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The map label for this gene is fdh [H]

Identifier: 158424895

GI number: 158424895

Start: 3777321

End: 3778337

Strand: Direct

Name: fdh [H]

Synonym: AZC_3271

Alternate gene names: 158424895

Gene position: 3777321-3778337 (Clockwise)

Preceding gene: 158424890

Following gene: 158424897

Centisome position: 70.34

GC content: 67.55

Gene sequence:

>1017_bases
ATGTTTGGGACCATGCTGTACGGCAAGGGCGACGTGAGGTGTGAGGCGGTTCCGGAGCCGGAGATCCTCAAGCCCACGGA
CGCCATCATCAAGCTGTCCGCCAGTTGCATCTGCGGCTCGGATCTCTGGCCGTACCGGGGCCTGAATGACGTCACCGCGC
CGATGGCGATGGGTCACGAATACTGCGGCATCGTCACGCAAGTCGGCAGCGCGGTGCGCACCGTGCGCCCCGGCCAGTTC
GTGGTCGGCTCCTTCTGCCTGTCGGACAACACCTGCCCCCACTGCCGGTTCGGCTTTCAGTCTTCCTGCGAGCAGCGCGA
ATTCATGAGCGGCGCCCAGGCGCCCTACGCCCGCGTGCCGTTGGCGGATGGCACGCTGGTGGCGACCGACACGGTTCCCG
ACGATGATCTCCTCCCCAGCCTGCTGGCGACATCCGATGTGCTGGGAACGGGATGGTATGCGGCCGACGCGGCGCGCGTG
CAGCCGGGCTCCACGGTCGTCGTGGTGGGCGACGGTGCGGTGGGCCTCATGGGCGTTCTCGCGGCCAGGCAGATGGAGGC
CGGGCGTATCATCGCAATGAGCCGCCACAAGAGCCGCCAAGACCTGGCGCTGGAGTTCGGCGCCACGGACATCGTCTCCG
CGCGTGGCGCGGAAGGGATTGCCGAGGTCAAGCGCCTGACCGGGAACGTCGGCGCGGACTCGGTGCTCGAATGCGTGGGA
ACGGGGGAATCCATGGCCCAGGCCATCGCCTGCGCGCGCCCCGGCGCCATGATCGGCTATGTGGGCGTGCCCCACGGCGT
CGAACTCAATGGCGAACAGCTCTTCTTCTCGCAGACCGGCATGCTTGGCGGCCCAGCCCCGGTGCGCCGTTTCCTGCCGC
ATCTGATGGATCTCGTGCTGAGCCGCAAGATCAATCCGGGCAAGGTCTTCGACCTGACGCTGCCGCTGGAGGACGTGGCC
GAAGGCTATCGCGCCATGGACGAGCGGCGGGCCATCAAGACCCTGCTTCGGGTCTGA

Upstream 100 bases:

>100_bases
TGACAGTGGCCCGGCGCATCCCCTCCCCATCCGTTGCTTCCCCCGCAGCCAGACGGGGACGGCGGTGCGCCGGTGCTGCG
GACCTGAAGAGGACATGTGC

Downstream 100 bases:

>100_bases
GCCCATCCCACCATGGCCGGTCCGCGGGCGGCCATGGTGGGCACGGCCCCTGTCCTATCCGCGATGGCGCAGGGCCTCGA
CCAGCGCCACGAAAGCCGGA

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MFGTMLYGKGDVRCEAVPEPEILKPTDAIIKLSASCICGSDLWPYRGLNDVTAPMAMGHEYCGIVTQVGSAVRTVRPGQF
VVGSFCLSDNTCPHCRFGFQSSCEQREFMSGAQAPYARVPLADGTLVATDTVPDDDLLPSLLATSDVLGTGWYAADAARV
QPGSTVVVVGDGAVGLMGVLAARQMEAGRIIAMSRHKSRQDLALEFGATDIVSARGAEGIAEVKRLTGNVGADSVLECVG
TGESMAQAIACARPGAMIGYVGVPHGVELNGEQLFFSQTGMLGGPAPVRRFLPHLMDLVLSRKINPGKVFDLTLPLEDVA
EGYRAMDERRAIKTLLRV

Sequences:

>Translated_338_residues
MFGTMLYGKGDVRCEAVPEPEILKPTDAIIKLSASCICGSDLWPYRGLNDVTAPMAMGHEYCGIVTQVGSAVRTVRPGQF
VVGSFCLSDNTCPHCRFGFQSSCEQREFMSGAQAPYARVPLADGTLVATDTVPDDDLLPSLLATSDVLGTGWYAADAARV
QPGSTVVVVGDGAVGLMGVLAARQMEAGRIIAMSRHKSRQDLALEFGATDIVSARGAEGIAEVKRLTGNVGADSVLECVG
TGESMAQAIACARPGAMIGYVGVPHGVELNGEQLFFSQTGMLGGPAPVRRFLPHLMDLVLSRKINPGKVFDLTLPLEDVA
EGYRAMDERRAIKTLLRV
>Mature_338_residues
MFGTMLYGKGDVRCEAVPEPEILKPTDAIIKLSASCICGSDLWPYRGLNDVTAPMAMGHEYCGIVTQVGSAVRTVRPGQF
VVGSFCLSDNTCPHCRFGFQSSCEQREFMSGAQAPYARVPLADGTLVATDTVPDDDLLPSLLATSDVLGTGWYAADAARV
QPGSTVVVVGDGAVGLMGVLAARQMEAGRIIAMSRHKSRQDLALEFGATDIVSARGAEGIAEVKRLTGNVGADSVLECVG
TGESMAQAIACARPGAMIGYVGVPHGVELNGEQLFFSQTGMLGGPAPVRRFLPHLMDLVLSRKINPGKVFDLTLPLEDVA
EGYRAMDERRAIKTLLRV

