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The map label for this gene is tlpA [H]

Identifier: 158425105

GI number: 158425105

Start: 3998292

End: 4000019

Strand: Reverse

Name: tlpA [H]

Synonym: AZC_3481

Alternate gene names: 158425105

Gene position: 4000019-3998292 (Counterclockwise)

Preceding gene: 158425106

Following gene: 158425104

Centisome position: 74.49

GC content: 68.69

Gene sequence:

>1728_bases
TTGCTTGGCCCGCCCGGACGCGCAGTGCTGGAGTCCATGATGCGTTACGCCAATTTTCCGATCATTTTGAAGGTCCTTGT
CCTTCTTCTGGCGCTCGGTATTACGAGCCTCGCGGGTGCCGGCTATGCGGCCTGGCAGATGTCGCGGATCGACGATGCCT
ATACGGGTCTCGTGGATGGCGCGCAGGTGGCGGTGCTGAAGATTGCCCGCGCCGCCCGCTTCTCGGTGGTTGTTCGCGCC
GAGCTTCAGAGCGCGCTGCTCGCCACCTCCGAGGCCGAGATGCGGGCCGCTGCCGGACGGCGGGAAGATGCCATCGCGCA
ATATCGCCAGTTGATGTCGGAAGCGGCGCAGGCGATGCCCTCGCAGGCCGCCGGCATCCAGCGGCTGCGCGATCTGACCC
ACGCGGCCTTCGTCGATGCCTGCGGCGGCGTGGTCAAGGCCGCGGGCGGTGCCGACAGCGGGGCGGATGCGCGCCGGCTG
ATGGCTTCTTCCTGCGCCCCCGCCATCGACGCCTCCATCGCCGAGGCGCTGAAGTTCAACGAGGGCCTGCGCGTCGCCGT
GCAGGACCAGCGCCAGGGCATCAGCGACACCACCGTCTCCTCCATCACCGTCACCTTCGCGGTCATCGCCGGAGCGACGC
TGCTGGTGATGTTCGTTGCCTACTGGCTGGTGCGCGACGCCATCGTCAAGCCGCTCCGCCGCCTGATGTTCTCCATGGAC
GCGCTCGGCGAGGGACGCCTGCATGAGGAAGTCACGGGCACCGAGCGCAAGGACGAGGTGGGGGCCATGGCGCGGACCCT
CGACGTGCTGCGCGGGCATCTCGCAGATGCGGAGGACATGCGCGTGGCGCAGGCACGCCGCGAGGCCGACGAGCGGGATC
AGCTTGCCAAGCGCGAGCGGCTCGCCACCTCCTTCATCGATCGCATGACACAGCTTGCGTCCGGCTTTGCCAGCTCGGCG
GGCGAGGTGGCCGATGCGGCGCGCAGCCTCTCGGCAACGGCGGAGCAGACCGCCCAGCAGGCGAATGCGGTCGCTGCTGC
GGCTGAGCAGGCCTCCGCCAACGTGCAGACGGTTGCGGCCTCCTCCGAGGAACTTGCCACCTCGGTGCGTGAGATCACCG
GTCAGGTGAGCCACTCTGCGGACGTGGCCGAGCAGGCCTTCCGCGAGGTCGAAGCCTCCAGCACGCGCATCGGTGCTCTG
TCCACCGCCGCGGCCGATATCGGTGACGTCATCGGTCTCATCCGCGGCATTGCCGACCAGACCAATCTGCTCGCGCTCAA
CGCCACCATCGAGGCGGCACGTGCCGGAGACGCGGGACGGGGCTTCGCGGTCGTGGCTTCCGAGGTGAAGCAGCTCGCCG
CCCAGACGGCACGGGCGACCGCCGACATTTCCGGCAAGGTGACGGAGATCCAGACCGCCACCGAGGGCACGGTCTCCTCC
ATGTCGCAGATCCAGCGAGTGGTGACCGACATCAAGCAGATCTCCTCCTCCATCGCCGGTGCGGTGGAAGAGCAGGGCGC
GGCCACCGGTGAGATCGCGCAGAACTGCCAGCAGGCCGCCACGGGCACCCAGCAGGTCACCGACAATATCGGCGGCGTGG
GGCAGGCGGCGCAGATGACGGGGGCGGCCTCCGACCAGCTTCTCGCGCTCTCTCAGGACCTGTCCAGTCAGGCCTCCGAA
CTGCGGGAGGTGGTGGAGACCTTCGTCCAGGACCTCGCGGCGGCCTGA

Upstream 100 bases:

>100_bases
AGGGCTTCGCGCCGGTAGTCATCATGACCCGCCGGGCCGGGAACGTGCGCGACATGACGCGCCCGCCTTGACAGTTCCCT
GACCGGACCGCCGGCCGCTT

Downstream 100 bases:

