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The map label for this gene is accC [H]

Identifier: 158424699

GI number: 158424699

Start: 3514900

End: 3516246

Strand: Direct

Name: accC [H]

Synonym: AZC_3075

Alternate gene names: 158424699

Gene position: 3514900-3516246 (Clockwise)

Preceding gene: 158424698

Following gene: 158424713

Centisome position: 65.46

GC content: 66.15

Gene sequence:

>1347_bases
ATGTTCGAGAAAATCCTGATTGCCAACCGCGGCGAGATTGCCCTGCGCATCCTGCGCGCGTGTAAGGAGCTGGGCATCGC
CACCGTCGCCGTGCACTCCACCGCCGATGCGGATGCCATGCACGTGCGCCTTGCCGACGAGAGCGTGTGCATCGGCCCGC
CGCAGGCCCGCGAGAGCTACCTCAACATTCCCTCGCTGCTCGCCGCCTGCGAGATCACCGGCGCGGACGCAGTTCACCCC
GGCTACGGCTTCCTCGCCGAGAACGCCCGCTTCGCCGAGATCCTGGCGGACCACAAGGTCCACTTCATCGGTCCGAAGCC
CGAGCATATCCGCATCATGGGCGACAAGATCGAGGCCAAGAAGACCGCGCAGAAGCTCGGCATCCCGGTGGTGCCCGGCT
CCGACGGCGGCATCAATTCGGATGAGGAGGCCCATCGGGTCGCGGCCGAGATCGGCTTCCCGGTGCTGGTGAAGGCCGCC
GCGGGTGGCGGCGGGCGCGGCATGAAGGTGGCGATGACCGCCGACGACCTGAGCCAGGCCCTCTCCACCGCCCGCACCGA
GGCCAAGGCGGCCTTCGGCGATGACGCGGTCTATCTGGAGAAATATCTCGTCACCCCGCGCCACATCGAGATTCAGGTGC
TGGGCGACGGCAAGGGCAATGCGGTGCACCTCGGCGAGCGCGACTGCTCGCTCCAGCGCCGTCACCAAAAGGTGTGGGAG
GAAGCCCCCTCCCCGGCGCTCGAAGCCGCCCAGCGCCAGGAGATCGGCGAGACGGTGGCGAAAGCCATGCGCGAGCTGAA
GTATCTCGGCGTCGGCACGGTCGAGTTCCTGTACGAGAACGGCCGCTTCTATTTCATCGAGATGAACACCCGCATCCAGG
TGGAGCATCCGGTGACGGAAGAGATCACCGGAATCGATCTCATCAACGAGCAGATCCGCGTCGCCGCCGGCCTGCCGATG
ACGCTCACGCAGGACGACGTCAAGATCACCGGCCACGCCATCGAGTGCCGCATCAATGCCGAGCACCCGACGACCTTCCG
GCCCTCGCCCGGCAAGATCACCCACTATCACGTGCCCGGCGGCCTCGGCATCCGCGTGGATAGCAATGCCTATCAGGGCT
ATTCGATCCCGCCCCACTACGATTCGCTGGTGGGCAAGCTGATCGTGCACGGCTCCAACCGCGAGGAATGCCTGCGCCGC
CTGCGCCGGGCGCTCGACGAGTTCGTGGTGGACGGCATCGAGACGACCCTGCCCCTGTTCCGCACGCTGGTGCGCACCAA
GGACATTCAGGACGGCCAGTATGACATCCACTGGCTGGAGCACTTCCTGGCCAAGGGTGAAGGCTGA

Upstream 100 bases:

>100_bases
GCCCCGCCGGGACGCGCCTTCCCTTAAAGGACCCGCGCACCCGGACCCGTCCCGCGGCGACCCCGCCCGGCGGAGCGGCT
GCCAAGCAGGCTGAAGCCCG

Downstream 100 bases:

>100_bases
ACTTCACCGATCCTGAAACAAGAACGGCGGGCCTCGGGCCCGCCGTTTGCGTTTCCAGGCGCCGGAACGCGTCAGTCTTC
CTCGATCAGGCTGAACTGGG

Product: acetyl-CoA carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MFEKILIANRGEIALRILRACKELGIATVAVHSTADADAMHVRLADESVCIGPPQARESYLNIPSLLAACEITGADAVHP
GYGFLAENARFAEILADHKVHFIGPKPEHIRIMGDKIEAKKTAQKLGIPVVPGSDGGINSDEEAHRVAAEIGFPVLVKAA
AGGGGRGMKVAMTADDLSQALSTARTEAKAAFGDDAVYLEKYLVTPRHIEIQVLGDGKGNAVHLGERDCSLQRRHQKVWE
EAPSPALEAAQRQEIGETVAKAMRELKYLGVGTVEFLYENGRFYFIEMNTRIQVEHPVTEEITGIDLINEQIRVAAGLPM
TLTQDDVKITGHAIECRINAEHPTTFRPSPGKITHYHVPGGLGIRVDSNAYQGYSIPPHYDSLVGKLIVHGSNREECLRR
LRRALDEFVVDGIETTLPLFRTLVRTKDIQDGQYDIHWLEHFLAKGEG

Sequences:

>Translated_448_residues
MFEKILIANRGEIALRILRACKELGIATVAVHSTADADAMHVRLADESVCIGPPQARESYLNIPSLLAACEITGADAVHP
GYGFLAENARFAEILADHKVHFIGPKPEHIRIMGDKIEAKKTAQKLGIPVVPGSDGGINSDEEAHRVAAEIGFPVLVKAA
AGGGGRGMKVAMTADDLSQALSTARTEAKAAFGDDAVYLEKYLVTPRHIEIQVLGDGKGNAVHLGERDCSLQRRHQKVWE
EAPSPALEAAQRQEIGETVAKAMRELKYLGVGTVEFLYENGRFYFIEMNTRIQVEHPVTEEITGIDLINEQIRVAAGLPM
TLTQDDVKITGHAIECRINAEHPTTFRPSPGKITHYHVPGGLGIRVDSNAYQGYSIPPHYDSLVGKLIVHGSNREECLRR
LRRALDEFVVDGIETTLPLFRTLVRTKDIQDGQYDIHWLEHFLAKGEG
>Mature_448_residues
MFEKILIANRGEIALRILRACKELGIATVAVHSTADADAMHVRLADESVCIGPPQARESYLNIPSLLAACEITGADAVHP
GYGFLAENARFAEILADHKVHFIGPKPEHIRIMGDKIEAKKTAQKLGIPVVPGSDGGINSDEEAHRVAAEIGFPVLVKAA
AGGGGRGMKVAMTADDLSQALSTARTEAKAAFGDDAVYLEKYLVTPRHIEIQVLGDGKGNAVHLGERDCSLQRRHQKVWE
EAPSPALEAAQRQEIGETVAKAMRELKYLGVGTVEFLYENGRFYFIEMNTRIQVEHPVTEEITGIDLINEQIRVAAGLPM
TLTQDDVKITGHAIECRINAEHPTTFRPSPGKITHYHVPGGLGIRVDSNAYQGYSIPPHYDSLVGKLIVHGSNREECLRR
LRRALDEFVVDGIETTLPLFRTLVRTKDIQDGQYDIHWLEHFLAKGEG

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=459, Percent_Identity=48.5838779956427, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI65506442, Length=459, Percent_Identity=48.5838779956427, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI295821183, Length=459, Percent_Identity=48.5838779956427, Blast_Score=428, Evalue=1e-120,
Organism=Homo sapiens, GI116805327, Length=423, Percent_Identity=44.9172576832151, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI106049528, Length=448, Percent_Identity=46.6517857142857, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI106049295, Length=448, Percent_Identity=46.6517857142857, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI106049292, Length=448, Percent_Identity=46.6517857142857, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI38679960, Length=513, Percent_Identity=29.6296296296296, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI38679977, Length=513, Percent_Identity=29.6296296296296, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI38679967, Length=513, Percent_Identity=29.6296296296296, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI38679974, Length=513, Percent_Identity=29.6296296296296, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI38679971, Length=513, Percent_Identity=29.6296296296296, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI134142062, Length=515, Percent_Identity=29.5145631067961, Blast_Score=229, Evalue=6e-60,
Organism=Homo sapiens, GI18105007, Length=256, Percent_Identity=25.78125, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1789654, Length=448, Percent_Identity=59.1517857142857, Blast_Score=540, Evalue=1e-155,
Organism=Escherichia coli, GI1786216, Length=240, Percent_Identity=25, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17567343, Length=449, Percent_Identity=45.43429844098, Blast_Score=396, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI71987519, Length=425, Percent_Identity=44.2352941176471, Blast_Score=369, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17562816, Length=448, Percent_Identity=42.8571428571429, Blast_Score=356, Evalue=1e-98,
Organism=Caenorhabditis elegans, GI71997168, Length=508, Percent_Identity=27.3622047244095, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI71997163, Length=508, Percent_Identity=27.3622047244095, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI133931226, Length=493, Percent_Identity=26.9776876267748, Blast_Score=192, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6319685, Length=429, Percent_Identity=42.4242424242424, Blast_Score=349, Evalue=4e-97,
Organism=Saccharomyces cerevisiae, GI6319695, Length=440, Percent_Identity=43.8636363636364, Blast_Score=342, Evalue=6e-95,
Organism=Saccharomyces cerevisiae, GI6321376, Length=440, Percent_Identity=45, Blast_Score=334, Evalue=2e-92,
Organism=Saccharomyces cerevisiae, GI6323863, Length=481, Percent_Identity=31.6008316008316, Blast_Score=228, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6324343, Length=520, Percent_Identity=30.5769230769231, Blast_Score=226, Evalue=7e-60,
Organism=Drosophila melanogaster, GI281363050, Length=445, Percent_Identity=47.6404494382022, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652224, Length=445, Percent_Identity=47.6404494382022, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652222, Length=445, Percent_Identity=47.6404494382022, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652220, Length=445, Percent_Identity=47.6404494382022, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652218, Length=445, Percent_Identity=47.6404494382022, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652212, Length=445, Percent_Identity=47.6404494382022, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652210, Length=445, Percent_Identity=47.6404494382022, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652214, Length=445, Percent_Identity=47.6404494382022, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI19921944, Length=445, Percent_Identity=47.6404494382022, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652216, Length=445, Percent_Identity=47.6404494382022, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24651757, Length=431, Percent_Identity=45.0116009280742, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24651759, Length=395, Percent_Identity=44.0506329113924, Blast_Score=343, Evalue=1e-94,
Organism=Drosophila melanogaster, GI161076409, Length=508, Percent_Identity=28.3464566929134, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24586458, Length=508, Percent_Identity=28.3464566929134, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI161076407, Length=508, Percent_Identity=28.3464566929134, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24586460, Length=508, Percent_Identity=28.3464566929134, Blast_Score=213, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49118; Mature: 49118