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI156523966, Length=351, Percent_Identity=27.9202279202279, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI262073058, Length=384, Percent_Identity=27.34375, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI71743840, Length=358, Percent_Identity=27.9329608938547, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4501929, Length=352, Percent_Identity=26.7045454545455, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI34577061, Length=372, Percent_Identity=26.0752688172043, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI4501933, Length=357, Percent_Identity=26.890756302521, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI4501939, Length=341, Percent_Identity=28.1524926686217, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI71565152, Length=363, Percent_Identity=26.4462809917355, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI156627571, Length=353, Percent_Identity=25.4957507082153, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI71565154, Length=355, Percent_Identity=26.1971830985915, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1786825, Length=384, Percent_Identity=27.8645833333333, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI1788075, Length=347, Percent_Identity=26.5129682997118, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786552, Length=344, Percent_Identity=27.6162790697674, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1788073, Length=267, Percent_Identity=29.2134831460674, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1788407, Length=260, Percent_Identity=26.9230769230769, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI226510992, Length=319, Percent_Identity=22.884012539185, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI87082125, Length=352, Percent_Identity=25.8522727272727, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790045, Length=330, Percent_Identity=24.2424242424242, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17562876, Length=355, Percent_Identity=27.0422535211268, Blast_Score=107, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17562878, Length=269, Percent_Identity=27.1375464684015, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319955, Length=337, Percent_Identity=28.486646884273, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6322619, Length=337, Percent_Identity=28.486646884273, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323099, Length=269, Percent_Identity=28.996282527881, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=353, Percent_Identity=25.2124645892351, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17737895, Length=346, Percent_Identity=24.2774566473988, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17737897, Length=264, Percent_Identity=30.6818181818182, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17137530, Length=264, Percent_Identity=30.3030303030303, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 35810; Mature: 35810

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGTMLYGKGDVRCEAVPEPEILKPTDAIIKLSASCICGSDLWPYRGLNDVTAPMAMGHE
CCCCEEECCCCEEEEECCCCCCCCCCHHHHEEHHHEEECCCCCCCCCCCHHHHHHHHCHH
YCGIVTQVGSAVRTVRPGQFVVGSFCLSDNTCPHCRFGFQSSCEQREFMSGAQAPYARVP
HHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCHHCHHHHHHHCCCCCCCEECC
LADGTLVATDTVPDDDLLPSLLATSDVLGTGWYAADAARVQPGSTVVVVGDGAVGLMGVL
CCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCEECCCCEECCCCEEEEECCCHHHHHHHH
AARQMEAGRIIAMSRHKSRQDLALEFGATDIVSARGAEGIAEVKRLTGNVGADSVLECVG
HHHHHCCCCEEEECCCCCCCCCEEECCCHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHC
TGESMAQAIACARPGAMIGYVGVPHGVELNGEQLFFSQTGMLGGPAPVRRFLPHLMDLVL
CCHHHHHHHHHCCCCCEEEEECCCCCCEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
SRKINPGKVFDLTLPLEDVAEGYRAMDERRAIKTLLRV
HCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFGTMLYGKGDVRCEAVPEPEILKPTDAIIKLSASCICGSDLWPYRGLNDVTAPMAMGHE
CCCCEEECCCCEEEEECCCCCCCCCCHHHHEEHHHEEECCCCCCCCCCCHHHHHHHHCHH
YCGIVTQVGSAVRTVRPGQFVVGSFCLSDNTCPHCRFGFQSSCEQREFMSGAQAPYARVP
HHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCHHCHHHHHHHCCCCCCCEECC
LADGTLVATDTVPDDDLLPSLLATSDVLGTGWYAADAARVQPGSTVVVVGDGAVGLMGVL
CCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCEECCCCEECCCCEEEEECCCHHHHHHHH
AARQMEAGRIIAMSRHKSRQDLALEFGATDIVSARGAEGIAEVKRLTGNVGADSVLECVG
HHHHHCCCCEEEECCCCCCCCCEEECCCHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHC
TGESMAQAIACARPGAMIGYVGVPHGVELNGEQLFFSQTGMLGGPAPVRRFLPHLMDLVL
CCHHHHHHHHHCCCCCEEEEECCCCCCEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
SRKINPGKVFDLTLPLEDVAEGYRAMDERRAIKTLLRV
HCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]