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The map label for this gene is kefBC [H]

Identifier: 158424586

GI number: 158424586

Start: 3382816

End: 3384717

Strand: Direct

Name: kefBC [H]

Synonym: AZC_2962

Alternate gene names: 158424586

Gene position: 3382816-3384717 (Clockwise)

Preceding gene: 158424585

Following gene: 158424587

Centisome position: 63.0

GC content: 69.45

Gene sequence:

>1902_bases
GTGCCGCCTTGCAGTGCGGGAGGCGCCACGGATGCTCTGGCGGGCCGCGGGGAGACGGAGCGGATGCATGGCGATGAACA
CACGCTCTTCCTGAGCGCCCTCGCCTTCCTCGCCGCGGCCGTCGTTTCCGTTCCCATCGCCCGCCGCCTCGGCCTTTCGC
CAGTGGTCGGCTATCTCGCCGCCGGCGTCGCCATCGGCCCGGCCGGCCTCAGCGTGGCAGACCCCTCCACAGTCATCACG
GTGGCCGAGCTCGGCGTCGTCCTGCTGCTGTTCCTCATCGGCCTCGAGCTCCAGCCCTCCCGCCTCCTTTCCATGGGGCG
CTACATCTTCGGCCTCGGCACGGCGCAGCTTCTGCTCACCGGCGCGGTGATCGCGGTGGTGGAAATGCTGCTCGGCTTCG
GCTGGGCGGCGGCGGTCATCTCGGGCCTGGCGCTCGCCATGTCGGCCACCTCCATCGCGCTCCAGCTGCTCTCGGAGCGT
GGCGACGTCTCGTCCGGCTACGGCCAGCGGGCCTTCTCCATCCTGCTGTTGCAGGACATCGCCATCGTGCCGCTGCTGGC
GCTGGTGCCCCTGCTGGCGCCGGGCGAATCCGCGACACCGCGCAACCCCACCGGCGTGCTGCTCCAGGCCGGCGCCATGA
TCGGCGCTATCGCCGTGGTGGTGGTGGCGGGGCGCTATCTCCTCAATCCGCTCTTCCGTCTGCTCGCCCGCACCGGCGCG
CGCGAGGCGATGACGGCGGCCGCCCTCCTCGTGGTGATGGGTGCGGCGGGCCTCATGGCGTTTGCCGGCCTGTCCATGGC
GCTGGGCGCCTTCCTTGCCGGCCTGCTGCTGTCGGAAAGCACCTTCCGTCACGAGCTGGAAGCCAATATCGACGCCTTCC
GCGGGCTCCTGCTGGCGCTGTTCTTCATGGGCGTCGGCATGTCGCTGGACCTGAAGGTGGTCATTCCCTACCTCGGTCCC
GTGCTCTCCGGCGCTCTCGTCATCACAGCGATCAAGTTCGCCGTGGTGTTCGTGCTCTATCGGGGGGACCACCGCGATCT
CGCGGACGGGCTCAGGGCGGGCGCCGTGCTGATGCCGGCGGGCGAGTTCGCCTTCGTGCTGTTCCCGCTCGCCCTCTCGA
ACGGCATCCTCGACCAGCAGCAGACCTCGCTCCTCACCGCTACGGCGGCGGTGACGATGATGATCGGTCCGCTGGCCTTC
GCCGGCATCGAGGTGCTGCTGCCGCGCCTGCGCAAGGATGCGCCGGAGCCCGAGCCGGACGATTTCACGGATGCCAACGG
CAGCGTGCTCGTGATCGGCTTCGGCCGTTTCGGGCAGGTGGTCTCCCAGTGCCTGCTGGCCGAGAATGTCGGCGTCACCA
TCATCGACAACGATGTGGAGATGATCCAGAGCGCCGGCCGTTTCGGCGTGCACATCTATTATGGCGACGGCACGCGGCTC
GACGTGCTGCGCGCCGCCGGCGCCGAGACCGCCGAGGTCATCGCGGTGTGCGTGGACGACAAGGACACGGCCACCCGCAT
CGTGGAGATCGTGAAGGCCTCCATGCCGCAGGCCCGCCTCTTCGTGCGCAGCTTCGACCGCGTGCACACCATGGATCTCC
TGCGCAAGGGCGTGGATTTCGAGATCCGTGAGACGCTGGAATCGGCCTTCGCCTTCGGCACGCGGACCTTGGAATCGCTG
GGGCTGGATACGGAGACCGCCCGCCAGCGCGTCGCCGAGGTGCGCGAGCGCGACCGGGCGCGGCTGCTGCGCCAGATGGA
GGAAGGCCTTTACGCCGGCCTCGACCAGTTCACGCCCCGCAAGGTGGAGCCGGAACCGCTCACCCGGCCCGAGAAGCCCG
CCCGCCCGCTCAACCCCGAGGCGCAGGACGTGCTCACCCACGAGACCGAATTCTCCGGCTGA

