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The map label for this gene is fadA [H]

Identifier: 158424596

GI number: 158424596

Start: 3395615

End: 3396751

Strand: Direct

Name: fadA [H]

Synonym: AZC_2972

Alternate gene names: 158424596

Gene position: 3395615-3396751 (Clockwise)

Preceding gene: 158424595

Following gene: 158424597

Centisome position: 63.24

GC content: 68.69

Gene sequence:

>1137_bases
ATGTCGAACGTCGTCATCGCGGGATATGCCCGCTCGCCCTTCGCCCCCGCCAAGAAGGGCGATCTTGCCCGCGTGCGGCC
GGACGATCTCGCCGCCCAGGTGGTGCGCGAGCTGATCGCCCGGACGAAGGTCAATCCCGAGGACATCGAGGACCTGATCG
TCGGCTGCGCCTTTCCCGAGGCTGAGCAGGGCTTCAACATCGCCCGCCTCATCGGCATGATCGCGGAGCTGCCCCAGTCG
GTGGCGGGCGTCACCGTCAACCGCTTCTGCGGTTCCTCCATGCAGTCCGTGCATATGGCCGCCGGCCAGATCCTGCTGGG
TGCCGGCGAGGCCTTCATCTGCGCGGGCGTGGAGAGCATGAGCCGCGTGCCCATGACCGGCTTCAACCCCATGCCGAACC
CGGCGCTCTACGCCAAGAATGCCGCCGCCTACATGGGCATGGGCGACACGGCGGAGAATGTCGCGCGCAAGTGGCAGATC
ACCCGCGCCGATCAGGAGGCCTTCGCGGTGGAGAGCCAGCGCAAGGCGGCGAAAGCCCAGGCCGAAGGCAAGCTGAAGGA
CGAGATCGTCCCCATCCGCATCAACGGCAAGAGCGTGGACGCCGACAGCTGCATCCGGCCCGAGACCACGGCGGACGACC
TCGCCGGCCTCAAGCCCGCGTTCGACCAGAACGGCACGGTCACCGCCGGCACCTCCTCCCCGCTCACCGATGGTGCCTCC
GCCGTTCTCGTCTGCTCGGAAGCCTATGCGGAAAAGCACGGCCTTGAGGTCCTTGCCCGCCTGCGCTCGGTGGCGGTCGC
CGGCTGCGCACCGGAAATCATGGGCATCGGCCCCGTGGATGCGACGCGCAAGGCGCTCGCCCGCGCCAACATCAAGATCG
AGGACGTGGACGTGGTGGAACTGAACGAGGCTTTCGCCTCGCAGGCCATCGCCTGCGCCCGCGACCTCAATGTGAAGCCC
GAGACGCTGAACATCGACGGCGGCGCGATCGCGCTCGGACATCCGCTGGGCGCCACCGGGGCGCGGATCGTCGGCAAGGC
GGCGTCCCTGCTGAAGCGCGAGGGCGGTCGCTATGCGGTCGCCACCCAGTGCATTGGCGGCGGCCAGGGCATCGCCACCG
TTCTCGAGCGCGTGTGA

Upstream 100 bases:

>100_bases
GGCAAGCGGCGGGGATGAGTCCCGCGGGGCGCCGTCGGGCGCCGGAATAAACAAGAAGACCGAAAGCCGAACGGCATTTT
GAAAGCTTGCAGGAGCGCCC

Downstream 100 bases:

>100_bases
GCGGAGGCGCCACCATGAGCGAGATCCGCAAGGCCGCCGTCATCGGCGCCGGCGTCATGGGCGCCGGCATTGCCGCCCAC
ATCGCCAATGCCGGGGTGGA

Product: thiolase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 378; Mature: 377

Protein sequence:

>378_residues
MSNVVIAGYARSPFAPAKKGDLARVRPDDLAAQVVRELIARTKVNPEDIEDLIVGCAFPEAEQGFNIARLIGMIAELPQS
VAGVTVNRFCGSSMQSVHMAAGQILLGAGEAFICAGVESMSRVPMTGFNPMPNPALYAKNAAAYMGMGDTAENVARKWQI
TRADQEAFAVESQRKAAKAQAEGKLKDEIVPIRINGKSVDADSCIRPETTADDLAGLKPAFDQNGTVTAGTSSPLTDGAS
AVLVCSEAYAEKHGLEVLARLRSVAVAGCAPEIMGIGPVDATRKALARANIKIEDVDVVELNEAFASQAIACARDLNVKP
ETLNIDGGAIALGHPLGATGARIVGKAASLLKREGGRYAVATQCIGGGQGIATVLERV

Sequences:

>Translated_378_residues
MSNVVIAGYARSPFAPAKKGDLARVRPDDLAAQVVRELIARTKVNPEDIEDLIVGCAFPEAEQGFNIARLIGMIAELPQS
VAGVTVNRFCGSSMQSVHMAAGQILLGAGEAFICAGVESMSRVPMTGFNPMPNPALYAKNAAAYMGMGDTAENVARKWQI
TRADQEAFAVESQRKAAKAQAEGKLKDEIVPIRINGKSVDADSCIRPETTADDLAGLKPAFDQNGTVTAGTSSPLTDGAS
AVLVCSEAYAEKHGLEVLARLRSVAVAGCAPEIMGIGPVDATRKALARANIKIEDVDVVELNEAFASQAIACARDLNVKP
ETLNIDGGAIALGHPLGATGARIVGKAASLLKREGGRYAVATQCIGGGQGIATVLERV
>Mature_377_residues
SNVVIAGYARSPFAPAKKGDLARVRPDDLAAQVVRELIARTKVNPEDIEDLIVGCAFPEAEQGFNIARLIGMIAELPQSV
AGVTVNRFCGSSMQSVHMAAGQILLGAGEAFICAGVESMSRVPMTGFNPMPNPALYAKNAAAYMGMGDTAENVARKWQIT
RADQEAFAVESQRKAAKAQAEGKLKDEIVPIRINGKSVDADSCIRPETTADDLAGLKPAFDQNGTVTAGTSSPLTDGASA
VLVCSEAYAEKHGLEVLARLRSVAVAGCAPEIMGIGPVDATRKALARANIKIEDVDVVELNEAFASQAIACARDLNVKPE
TLNIDGGAIALGHPLGATGARIVGKAASLLKREGGRYAVATQCIGGGQGIATVLERV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=392, Percent_Identity=36.734693877551, Blast_Score=261, Evalue=8e-70,
Organism=Homo sapiens, GI4501853, Length=386, Percent_Identity=40.4145077720207, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=38.3631713554987, Blast_Score=242, Evalue=3e-64,
Organism=Homo sapiens, GI4504327, Length=423, Percent_Identity=32.8605200945626, Blast_Score=181, Evalue=8e-46,
Organism=Homo sapiens, GI4557237, Length=394, Percent_Identity=30.2030456852792, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI194353979, Length=378, Percent_Identity=31.4814814814815, Blast_Score=146, Evalue=2e-35,
Organism=Escherichia coli, GI48994986, Length=389, Percent_Identity=46.7866323907455, Blast_Score=315, Evalue=2e-87,
Organism=Escherichia coli, GI1787663, Length=383, Percent_Identity=45.1697127937337, Blast_Score=301, Evalue=7e-83,
Organism=Escherichia coli, GI87082165, Length=395, Percent_Identity=40, Blast_Score=254, Evalue=7e-69,
Organism=Escherichia coli, GI1788554, Length=397, Percent_Identity=38.5390428211587, Blast_Score=244, Evalue=7e-66,
Organism=Escherichia coli, GI1788683, Length=400, Percent_Identity=34.75, Blast_Score=177, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI133906874, Length=391, Percent_Identity=38.618925831202, Blast_Score=251, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI17535921, Length=395, Percent_Identity=35.1898734177215, Blast_Score=204, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI25147385, Length=392, Percent_Identity=32.3979591836735, Blast_Score=181, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17551802, Length=429, Percent_Identity=31.4685314685315, Blast_Score=181, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17535917, Length=392, Percent_Identity=26.7857142857143, Blast_Score=105, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6322031, Length=384, Percent_Identity=36.1979166666667, Blast_Score=205, Evalue=8e-54,
Organism=Saccharomyces cerevisiae, GI6325229, Length=404, Percent_Identity=33.6633663366337, Blast_Score=192, Evalue=8e-50,
Organism=Drosophila melanogaster, GI24655093, Length=393, Percent_Identity=37.4045801526718, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI17648125, Length=349, Percent_Identity=40.974212034384, Blast_Score=247, Evalue=8e-66,
Organism=Drosophila melanogaster, GI24640423, Length=393, Percent_Identity=33.3333333333333, Blast_Score=191, Evalue=7e-49,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=29.6470588235294, Blast_Score=165, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 39352; Mature: 39221

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNVVIAGYARSPFAPAKKGDLARVRPDDLAAQVVRELIARTKVNPEDIEDLIVGCAFPE
CCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
AEQGFNIARLIGMIAELPQSVAGVTVNRFCGSSMQSVHMAAGQILLGAGEAFICAGVESM
HHHCCCHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHCEEEEECCCEEEEECHHHH
SRVPMTGFNPMPNPALYAKNAAAYMGMGDTAENVARKWQITRADQEAFAVESQRKAAKAQ
HCCCCCCCCCCCCCCEEECCCHHCCCCCCHHHHHHHHHEEECCCHHHHHHHHHHHHHHHH
AEGKLKDEIVPIRINGKSVDADSCIRPETTADDLAGLKPAFDQNGTVTAGTSSPLTDGAS
HCCCHHHCEEEEEECCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCEEECCCCCCCCCCC
AVLVCSEAYAEKHGLEVLARLRSVAVAGCAPEIMGIGPVDATRKALARANIKIEDVDVVE
EEEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHEECCCCHHHHHHHHHCCCEEECCCEEE
LNEAFASQAIACARDLNVKPETLNIDGGAIALGHPLGATGARIVGKAASLLKREGGRYAV
HHHHHHHHHHHHHHCCCCCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEE
ATQCIGGGQGIATVLERV
EEEECCCCCHHHHHHHCC
>Mature Secondary Structure 
SNVVIAGYARSPFAPAKKGDLARVRPDDLAAQVVRELIARTKVNPEDIEDLIVGCAFPE
CCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
AEQGFNIARLIGMIAELPQSVAGVTVNRFCGSSMQSVHMAAGQILLGAGEAFICAGVESM
HHHCCCHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHCEEEEECCCEEEEECHHHH
SRVPMTGFNPMPNPALYAKNAAAYMGMGDTAENVARKWQITRADQEAFAVESQRKAAKAQ
HCCCCCCCCCCCCCCEEECCCHHCCCCCCHHHHHHHHHEEECCCHHHHHHHHHHHHHHHH
AEGKLKDEIVPIRINGKSVDADSCIRPETTADDLAGLKPAFDQNGTVTAGTSSPLTDGAS
HCCCHHHCEEEEEECCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCEEECCCCCCCCCCC
AVLVCSEAYAEKHGLEVLARLRSVAVAGCAPEIMGIGPVDATRKALARANIKIEDVDVVE
EEEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHEECCCCHHHHHHHHHCCCEEECCCEEE
LNEAFASQAIACARDLNVKPETLNIDGGAIALGHPLGATGARIVGKAASLLKREGGRYAV
HHHHHHHHHHHHHHCCCCCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEE
ATQCIGGGQGIATVLERV
EEEECCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]