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The map label for this gene is cobT [H]

Identifier: 158425304

GI number: 158425304

Start: 4226437

End: 4228329

Strand: Direct

Name: cobT [H]

Synonym: AZC_3680

Alternate gene names: 158425304

Gene position: 4226437-4228329 (Clockwise)

Preceding gene: 158425303

Following gene: 158425305

Centisome position: 78.71

GC content: 69.41

Gene sequence:

>1893_bases
ATGGCTGCCCCGACCAACAAGACCGTCAAGACCGCCCCCAAGGAAGCGCCTGCGGAGCCTTTCAAGCGCGCCGTGGCCGG
CTGCTTCAAGGCCATCGCCGGGGTGGGCGAGTTCGAGGTCTCCTACGCTTCCGAACGTCCCTCGCTCGGCCCGGACCGGG
CGCGTCTGCCCGACCTGCCCCGCCGCTTCACGGCGCAGGACGCGGCCGTGCTGCGCGGCCACGCCGATTCCATGGCGCTG
CGCCTCGCCTGCCACGATCCCTCCGTGCATCGCCGCATGCTGCCCTCCGGCGACATCGCCCGCGCCGTGTTCGAGGCGGT
GGAGCAGGCGCGCGTGGAAGCGCTCGGCTCCCAGCGCATGCTGGGCACCAAGAACAATCTCACCGCCATGCTGAGCGACC
GCTACCATCGCGGTCCCTATGCGGAAATCACCGAGCGCGCCGACGCCCCCATCCAGGACGCGGTGGCCCTCATGGTGCGC
GAGCGCCTGACCGGACAGGCGCCGCCGGCCGACGCGCGCAAGATCGTCGATCTCTGGCGCGACTATATCGAGGCGCGCGC
GGACAAGGACCTTTCCCGCCTCACCGACGTGCTGGGCGACCAGAAGAAGTTCGGCGAGATCACCCGCGATCTCCTCACCT
CGCTCGAAATGGGCGAGGACCGCGGCCTCGAAAACGAGGACGACAACGAGAGCGACGAGGAATCCTCCGGAAATCAGGAG
CAGGGCGACGAAGACGCCCAGCGTTCCGAGGACGACACGCAGGACGGCGCTACCGAGGTGGAAGCCGAAATGTCCCAGGA
GGAGCTGCCCGACAGCGCCTCGGAGAGCGAAGCCGGTCCGCCCGCCGAAATGCCGGACGATGCGGAACTGGGCGATTCCG
ACGAGGCCGCCGAGCCGTGGCAGCCCCGCCAGCCCCCTGCGCACGACACCAAGGGGCCGGAGTATCACGCCTACACGACG
AAGTTCGACGAGGAGACCTCCGCCGAGGAGCTCTGCGACGCCGAGGAGCTGACGCGCCTGCGCGCCTATCTCGACAAGCA
GTTGAACAACCTTCAGGGCGTCGTGGCCCGCCTCGCCAACCGCCTCCAGCGCCGCCTCCTGGCGCAGCAGAACCGGGCGT
GGGAGTTCGATCTGGAGGAAGGCGTGCTGGACCCGGCCCGCCTCTCCCGCGTGGTCACCGATCCCACCGCCGCGCTCTCC
TTCAAGCGCGAGCGCGACACCGAGTTCCGCGACACGGTGGTGACGCTGCTCATCGACAATTCCGGCTCCATGCGCGGCCG
GCCGATCACGGTCGCTGCCACCTGCGCCGACATTCTCGCCCGCACGCTGGAGCGTTGCGCGGTGAAGGTGGAGGTGCTCG
GCTTCACCACCCGCGCCTGGAAGGGCGGTCAGTCCCGCGAGGCGTGGCTGGCGGGCGGCAAGCCGGCCAATCCGGGCCGC
CTCAACGACCTGCGCCACATCGTCTACAAGTCCGCCGACGCCCCCTGGCGCCGCGCCCGGCGCAACCTCGGCCTGATGAT
GCGCGAGGGGCTGCTGAAGGAGAATATCGACGGCGAGGCGCTCGACTGGGCGCACAAGCGCCTGCTCGGCCGGCCCGAGG
CGCGCAAGATCCTGATGATGATCTCCGACGGCGCGCCGGTGGACGATTCCACCCTCTCGGTGAATGCCGGCAATTATCTC
GAGCGCCATCTGCGCCATATCATCACGCAGATCGAGGACCGCTCGCCGGTGGAGCTCATCGCCATCGGCATCGGCCATGA
CGTCACGCGCTATTACAAGCGTGCCGTGACCATCGTGGACGCCGAGGAGCTGGGCGGCGCCATGACCGAGAAGCTGGCGG
AGCTGTTCGACGACAAGCCCGCCCCCGCTCCGCGCGGCCGGCGCCTGCACTGA