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEKILIANRGEIALRILRACKELGIATVAVHSTADADAMHVRLADESVCIGPPQARESY
CCCEEEEECCCHHHHHHHHHHHHCCEEEEEEECCCCCCEEEEEECCCCEECCCCHHHHHH
LNIPSLLAACEITGADAVHPGYGFLAENARFAEILADHKVHFIGPKPEHIRIMGDKIEAK
CCHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHCCEEEEECCCCCEEEEECCHHHHH
KTAQKLGIPVVPGSDGGINSDEEAHRVAAEIGFPVLVKAAAGGGGRGMKVAMTADDLSQA
HHHHHCCCEEECCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEEHHHHHHH
LSTARTEAKAAFGDDAVYLEKYLVTPRHIEIQVLGDGKGNAVHLGERDCSLQRRHQKVWE
HHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHH
EAPSPALEAAQRQEIGETVAKAMRELKYLGVGTVEFLYENGRFYFIEMNTRIQVEHPVTE
HCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEECCEEEECCCCCH
EITGIDLINEQIRVAAGLPMTLTQDDVKITGHAIECRINAEHPTTFRPSPGKITHYHVPG
HHCCHHHHCCHHHEECCCCEEEECCCEEEECEEEEEEEECCCCCCCCCCCCCEEEEECCC
GLGIRVDSNAYQGYSIPPHYDSLVGKLIVHGSNREECLRRLRRALDEFVVDGIETTLPLF
CEEEEECCCCCCCCCCCCCHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHH
RTLVRTKDIQDGQYDIHWLEHFLAKGEG
HHHHHHCCCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MFEKILIANRGEIALRILRACKELGIATVAVHSTADADAMHVRLADESVCIGPPQARESY
CCCEEEEECCCHHHHHHHHHHHHCCEEEEEEECCCCCCEEEEEECCCCEECCCCHHHHHH
LNIPSLLAACEITGADAVHPGYGFLAENARFAEILADHKVHFIGPKPEHIRIMGDKIEAK
CCHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHCCEEEEECCCCCEEEEECCHHHHH
KTAQKLGIPVVPGSDGGINSDEEAHRVAAEIGFPVLVKAAAGGGGRGMKVAMTADDLSQA
HHHHHCCCEEECCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEEHHHHHHH
LSTARTEAKAAFGDDAVYLEKYLVTPRHIEIQVLGDGKGNAVHLGERDCSLQRRHQKVWE
HHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHH
EAPSPALEAAQRQEIGETVAKAMRELKYLGVGTVEFLYENGRFYFIEMNTRIQVEHPVTE
HCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEECCEEEECCCCCH
EITGIDLINEQIRVAAGLPMTLTQDDVKITGHAIECRINAEHPTTFRPSPGKITHYHVPG
HHCCHHHHCCHHHEECCCCEEEECCCEEEECEEEEEEEECCCCCCCCCCCCCEEEEECCC
GLGIRVDSNAYQGYSIPPHYDSLVGKLIVHGSNREECLRRLRRALDEFVVDGIETTLPLF
CEEEEECCCCCCCCCCCCCHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHH
RTLVRTKDIQDGQYDIHWLEHFLAKGEG
HHHHHHCCCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7693652; 10984043 [H]