVEIVLAKSKHYQNPQG
EECCCCCCCCCCCCCCCCHHHHCCCCCCCEEEEEEHHCCCCCCCEEEEEECCCCCCCCCH
RETVARMVRLADLTRSAFINGDLSTVMSPRTVLTWAENAEIFKDIGFALRVTFLNKCDEL
HHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
ERPLVAEFYQRCFGQELQESAVNLVLS
CCCHHHHHHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1917840 [H]