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The map label for this gene is argH1 [H]

Identifier: 158424661

GI number: 158424661

Start: 3468106

End: 3469623

Strand: Reverse

Name: argH1 [H]

Synonym: AZC_3037

Alternate gene names: 158424661

Gene position: 3469623-3468106 (Counterclockwise)

Preceding gene: 158424662

Following gene: 158424660

Centisome position: 64.61

GC content: 67.33

Gene sequence:

>1518_bases
ATGCGGATGGCGGCAAAGGTCGCGGGAGCCGTGATGATGAGTGCCCTCACCCTGTCCACCGGCACCGCGCAGGCGCAGTC
GGAGGCGCGGCGCGACGAGTTCTATTGGCTCGGGGAGATCAACAAGGCCTCGCTGGTCATCAATTCCAGCCAGGGGCTGC
TGGATCCGGCGCTGGCGCCGCGCATCGCGCAGGGGCTCGACAAGGTGCTGAAGGACGGCGCGAGGCCCGGCGCCAAGCGG
CCGACTCTGGTCATCACCTTCGAGCCGCTGCTCATCGAGGCGGCGGGCGTCGAGGCGACGCTCCTGCATGCGGGCCGCTC
CAGCCAGGACATGCTCTCGACCGTCCGCGCCGCCGTGATGCGGGACGAACTTCTCGCTCTGGCGGAGCAGTTGCGCACGA
CCACCGCCACCCTGCGGGCGGTGGCGGAGGCGCAGCAGGACACGATCGTCCCTAATTACACCAATGGCGTCGCTGCCCAG
CCCAACAGCTATGGTCATTATCTGCTCGGCTTCGTGGCCGGCTTCGAGCGCGATGCCGAGCGTCTGCGCCAGGCCTATGC
GCGGCTCGACCGCTCACCCATGGGAACGACGGTGCTGAACGGCACGAGCTGGCCGCTCGACCGCGACCGCATGGCGGCCT
ATCTCGGCTTTCCGGCCAAGGTGGACAATGCCTATGACGCCGCCCAGATCTCCGCCGCCGAAATGCCGGTGGAGATCGGC
GCGGTGGCGACCTCCATCGCCCTGCACACCGGCGCCTTCATCCAGGACGTGATGGTGCAATATGCGCAGCCGCGCCCGTG
GATCCTGCTGCGGGAGGGGGATGGTAACACCTATGTGTCGAGCGCCATGCCCCAGAAGCGCAATCCGGGGCTCCTGAACG
ACACGCGCGGACAGGCCTCCATGGTGCTGACGCTCGCCATGGGCCGGGCCATCGCCGCCCACAACATCCCGCCGGGCATG
AACGACCCCAAGAGCGTGCGCGACAATGCAGAGGTAATCACCCGTACGGTGGCAACCCTGCGCAACCTCGACCGCATCCT
GAAGGCGCTGGTGATCGACCGCGACCGGGCGCTGGAGGAACTGAACAGCGACTGGACGGCCTCGCAGGAAATTGCCGATG
AACTGATGCGGACCTACAAGCTGCCCTTCCGCGTCGGGCATCATTTCGCCTCCGAGGTGGTGGGCTATGCCAAGGCCCAC
GACATCCGGCCCTCGGACTTTCCCTATGCCGAGGCCCAGCGCATCTATCGCGAGACGCTGGCGGAGATGAAGCTGCCAGT
CGGTGAACTTCCGATGAGCGAGGCCCAGTTCCGGGCCGCGCTCGATCCGGTGGCCATCTTGCGCAACCGCGCGACCAGCG
GCGGCCCGCAGCCGGCGGAGATGAAGCGGATGCTGGCGGAGACGGACCAGAACCTCGCCGCCCAGCAGCGCTGGATCTCC
GAGCACCGGCAGGCCATCGATACGGCGCTGGCGCGACTGGATTCTGATTTCGCCCAGGTGCTCGCCAAGGCGAAATAG

Upstream 100 bases:

