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The map label for this gene is hppA [H]

Identifier: 158424693

GI number: 158424693

Start: 3507684

End: 3509825

Strand: Reverse

Name: hppA [H]

Synonym: AZC_3069

Alternate gene names: 158424693

Gene position: 3509825-3507684 (Counterclockwise)

Preceding gene: 158424694

Following gene: 158424692

Centisome position: 65.36

GC content: 67.46

Gene sequence:

>2142_bases
ATGTTGGCACTCGTGCTGATCATTGCCTGCGGACTGTTCGCCGTGGGCTACGGAATCTGGGCCGGGCGGGCGGTCATGGC
CGCCGATCCCGGCTCGCCACGCATGCAGGAGATCGCCGCCGCGATCGCCGAAGGCGCGCAGGCCTACCTGCGCCGGCAGT
ACGCCACCATCGGCATCGTGGGCGTCGTCATCTTCCTGGCGGTGGGCGTCTTCCTCGGTTGGCTCGTGGCCATCGGCTTT
GCCCTCGGCGCCATTCTCTCCGGCCTTGCCGGCTTCATCGGCATGAATGTCTCGGTGCGTGCCAATGTGCGCACGGCGCA
GGCGGCGACGAAATCGCTCGCCGGCGGGCTCGACCTCGCTTTCAAGGCGGGCGCCGTCACCGGCCTTCTGGTGGCCGGCC
TCGCCCTGCTGGGGGTCGCGGTCTACTTCACCTTCCTCACCCGCATCATGGGCTATGGCCTCACCGAGCGCGTTGTGGTG
GATGCCCTCGTGGCGCTGGGCTTCGGCGCCTCGCTCATCTCCATCTTCGCCCGCCTCGGCGGCGGCATCTTCACCAAGGG
CGCCGACGTGGGCGGCGATCTGGTCGGCAAGGTAGAGGCAGGCATTCCCGAGGACGACCCGCGCAACCCCGCCACCATCG
CCGACAACGTGGGCGACAATGTCGGCGACTGCGCGGGCATGGCGGCGGACCTGTTCGAGACCTATGCCGTGACGGTGGTG
GCGACCATGGTGCTCGCCATCATCTTCTATTCCGGCGCCCCAGGCGTTCTGGGCAATCTCGTGCTCTATCCGCTGGCCAT
CGGCGGCGTGTGCATCCTCACCTCCATCGCCGGCACCTTCTTCGTTAAGCTCGGGCCGACCTCCTCCATCATGGGGGCGC
TCTACAAGGGCTTTGCGGCGAGCGCCGGCCTCTCGGTCTTCGCGCTGGCACTGGTGACGGGGCTGCTGACAGGCTTCGGC
CCCATCGCGGGGACCGCGCTCACCGGCACGCAGCTTTTCCTCTCGGGAATCGTCGGACTGGCGGTGACCGGGGCCATCGT
CGTCATCACCGAATATTACACCGGCACGGGCTATCGGCCGGTGGTCTCCATTGCGCAGGCCTCGGTGACCGGCCACGGCA
CCAACATCATCCAGGGCCTCGCCGTCTCGCTCGAATCGACGGCGCTGCCCACGCTCGTCATCATCGCCGGCATCCTCGTC
GCCTATGGCTTGGCCGGCCTGTTCGGCATTGCGGTGGCGGCAACGACCATGCTGGCGCTGGCGGGCATGGTGGTGGCGCT
CGATGCCTTCGGCCCGGTGACGGACAATGCCGGCGGTATCGCCGAAATGGCCGGCCTGCCCAAGGAGGTTCGCCACTCCA
CCGATGCGCTGGATGCGGTGGGCAACACCACGAAGGCCGTCACCAAGGGCTATGCCATCGGCTCGGCGGGCCTCGGCGCG
CTGGTGCTGTTCGCCGCCTACAATGCGGACCTGCGCTATTTCATCTCGCAGGCCCGGCCGGGCAGCTATTTCGCCGGCGT
GTCCCCCAACTTCTCGCTGGAAAATCCCTATGTGGTCGTCGGCCTGCTGTTCGGCGGCCTGCTGCCCTTCCTCTTCGCCG
CCATGGGCATGACGGCGGTCGGAAGAGCGGCAGGCGCCATCGTGGAGGAGGTGCGCCGGCAGTTCCGCGAGAAGCCGGGA
ATCATGGCCGGCACCGACAAGCCGGACTATTCCCGCGCCGTGGACATGCTAACCCGCGCCGCCATCAAGGAGATGATCAT
CCCCTCCCTGTTGCCGGTGCTCTCGCCCATCGTCTGCTATTTCGTCATCTATCTGGTGGCGGGCGGCGGGGCGGCCGGCA
AGTCGGCGGCCTTCTCGGCGGTGGGGGCGATGCTGCTCGGCGTCATCGTCACCGGCCTGTTCGTCGCCATCTCCATGACC
TCCGGCGGCGGCGCCTGGGACAATGCGAAGAAGTCCTTCGAGGACGGATTCGTGGACAAGGACGGGGTGCGCCACCTCAA
GGGGTCTGACGCGCACAAGGCGTCCGTCACTGGCGACACCGTGGGCGATCCCTACAAGGACACGGCGGGGCCGGCCGTGA
ATCCCATGATCAAGATCACCAACATCGTGGCGCTGCTGCTTCTGGCGGTGCTCGGGCATTGA

