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The map label for this gene is iclR [H]

Identifier: 158424662

GI number: 158424662

Start: 3469721

End: 3470599

Strand: Reverse

Name: iclR [H]

Synonym: AZC_3038

Alternate gene names: 158424662

Gene position: 3470599-3469721 (Counterclockwise)

Preceding gene: 158424673

Following gene: 158424661

Centisome position: 64.63

GC content: 68.37

Gene sequence:

>879_bases
ATGTGCACGTTTCCAGTCCAGTTTCATTCAGTGAAATTTTATGCTTCATTGAATGATATGAGTTTCATTTGGCGGAATAT
GGCTGATAGTACATCGGCGACCGGGCGCATCTTCGCCCTTCTGAGAGCGCTTTCGCGGGGCGAACGGCAGGGCATGCGGC
TCAAGGATCTGGCTGCGGCGGTCGATCTGCCGCGCCCGACCACCCATCGCCTGCTGCATGGGCTGATGGCCGAGGGCATG
GTGGAGCACGATCCGCGCACCAAGCACTATCGGTTGGGCCTCGAACTGTTCGTATTGGCCGCCAAGGCCGGCAGCCCCCT
CAACCTGCGCGACATCGGCCGGCCGGCGCTGCTGCGCCTGACGGCGGCGCTGGGGGAGACCGTCTTCCTCATGGTGCGCA
ACGGGTTCGACGCGGTGTGCGTGGACCGCTCCGCCGGCCCGCTGCCCATCCGCACCTTCACCGGCGACGTGGGCGGCACG
GTGATGCTCGGCGTGGGGCAGGCTGCCATGGCCATCCTCGCCTTCCTGCCGGACCGCGAGCAGGACGAGGTGATCCGCTA
CAACCTCCCCCGCATGCGCGCCCTTTCGGCTTTCGACGAGGGCTTCCTGCGGGCCGAGATCGCCCGCGTGCGGGACCTCG
GCTATGCGGACGGCGCGGCGGGCCTCATTCCCGGCATGGCCGGGCTCGGCGTGCCCATCCTCGGGCGGGACGGGGATGCG
GTGGCGGCGCTCAGCGTCGGCAGCACCACCGACCGCATGACCCCCGAGCGCAACAAGGTCATCGCCGACCTCCTGAAGCG
CGAAGCCGCCGAGATCGGCGCCCGCCTCAACCCCTTCGACCCCGCCCTCCGCCGCCCCGGCGCGGCGATCATGGGGTGA

Upstream 100 bases:

>100_bases
CGACGCGCCAGCGAGCCATGACCGGATCCCAAAATTACCGTGTCTATGGCTTCAGCCTCCCCCTGCATGGCTTGCCTCGC
AAGCGTAAAAATTCCATTCA

Downstream 100 bases:

>100_bases
GGGAAGGTCTGCCCTTCCGCAACGAGAGCGCGAATGCGGACGTTTCTCGCCCGCCGATCGCTCGCTATGCTCCGGCCAAC
AAACGGGAGGATAAGCCATG

Product: transcriptional regulator

Products: NA

Alternate protein names: Kip operon repressor protein [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MCTFPVQFHSVKFYASLNDMSFIWRNMADSTSATGRIFALLRALSRGERQGMRLKDLAAAVDLPRPTTHRLLHGLMAEGM
VEHDPRTKHYRLGLELFVLAAKAGSPLNLRDIGRPALLRLTAALGETVFLMVRNGFDAVCVDRSAGPLPIRTFTGDVGGT
VMLGVGQAAMAILAFLPDREQDEVIRYNLPRMRALSAFDEGFLRAEIARVRDLGYADGAAGLIPGMAGLGVPILGRDGDA
VAALSVGSTTDRMTPERNKVIADLLKREAAEIGARLNPFDPALRRPGAAIMG

Sequences:

>Translated_292_residues
MCTFPVQFHSVKFYASLNDMSFIWRNMADSTSATGRIFALLRALSRGERQGMRLKDLAAAVDLPRPTTHRLLHGLMAEGM
VEHDPRTKHYRLGLELFVLAAKAGSPLNLRDIGRPALLRLTAALGETVFLMVRNGFDAVCVDRSAGPLPIRTFTGDVGGT
VMLGVGQAAMAILAFLPDREQDEVIRYNLPRMRALSAFDEGFLRAEIARVRDLGYADGAAGLIPGMAGLGVPILGRDGDA
VAALSVGSTTDRMTPERNKVIADLLKREAAEIGARLNPFDPALRRPGAAIMG
>Mature_292_residues
MCTFPVQFHSVKFYASLNDMSFIWRNMADSTSATGRIFALLRALSRGERQGMRLKDLAAAVDLPRPTTHRLLHGLMAEGM
VEHDPRTKHYRLGLELFVLAAKAGSPLNLRDIGRPALLRLTAALGETVFLMVRNGFDAVCVDRSAGPLPIRTFTGDVGGT
VMLGVGQAAMAILAFLPDREQDEVIRYNLPRMRALSAFDEGFLRAEIARVRDLGYADGAAGLIPGMAGLGVPILGRDGDA
VAALSVGSTTDRMTPERNKVIADLLKREAAEIGARLNPFDPALRRPGAAIMG

Specific function: Transcriptional repressor of the kip gene-containing operon [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1788131, Length=263, Percent_Identity=25.8555133079848, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786715, Length=245, Percent_Identity=26.530612244898, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI87082359, Length=248, Percent_Identity=25.4032258064516, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1786468, Length=203, Percent_Identity=21.6748768472906, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 31553; Mature: 31553

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCTFPVQFHSVKFYASLNDMSFIWRNMADSTSATGRIFALLRALSRGERQGMRLKDLAAA
CCCCCCEEEEEEEEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHH
VDLPRPTTHRLLHGLMAEGMVEHDPRTKHYRLGLELFVLAAKAGSPLNLRDIGRPALLRL
HCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHCCCEEEEEEECCCCCCCHHHCCCHHHHHH
TAALGETVFLMVRNGFDAVCVDRSAGPLPIRTFTGDVGGTVMLGVGQAAMAILAFLPDRE
HHHHCCEEEEEEECCCCEEEEECCCCCCEEEEECCCCCCEEEEECCHHHHHHHHHCCCCC
QDEVIRYNLPRMRALSAFDEGFLRAEIARVRDLGYADGAAGLIPGMAGLGVPILGRDGDA
CCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCHHHCCCEEECCCCCE
VAALSVGSTTDRMTPERNKVIADLLKREAAEIGARLNPFDPALRRPGAAIMG
EEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCC
>Mature Secondary Structure
MCTFPVQFHSVKFYASLNDMSFIWRNMADSTSATGRIFALLRALSRGERQGMRLKDLAAA
CCCCCCEEEEEEEEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHH
VDLPRPTTHRLLHGLMAEGMVEHDPRTKHYRLGLELFVLAAKAGSPLNLRDIGRPALLRL
HCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHCCCEEEEEEECCCCCCCHHHCCCHHHHHH
TAALGETVFLMVRNGFDAVCVDRSAGPLPIRTFTGDVGGTVMLGVGQAAMAILAFLPDRE
HHHHCCEEEEEEECCCCEEEEECCCCCCEEEEECCCCCCEEEEECCHHHHHHHHHCCCCC
QDEVIRYNLPRMRALSAFDEGFLRAEIARVRDLGYADGAAGLIPGMAGLGVPILGRDGDA
CCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCHHHCCCEEECCCCCE
VAALSVGSTTDRMTPERNKVIADLLKREAAEIGARLNPFDPALRRPGAAIMG
EEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]