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The map label for this gene is glyA [H]

Identifier: 158424675

GI number: 158424675

Start: 3487324

End: 3488625

Strand: Direct

Name: glyA [H]

Synonym: AZC_3051

Alternate gene names: 158424675

Gene position: 3487324-3488625 (Clockwise)

Preceding gene: 158424674

Following gene: 158424677

Centisome position: 64.94

GC content: 68.28

Gene sequence:

>1302_bases
ATGCCTTCCAGAAGAAGAGGACGCCCCATGAACGTGCAAGTGAAGCCCCCTCCCTTCGCCGACCGCGCGGTGTTCGACGC
CATCGCCCGCGAGCTGGGCCGCCAGCGCGACCAGATCGAGCTCATCGCTTCGGAGAACATCGTCTCGGAGGCGGTGCTGG
CCGCCCAGGGCTCGGTGCTGACGAACAAGTATGCGGAAGGCCTGCCGGGCAAGCGCTATTACGGCGGCTGCGAGCATGTG
GACGTGGTGGAGGAGATCGCCATCGACCGGGCGAAGCAGCTCTTCGGCTGCGGCTTCGCCAACGTGCAGCCGCACTCGGG
CGCGCAGGCCAATGCGGCGGTGCTGATGGCCCTGCTCCAGCCCGGCGACACCCTGCTTGGCATGTCGCTCGCCGCCGGCG
GCCACCTCACCCACGGCGCCCCGCCCACCCTCTCGGGCAAATGGTTCAACGCGGTCGGCTACGGCGTCAGCCCCGAGACC
GCGCTCATCGATTATGACGAGGTGGAGCGCCTCGCCCATGCGCACAGGCCGAAGCTCATCATCGCTGGCGGCTCGTCCTA
TCCGCGCATCATCGATTTCGCGCGCTTCCGCGCCATTGCCGATGCCGTGGGCGCGCATCTGATGGTGGATGCCGCCCATT
ATGCCGGGCTCATCGTGGCCGGGGCCTATCCCTCCCCCTTCCCGCACGCCCACATTGTCACCACCACCACCCACAAGACC
CTGCGCGGGCCGCGCGGCGGCCTCATCCTCACCAATGACGAGGCGTTGGCGAAGAAGCTCAACTCTGCGGTGTTTCCCGG
CCTTCAGGGCGGGCCACTGATGCATGTGATCGCGGCAAAGGCGGTGGCCTTCGGCGAAGCGCTCCAGCCGGATTTCCGCA
CCTATGCGCTTCAGGTGGTCTCGAACGCCCGCGCGCTCGCGGCGCGGCTGGCGGAGAAGGGTGCCGCCATCGTCTCGGGC
GGCACCGACAGCCATATGGTGCTGGTGGACCTGCGCCCCTTCAACGTCACCGGCAAGGCGGCTGAGATCGCGCTGGAACG
GGCGGGCCTCACCTGCAACAAGAACGGCATTCCGTTCGATCCGCAGAAGCCTGCCGTCACCTCCGGCATCCGCCTCGGCA
CGCCGGCGGGGACCACGCGCGGCTTCGGCCTCGGGGAATTTGAGCAGGTGGGCGACATGATCGCCGAAGTGCTCAAGGGC
CTCGCCCAGAGCGGGGATGAGGGCAACAGCCTTACCGAAGCGCGGGTGCGGGGCGAGGTGGAAGCGCTCTGCCGGCGCTT
CCCGCTCTACCCCACCCTCTGA

Upstream 100 bases:

>100_bases
GCCTCGCCGTGAACGTGCCCGAGTGCTGAGGCGGCACGCCGCCTGATTTTTCCATCTTCACGAGACCGACGCGCCGGCCC
TCCGGCGTGAACGATGTGCC

Downstream 100 bases:

>100_bases
CGCGCCCGAAGGCGCCGTTCTCACTGCGCGGGCGGATGCGCCCGCGCGACATGGTCGCGCAGTTCCTGAAGCGAACCGAA
GCGCACCACGCCGTCGGGCA

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MPSRRRGRPMNVQVKPPPFADRAVFDAIARELGRQRDQIELIASENIVSEAVLAAQGSVLTNKYAEGLPGKRYYGGCEHV
DVVEEIAIDRAKQLFGCGFANVQPHSGAQANAAVLMALLQPGDTLLGMSLAAGGHLTHGAPPTLSGKWFNAVGYGVSPET
ALIDYDEVERLAHAHRPKLIIAGGSSYPRIIDFARFRAIADAVGAHLMVDAAHYAGLIVAGAYPSPFPHAHIVTTTTHKT
LRGPRGGLILTNDEALAKKLNSAVFPGLQGGPLMHVIAAKAVAFGEALQPDFRTYALQVVSNARALAARLAEKGAAIVSG
GTDSHMVLVDLRPFNVTGKAAEIALERAGLTCNKNGIPFDPQKPAVTSGIRLGTPAGTTRGFGLGEFEQVGDMIAEVLKG
LAQSGDEGNSLTEARVRGEVEALCRRFPLYPTL

Sequences:

>Translated_433_residues
MPSRRRGRPMNVQVKPPPFADRAVFDAIARELGRQRDQIELIASENIVSEAVLAAQGSVLTNKYAEGLPGKRYYGGCEHV
DVVEEIAIDRAKQLFGCGFANVQPHSGAQANAAVLMALLQPGDTLLGMSLAAGGHLTHGAPPTLSGKWFNAVGYGVSPET
ALIDYDEVERLAHAHRPKLIIAGGSSYPRIIDFARFRAIADAVGAHLMVDAAHYAGLIVAGAYPSPFPHAHIVTTTTHKT
LRGPRGGLILTNDEALAKKLNSAVFPGLQGGPLMHVIAAKAVAFGEALQPDFRTYALQVVSNARALAARLAEKGAAIVSG
GTDSHMVLVDLRPFNVTGKAAEIALERAGLTCNKNGIPFDPQKPAVTSGIRLGTPAGTTRGFGLGEFEQVGDMIAEVLKG
LAQSGDEGNSLTEARVRGEVEALCRRFPLYPTL
>Mature_432_residues
PSRRRGRPMNVQVKPPPFADRAVFDAIARELGRQRDQIELIASENIVSEAVLAAQGSVLTNKYAEGLPGKRYYGGCEHVD
VVEEIAIDRAKQLFGCGFANVQPHSGAQANAAVLMALLQPGDTLLGMSLAAGGHLTHGAPPTLSGKWFNAVGYGVSPETA
LIDYDEVERLAHAHRPKLIIAGGSSYPRIIDFARFRAIADAVGAHLMVDAAHYAGLIVAGAYPSPFPHAHIVTTTTHKTL
RGPRGGLILTNDEALAKKLNSAVFPGLQGGPLMHVIAAKAVAFGEALQPDFRTYALQVVSNARALAARLAEKGAAIVSGG
TDSHMVLVDLRPFNVTGKAAEIALERAGLTCNKNGIPFDPQKPAVTSGIRLGTPAGTTRGFGLGEFEQVGDMIAEVLKGL
AQSGDEGNSLTEARVRGEVEALCRRFPLYPTL

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI261862352, Length=449, Percent_Identity=46.7706013363029, Blast_Score=352, Evalue=3e-97,
Organism=Homo sapiens, GI261862350, Length=449, Percent_Identity=46.7706013363029, Blast_Score=352, Evalue=3e-97,
Organism=Homo sapiens, GI261862348, Length=449, Percent_Identity=46.7706013363029, Blast_Score=352, Evalue=3e-97,
Organism=Homo sapiens, GI19923315, Length=449, Percent_Identity=46.7706013363029, Blast_Score=352, Evalue=4e-97,
Organism=Homo sapiens, GI261862346, Length=449, Percent_Identity=45.43429844098, Blast_Score=329, Evalue=2e-90,
Organism=Homo sapiens, GI22547186, Length=459, Percent_Identity=44.4444444444444, Blast_Score=324, Evalue=9e-89,
Organism=Homo sapiens, GI22547189, Length=442, Percent_Identity=41.8552036199095, Blast_Score=290, Evalue=2e-78,
Organism=Escherichia coli, GI1788902, Length=412, Percent_Identity=58.252427184466, Blast_Score=456, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI25144732, Length=410, Percent_Identity=48.5365853658537, Blast_Score=352, Evalue=2e-97,
Organism=Caenorhabditis elegans, GI25144729, Length=410, Percent_Identity=48.5365853658537, Blast_Score=352, Evalue=3e-97,
Organism=Saccharomyces cerevisiae, GI6319739, Length=440, Percent_Identity=44.5454545454545, Blast_Score=345, Evalue=8e-96,
Organism=Saccharomyces cerevisiae, GI6323087, Length=407, Percent_Identity=44.7174447174447, Blast_Score=325, Evalue=1e-89,
Organism=Drosophila melanogaster, GI24640005, Length=449, Percent_Identity=45.43429844098, Blast_Score=355, Evalue=2e-98,
Organism=Drosophila melanogaster, GI221329721, Length=449, Percent_Identity=45.43429844098, Blast_Score=354, Evalue=6e-98,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 45753; Mature: 45622