>100_bases
TGAGGGAAGGTCTGCCCTTCCGCAACGAGAGCGCGAATGCGGACGTTTCTCGCCCGCCGATCGCTCGCTATGCTCCGGCC
AACAAACGGGAGGATAAGCC

Downstream 100 bases:

>100_bases
CCGGTGCCACATCGCGTGCGCGCGCTCGGCGCGCGTGCACGCCGGTGCCTCCTGTCCATTGCGGACATGCGCCGTTCGTG
CCCTATGGGACGCACGTTTC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL 1; Arginosuccinase 1 [H]

Number of amino acids: Translated: 505; Mature: 505

Protein sequence:

>505_residues
MRMAAKVAGAVMMSALTLSTGTAQAQSEARRDEFYWLGEINKASLVINSSQGLLDPALAPRIAQGLDKVLKDGARPGAKR
PTLVITFEPLLIEAAGVEATLLHAGRSSQDMLSTVRAAVMRDELLALAEQLRTTTATLRAVAEAQQDTIVPNYTNGVAAQ
PNSYGHYLLGFVAGFERDAERLRQAYARLDRSPMGTTVLNGTSWPLDRDRMAAYLGFPAKVDNAYDAAQISAAEMPVEIG
AVATSIALHTGAFIQDVMVQYAQPRPWILLREGDGNTYVSSAMPQKRNPGLLNDTRGQASMVLTLAMGRAIAAHNIPPGM
NDPKSVRDNAEVITRTVATLRNLDRILKALVIDRDRALEELNSDWTASQEIADELMRTYKLPFRVGHHFASEVVGYAKAH
DIRPSDFPYAEAQRIYRETLAEMKLPVGELPMSEAQFRAALDPVAILRNRATSGGPQPAEMKRMLAETDQNLAAQQRWIS
EHRQAIDTALARLDSDFAQVLAKAK

Sequences:

>Translated_505_residues
MRMAAKVAGAVMMSALTLSTGTAQAQSEARRDEFYWLGEINKASLVINSSQGLLDPALAPRIAQGLDKVLKDGARPGAKR
PTLVITFEPLLIEAAGVEATLLHAGRSSQDMLSTVRAAVMRDELLALAEQLRTTTATLRAVAEAQQDTIVPNYTNGVAAQ
PNSYGHYLLGFVAGFERDAERLRQAYARLDRSPMGTTVLNGTSWPLDRDRMAAYLGFPAKVDNAYDAAQISAAEMPVEIG
AVATSIALHTGAFIQDVMVQYAQPRPWILLREGDGNTYVSSAMPQKRNPGLLNDTRGQASMVLTLAMGRAIAAHNIPPGM
NDPKSVRDNAEVITRTVATLRNLDRILKALVIDRDRALEELNSDWTASQEIADELMRTYKLPFRVGHHFASEVVGYAKAH
DIRPSDFPYAEAQRIYRETLAEMKLPVGELPMSEAQFRAALDPVAILRNRATSGGPQPAEMKRMLAETDQNLAAQQRWIS
EHRQAIDTALARLDSDFAQVLAKAK
>Mature_505_residues
MRMAAKVAGAVMMSALTLSTGTAQAQSEARRDEFYWLGEINKASLVINSSQGLLDPALAPRIAQGLDKVLKDGARPGAKR
PTLVITFEPLLIEAAGVEATLLHAGRSSQDMLSTVRAAVMRDELLALAEQLRTTTATLRAVAEAQQDTIVPNYTNGVAAQ
PNSYGHYLLGFVAGFERDAERLRQAYARLDRSPMGTTVLNGTSWPLDRDRMAAYLGFPAKVDNAYDAAQISAAEMPVEIG
AVATSIALHTGAFIQDVMVQYAQPRPWILLREGDGNTYVSSAMPQKRNPGLLNDTRGQASMVLTLAMGRAIAAHNIPPGM
NDPKSVRDNAEVITRTVATLRNLDRILKALVIDRDRALEELNSDWTASQEIADELMRTYKLPFRVGHHFASEVVGYAKAH
DIRPSDFPYAEAQRIYRETLAEMKLPVGELPMSEAQFRAALDPVAILRNRATSGGPQPAEMKRMLAETDQNLAAQQRWIS
EHRQAIDTALARLDSDFAQVLAKAK