>100_bases
CCCCTCGGCCGTTGCCCTTTTCATCAGCACAAGGCCGCCGGTCCCCCGGCGGCCTTTCGCATTTCTGGGCGCCCTGTCAC
GGGGCAGGGCCCGCCGGCGT

Product: IMP dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 575; Mature: 575

Protein sequence:

>575_residues
MLGPPGRAVLESMMRYANFPIILKVLVLLLALGITSLAGAGYAAWQMSRIDDAYTGLVDGAQVAVLKIARAARFSVVVRA
ELQSALLATSEAEMRAAAGRREDAIAQYRQLMSEAAQAMPSQAAGIQRLRDLTHAAFVDACGGVVKAAGGADSGADARRL
MASSCAPAIDASIAEALKFNEGLRVAVQDQRQGISDTTVSSITVTFAVIAGATLLVMFVAYWLVRDAIVKPLRRLMFSMD
ALGEGRLHEEVTGTERKDEVGAMARTLDVLRGHLADAEDMRVAQARREADERDQLAKRERLATSFIDRMTQLASGFASSA
GEVADAARSLSATAEQTAQQANAVAAAAEQASANVQTVAASSEELATSVREITGQVSHSADVAEQAFREVEASSTRIGAL
STAAADIGDVIGLIRGIADQTNLLALNATIEAARAGDAGRGFAVVASEVKQLAAQTARATADISGKVTEIQTATEGTVSS
MSQIQRVVTDIKQISSSIAGAVEEQGAATGEIAQNCQQAATGTQQVTDNIGGVGQAAQMTGAASDQLLALSQDLSSQASE
LREVVETFVQDLAAA

Sequences:

>Translated_575_residues
MLGPPGRAVLESMMRYANFPIILKVLVLLLALGITSLAGAGYAAWQMSRIDDAYTGLVDGAQVAVLKIARAARFSVVVRA
ELQSALLATSEAEMRAAAGRREDAIAQYRQLMSEAAQAMPSQAAGIQRLRDLTHAAFVDACGGVVKAAGGADSGADARRL
MASSCAPAIDASIAEALKFNEGLRVAVQDQRQGISDTTVSSITVTFAVIAGATLLVMFVAYWLVRDAIVKPLRRLMFSMD
ALGEGRLHEEVTGTERKDEVGAMARTLDVLRGHLADAEDMRVAQARREADERDQLAKRERLATSFIDRMTQLASGFASSA
GEVADAARSLSATAEQTAQQANAVAAAAEQASANVQTVAASSEELATSVREITGQVSHSADVAEQAFREVEASSTRIGAL
STAAADIGDVIGLIRGIADQTNLLALNATIEAARAGDAGRGFAVVASEVKQLAAQTARATADISGKVTEIQTATEGTVSS
MSQIQRVVTDIKQISSSIAGAVEEQGAATGEIAQNCQQAATGTQQVTDNIGGVGQAAQMTGAASDQLLALSQDLSSQASE
LREVVETFVQDLAAA
>Mature_575_residues
MLGPPGRAVLESMMRYANFPIILKVLVLLLALGITSLAGAGYAAWQMSRIDDAYTGLVDGAQVAVLKIARAARFSVVVRA
ELQSALLATSEAEMRAAAGRREDAIAQYRQLMSEAAQAMPSQAAGIQRLRDLTHAAFVDACGGVVKAAGGADSGADARRL
MASSCAPAIDASIAEALKFNEGLRVAVQDQRQGISDTTVSSITVTFAVIAGATLLVMFVAYWLVRDAIVKPLRRLMFSMD
ALGEGRLHEEVTGTERKDEVGAMARTLDVLRGHLADAEDMRVAQARREADERDQLAKRERLATSFIDRMTQLASGFASSA
GEVADAARSLSATAEQTAQQANAVAAAAEQASANVQTVAASSEELATSVREITGQVSHSADVAEQAFREVEASSTRIGAL
STAAADIGDVIGLIRGIADQTNLLALNATIEAARAGDAGRGFAVVASEVKQLAAQTARATADISGKVTEIQTATEGTVSS
MSQIQRVVTDIKQISSSIAGAVEEQGAATGEIAQNCQQAATGTQQVTDNIGGVGQAAQMTGAASDQLLALSQDLSSQASE
LREVVETFVQDLAAA

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI2367378, Length=364, Percent_Identity=30.7692307692308, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1787690, Length=375, Percent_Identity=28.5333333333333, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1788194, Length=404, Percent_Identity=27.7227722772277, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI1788195, Length=232, Percent_Identity=32.7586206896552, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI1789453, Length=190, Percent_Identity=31.5789473684211, Blast_Score=75, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 59783; Mature: 59783

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS50885 HAMP ; PS00430 TONB_DEPENDENT_REC_1 ; PS50111 CHEMOTAXIS_TRANSDUC_2 ; PS50192 T_SNARE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure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CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]