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The map label for this gene is chaA [C]

Identifier: 158424660

GI number: 158424660

Start: 3466880

End: 3468061

Strand: Reverse

Name: chaA [C]

Synonym: AZC_3036

Alternate gene names: 158424660

Gene position: 3468061-3466880 (Counterclockwise)

Preceding gene: 158424661

Following gene: 158424655

Centisome position: 64.58

GC content: 64.38

Gene sequence:

>1182_bases
GTGCCTCCTGTCCATTGCGGACATGCGCCGTTCGTGCCCTATGGGACGCACGTTTCCAAAGGAGAAGAAATGGCCGCCGA
TGTTTCCGGGCCCATGCCCAAGTCCGCCTGGCTCTATCCCATCGTCGCGCTCGGCTATTTCGGGCTCGCCACGGGGCTCG
GCTTCGATGAGGGCTTCACCGGCAGCACGAGCGGCATCCTGCTCGCCATCGTCCTCATTCCCGTGATCTTCGGGGCGATC
TTCGCGGCGGTGTATCATGCTGAGGTGATCGGTCATGCGACCGGCGAGCCGTTCGGCACGCTGGTGCTCACCGCCGCGGT
CACCATCATCGAGGTGGCGCTGATCGCCTCGGTGATGCTCTCCGACGACGGCGGCAGCCCGGAGCTGGCGCGCGATACGG
TGTTCTCGGTGGTGATGACCGTATGCACCGGCCTCACGGGCATCTGCATTCTGGGAGGCGGCCTGCGCTTCAAGGAGCAG
GTCTATGAGACCACGGGCGCCGGTGCCTATCTCACGGTGCTCATCGTTCTGGTGACACTGACGCTGGTGCTGCCGAACTA
TACGCAGGGCACGCCGGGGCCATTCTATTCCAGCAGCCAGCTTGCCTTCTTCAGCGTGCTGACGCTGATCCTCTATGGCG
TCTTCCTGTACATCCAGATGGTTCGTCACCGCGACTATTTTGTCAGCAGCAACGGCAGCGTGGTGGCGGTCGAGCATGCC
ATTCCCACCGCGCGGGCGCTGTTGAGCGCGGGCCTGCTGTTTGCCGCCCTCACGGCGATCGTGCTGCTGTCGAAGAAGTT
TGCCATCGTGGTGGAGGCGGGGCGCGAGGCGGTGGGGTCACCGCCGGCGGTGACTGGCCTCATCGTCGCCATCCTGATCC
TGCTGCCGGAATCCATTCCAGCCTTCCAGGCGGCGCGGCGCGATCAGTTGCAGAAGTCGCTCAATCTGGCGCTGGGCTCG
TCTCTCGCCACCATCGGCATGACGTTTCCGGCGGTCGCAGTCGTGTCGCTGGCGCTGAACAAGCCGCTCGTGCTCGGGCT
TACGCCGCGCGACACCGTGCTCATGGCGACGACGCTGCTCGTGAGTTCGCTGACGCTGGGCAGCGGGAGGACGAACATCC
TCTACGGCTTCACCCATCTCGTCATCTTCGCGGCGTTCCTGTTTCTCACCTTCCAGCCGTGA

Upstream 100 bases:

>100_bases
CGGCGCTGGCGCGACTGGATTCTGATTTCGCCCAGGTGCTCGCCAAGGCGAAATAGCCGGTGCCACATCGCGTGCGCGCG
CTCGGCGCGCGTGCACGCCG

Downstream 100 bases:

>100_bases
GGCCATCCGTCGTCCGCCGCCCGGGGTACGACCCGGAGCGGCAGGCGGCGCGATCAGATGAGCGCGCGGCGCCGGAGGTA
GATTTCAAGGCTGTCGGTGG

Product: Ca2+/H+ antiporter

Products: Na (I) [Periplasm]; Ca (II) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MPPVHCGHAPFVPYGTHVSKGEEMAADVSGPMPKSAWLYPIVALGYFGLATGLGFDEGFTGSTSGILLAIVLIPVIFGAI
FAAVYHAEVIGHATGEPFGTLVLTAAVTIIEVALIASVMLSDDGGSPELARDTVFSVVMTVCTGLTGICILGGGLRFKEQ
VYETTGAGAYLTVLIVLVTLTLVLPNYTQGTPGPFYSSSQLAFFSVLTLILYGVFLYIQMVRHRDYFVSSNGSVVAVEHA
IPTARALLSAGLLFAALTAIVLLSKKFAIVVEAGREAVGSPPAVTGLIVAILILLPESIPAFQAARRDQLQKSLNLALGS
SLATIGMTFPAVAVVSLALNKPLVLGLTPRDTVLMATTLLVSSLTLGSGRTNILYGFTHLVIFAAFLFLTFQP

Sequences:

>Translated_393_residues
MPPVHCGHAPFVPYGTHVSKGEEMAADVSGPMPKSAWLYPIVALGYFGLATGLGFDEGFTGSTSGILLAIVLIPVIFGAI
FAAVYHAEVIGHATGEPFGTLVLTAAVTIIEVALIASVMLSDDGGSPELARDTVFSVVMTVCTGLTGICILGGGLRFKEQ
VYETTGAGAYLTVLIVLVTLTLVLPNYTQGTPGPFYSSSQLAFFSVLTLILYGVFLYIQMVRHRDYFVSSNGSVVAVEHA
IPTARALLSAGLLFAALTAIVLLSKKFAIVVEAGREAVGSPPAVTGLIVAILILLPESIPAFQAARRDQLQKSLNLALGS
SLATIGMTFPAVAVVSLALNKPLVLGLTPRDTVLMATTLLVSSLTLGSGRTNILYGFTHLVIFAAFLFLTFQP
>Mature_392_residues
PPVHCGHAPFVPYGTHVSKGEEMAADVSGPMPKSAWLYPIVALGYFGLATGLGFDEGFTGSTSGILLAIVLIPVIFGAIF
AAVYHAEVIGHATGEPFGTLVLTAAVTIIEVALIASVMLSDDGGSPELARDTVFSVVMTVCTGLTGICILGGGLRFKEQV
YETTGAGAYLTVLIVLVTLTLVLPNYTQGTPGPFYSSSQLAFFSVLTLILYGVFLYIQMVRHRDYFVSSNGSVVAVEHAI
PTARALLSAGLLFAALTAIVLLSKKFAIVVEAGREAVGSPPAVTGLIVAILILLPESIPAFQAARRDQLQKSLNLALGSS
LATIGMTFPAVAVVSLALNKPLVLGLTPRDTVLMATTLLVSSLTLGSGRTNILYGFTHLVIFAAFLFLTFQP

Specific function: Possible cation transporter [H]

COG id: COG0387

COG function: function code P; Ca2+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium/potassium/calcium exchanger family [H]

Homologues:

Organism=Escherichia coli, GI1787468, Length=320, Percent_Identity=35.3125, Blast_Score=186, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004713
- InterPro:   IPR004837 [H]

Pfam domain/function: PF01699 Na_Ca_ex [H]

EC number: NA

Molecular weight: Translated: 41107; Mature: 40976

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPVHCGHAPFVPYGTHVSKGEEMAADVSGPMPKSAWLYPIVALGYFGLATGLGFDEGFT
CCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
GSTSGILLAIVLIPVIFGAIFAAVYHAEVIGHATGEPFGTLVLTAAVTIIEVALIASVML
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
SDDGGSPELARDTVFSVVMTVCTGLTGICILGGGLRFKEQVYETTGAGAYLTVLIVLVTL
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHH
TLVLPNYTQGTPGPFYSSSQLAFFSVLTLILYGVFLYIQMVRHRDYFVSSNGSVVAVEHA
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEECC
IPTARALLSAGLLFAALTAIVLLSKKFAIVVEAGREAVGSPPAVTGLIVAILILLPESIP
CHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHCCCCCHHHHHHHHHHHHHCCCCH
AFQAARRDQLQKSLNLALGSSLATIGMTFPAVAVVSLALNKPLVLGLTPRDTVLMATTLL
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHH
VSSLTLGSGRTNILYGFTHLVIFAAFLFLTFQP
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PPVHCGHAPFVPYGTHVSKGEEMAADVSGPMPKSAWLYPIVALGYFGLATGLGFDEGFT
CCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
GSTSGILLAIVLIPVIFGAIFAAVYHAEVIGHATGEPFGTLVLTAAVTIIEVALIASVML
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
SDDGGSPELARDTVFSVVMTVCTGLTGICILGGGLRFKEQVYETTGAGAYLTVLIVLVTL
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHH
TLVLPNYTQGTPGPFYSSSQLAFFSVLTLILYGVFLYIQMVRHRDYFVSSNGSVVAVEHA
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEECC
IPTARALLSAGLLFAALTAIVLLSKKFAIVVEAGREAVGSPPAVTGLIVAILILLPESIP
CHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHCCCCCHHHHHHHHHHHHHCCCCH
AFQAARRDQLQKSLNLALGSSLATIGMTFPAVAVVSLALNKPLVLGLTPRDTVLMATTLL
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHH
VSSLTLGSGRTNILYGFTHLVIFAAFLFLTFQP
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm]; Ca (II) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + Proton [Periplasm] = Proton [Cytoplasm] + Na (I) [Periplasm] Ca (II) [Cytoplasm] + Proton [Periplasm] = Ca (II) [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]