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=372, Percent_Identity=27.4193548387097, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI68303542, Length=372, Percent_Identity=27.4193548387097, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI68303547, Length=368, Percent_Identity=27.1739130434783, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI68303549, Length=373, Percent_Identity=26.2734584450402, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI1790398, Length=385, Percent_Identity=28.8311688311688, Blast_Score=138, Evalue=9e-34,
Organism=Saccharomyces cerevisiae, GI6321806, Length=302, Percent_Identity=28.1456953642384, Blast_Score=107, Evalue=6e-24,
Organism=Drosophila melanogaster, GI221473854, Length=332, Percent_Identity=25.6024096385542, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI78706858, Length=332, Percent_Identity=25.6024096385542, Blast_Score=102, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 55186; Mature: 55186

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMAAKVAGAVMMSALTLSTGTAQAQSEARRDEFYWLGEINKASLVINSSQGLLDPALAP
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEEECCCCEEEEEECCCCCCCHHHHH
RIAQGLDKVLKDGARPGAKRPTLVITFEPLLIEAAGVEATLLHAGRSSQDMLSTVRAAVM
HHHHHHHHHHHCCCCCCCCCCEEEEEECHHHEEECCCCEEEEECCCCHHHHHHHHHHHHH
RDELLALAEQLRTTTATLRAVAEAQQDTIVPNYTNGVAAQPNSYGHYLLGFVAGFERDAE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RLRQAYARLDRSPMGTTVLNGTSWPLDRDRMAAYLGFPAKVDNAYDAAQISAAEMPVEIG
HHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHCCCHHCCCCHHHHHHHHHHCCHHHH
AVATSIALHTGAFIQDVMVQYAQPRPWILLREGDGNTYVSSAMPQKRNPGLLNDTRGQAS
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEECCCCCCCCCCCCCCCCCCHHH
MVLTLAMGRAIAAHNIPPGMNDPKSVRDNAEVITRTVATLRNLDRILKALVIDRDRALEE
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNSDWTASQEIADELMRTYKLPFRVGHHFASEVVGYAKAHDIRPSDFPYAEAQRIYRETL
HCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
AEMKLPVGELPMSEAQFRAALDPVAILRNRATSGGPQPAEMKRMLAETDQNLAAQQRWIS
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EHRQAIDTALARLDSDFAQVLAKAK
HHHHHHHHHHHHHCHHHHHHHHCCC
>Mature Secondary Structure
MRMAAKVAGAVMMSALTLSTGTAQAQSEARRDEFYWLGEINKASLVINSSQGLLDPALAP
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEEECCCCEEEEEECCCCCCCHHHHH
RIAQGLDKVLKDGARPGAKRPTLVITFEPLLIEAAGVEATLLHAGRSSQDMLSTVRAAVM
HHHHHHHHHHHCCCCCCCCCCEEEEEECHHHEEECCCCEEEEECCCCHHHHHHHHHHHHH
RDELLALAEQLRTTTATLRAVAEAQQDTIVPNYTNGVAAQPNSYGHYLLGFVAGFERDAE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RLRQAYARLDRSPMGTTVLNGTSWPLDRDRMAAYLGFPAKVDNAYDAAQISAAEMPVEIG
HHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHCCCHHCCCCHHHHHHHHHHCCHHHH
AVATSIALHTGAFIQDVMVQYAQPRPWILLREGDGNTYVSSAMPQKRNPGLLNDTRGQAS
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEECCCCCCCCCCCCCCCCCCHHH
MVLTLAMGRAIAAHNIPPGMNDPKSVRDNAEVITRTVATLRNLDRILKALVIDRDRALEE
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNSDWTASQEIADELMRTYKLPFRVGHHFASEVVGYAKAHDIRPSDFPYAEAQRIYRETL
HCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
AEMKLPVGELPMSEAQFRAALDPVAILRNRATSGGPQPAEMKRMLAETDQNLAAQQRWIS
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EHRQAIDTALARLDSDFAQVLAKAK
HHHHHHHHHHHHHCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA