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The map label for this gene is fhuD [H]

Identifier: 158424872

GI number: 158424872

Start: 3748885

End: 3749901

Strand: Direct

Name: fhuD [H]

Synonym: AZC_3248

Alternate gene names: 158424872

Gene position: 3748885-3749901 (Clockwise)

Preceding gene: 158424871

Following gene: 158424873

Centisome position: 69.81

GC content: 70.4

Gene sequence:

>1017_bases
TTGACCTGCCGGAACCGGTGGTTTCGTGGACCAGCACCGGCGCGCCGCGGCAGCGGGCATCGGGTCTTCCGCGCACAGCC
GATGCCTGAACAGCCTTCCGCAGGAACGCGACGTAACATCGGCCGCCGCACCATTCTCACGCTTATGCGGGGTGGCCTTC
TGGCCGCCCCGTTCGGCGTTTCAGCCGGCCCGGCCCCTGCCGATGCCACGCCGCCGCTGCGCCGGCTGGTCGCGCTCGAC
TATGGGCTGGCGGAGACGCTGCTGTTGCTCGGTCTCCCGCCCGTCGGGCTGGTGGGGGCTCAGGACTGGAACCGATGGGT
CGGCGAGCCGGCGCTGCCGGCCGGCGTGGTCAATCTGGGCAGCAGCCGCGAGCCCAATCTGGAACTGCTTCAGCAGCTCG
CCCCCGACGCGATCCTGTCCACCCCCTACCTCGCGGGGATCTCGCACCGACTGGAGCGCATCGCCCCGGTGCTGTCCTTT
CCCATGTACGTTCCGGACGGCCAACCGCTGGCGCTGGCGACGGAAGCGCTTTCGCGGCTCGCCGCTCTGACCGGCCGCGT
CAGCCAGGGTATGGCGGCACTCGCGGCGGTGGAACAGGATTTCGCCTCCGCCCGCAGCCGCCTTTCGGGCACCGACCGGC
GCCCGCTGCTCATGGTGAGCCTCATGGACAGCCGCCATGTGCGCATCTATGGCGCCAACAGCCTGTTCGGCGCGGTGCTG
ACGCGGCTCGACGTCGCCAACGCCTACGCCGGCCAGACCAATTTCTGGGGCTTCACCACGCTCGGCATCGAGAGCCTGCC
ACCGCTTGCGGATGCGCGCCTCGTCTTTTTCGATCCGGTTCCACCCGGCACGCTGGCGGCGCTCGCCGCGAACCCGCTCT
GGACCCGCCTGCCTTATGTGCAGGCCGGGCGCGTGAGCCGGTTGCCGCCGGTGCTGATGTTCGGCGCACTGCCCTCAGCA
ACGCGGTTCGCCCGCCTCCTCGCCGACGCCCTGACAGGGGAACACTCCCATGGCTGA

Upstream 100 bases:

>100_bases
AGTCGCCACAGCCACGGCATCGCCGAACCCCAGCTCAGCCTCATGGCGTGGCGCAGTTCCGTGGTGGCGAACGCGCTGAC
CGGGCGGTCGCATTTCGACC

Downstream 100 bases:

>100_bases
AGCCACGGTCCGGCCCGCACATGGCATCGAGGTGCGCCCCTGGATGGTGGCTGGCGGCCTCCTGCTTGTTGCCACCGTAC
TTTCGCTGCAAAAGATCGGC

Product: ferrichrome-binding periplasmic protein precursor

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein D; Ferrichrome-binding periplasmic protein; Iron(III)-hydroxamate-binding protein fhuD [H]

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MTCRNRWFRGPAPARRGSGHRVFRAQPMPEQPSAGTRRNIGRRTILTLMRGGLLAAPFGVSAGPAPADATPPLRRLVALD
YGLAETLLLLGLPPVGLVGAQDWNRWVGEPALPAGVVNLGSSREPNLELLQQLAPDAILSTPYLAGISHRLERIAPVLSF
PMYVPDGQPLALATEALSRLAALTGRVSQGMAALAAVEQDFASARSRLSGTDRRPLLMVSLMDSRHVRIYGANSLFGAVL
TRLDVANAYAGQTNFWGFTTLGIESLPPLADARLVFFDPVPPGTLAALAANPLWTRLPYVQAGRVSRLPPVLMFGALPSA
TRFARLLADALTGEHSHG

Sequences:

>Translated_338_residues
MTCRNRWFRGPAPARRGSGHRVFRAQPMPEQPSAGTRRNIGRRTILTLMRGGLLAAPFGVSAGPAPADATPPLRRLVALD
YGLAETLLLLGLPPVGLVGAQDWNRWVGEPALPAGVVNLGSSREPNLELLQQLAPDAILSTPYLAGISHRLERIAPVLSF
PMYVPDGQPLALATEALSRLAALTGRVSQGMAALAAVEQDFASARSRLSGTDRRPLLMVSLMDSRHVRIYGANSLFGAVL
TRLDVANAYAGQTNFWGFTTLGIESLPPLADARLVFFDPVPPGTLAALAANPLWTRLPYVQAGRVSRLPPVLMFGALPSA
TRFARLLADALTGEHSHG
>Mature_337_residues
TCRNRWFRGPAPARRGSGHRVFRAQPMPEQPSAGTRRNIGRRTILTLMRGGLLAAPFGVSAGPAPADATPPLRRLVALDY
GLAETLLLLGLPPVGLVGAQDWNRWVGEPALPAGVVNLGSSREPNLELLQQLAPDAILSTPYLAGISHRLERIAPVLSFP
MYVPDGQPLALATEALSRLAALTGRVSQGMAALAAVEQDFASARSRLSGTDRRPLLMVSLMDSRHVRIYGANSLFGAVLT
RLDVANAYAGQTNFWGFTTLGIESLPPLADARLVFFDPVPPGTLAALAANPLWTRLPYVQAGRVSRLPPVLMFGALPSAT
RFARLLADALTGEHSHG

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Binds the iron(3+)-hydroxamate complex and transfers it to the membrane-bound permease. Required for the transport of all iron(3+)-hydroxamate siderophores such as ferrich

COG id: COG0614

COG function: function code P; ABC-type Fe3+-hydroxamate transport system, periplasmic component

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Fe/B12 periplasmic-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786346, Length=296, Percent_Identity=37.5, Blast_Score=175, Evalue=4e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008091
- InterPro:   IPR002491 [H]

Pfam domain/function: PF01497 Peripla_BP_2 [H]

EC number: NA

Molecular weight: Translated: 36091; Mature: 35960

Theoretical pI: Translated: 11.53; Mature: 11.53

Prosite motif: PS50983 FE_B12_PBP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTCRNRWFRGPAPARRGSGHRVFRAQPMPEQPSAGTRRNIGRRTILTLMRGGLLAAPFGV
CCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCEECCCCC
SAGPAPADATPPLRRLVALDYGLAETLLLLGLPPVGLVGAQDWNRWVGEPALPAGVVNLG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHCCCCCCCHHHHCCC
SSREPNLELLQQLAPDAILSTPYLAGISHRLERIAPVLSFPMYVPDGQPLALATEALSRL
CCCCCCHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
AALTGRVSQGMAALAAVEQDFASARSRLSGTDRRPLLMVSLMDSRHVRIYGANSLFGAVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEECHHHHHHHH
TRLDVANAYAGQTNFWGFTTLGIESLPPLADARLVFFDPVPPGTLAALAANPLWTRLPYV
HHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCEEEEECCCCCCHHHHHHCCCHHHHCCCH
QAGRVSRLPPVLMFGALPSATRFARLLADALTGEHSHG
HCCCCCCCCHHHEECCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TCRNRWFRGPAPARRGSGHRVFRAQPMPEQPSAGTRRNIGRRTILTLMRGGLLAAPFGV
CCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCEECCCCC
SAGPAPADATPPLRRLVALDYGLAETLLLLGLPPVGLVGAQDWNRWVGEPALPAGVVNLG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHCCCCCCCHHHHCCC
SSREPNLELLQQLAPDAILSTPYLAGISHRLERIAPVLSFPMYVPDGQPLALATEALSRL
CCCCCCHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
AALTGRVSQGMAALAAVEQDFASARSRLSGTDRRPLLMVSLMDSRHVRIYGANSLFGAVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEECHHHHHHHH
TRLDVANAYAGQTNFWGFTTLGIESLPPLADARLVFFDPVPPGTLAALAANPLWTRLPYV
HHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCEEEEECCCCCCHHHHHHCCCHHHHCCCH
QAGRVSRLPPVLMFGALPSATRFARLLADALTGEHSHG
HCCCCCCCCHHHEECCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3301821; 2823072; 8202364; 9278503; 7651325; 10742172 [H]