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The map label for this gene is iclR [H]

Identifier: 158424822

GI number: 158424822

Start: 3656383

End: 3657279

Strand: Direct

Name: iclR [H]

Synonym: AZC_3198

Alternate gene names: 158424822

Gene position: 3656383-3657279 (Clockwise)

Preceding gene: 158424821

Following gene: 158424823

Centisome position: 68.09

GC content: 71.91

Gene sequence:

>897_bases
TTGCGCTTCCAGCCCCGCCCGGCCTGTCGCATCGTACCCGGGCGCCGCTTCGCATCGGAGCGGCCGGGGCATGACGGGAT
AGGCCAGAGCATGGGCCGCAGGATTGCGGGCGCCCGTCCTGCGGGCGAGGACAAGAGCGAGGGGCTGGTGCGCGCCGTGG
ATCGGGCGCTCGGCCTTCTTGAACGGGTCAGCGATGCCCCGCGCGGCATCGCGCTGGCGCAGCTCGCCGCCGAGGCGGAT
CTTGCCGCCTCCACCGCCCATCGGCTGCTGTCCACCCTCGAGGATCGCGGCTTCGTTCGCTTCGAGCGCGCCAGCGGCCG
GTGGTTCATCGGCCGCACGGCACTCGCGGTCGGCGCCGGCTATGCCGGCTCGCGGGACATGGTGGCCTGCGCCCAGCCGA
TCCTGAAGCGCCTCGGACAGGCCTGCGGCGAGACGGTCAACCTCGGCATGCTGGACGAGGGCAAGGTCGTCTTCCTGCAT
CGCTTCGAGGCACGCACGCGGCGGGCCTTCGTGCCGTCCGGCACCTCCCTGCCCGCGCATTGCTCCAGCATCGGCAAGGC
CCTGCTCTCCGTGCTGCCTTTCGCCGAGGTGCGGGAGGCCGTGTCCGCCGATCGTCTGGTGCCCGTCACGGCCAAGACGA
TGTGCTCGCGCGACGTCTTCATGAGCGCGCTGGAAGAAACGCGGCGGGCGGGCTTCGCCCTCGATGACGAGGAGAACACG
CCCGGCCTGCGCTGTATCGCGGCCCCGGTGTTCGACGCCTATCACCGCCCCGTGGCGGCGGTTTCCCTCGCCGCGCCGGT
GGAGCGCCTAGAACTTGGGCAGGTTGCCGAATGCGGACGCAAGGTCGCCGCCGCAGCCCGTGAACTCACGCAGGCCTGGT
CCGGCGCGCGCCTCTGA

Upstream 100 bases:

>100_bases
GCCGGAGCTTCTTTGACCCGGACACCTACCCGAAGCTCGCCCGACAGGCGGCCGCGAGGGCCTGAACCGCGTCCTGAAGC
CGACGCATGCTGCCTGCTTT

Downstream 100 bases:

>100_bases
CGGCGCCTGAACCGCCTTTCCAAAAAGACACCAACCCCTTGTTCTGAATCGAATTTTCCGCTTTCCATCCCGCCAGATGG
AATGGGCTCGCCGGCCGGCG

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MRFQPRPACRIVPGRRFASERPGHDGIGQSMGRRIAGARPAGEDKSEGLVRAVDRALGLLERVSDAPRGIALAQLAAEAD
LAASTAHRLLSTLEDRGFVRFERASGRWFIGRTALAVGAGYAGSRDMVACAQPILKRLGQACGETVNLGMLDEGKVVFLH
RFEARTRRAFVPSGTSLPAHCSSIGKALLSVLPFAEVREAVSADRLVPVTAKTMCSRDVFMSALEETRRAGFALDDEENT
PGLRCIAAPVFDAYHRPVAAVSLAAPVERLELGQVAECGRKVAAAARELTQAWSGARL

Sequences:

>Translated_298_residues
MRFQPRPACRIVPGRRFASERPGHDGIGQSMGRRIAGARPAGEDKSEGLVRAVDRALGLLERVSDAPRGIALAQLAAEAD
LAASTAHRLLSTLEDRGFVRFERASGRWFIGRTALAVGAGYAGSRDMVACAQPILKRLGQACGETVNLGMLDEGKVVFLH
RFEARTRRAFVPSGTSLPAHCSSIGKALLSVLPFAEVREAVSADRLVPVTAKTMCSRDVFMSALEETRRAGFALDDEENT
PGLRCIAAPVFDAYHRPVAAVSLAAPVERLELGQVAECGRKVAAAARELTQAWSGARL
>Mature_298_residues
MRFQPRPACRIVPGRRFASERPGHDGIGQSMGRRIAGARPAGEDKSEGLVRAVDRALGLLERVSDAPRGIALAQLAAEAD
LAASTAHRLLSTLEDRGFVRFERASGRWFIGRTALAVGAGYAGSRDMVACAQPILKRLGQACGETVNLGMLDEGKVVFLH
RFEARTRRAFVPSGTSLPAHCSSIGKALLSVLPFAEVREAVSADRLVPVTAKTMCSRDVFMSALEETRRAGFALDDEENT
PGLRCIAAPVFDAYHRPVAAVSLAAPVERLELGQVAECGRKVAAAARELTQAWSGARL

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=253, Percent_Identity=37.5494071146245, Blast_Score=171, Evalue=7e-44,
Organism=Escherichia coli, GI1786468, Length=245, Percent_Identity=31.0204081632653, Blast_Score=131, Evalue=6e-32,
Organism=Escherichia coli, GI1786715, Length=243, Percent_Identity=31.2757201646091, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1789999, Length=274, Percent_Identity=31.021897810219, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1788131, Length=248, Percent_Identity=27.8225806451613, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1790752, Length=202, Percent_Identity=26.2376237623762, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788581, Length=232, Percent_Identity=28.448275862069, Blast_Score=75, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 31900; Mature: 31900

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFQPRPACRIVPGRRFASERPGHDGIGQSMGRRIAGARPAGEDKSEGLVRAVDRALGLL
CCCCCCCCCEECCCCHHHCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
ERVSDAPRGIALAQLAAEADLAASTAHRLLSTLEDRGFVRFERASGRWFIGRTALAVGAG
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEECHHHHHHCCC
YAGSRDMVACAQPILKRLGQACGETVNLGMLDEGKVVFLHRFEARTRRAFVPSGTSLPAH
CCCCCCHHHHHHHHHHHHHHHCCCEECCCCCCCCCEEEEEEHHHHHHHEECCCCCCCCHH
CSSIGKALLSVLPFAEVREAVSADRLVPVTAKTMCSRDVFMSALEETRRAGFALDDEENT
HHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PGLRCIAAPVFDAYHRPVAAVSLAAPVERLELGQVAECGRKVAAAARELTQAWSGARL
CCCEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRFQPRPACRIVPGRRFASERPGHDGIGQSMGRRIAGARPAGEDKSEGLVRAVDRALGLL
CCCCCCCCCEECCCCHHHCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
ERVSDAPRGIALAQLAAEADLAASTAHRLLSTLEDRGFVRFERASGRWFIGRTALAVGAG
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEECHHHHHHCCC
YAGSRDMVACAQPILKRLGQACGETVNLGMLDEGKVVFLHRFEARTRRAFVPSGTSLPAH
CCCCCCHHHHHHHHHHHHHHHCCCEECCCCCCCCCEEEEEEHHHHHHHEECCCCCCCCHH
CSSIGKALLSVLPFAEVREAVSADRLVPVTAKTMCSRDVFMSALEETRRAGFALDDEENT
HHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PGLRCIAAPVFDAYHRPVAAVSLAAPVERLELGQVAECGRKVAAAARELTQAWSGARL
CCCEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]