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The map label for this gene is serA [H]

Identifier: 158424649

GI number: 158424649

Start: 3458013

End: 3459329

Strand: Direct

Name: serA [H]

Synonym: AZC_3025

Alternate gene names: 158424649

Gene position: 3458013-3459329 (Clockwise)

Preceding gene: 158424648

Following gene: 158424650

Centisome position: 64.4

GC content: 67.05

Gene sequence:

>1317_bases
ATGCGGGCCTTGGCGCCGGGTCTCCGATCGCTGAAGGACGCCGAGACCGTGCAAGACAGCCATTCCGATTCGCCGCAACT
GTCGCTGGCCAAGGACAAGATCCGGGTGCTGCTTCTGGAAGGCGTCAATGACAGCGCCGTCCAGATCATGACGGACGCCG
GCTATACCAACGTCACCCGCCTGACCAAGGCGCTCGACGGCGAGGCGCTCAAGGAAGCCGTGAAGGGCGTCCACATCCTC
GGCATCCGCTCGCGCACCCATATCACCGCCGAGGTCCTGGAAGCCGCCGACCGCCTGATCGCCGTGGGCTGCTTCAGCGT
TGGCACCAATCAGGTGGACCTCGACGCCTGCCGCGTGCACGGCATTCCCGTTTTCAACGCGCCCTTCTCCAACACCCGCA
GCGTGGCGGAACTCGTCATCGGCGAGATCGTGATGCTGCTGCGCCGCATCCCGGCCCGCTCGGTGGCCGCCCATGACGGC
CGCTGGGACAAGTCGGCCCATGACAGCCACGAGGTGCGCGGCAAGACCCTCGGCATCGTCGGCTACGGCAACATCGGTTC
GCAGCTCTCGAACCTCGCCGAAGCCATGGGCATGAAGGTGATCTTCTACGACGTCACCGACAAGCTGCGCCACGGCAACA
CTGAATCCGTCGGCTCGCTGCAGGACCTCCTCGGCCAGAGCGACGTGGTGAGCCTGCACGTGCCCGAGACGCCGTCCACC
CACGGCCTCATCGGCGCCGCCGAGATCGCCGCCATGAAGGCCGGCGCCTATCTCATCAACAACAGCCGCGGCACCGTGGT
GGACCTCGACGCGCTCGCCGCCGCCCTCAAGAGCGGCCATCTGCGCGGCGCGGCCGTGGACGTGTTCCCGAAGGAGCCCG
GCTCCAATGGCGAGCGCTTCGTGACCCCGCTCCAGGGCCTCGACAACGTGATCCTCACCCCGCACATCGGCGGCTCGACC
GAAGAGGCGCAGGAGCGCATCGGCTCTGAAGTGGCGCGCAAGCTTGTCGATTACAGCGACAGCGGCTCCACCATGGGCGC
GGTGAACTTCCCGCAGGTGCAGCTGCCGGCCCGTCCGCAGGGCACGCGCTTCATCCAGGTCCAGCGCAACCTGCCCGGCA
TGCTCGGCCGCCTCAACGAGGTACTGGCCCGCCACTCGGTCAACATCGCCGGCCAGTATTACGAGACCTATGCCGACGTC
GGCTATGTGGTGCTCGATGCCGATGCCTCGCAGGCGGACAGCCAGCGCGTGCTGGAGGACATCCGCGCCATCGACGGCAC
CATCCGCGCCCGCCTGCTCTACGAATACAAGATCTGA

Upstream 100 bases:

>100_bases
GCGCCGGACGCCTAGACGCGGACCGCAAAAACGCTAAGTTCTCGCCCCCGAGGATCGCCCCTCCGGGGCGAGAGACTGAA
AGCCCGGCAAGACCCCATGG

Downstream 100 bases:

