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The map label for this gene is ftsJ

Identifier: 158424996

GI number: 158424996

Start: 3901530

End: 3902252

Strand: Reverse

Name: ftsJ

Synonym: AZC_3372

Alternate gene names: 158424996

Gene position: 3902252-3901530 (Counterclockwise)

Preceding gene: 158424997

Following gene: 158424994

Centisome position: 72.67

GC content: 67.63

Gene sequence:

>723_bases
TTGAGTTCCTCCCCCCGCAGTCCCGACGCACGTCCCCTCAAGGTGCGCGTGAAGTCGGCACGCACCCGCTCGTCCTCGTC
CCAGAAGTGGCTCCAGCGCCAGCTCAACGATCCCTATGTGGCCCGCGCCAAGCGCGAGGGCTGGCGCTCGCGTGCCGCCT
TCAAGCTGATCGAGATGGACGAAAAGCTCCACGTCCTGAAGCGGGGCATGCGCATCGTGGACCTTGGCGCCGCCCCCGGC
GGCTGGAGCCAGGTGGCGGCCAAGAAGATCGGCGCGGCGGAAGGGCAGGGCAAGATCGTCGCCATCGACCTTCTGGAGAT
GGATGCGGTGACGGGCGTCATGTTCGCCCAGATGGACTTCCTCGATCCCACTGCCCCCGAGCGGCTGTTCGCCATGCTGG
ACGGCAAGGCGGACCTCGTGATGTCGGACATGGCGGCCAACACCACCGGCCACAAGAAGACCGACCATCTCAAGATCATC
GCCCTCGTGGAACTGGCGGCGGATTTCGCCCGGCAGGTTCTGGCGCCGGGCGGGGCCTTCATCGCGAAGGTGTTCCAGGG
CGGCACCGAGGGCACGCTGCTGGCCGACCTGAAGCGCGACTATGCGCAGGTGCGCCATCTGAAGCCGGCGGCGAGCCGTG
CGGATTCGGCCGAGCTCTATCTCGTCGCGACCGGTTTTCGCGGCAGCGCCGACCGGACGGAAGACGAGACGGACGAGGCC
TGA

Upstream 100 bases:

>100_bases
CCGACCGTGGCCTGCGCGAAGGCATGCTGGTGCAGCTCATGCGCGCCGATGGTGTATGGAAGCGGCATCGCGCGCAGCCC
AGCTATTCGGAGTCCTGTAC

Downstream 100 bases:

>100_bases
ACCTTACGAGCCCGCGGTGTTCACCTCGCCGCGGGGATCGGGCAGCGTGCTCGGCTTTTCCTTGTGGCCGGAGAGTTCTG
CGCCCGCATCCTTCGGCAGG

Product: 23S rRNA methylase

Products: NA

Alternate protein names: 23S rRNA Um2552 methyltransferase; rRNA (uridine-2'-O-)-methyltransferase

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MSSSPRSPDARPLKVRVKSARTRSSSSQKWLQRQLNDPYVARAKREGWRSRAAFKLIEMDEKLHVLKRGMRIVDLGAAPG
GWSQVAAKKIGAAEGQGKIVAIDLLEMDAVTGVMFAQMDFLDPTAPERLFAMLDGKADLVMSDMAANTTGHKKTDHLKII
ALVELAADFARQVLAPGGAFIAKVFQGGTEGTLLADLKRDYAQVRHLKPAASRADSAELYLVATGFRGSADRTEDETDEA

Sequences:

>Translated_240_residues
MSSSPRSPDARPLKVRVKSARTRSSSSQKWLQRQLNDPYVARAKREGWRSRAAFKLIEMDEKLHVLKRGMRIVDLGAAPG
GWSQVAAKKIGAAEGQGKIVAIDLLEMDAVTGVMFAQMDFLDPTAPERLFAMLDGKADLVMSDMAANTTGHKKTDHLKII
ALVELAADFARQVLAPGGAFIAKVFQGGTEGTLLADLKRDYAQVRHLKPAASRADSAELYLVATGFRGSADRTEDETDEA
>Mature_239_residues
SSSPRSPDARPLKVRVKSARTRSSSSQKWLQRQLNDPYVARAKREGWRSRAAFKLIEMDEKLHVLKRGMRIVDLGAAPGG
WSQVAAKKIGAAEGQGKIVAIDLLEMDAVTGVMFAQMDFLDPTAPERLFAMLDGKADLVMSDMAANTTGHKKTDHLKIIA
LVELAADFARQVLAPGGAFIAKVFQGGTEGTLLADLKRDYAQVRHLKPAASRADSAELYLVATGFRGSADRTEDETDEA

Specific function: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit

COG id: COG0293

COG function: function code J; 23S rRNA methylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RlmE family

Homologues:

Organism=Homo sapiens, GI7019377, Length=216, Percent_Identity=38.4259259259259, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI29029591, Length=191, Percent_Identity=38.2198952879581, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI29029589, Length=191, Percent_Identity=38.2198952879581, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI7110661, Length=191, Percent_Identity=38.2198952879581, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI194097365, Length=196, Percent_Identity=37.2448979591837, Blast_Score=110, Evalue=1e-24,
Organism=Escherichia coli, GI1789569, Length=208, Percent_Identity=46.6346153846154, Blast_Score=181, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17553474, Length=215, Percent_Identity=32.093023255814, Blast_Score=124, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17554650, Length=195, Percent_Identity=35.3846153846154, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI71987550, Length=196, Percent_Identity=32.6530612244898, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71987561, Length=196, Percent_Identity=32.6530612244898, Blast_Score=100, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17553860, Length=196, Percent_Identity=32.6530612244898, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6319535, Length=205, Percent_Identity=33.1707317073171, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6319796, Length=194, Percent_Identity=31.9587628865979, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321302, Length=105, Percent_Identity=40.9523809523809, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21356387, Length=225, Percent_Identity=41.7777777777778, Blast_Score=164, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24647580, Length=198, Percent_Identity=35.3535353535354, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24648639, Length=196, Percent_Identity=35.7142857142857, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI18859957, Length=191, Percent_Identity=34.5549738219895, Blast_Score=106, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RLME_AZOC5 (A8II77)

Other databases:

- EMBL:   AP009384
- RefSeq:   YP_001526288.1
- ProteinModelPortal:   A8II77
- SMR:   A8II77
- GeneID:   5688579
- GenomeReviews:   AP009384_GR
- KEGG:   azc:AZC_3372
- HOGENOM:   HBG398270
- OMA:   SDMAANT
- ProtClustDB:   CLSK979300
- BioCyc:   ACAU438753:AZC_3372-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01547
- InterPro:   IPR015507
- InterPro:   IPR002877
- PANTHER:   PTHR10920
- PIRSF:   PIRSF005461

Pfam domain/function: PF01728 FtsJ

EC number: =2.1.1.166

Molecular weight: Translated: 26110; Mature: 25979

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: NA

Important sites: ACT_SITE 183-183 BINDING 80-80 BINDING 82-82 BINDING 103-103 BINDING 119-119 BINDING 143-143

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSPRSPDARPLKVRVKSARTRSSSSQKWLQRQLNDPYVARAKREGWRSRAAFKLIEMD
CCCCCCCCCCCCEEEEEEHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
EKLHVLKRGMRIVDLGAAPGGWSQVAAKKIGAAEGQGKIVAIDLLEMDAVTGVMFAQMDF
HHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHHHHHHHHHC
LDPTAPERLFAMLDGKADLVMSDMAANTTGHKKTDHLKIIALVELAADFARQVLAPGGAF
CCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHH
IAKVFQGGTEGTLLADLKRDYAQVRHLKPAASRADSAELYLVATGFRGSADRTEDETDEA
HHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SSSPRSPDARPLKVRVKSARTRSSSSQKWLQRQLNDPYVARAKREGWRSRAAFKLIEMD
CCCCCCCCCCCEEEEEEHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
EKLHVLKRGMRIVDLGAAPGGWSQVAAKKIGAAEGQGKIVAIDLLEMDAVTGVMFAQMDF
HHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHHHHHHHHHC
LDPTAPERLFAMLDGKADLVMSDMAANTTGHKKTDHLKIIALVELAADFARQVLAPGGAF
CCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHH
IAKVFQGGTEGTLLADLKRDYAQVRHLKPAASRADSAELYLVATGFRGSADRTEDETDEA
HHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA