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The map label for this gene is fhuB [H]

Identifier: 158424873

GI number: 158424873

Start: 3749945

End: 3751900

Strand: Direct

Name: fhuB [H]

Synonym: AZC_3249

Alternate gene names: 158424873

Gene position: 3749945-3751900 (Clockwise)

Preceding gene: 158424872

Following gene: 158424874

Centisome position: 69.83

GC content: 70.6

Gene sequence:

>1956_bases
ATGGTGGCTGGCGGCCTCCTGCTTGTTGCCACCGTACTTTCGCTGCAAAAGATCGGCGCTGCGCTACCGCCAGGACTTTG
GGCGCGGGCCTTTTTCGCCCCTGACGCGAGCGACGGGCAGCAACTGGTCATTCATTACAGTCTGCTGCCGCGCATCTTGG
CCGCCATTCTGGCAGGGGCCGCGCTTGCATTGGCCGGGGCGGTCTTCCAGCAGGTCCTGCGCAACCCGCTGGCCTCCCCC
ACCACGCTGGGCGTCTCCGCCGGCGCGAAACTCGCTCTGGCGCTCGCCACATTATGGGCGCCCGGTCTTTTCACCTTCGG
GCGGGAATGGGTGGCTCTGGCCGGCGGTGCCATCGCCGTTTCCCTGGTGTTTGCCCTGAGCTGGCACAAGGGGCTGTCGC
CGCTCGCGGTGGTCCTCGCCGGTCTGGTGCTCGGGCTCTATTGCGGTTCGGTTTCCGCCGCCCTGATCCTGTTCAGGGAA
CATTACCTCACCGGCCTGTTCATCTGGGGCAGCGGCTCGCTGAGCCAGCAGGGCTGGGAGGTGGTGTCCGCCCTCGCTCT
CCAATGTGCGGTCACCGCCGCGCTCATCGCGCTGATGATCCGGCCGCTTACGCTGCTGTCGCTGGAGGAGGCCGGTGCAG
CAAGCCTCGGTGTCTCGCTTCAGGGCACGCGGCTGATGGCTCTAGGTCTCGCCGTCGCGCTGACCGGCTTCGTGGTCAGC
GGCATCGGCGTCATCGGCTTCATCGGGCTCATCTCTCCTGCGCTCGCGCGCCTGTCGGGCGCACGGCGGTTGCGCGACCT
GTTCCTGTGGGCACCGACCATCGGGGCCGGCCTGCTGTGGACCACCGATCAACTGGTGCTGCGTACAGGCGGCCTCACCG
GCGGCCTCATCCCCACCGGCGCCGTCACGGCCCTGTTCGGTTCGCCTCTGCTGCTCTGGCTGCTGCCGCGCCTGCGCAAC
CCGACGCCGCCGACACGTCACGAGCCCATCCACGCGGTGGCGCGCAGCCGACCCCAGAAGCTGCGCCTGCTGGCACTCGG
CCTCGCGCTTGCGGGCGCCCTCGTGTTGTCGCTGCTGCTCGGACGCACACCGGACGGCGAATGGGCACTGGCGCGCGGCG
ACGAGCTTTCCGCCCTGATGCCATGGCGTGCGCCGCGCGCGGTGGCGGCACTCGTAGCGGGAGCCATGCTCGCGGTCGCC
GGGGCCATTCTCCAGCGCATGACGCGCAATCCCATGGCCAGCCCCGAAGTGCTGGGCGTGGGTGCGGGCGCCGCCCTCGG
CCTCATCGTCGTGCTCTTCACCCTCACCTCGGCCGGGCGCGGTGTGCAGGTCGCGGCCGCCTGCACGGGCGCCTTCTCGG
TGCTGTTCCTCATTCTTGTGGTGGGCCGTCGCTCCGGCTTCACGCCGGAGCGCGTCCTGCTGGCGGGCATCGCCATCGGC
GCGCTATTCGACGCGCTGGTGGGGGCGCTCACCGCCAGCGGGGATCCGCGCGGGCTGCTGCTGCTGAACTGGATGACCGG
CTCTACCTATCAGGTGGATGAGGTCCAGGCCGCCTGGTGCGTGGCCGGGGCGGTGATCCTGCTGGCCCTGGCGCCCTTGT
GCGGGCGTTGGCTCGACATGATGCCGCTCGGCGACGCTCCGGGTCAGGCGCTCGGCCTCGATCTCGGACGCGTGCGCCTG
ACGCTGCTGGCATTGGCAGCCGGGCTCACCGCCATCGCCACGCTGGTGGTGGGGCCGCTCACCTTCGTGGGCCTCATGGC
GCCCCATCTCGCCACCCGCGTCGGACTGCGCCGCGCCCTGGCCCAGCTCGCGGGTGCGGCCCTCGTGGGTGCCCTCCTCA
TGCTCGTGGCCGACTGGCTCGGCCGCATGATCGCCTTCCCCTGGCAGATGCCGGCCGGGCTCATCGCCACGCTGATCGGC
GGCCCGGCCCTGATGTGGCTGCTCGCACGCAGATGA

Upstream 100 bases:

>100_bases
ACGCGGTTCGCCCGCCTCCTCGCCGACGCCCTGACAGGGGAACACTCCCATGGCTGAAGCCACGGTCCGGCCCGCACATG
GCATCGAGGTGCGCCCCTGG

Downstream 100 bases:

>100_bases
CCATGACCGAAAACGCCCCTTCCATTCCTGAAACCATCGTCTTCGATCTCGCGCCCAAGGCCGGAGGACCGCCCTATCGC
ATTTTCCTGCGCGTGCCGCC

Product: iron-hydroxamate transporter permease subunit

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Ferrichrome uptake protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 651; Mature: 651

Protein sequence:

>651_residues
MVAGGLLLVATVLSLQKIGAALPPGLWARAFFAPDASDGQQLVIHYSLLPRILAAILAGAALALAGAVFQQVLRNPLASP
TTLGVSAGAKLALALATLWAPGLFTFGREWVALAGGAIAVSLVFALSWHKGLSPLAVVLAGLVLGLYCGSVSAALILFRE
HYLTGLFIWGSGSLSQQGWEVVSALALQCAVTAALIALMIRPLTLLSLEEAGAASLGVSLQGTRLMALGLAVALTGFVVS
GIGVIGFIGLISPALARLSGARRLRDLFLWAPTIGAGLLWTTDQLVLRTGGLTGGLIPTGAVTALFGSPLLLWLLPRLRN
PTPPTRHEPIHAVARSRPQKLRLLALGLALAGALVLSLLLGRTPDGEWALARGDELSALMPWRAPRAVAALVAGAMLAVA
GAILQRMTRNPMASPEVLGVGAGAALGLIVVLFTLTSAGRGVQVAAACTGAFSVLFLILVVGRRSGFTPERVLLAGIAIG
ALFDALVGALTASGDPRGLLLLNWMTGSTYQVDEVQAAWCVAGAVILLALAPLCGRWLDMMPLGDAPGQALGLDLGRVRL
TLLALAAGLTAIATLVVGPLTFVGLMAPHLATRVGLRRALAQLAGAALVGALLMLVADWLGRMIAFPWQMPAGLIATLIG
GPALMWLLARR

Sequences:

>Translated_651_residues
MVAGGLLLVATVLSLQKIGAALPPGLWARAFFAPDASDGQQLVIHYSLLPRILAAILAGAALALAGAVFQQVLRNPLASP
TTLGVSAGAKLALALATLWAPGLFTFGREWVALAGGAIAVSLVFALSWHKGLSPLAVVLAGLVLGLYCGSVSAALILFRE
HYLTGLFIWGSGSLSQQGWEVVSALALQCAVTAALIALMIRPLTLLSLEEAGAASLGVSLQGTRLMALGLAVALTGFVVS
GIGVIGFIGLISPALARLSGARRLRDLFLWAPTIGAGLLWTTDQLVLRTGGLTGGLIPTGAVTALFGSPLLLWLLPRLRN
PTPPTRHEPIHAVARSRPQKLRLLALGLALAGALVLSLLLGRTPDGEWALARGDELSALMPWRAPRAVAALVAGAMLAVA
GAILQRMTRNPMASPEVLGVGAGAALGLIVVLFTLTSAGRGVQVAAACTGAFSVLFLILVVGRRSGFTPERVLLAGIAIG
ALFDALVGALTASGDPRGLLLLNWMTGSTYQVDEVQAAWCVAGAVILLALAPLCGRWLDMMPLGDAPGQALGLDLGRVRL
TLLALAAGLTAIATLVVGPLTFVGLMAPHLATRVGLRRALAQLAGAALVGALLMLVADWLGRMIAFPWQMPAGLIATLIG
GPALMWLLARR
>Mature_651_residues
MVAGGLLLVATVLSLQKIGAALPPGLWARAFFAPDASDGQQLVIHYSLLPRILAAILAGAALALAGAVFQQVLRNPLASP
TTLGVSAGAKLALALATLWAPGLFTFGREWVALAGGAIAVSLVFALSWHKGLSPLAVVLAGLVLGLYCGSVSAALILFRE
HYLTGLFIWGSGSLSQQGWEVVSALALQCAVTAALIALMIRPLTLLSLEEAGAASLGVSLQGTRLMALGLAVALTGFVVS
GIGVIGFIGLISPALARLSGARRLRDLFLWAPTIGAGLLWTTDQLVLRTGGLTGGLIPTGAVTALFGSPLLLWLLPRLRN
PTPPTRHEPIHAVARSRPQKLRLLALGLALAGALVLSLLLGRTPDGEWALARGDELSALMPWRAPRAVAALVAGAMLAVA
GAILQRMTRNPMASPEVLGVGAGAALGLIVVLFTLTSAGRGVQVAAACTGAFSVLFLILVVGRRSGFTPERVLLAGIAIG
ALFDALVGALTASGDPRGLLLLNWMTGSTYQVDEVQAAWCVAGAVILLALAPLCGRWLDMMPLGDAPGQALGLDLGRVRL
TLLALAAGLTAIATLVVGPLTFVGLMAPHLATRVGLRRALAQLAGAALVGALLMLVADWLGRMIAFPWQMPAGLIATLIG
GPALMWLLARR

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786347, Length=646, Percent_Identity=45.9752321981424, Blast_Score=432, Evalue=1e-122,
Organism=Escherichia coli, GI1790740, Length=309, Percent_Identity=34.3042071197411, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1790741, Length=298, Percent_Identity=33.8926174496644, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788004, Length=293, Percent_Identity=32.7645051194539, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI1786804, Length=244, Percent_Identity=32.7868852459016, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786805, Length=286, Percent_Identity=32.1678321678322, Blast_Score=84, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522
- InterPro:   IPR006311 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 66863; Mature: 66863

Theoretical pI: Translated: 11.64; Mature: 11.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAGGLLLVATVLSLQKIGAALPPGLWARAFFAPDASDGQQLVIHYSLLPRILAAILAGA
CCCCHHHHHHHHHHHHHHCCCCCCCHHHHHEECCCCCCCCEEEHHHHHHHHHHHHHHHHH
ALALAGAVFQQVLRNPLASPTTLGVSAGAKLALALATLWAPGLFTFGREWVALAGGAIAV
HHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHCCHHHHHCHHHHHHCCHHHHH
SLVFALSWHKGLSPLAVVLAGLVLGLYCGSVSAALILFREHYLTGLFIWGSGSLSQQGWE
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHH
VVSALALQCAVTAALIALMIRPLTLLSLEEAGAASLGVSLQGTRLMALGLAVALTGFVVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHHHHHHHHHH
GIGVIGFIGLISPALARLSGARRLRDLFLWAPTIGAGLLWTTDQLVLRTGGLTGGLIPTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHEECCCCCCCCCHH
AVTALFGSPLLLWLLPRLRNPTPPTRHEPIHAVARSRPQKLRLLALGLALAGALVLSLLL
HHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
GRTPDGEWALARGDELSALMPWRAPRAVAALVAGAMLAVAGAILQRMTRNPMASPEVLGV
CCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEC
GAGAALGLIVVLFTLTSAGRGVQVAAACTGAFSVLFLILVVGRRSGFTPERVLLAGIAIG
CCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
ALFDALVGALTASGDPRGLLLLNWMTGSTYQVDEVQAAWCVAGAVILLALAPLCGRWLDM
HHHHHHHHHHHCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MPLGDAPGQALGLDLGRVRLTLLALAAGLTAIATLVVGPLTFVGLMAPHLATRVGLRRAL
CCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQLAGAALVGALLMLVADWLGRMIAFPWQMPAGLIATLIGGPALMWLLARR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHCC
>Mature Secondary Structure
MVAGGLLLVATVLSLQKIGAALPPGLWARAFFAPDASDGQQLVIHYSLLPRILAAILAGA
CCCCHHHHHHHHHHHHHHCCCCCCCHHHHHEECCCCCCCCEEEHHHHHHHHHHHHHHHHH
ALALAGAVFQQVLRNPLASPTTLGVSAGAKLALALATLWAPGLFTFGREWVALAGGAIAV
HHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHCCHHHHHCHHHHHHCCHHHHH
SLVFALSWHKGLSPLAVVLAGLVLGLYCGSVSAALILFREHYLTGLFIWGSGSLSQQGWE
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHH
VVSALALQCAVTAALIALMIRPLTLLSLEEAGAASLGVSLQGTRLMALGLAVALTGFVVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHHHHHHHHHH
GIGVIGFIGLISPALARLSGARRLRDLFLWAPTIGAGLLWTTDQLVLRTGGLTGGLIPTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHEECCCCCCCCCHH
AVTALFGSPLLLWLLPRLRNPTPPTRHEPIHAVARSRPQKLRLLALGLALAGALVLSLLL
HHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
GRTPDGEWALARGDELSALMPWRAPRAVAALVAGAMLAVAGAILQRMTRNPMASPEVLGV
CCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEC
GAGAALGLIVVLFTLTSAGRGVQVAAACTGAFSVLFLILVVGRRSGFTPERVLLAGIAIG
CCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
ALFDALVGALTASGDPRGLLLLNWMTGSTYQVDEVQAAWCVAGAVILLALAPLCGRWLDM
HHHHHHHHHHHCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MPLGDAPGQALGLDLGRVRLTLLALAAGLTAIATLVVGPLTFVGLMAPHLATRVGLRRAL
CCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQLAGAALVGALLMLVADWLGRMIAFPWQMPAGLIATLIGGPALMWLLARR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677609; 10103258 [H]