>100_bases
GCCGCGCCCTCATCTTTACAGCCGTTCCAGAAGGCCGCCGCGCATCCACGCGGCGGCCTTCTCCCGTATGAGAGCGTGGC
AAAAGGCGGCGGCGGGGCGA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MRALAPGLRSLKDAETVQDSHSDSPQLSLAKDKIRVLLLEGVNDSAVQIMTDAGYTNVTRLTKALDGEALKEAVKGVHIL
GIRSRTHITAEVLEAADRLIAVGCFSVGTNQVDLDACRVHGIPVFNAPFSNTRSVAELVIGEIVMLLRRIPARSVAAHDG
RWDKSAHDSHEVRGKTLGIVGYGNIGSQLSNLAEAMGMKVIFYDVTDKLRHGNTESVGSLQDLLGQSDVVSLHVPETPST
HGLIGAAEIAAMKAGAYLINNSRGTVVDLDALAAALKSGHLRGAAVDVFPKEPGSNGERFVTPLQGLDNVILTPHIGGST
EEAQERIGSEVARKLVDYSDSGSTMGAVNFPQVQLPARPQGTRFIQVQRNLPGMLGRLNEVLARHSVNIAGQYYETYADV
GYVVLDADASQADSQRVLEDIRAIDGTIRARLLYEYKI

Sequences:

>Translated_438_residues
MRALAPGLRSLKDAETVQDSHSDSPQLSLAKDKIRVLLLEGVNDSAVQIMTDAGYTNVTRLTKALDGEALKEAVKGVHIL
GIRSRTHITAEVLEAADRLIAVGCFSVGTNQVDLDACRVHGIPVFNAPFSNTRSVAELVIGEIVMLLRRIPARSVAAHDG
RWDKSAHDSHEVRGKTLGIVGYGNIGSQLSNLAEAMGMKVIFYDVTDKLRHGNTESVGSLQDLLGQSDVVSLHVPETPST
HGLIGAAEIAAMKAGAYLINNSRGTVVDLDALAAALKSGHLRGAAVDVFPKEPGSNGERFVTPLQGLDNVILTPHIGGST
EEAQERIGSEVARKLVDYSDSGSTMGAVNFPQVQLPARPQGTRFIQVQRNLPGMLGRLNEVLARHSVNIAGQYYETYADV
GYVVLDADASQADSQRVLEDIRAIDGTIRARLLYEYKI
>Mature_438_residues
MRALAPGLRSLKDAETVQDSHSDSPQLSLAKDKIRVLLLEGVNDSAVQIMTDAGYTNVTRLTKALDGEALKEAVKGVHIL
GIRSRTHITAEVLEAADRLIAVGCFSVGTNQVDLDACRVHGIPVFNAPFSNTRSVAELVIGEIVMLLRRIPARSVAAHDG
RWDKSAHDSHEVRGKTLGIVGYGNIGSQLSNLAEAMGMKVIFYDVTDKLRHGNTESVGSLQDLLGQSDVVSLHVPETPST
HGLIGAAEIAAMKAGAYLINNSRGTVVDLDALAAALKSGHLRGAAVDVFPKEPGSNGERFVTPLQGLDNVILTPHIGGST
EEAQERIGSEVARKLVDYSDSGSTMGAVNFPQVQLPARPQGTRFIQVQRNLPGMLGRLNEVLARHSVNIAGQYYETYADV
GYVVLDADASQADSQRVLEDIRAIDGTIRARLLYEYKI

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=317, Percent_Identity=36.2776025236593, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI145580578, Length=290, Percent_Identity=35.8620689655172, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI4557499, Length=290, Percent_Identity=35.8620689655172, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI61743967, Length=284, Percent_Identity=34.1549295774648, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI4557497, Length=284, Percent_Identity=34.1549295774648, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI145580575, Length=291, Percent_Identity=35.7388316151203, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI6912396, Length=285, Percent_Identity=28.4210526315789, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI1789279, Length=409, Percent_Identity=57.7017114914425, Blast_Score=475, Evalue=1e-135,
Organism=Escherichia coli, GI87082289, Length=278, Percent_Identity=33.8129496402878, Blast_Score=125, Evalue=8e-30,
Organism=Escherichia coli, GI1787645, Length=250, Percent_Identity=31.2, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI87081824, Length=287, Percent_Identity=26.8292682926829, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788660, Length=256, Percent_Identity=32.03125, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=322, Percent_Identity=35.7142857142857, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI25147481, Length=374, Percent_Identity=27.5401069518717, Blast_Score=115, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6320925, Length=414, Percent_Identity=46.6183574879227, Blast_Score=379, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6322116, Length=414, Percent_Identity=46.1352657004831, Blast_Score=376, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6324964, Length=256, Percent_Identity=32.03125, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6324055, Length=274, Percent_Identity=28.1021897810219, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6324980, Length=199, Percent_Identity=31.1557788944724, Blast_Score=83, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6325144, Length=188, Percent_Identity=28.7234042553192, Blast_Score=66, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6321253, Length=162, Percent_Identity=28.3950617283951, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI19921140, Length=305, Percent_Identity=32.4590163934426, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24646446, Length=265, Percent_Identity=36.6037735849057, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24646448, Length=265, Percent_Identity=36.6037735849057, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24646452, Length=265, Percent_Identity=36.6037735849057, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24646450, Length=265, Percent_Identity=36.6037735849057, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI62472511, Length=265, Percent_Identity=36.6037735849057, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI28574286, Length=261, Percent_Identity=30.6513409961686, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24585514, Length=263, Percent_Identity=27.3764258555133, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI28574282, Length=263, Percent_Identity=27.3764258555133, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI45552429, Length=263, Percent_Identity=27.3764258555133, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI45551003, Length=263, Percent_Identity=27.3764258555133, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI28574284, Length=263, Percent_Identity=27.3764258555133, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI28571528, Length=303, Percent_Identity=28.3828382838284, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24585516, Length=318, Percent_Identity=23.5849056603774, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR010771
- InterPro:   IPR016040
- ProDom:   PD147088 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 46996; Mature: 46996

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALAPGLRSLKDAETVQDSHSDSPQLSLAKDKIRVLLLEGVNDSAVQIMTDAGYTNVTR
CCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCEEEEEEECCCCCEEEEEECCCCHHHHH
LTKALDGEALKEAVKGVHILGIRSRTHITAEVLEAADRLIAVGCFSVGTNQVDLDACRVH
HHHHHCHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHEEEEEEEECCCCEEEHHHHEEC
GIPVFNAPFSNTRSVAELVIGEIVMLLRRIPARSVAAHDGRWDKSAHDSHEVRGKTLGIV
CCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCHHCCCCEEEEE
GYGNIGSQLSNLAEAMGMKVIFYDVTDKLRHGNTESVGSLQDLLGQSDVVSLHVPETPST
EECCHHHHHHHHHHHHCCEEEEEECHHHHHCCCCCCHHHHHHHCCCCCEEEEECCCCCCC
HGLIGAAEIAAMKAGAYLINNSRGTVVDLDALAAALKSGHLRGAAVDVFPKEPGSNGERF
CCCCHHHHHHHHHCCEEEEECCCCCEEEHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEE
VTPLQGLDNVILTPHIGGSTEEAQERIGSEVARKLVDYSDSGSTMGAVNFPQVQLPARPQ
ECHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEECCCCCC
GTRFIQVQRNLPGMLGRLNEVLARHSVNIAGQYYETYADVGYVVLDADASQADSQRVLED
CCEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEECCCCCCHHHHHHHH
IRAIDGTIRARLLYEYKI
HHHHCHHEEEEEEEEECC
>Mature Secondary Structure
MRALAPGLRSLKDAETVQDSHSDSPQLSLAKDKIRVLLLEGVNDSAVQIMTDAGYTNVTR
CCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCEEEEEEECCCCCEEEEEECCCCHHHHH
LTKALDGEALKEAVKGVHILGIRSRTHITAEVLEAADRLIAVGCFSVGTNQVDLDACRVH
HHHHHCHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHEEEEEEEECCCCEEEHHHHEEC
GIPVFNAPFSNTRSVAELVIGEIVMLLRRIPARSVAAHDGRWDKSAHDSHEVRGKTLGIV
CCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCHHCCCCEEEEE
GYGNIGSQLSNLAEAMGMKVIFYDVTDKLRHGNTESVGSLQDLLGQSDVVSLHVPETPST
EECCHHHHHHHHHHHHCCEEEEEECHHHHHCCCCCCHHHHHHHCCCCCEEEEECCCCCCC
HGLIGAAEIAAMKAGAYLINNSRGTVVDLDALAAALKSGHLRGAAVDVFPKEPGSNGERF
CCCCHHHHHHHHHCCEEEEECCCCCEEEHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEE
VTPLQGLDNVILTPHIGGSTEEAQERIGSEVARKLVDYSDSGSTMGAVNFPQVQLPARPQ
ECHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEECCCCCC
GTRFIQVQRNLPGMLGRLNEVLARHSVNIAGQYYETYADVGYVVLDADASQADSQRVLED
CCEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEECCCCCCHHHHHHHH
IRAIDGTIRARLLYEYKI
HHHHCHHEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]