Upstream 100 bases:

>100_bases
GCGCGGTCAACCTCGTCCTCTCCTGACGTCCCATGATGTGCGGCCCCTCCCATGCGGAGGGGCCATTCCGCCCGCGCCGG
CGTCCGTGACAGGCTGAGCT

Downstream 100 bases:

>100_bases
TGCGCCTCGTCAGCCGCCGCACCGCCCTCACGAGCCTCGTGGCGGCGGGCGGCGCGCTCGCCGCGCACAGGGCCTTTGCC
AAGCCGCGCGAATTTCCCCT

Product: cobalt chelatase

Products: NA

Alternate protein names: Hydrogenobyrinic acid a,c-diamide cobaltochelatase subunit CobT [H]

Number of amino acids: Translated: 630; Mature: 629

Protein sequence:

>630_residues
MAAPTNKTVKTAPKEAPAEPFKRAVAGCFKAIAGVGEFEVSYASERPSLGPDRARLPDLPRRFTAQDAAVLRGHADSMAL
RLACHDPSVHRRMLPSGDIARAVFEAVEQARVEALGSQRMLGTKNNLTAMLSDRYHRGPYAEITERADAPIQDAVALMVR
ERLTGQAPPADARKIVDLWRDYIEARADKDLSRLTDVLGDQKKFGEITRDLLTSLEMGEDRGLENEDDNESDEESSGNQE
QGDEDAQRSEDDTQDGATEVEAEMSQEELPDSASESEAGPPAEMPDDAELGDSDEAAEPWQPRQPPAHDTKGPEYHAYTT
KFDEETSAEELCDAEELTRLRAYLDKQLNNLQGVVARLANRLQRRLLAQQNRAWEFDLEEGVLDPARLSRVVTDPTAALS
FKRERDTEFRDTVVTLLIDNSGSMRGRPITVAATCADILARTLERCAVKVEVLGFTTRAWKGGQSREAWLAGGKPANPGR
LNDLRHIVYKSADAPWRRARRNLGLMMREGLLKENIDGEALDWAHKRLLGRPEARKILMMISDGAPVDDSTLSVNAGNYL
ERHLRHIITQIEDRSPVELIAIGIGHDVTRYYKRAVTIVDAEELGGAMTEKLAELFDDKPAPAPRGRRLH

Sequences:

>Translated_630_residues
MAAPTNKTVKTAPKEAPAEPFKRAVAGCFKAIAGVGEFEVSYASERPSLGPDRARLPDLPRRFTAQDAAVLRGHADSMAL
RLACHDPSVHRRMLPSGDIARAVFEAVEQARVEALGSQRMLGTKNNLTAMLSDRYHRGPYAEITERADAPIQDAVALMVR
ERLTGQAPPADARKIVDLWRDYIEARADKDLSRLTDVLGDQKKFGEITRDLLTSLEMGEDRGLENEDDNESDEESSGNQE
QGDEDAQRSEDDTQDGATEVEAEMSQEELPDSASESEAGPPAEMPDDAELGDSDEAAEPWQPRQPPAHDTKGPEYHAYTT
KFDEETSAEELCDAEELTRLRAYLDKQLNNLQGVVARLANRLQRRLLAQQNRAWEFDLEEGVLDPARLSRVVTDPTAALS
FKRERDTEFRDTVVTLLIDNSGSMRGRPITVAATCADILARTLERCAVKVEVLGFTTRAWKGGQSREAWLAGGKPANPGR
LNDLRHIVYKSADAPWRRARRNLGLMMREGLLKENIDGEALDWAHKRLLGRPEARKILMMISDGAPVDDSTLSVNAGNYL
ERHLRHIITQIEDRSPVELIAIGIGHDVTRYYKRAVTIVDAEELGGAMTEKLAELFDDKPAPAPRGRRLH
>Mature_629_residues
AAPTNKTVKTAPKEAPAEPFKRAVAGCFKAIAGVGEFEVSYASERPSLGPDRARLPDLPRRFTAQDAAVLRGHADSMALR
LACHDPSVHRRMLPSGDIARAVFEAVEQARVEALGSQRMLGTKNNLTAMLSDRYHRGPYAEITERADAPIQDAVALMVRE
RLTGQAPPADARKIVDLWRDYIEARADKDLSRLTDVLGDQKKFGEITRDLLTSLEMGEDRGLENEDDNESDEESSGNQEQ
GDEDAQRSEDDTQDGATEVEAEMSQEELPDSASESEAGPPAEMPDDAELGDSDEAAEPWQPRQPPAHDTKGPEYHAYTTK
FDEETSAEELCDAEELTRLRAYLDKQLNNLQGVVARLANRLQRRLLAQQNRAWEFDLEEGVLDPARLSRVVTDPTAALSF
KRERDTEFRDTVVTLLIDNSGSMRGRPITVAATCADILARTLERCAVKVEVLGFTTRAWKGGQSREAWLAGGKPANPGRL
NDLRHIVYKSADAPWRRARRNLGLMMREGLLKENIDGEALDWAHKRLLGRPEARKILMMISDGAPVDDSTLSVNAGNYLE
RHLRHIITQIEDRSPVELIAIGIGHDVTRYYKRAVTIVDAEELGGAMTEKLAELFDDKPAPAPRGRRLH