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSRRRGRPMNVQVKPPPFADRAVFDAIARELGRQRDQIELIASENIVSEAVLAAQGSVL
CCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEHHCHHHHHHHHHHCCCHH
TNKYAEGLPGKRYYGGCEHVDVVEEIAIDRAKQLFGCGFANVQPHSGAQANAAVLMALLQ
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHC
PGDTLLGMSLAAGGHLTHGAPPTLSGKWFNAVGYGVSPETALIDYDEVERLAHAHRPKLI
CCCCEEEHHHHCCCCCCCCCCCCCCCCCHHHCCCCCCCCCEEECHHHHHHHHHHCCCEEE
IAGGSSYPRIIDFARFRAIADAVGAHLMVDAAHYAGLIVAGAYPSPFPHAHIVTTTTHKT
EECCCCCCHHHHHHHHHHHHHHHHHHHEEEHHHHCCEEEECCCCCCCCCCEEEEECCHHH
LRGPRGGLILTNDEALAKKLNSAVFPGLQGGPLMHVIAAKAVAFGEALQPDFRTYALQVV
HCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SNARALAARLAEKGAAIVSGGTDSHMVLVDLRPFNVTGKAAEIALERAGLTCNKNGIPFD
HHHHHHHHHHHHCCCEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHCCCEECCCCCCCC
PQKPAVTSGIRLGTPAGTTRGFGLGEFEQVGDMIAEVLKGLAQSGDEGNSLTEARVRGEV
CCCCCHHCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
EALCRRFPLYPTL
HHHHHHCCCCCCC
>Mature Secondary Structure 
PSRRRGRPMNVQVKPPPFADRAVFDAIARELGRQRDQIELIASENIVSEAVLAAQGSVL
CCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEHHCHHHHHHHHHHCCCHH
TNKYAEGLPGKRYYGGCEHVDVVEEIAIDRAKQLFGCGFANVQPHSGAQANAAVLMALLQ
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHC
PGDTLLGMSLAAGGHLTHGAPPTLSGKWFNAVGYGVSPETALIDYDEVERLAHAHRPKLI
CCCCEEEHHHHCCCCCCCCCCCCCCCCCHHHCCCCCCCCCEEECHHHHHHHHHHCCCEEE
IAGGSSYPRIIDFARFRAIADAVGAHLMVDAAHYAGLIVAGAYPSPFPHAHIVTTTTHKT
EECCCCCCHHHHHHHHHHHHHHHHHHHEEEHHHHCCEEEECCCCCCCCCCEEEEECCHHH
LRGPRGGLILTNDEALAKKLNSAVFPGLQGGPLMHVIAAKAVAFGEALQPDFRTYALQVV
HCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SNARALAARLAEKGAAIVSGGTDSHMVLVDLRPFNVTGKAAEIALERAGLTCNKNGIPFD
HHHHHHHHHHHHCCCEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHCCCEECCCCCCCC
PQKPAVTSGIRLGTPAGTTRGFGLGEFEQVGDMIAEVLKGLAQSGDEGNSLTEARVRGEV
CCCCCHHCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
EALCRRFPLYPTL
HHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]