Upstream 100 bases:

>100_bases
TTGGGTTCCAAAAGGCACGCCCATGGAGCCGACCGGCCGGATCATTGGTCCCAAGCCGTGACACCGTCTCCGATTCTTTG
GTAGAGAGAGCGTCTGGCCG

Downstream 100 bases:

>100_bases
CGGGTCACCGCCGTCAGCGGTGTTCTTCCGCATCGGTCTGGGGCATGGTCCGCCCCCGCCGGCCCACGGAGCCGGATCGG
GCGCGTTCAGCCTGATCGCA

Product: potassium efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 633; Mature: 632

Protein sequence:

>633_residues
MPPCSAGGATDALAGRGETERMHGDEHTLFLSALAFLAAAVVSVPIARRLGLSPVVGYLAAGVAIGPAGLSVADPSTVIT
VAELGVVLLLFLIGLELQPSRLLSMGRYIFGLGTAQLLLTGAVIAVVEMLLGFGWAAAVISGLALAMSATSIALQLLSER
GDVSSGYGQRAFSILLLQDIAIVPLLALVPLLAPGESATPRNPTGVLLQAGAMIGAIAVVVVAGRYLLNPLFRLLARTGA
REAMTAAALLVVMGAAGLMAFAGLSMALGAFLAGLLLSESTFRHELEANIDAFRGLLLALFFMGVGMSLDLKVVIPYLGP
VLSGALVITAIKFAVVFVLYRGDHRDLADGLRAGAVLMPAGEFAFVLFPLALSNGILDQQQTSLLTATAAVTMMIGPLAF
AGIEVLLPRLRKDAPEPEPDDFTDANGSVLVIGFGRFGQVVSQCLLAENVGVTIIDNDVEMIQSAGRFGVHIYYGDGTRL
DVLRAAGAETAEVIAVCVDDKDTATRIVEIVKASMPQARLFVRSFDRVHTMDLLRKGVDFEIRETLESAFAFGTRTLESL
GLDTETARQRVAEVRERDRARLLRQMEEGLYAGLDQFTPRKVEPEPLTRPEKPARPLNPEAQDVLTHETEFSG

Sequences:

>Translated_633_residues
MPPCSAGGATDALAGRGETERMHGDEHTLFLSALAFLAAAVVSVPIARRLGLSPVVGYLAAGVAIGPAGLSVADPSTVIT
VAELGVVLLLFLIGLELQPSRLLSMGRYIFGLGTAQLLLTGAVIAVVEMLLGFGWAAAVISGLALAMSATSIALQLLSER
GDVSSGYGQRAFSILLLQDIAIVPLLALVPLLAPGESATPRNPTGVLLQAGAMIGAIAVVVVAGRYLLNPLFRLLARTGA
REAMTAAALLVVMGAAGLMAFAGLSMALGAFLAGLLLSESTFRHELEANIDAFRGLLLALFFMGVGMSLDLKVVIPYLGP
VLSGALVITAIKFAVVFVLYRGDHRDLADGLRAGAVLMPAGEFAFVLFPLALSNGILDQQQTSLLTATAAVTMMIGPLAF
AGIEVLLPRLRKDAPEPEPDDFTDANGSVLVIGFGRFGQVVSQCLLAENVGVTIIDNDVEMIQSAGRFGVHIYYGDGTRL
DVLRAAGAETAEVIAVCVDDKDTATRIVEIVKASMPQARLFVRSFDRVHTMDLLRKGVDFEIRETLESAFAFGTRTLESL
GLDTETARQRVAEVRERDRARLLRQMEEGLYAGLDQFTPRKVEPEPLTRPEKPARPLNPEAQDVLTHETEFSG
>Mature_632_residues
PPCSAGGATDALAGRGETERMHGDEHTLFLSALAFLAAAVVSVPIARRLGLSPVVGYLAAGVAIGPAGLSVADPSTVITV
AELGVVLLLFLIGLELQPSRLLSMGRYIFGLGTAQLLLTGAVIAVVEMLLGFGWAAAVISGLALAMSATSIALQLLSERG
DVSSGYGQRAFSILLLQDIAIVPLLALVPLLAPGESATPRNPTGVLLQAGAMIGAIAVVVVAGRYLLNPLFRLLARTGAR
EAMTAAALLVVMGAAGLMAFAGLSMALGAFLAGLLLSESTFRHELEANIDAFRGLLLALFFMGVGMSLDLKVVIPYLGPV
LSGALVITAIKFAVVFVLYRGDHRDLADGLRAGAVLMPAGEFAFVLFPLALSNGILDQQQTSLLTATAAVTMMIGPLAFA
GIEVLLPRLRKDAPEPEPDDFTDANGSVLVIGFGRFGQVVSQCLLAENVGVTIIDNDVEMIQSAGRFGVHIYYGDGTRLD
VLRAAGAETAEVIAVCVDDKDTATRIVEIVKASMPQARLFVRSFDRVHTMDLLRKGVDFEIRETLESAFAFGTRTLESLG
LDTETARQRVAEVRERDRARLLRQMEEGLYAGLDQFTPRKVEPEPLTRPEKPARPLNPEAQDVLTHETEFSG

Specific function: Transport system that facilitate potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=384, Percent_Identity=26.5625, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1789749, Length=601, Percent_Identity=41.0981697171381, Blast_Score=396, Evalue=1e-111,
Organism=Escherichia coli, GI1786232, Length=579, Percent_Identity=40.4145077720207, Blast_Score=380, Evalue=1e-106,
Organism=Escherichia coli, GI1786685, Length=493, Percent_Identity=28.8032454361055, Blast_Score=154, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 66895; Mature: 66764

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPCSAGGATDALAGRGETERMHGDEHTLFLSALAFLAAAVVSVPIARRLGLSPVVGYLA
CCCCCCCCCCHHHCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
AGVAIGPAGLSVADPSTVITVAELGVVLLLFLIGLELQPSRLLSMGRYIFGLGTAQLLLT
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
GAVIAVVEMLLGFGWAAAVISGLALAMSATSIALQLLSERGDVSSGYGQRAFSILLLQDI
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
AIVPLLALVPLLAPGESATPRNPTGVLLQAGAMIGAIAVVVVAGRYLLNPLFRLLARTGA
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
REAMTAAALLVVMGAAGLMAFAGLSMALGAFLAGLLLSESTFRHELEANIDAFRGLLLAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
FFMGVGMSLDLKVVIPYLGPVLSGALVITAIKFAVVFVLYRGDHRDLADGLRAGAVLMPA
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEEECC
GEFAFVLFPLALSNGILDQQQTSLLTATAAVTMMIGPLAFAGIEVLLPRLRKDAPEPEPD
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DFTDANGSVLVIGFGRFGQVVSQCLLAENVGVTIIDNDVEMIQSAGRFGVHIYYGDGTRL
CCCCCCCCEEEEECCHHHHHHHHHHHHCCCCEEEECCHHHHHHCCCCCEEEEEECCCCEE
DVLRAAGAETAEVIAVCVDDKDTATRIVEIVKASMPQARLFVRSFDRVHTMDLLRKGVDF
HHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCH
EIRETLESAFAFGTRTLESLGLDTETARQRVAEVRERDRARLLRQMEEGLYAGLDQFTPR
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCC
KVEPEPLTRPEKPARPLNPEAQDVLTHETEFSG
CCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCC
>Mature Secondary Structure 
PPCSAGGATDALAGRGETERMHGDEHTLFLSALAFLAAAVVSVPIARRLGLSPVVGYLA
CCCCCCCCCHHHCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
AGVAIGPAGLSVADPSTVITVAELGVVLLLFLIGLELQPSRLLSMGRYIFGLGTAQLLLT
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
GAVIAVVEMLLGFGWAAAVISGLALAMSATSIALQLLSERGDVSSGYGQRAFSILLLQDI
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
AIVPLLALVPLLAPGESATPRNPTGVLLQAGAMIGAIAVVVVAGRYLLNPLFRLLARTGA
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
REAMTAAALLVVMGAAGLMAFAGLSMALGAFLAGLLLSESTFRHELEANIDAFRGLLLAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
FFMGVGMSLDLKVVIPYLGPVLSGALVITAIKFAVVFVLYRGDHRDLADGLRAGAVLMPA
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEEECC
GEFAFVLFPLALSNGILDQQQTSLLTATAAVTMMIGPLAFAGIEVLLPRLRKDAPEPEPD
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DFTDANGSVLVIGFGRFGQVVSQCLLAENVGVTIIDNDVEMIQSAGRFGVHIYYGDGTRL
CCCCCCCCEEEEECCHHHHHHHHHHHHCCCCEEEECCHHHHHHCCCCCEEEEEECCCCEE
DVLRAAGAETAEVIAVCVDDKDTATRIVEIVKASMPQARLFVRSFDRVHTMDLLRKGVDF
HHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCH
EIRETLESAFAFGTRTLESLGLDTETARQRVAEVRERDRARLLRQMEEGLYAGLDQFTPR
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCC
KVEPEPLTRPEKPARPLNPEAQDVLTHETEFSG
CCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]