Specific function: Catalyzes cobalt insertion in the corrin ring [H]

COG id: COG4547

COG function: function code H; Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 VWFA domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006538
- InterPro:   IPR002035 [H]

Pfam domain/function: PF06213 CobT [H]

EC number: =6.6.1.2 [H]

Molecular weight: Translated: 69919; Mature: 69788

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS50234 VWFA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAPTNKTVKTAPKEAPAEPFKRAVAGCFKAIAGVGEFEVSYASERPSLGPDRARLPDLP
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCC
RRFTAQDAAVLRGHADSMALRLACHDPSVHRRMLPSGDIARAVFEAVEQARVEALGSQRM
HHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCC
LGTKNNLTAMLSDRYHRGPYAEITERADAPIQDAVALMVRERLTGQAPPADARKIVDLWR
CCCCCCHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
DYIEARADKDLSRLTDVLGDQKKFGEITRDLLTSLEMGEDRGLENEDDNESDEESSGNQE
HHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCCC
QGDEDAQRSEDDTQDGATEVEAEMSQEELPDSASESEAGPPAEMPDDAELGDSDEAAEPW
CCCHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
QPRQPPAHDTKGPEYHAYTTKFDEETSAEELCDAEELTRLRAYLDKQLNNLQGVVARLAN
CCCCCCCCCCCCCCCEEEECCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLQRRLLAQQNRAWEFDLEEGVLDPARLSRVVTDPTAALSFKRERDTEFRDTVVTLLIDN
HHHHHHHHHHCCCEECCHHHCCCCHHHHHHHHCCCHHHHHCCHHCCCHHHHEEEEEEECC
SGSMRGRPITVAATCADILARTLERCAVKVEVLGFTTRAWKGGQSREAWLAGGKPANPGR
CCCCCCCCEEHHHHHHHHHHHHHHHHHEEHHEEEEEHHHCCCCCCCCHHCCCCCCCCCCH
LNDLRHIVYKSADAPWRRARRNLGLMMREGLLKENIDGEALDWAHKRLLGRPEARKILMM
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHEEEEE
ISDGAPVDDSTLSVNAGNYLERHLRHIITQIEDRSPVELIAIGIGHDVTRYYKRAVTIVD
EECCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHEEE
AEELGGAMTEKLAELFDDKPAPAPRGRRLH
HHHHCCHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
AAPTNKTVKTAPKEAPAEPFKRAVAGCFKAIAGVGEFEVSYASERPSLGPDRARLPDLP
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCC
RRFTAQDAAVLRGHADSMALRLACHDPSVHRRMLPSGDIARAVFEAVEQARVEALGSQRM
HHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCC
LGTKNNLTAMLSDRYHRGPYAEITERADAPIQDAVALMVRERLTGQAPPADARKIVDLWR
CCCCCCHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
DYIEARADKDLSRLTDVLGDQKKFGEITRDLLTSLEMGEDRGLENEDDNESDEESSGNQE
HHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCCC
QGDEDAQRSEDDTQDGATEVEAEMSQEELPDSASESEAGPPAEMPDDAELGDSDEAAEPW
CCCHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
QPRQPPAHDTKGPEYHAYTTKFDEETSAEELCDAEELTRLRAYLDKQLNNLQGVVARLAN
CCCCCCCCCCCCCCCEEEECCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLQRRLLAQQNRAWEFDLEEGVLDPARLSRVVTDPTAALSFKRERDTEFRDTVVTLLIDN
HHHHHHHHHHCCCEECCHHHCCCCHHHHHHHHCCCHHHHHCCHHCCCHHHHEEEEEEECC
SGSMRGRPITVAATCADILARTLERCAVKVEVLGFTTRAWKGGQSREAWLAGGKPANPGR
CCCCCCCCEEHHHHHHHHHHHHHHHHHEEHHEEEEEHHHCCCCCCCCHHCCCCCCCCCCH
LNDLRHIVYKSADAPWRRARRNLGLMMREGLLKENIDGEALDWAHKRLLGRPEARKILMM
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHEEEEE
ISDGAPVDDSTLSVNAGNYLERHLRHIITQIEDRSPVELIAIGIGHDVTRYYKRAVTIVD
EECCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHEEE
AEELGGAMTEKLAELFDDKPAPAPRGRRLH
HHHHCCHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1917840 [H]