Upstream 100 bases:

>100_bases
CTGCTGTCGCATTACTTGGTTGCGCCCCTGTCGTCCGGCCCTCACACTCCCGTCCCATAAAAACAAAGGCATACGGGACG
AAAACGGGAGGGCTGGTCAT

Downstream 100 bases:

>100_bases
GGACGGGCCGGCGGCTGTTCACAGGGGCAGGGCTCCTTTCGGACGGCCGCCGGCGGCCTATATGAAGGCGCGGCGGGGCT
TTGCCATGGCCGCGCGGCAG

Product: membrane-bound proton-translocating pyrophosphatase

Products: NA

Alternate protein names: Membrane-bound proton-translocating pyrophosphatase; Pyrophosphate-energized inorganic pyrophosphatase; H(+)-PPase [H]

Number of amino acids: Translated: 713; Mature: 713

Protein sequence:

>713_residues
MLALVLIIACGLFAVGYGIWAGRAVMAADPGSPRMQEIAAAIAEGAQAYLRRQYATIGIVGVVIFLAVGVFLGWLVAIGF
ALGAILSGLAGFIGMNVSVRANVRTAQAATKSLAGGLDLAFKAGAVTGLLVAGLALLGVAVYFTFLTRIMGYGLTERVVV
DALVALGFGASLISIFARLGGGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVTVV
ATMVLAIIFYSGAPGVLGNLVLYPLAIGGVCILTSIAGTFFVKLGPTSSIMGALYKGFAASAGLSVFALALVTGLLTGFG
PIAGTALTGTQLFLSGIVGLAVTGAIVVITEYYTGTGYRPVVSIAQASVTGHGTNIIQGLAVSLESTALPTLVIIAGILV
AYGLAGLFGIAVAATTMLALAGMVVALDAFGPVTDNAGGIAEMAGLPKEVRHSTDALDAVGNTTKAVTKGYAIGSAGLGA
LVLFAAYNADLRYFISQARPGSYFAGVSPNFSLENPYVVVGLLFGGLLPFLFAAMGMTAVGRAAGAIVEEVRRQFREKPG
IMAGTDKPDYSRAVDMLTRAAIKEMIIPSLLPVLSPIVCYFVIYLVAGGGAAGKSAAFSAVGAMLLGVIVTGLFVAISMT
SGGGAWDNAKKSFEDGFVDKDGVRHLKGSDAHKASVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAVLGH

Sequences:

>Translated_713_residues
MLALVLIIACGLFAVGYGIWAGRAVMAADPGSPRMQEIAAAIAEGAQAYLRRQYATIGIVGVVIFLAVGVFLGWLVAIGF
ALGAILSGLAGFIGMNVSVRANVRTAQAATKSLAGGLDLAFKAGAVTGLLVAGLALLGVAVYFTFLTRIMGYGLTERVVV
DALVALGFGASLISIFARLGGGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVTVV
ATMVLAIIFYSGAPGVLGNLVLYPLAIGGVCILTSIAGTFFVKLGPTSSIMGALYKGFAASAGLSVFALALVTGLLTGFG
PIAGTALTGTQLFLSGIVGLAVTGAIVVITEYYTGTGYRPVVSIAQASVTGHGTNIIQGLAVSLESTALPTLVIIAGILV
AYGLAGLFGIAVAATTMLALAGMVVALDAFGPVTDNAGGIAEMAGLPKEVRHSTDALDAVGNTTKAVTKGYAIGSAGLGA
LVLFAAYNADLRYFISQARPGSYFAGVSPNFSLENPYVVVGLLFGGLLPFLFAAMGMTAVGRAAGAIVEEVRRQFREKPG
IMAGTDKPDYSRAVDMLTRAAIKEMIIPSLLPVLSPIVCYFVIYLVAGGGAAGKSAAFSAVGAMLLGVIVTGLFVAISMT
SGGGAWDNAKKSFEDGFVDKDGVRHLKGSDAHKASVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAVLGH
>Mature_713_residues
MLALVLIIACGLFAVGYGIWAGRAVMAADPGSPRMQEIAAAIAEGAQAYLRRQYATIGIVGVVIFLAVGVFLGWLVAIGF
ALGAILSGLAGFIGMNVSVRANVRTAQAATKSLAGGLDLAFKAGAVTGLLVAGLALLGVAVYFTFLTRIMGYGLTERVVV
DALVALGFGASLISIFARLGGGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVTVV
ATMVLAIIFYSGAPGVLGNLVLYPLAIGGVCILTSIAGTFFVKLGPTSSIMGALYKGFAASAGLSVFALALVTGLLTGFG
PIAGTALTGTQLFLSGIVGLAVTGAIVVITEYYTGTGYRPVVSIAQASVTGHGTNIIQGLAVSLESTALPTLVIIAGILV
AYGLAGLFGIAVAATTMLALAGMVVALDAFGPVTDNAGGIAEMAGLPKEVRHSTDALDAVGNTTKAVTKGYAIGSAGLGA
LVLFAAYNADLRYFISQARPGSYFAGVSPNFSLENPYVVVGLLFGGLLPFLFAAMGMTAVGRAAGAIVEEVRRQFREKPG
IMAGTDKPDYSRAVDMLTRAAIKEMIIPSLLPVLSPIVCYFVIYLVAGGGAAGKSAAFSAVGAMLLGVIVTGLFVAISMT
SGGGAWDNAKKSFEDGFVDKDGVRHLKGSDAHKASVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAVLGH

Specific function: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force [H]

COG id: COG3808

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004131 [H]

Pfam domain/function: PF03030 H_PPase [H]

EC number: =3.6.1.1 [H]

Molecular weight: Translated: 72120; Mature: 72120

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLALVLIIACGLFAVGYGIWAGRAVMAADPGSPRMQEIAAAIAEGAQAYLRRQYATIGIV
CHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVVIFLAVGVFLGWLVAIGFALGAILSGLAGFIGMNVSVRANVRTAQAATKSLAGGLDLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHCCCHHH
FKAGAVTGLLVAGLALLGVAVYFTFLTRIMGYGLTERVVVDALVALGFGASLISIFARLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHC
GGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVTVV
CCEEECCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ATMVLAIIFYSGAPGVLGNLVLYPLAIGGVCILTSIAGTFFVKLGPTSSIMGALYKGFAA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHH
SAGLSVFALALVTGLLTGFGPIAGTALTGTQLFLSGIVGLAVTGAIVVITEYYTGTGYRP
HHHHHHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHHHHHHHHHHHHEEEEEHHCCCCCHH
VVSIAQASVTGHGTNIIQGLAVSLESTALPTLVIIAGILVAYGLAGLFGIAVAATTMLAL
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGMVVALDAFGPVTDNAGGIAEMAGLPKEVRHSTDALDAVGNTTKAVTKGYAIGSAGLGA
HHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHH
LVLFAAYNADLRYFISQARPGSYFAGVSPNFSLENPYVVVGLLFGGLLPFLFAAMGMTAV
HHHHHHHCHHHHHHHHHCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GRAAGAIVEEVRRQFREKPGIMAGTDKPDYSRAVDMLTRAAIKEMIIPSLLPVLSPIVCY
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVIYLVAGGGAAGKSAAFSAVGAMLLGVIVTGLFVAISMTSGGGAWDNAKKSFEDGFVDK
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCC
DGVRHLKGSDAHKASVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAVLGH
CHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLALVLIIACGLFAVGYGIWAGRAVMAADPGSPRMQEIAAAIAEGAQAYLRRQYATIGIV
CHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVVIFLAVGVFLGWLVAIGFALGAILSGLAGFIGMNVSVRANVRTAQAATKSLAGGLDLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHCCCHHH
FKAGAVTGLLVAGLALLGVAVYFTFLTRIMGYGLTERVVVDALVALGFGASLISIFARLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHC
GGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVTVV
CCEEECCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ATMVLAIIFYSGAPGVLGNLVLYPLAIGGVCILTSIAGTFFVKLGPTSSIMGALYKGFAA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHH
SAGLSVFALALVTGLLTGFGPIAGTALTGTQLFLSGIVGLAVTGAIVVITEYYTGTGYRP
HHHHHHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHHHHHHHHHHHHEEEEEHHCCCCCHH
VVSIAQASVTGHGTNIIQGLAVSLESTALPTLVIIAGILVAYGLAGLFGIAVAATTMLAL
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGMVVALDAFGPVTDNAGGIAEMAGLPKEVRHSTDALDAVGNTTKAVTKGYAIGSAGLGA
HHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHH
LVLFAAYNADLRYFISQARPGSYFAGVSPNFSLENPYVVVGLLFGGLLPFLFAAMGMTAV
HHHHHHHCHHHHHHHHHCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GRAAGAIVEEVRRQFREKPGIMAGTDKPDYSRAVDMLTRAAIKEMIIPSLLPVLSPIVCY
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVIYLVAGGGAAGKSAAFSAVGAMLLGVIVTGLFVAISMTSGGGAWDNAKKSFEDGFVDK
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCC
DGVRHLKGSDAHKASVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAVLGH
CHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]