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The map label for this gene is acxA [H]

Identifier: 158424547

GI number: 158424547

Start: 3340114

End: 3342267

Strand: Reverse

Name: acxA [H]

Synonym: AZC_2923

Alternate gene names: 158424547

Gene position: 3342267-3340114 (Counterclockwise)

Preceding gene: 158424548

Following gene: 158424546

Centisome position: 62.24

GC content: 65.04

Gene sequence:

>2154_bases
GTGAACATCCAGGCACGGCACGTCAGAAGCGTCCAAGTACTCGGCATCGATGCCGGCGGCACCATGACCGATACGTTCTT
CGTCGATTCCGAAGGCGATTTCGTCGTCGGCAAGGCGCAAAGCACACCACAGAATGAGGCCCTCGGCCTCATTGCCTCCA
GCGAGGACGGCCTCGGCAGTTGGGGCCTGTCGCTGGCGGACGGCCTGAAGCACCTGCAAACCGGAGTCTATTCCGGCACC
GCCATGCTGAACCGCGTGGTGCAGCGCAAGGGGCTGAAATGCGGCCTCATCGTCAACAGCGGCCTCGAAGACTTCCACCG
CATGGGCCGGGCGATCCAATGCTACCTCGGCTATGCCTATGAGGACCGCATCCACCTCAATACCCACCGCTACGACCCGC
CTTTGGTGCCGCGCAACCTCACCCGCGGCGTGGCCGAGCGCACCGACATGTTCGGCAAGGTGGTGATCCCGCTGCGCGAG
GAGACCGCCCGCGCCGCCGCCCGCGACCTGATCGCGGCGGATGTGGAAGGCATCGTCATCAGCCTGCTGCATTCCTACAA
GAACCCGGCCCATGAGCGCCGGGTGCGCGACATCGTCCTTGAGGAAATCGCCAAGAGCGGCAAGGCGATCCCGGTCTTCG
CCTCGGCTGATTATTATCCGGTGCGCAAGGAGACCCACCGCACCAACACCACCATCCTGGAAGGCTATGCCGCCGAGCCC
TCGCGGCAGACGCTGAAGAAGATCTCCGACGCCTTCAAGGAGCATGGCACCAAGTTCGACTTCCGCGTCATGGCCACCCA
TGGCGGCACCATCTCCTGGAAGGCGAAGGAACTGGCCCGCACCATCGTCTCCGGCCCCATCGGGGGCGTCATCGGCGCCA
AATATCTGGGCGAAGTGCTGGGCTACAACAACATCGCCTGCTCGGACATCGGCGGCACCTCGTTCGACGTGGCGCTCATC
ACCCAGGGTGAGCTGACCATCAAGAACGACCCGGACATGGCCCGCCTCGTCCTCTCGCTGCCGCTGGTGGCCATGGACAG
CGTGGGCGCTGGCGCCGGCTCCTTCATCCGGCTCGATCCCTACACCAAGGCGATCAAGCTCGGCCCGGATTCTGCCGGCT
ATCGGGTCGGCGTGTGCTGGAAGGAGAGCGGCATCGAGACCGTGACCATCTCCGACTGCCACATGGTGCTGGGCTATCTC
AACCCGGACAACTTCCTCGGCGGCGCGGTGAAATTGGATCGCCAGCGCTCGGTGGATGCCATCAAGGCCCAGGTCGCCGA
TCCGCTCGGCCTCTCGGTGGAGGATGCGGCGGCGGGCGTGATCGAGCTCTTGGACAGCGACCTGCGCGACTATCTGCGCT
CGATGATCTCGGCCAAGGGCTATAGCCCGCAGAGCTTTGTCTGCTTCTCCTACGGCGGCGCCGGCCCGGTGCATACCTAT
GGCTATACGGAAGGGCTCGGTTTCGAAGACGTCATCGTGCCCGCCTGGGCCGCCGGCTTCTCCGCCTTCGGCTGCGCAGC
GGCGGATTTCGAATATCGCTACGACAAGTCGCTGGACATCAATCTCGCCCCCGACGCGCCGGACGACTTGTCCGAGAAAG
CGGCGAGGACCCTCCAGGGCGCGTGGGACGAACTGACCCGCAACGTGCTGGAGGAGTTCAAGCTGAACGGCTACGAGGCC
GACCAGGTGACACTCCAGCCCGGCTACCGCATGCAGTATCGCGGCCAGCTCAACGACCTGGAGATCGAGTCCCCTCTGGC
GTCCGCCGATAGCGCGCAGGACTGGGCTAAGCTGGTGGAGGCGTTCAACGCCACCTATGGCCGCGTCTATGCGGCCTCCG
CCCGCTCGCCGGAATTAGGCTATTCGGTCACCGGCGCCATCATGCGCGGCTCGGTGCCGATCCAGAAGCCGAAGATCCCC
AAGGAGCCCCTGGAGGGCGAGACCCCGCCCGCCGACGCCTTCCTCGGGACCCGGAAGTTCTACCGCAAGAAACGCTGGGT
GGATGCACAGCTCTACCGGATGGAAAGCCTGCGCCCCGGCAACCGCGTCGCCGGCCCCGCCATCATCGAATCCGACGCCA
CCACCTTCGTGGTGCCGGACGGCTTCGAAACCTTCCTCGACGGCCACCGCCTCTTCCACCTCAAGGAAATCTGA

Upstream 100 bases:

>100_bases
GCAAGACTTGAACTGACCATCTGCCAAATAACTGGCACGGCTTGTGCCCCTCTCCCGATAGCCCGGCTCAACAGAAGCCG
GCTCGGACAGGAGGACACGC

Downstream 100 bases:

>100_bases
GCGCTGCCCTCACCGACACCCATTCAAGGAAACGTCAAGATGAACATCAATGTCCGGGCCACCCAAACCAAAGGGGCCAC
GCGCGGCATCGTGCGCGGCG

Product: acetone carboxylase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 717; Mature: 717

Protein sequence:

>717_residues
MNIQARHVRSVQVLGIDAGGTMTDTFFVDSEGDFVVGKAQSTPQNEALGLIASSEDGLGSWGLSLADGLKHLQTGVYSGT
AMLNRVVQRKGLKCGLIVNSGLEDFHRMGRAIQCYLGYAYEDRIHLNTHRYDPPLVPRNLTRGVAERTDMFGKVVIPLRE
ETARAAARDLIAADVEGIVISLLHSYKNPAHERRVRDIVLEEIAKSGKAIPVFASADYYPVRKETHRTNTTILEGYAAEP
SRQTLKKISDAFKEHGTKFDFRVMATHGGTISWKAKELARTIVSGPIGGVIGAKYLGEVLGYNNIACSDIGGTSFDVALI
TQGELTIKNDPDMARLVLSLPLVAMDSVGAGAGSFIRLDPYTKAIKLGPDSAGYRVGVCWKESGIETVTISDCHMVLGYL
NPDNFLGGAVKLDRQRSVDAIKAQVADPLGLSVEDAAAGVIELLDSDLRDYLRSMISAKGYSPQSFVCFSYGGAGPVHTY
GYTEGLGFEDVIVPAWAAGFSAFGCAAADFEYRYDKSLDINLAPDAPDDLSEKAARTLQGAWDELTRNVLEEFKLNGYEA
DQVTLQPGYRMQYRGQLNDLEIESPLASADSAQDWAKLVEAFNATYGRVYAASARSPELGYSVTGAIMRGSVPIQKPKIP
KEPLEGETPPADAFLGTRKFYRKKRWVDAQLYRMESLRPGNRVAGPAIIESDATTFVVPDGFETFLDGHRLFHLKEI

Sequences:

>Translated_717_residues
MNIQARHVRSVQVLGIDAGGTMTDTFFVDSEGDFVVGKAQSTPQNEALGLIASSEDGLGSWGLSLADGLKHLQTGVYSGT
AMLNRVVQRKGLKCGLIVNSGLEDFHRMGRAIQCYLGYAYEDRIHLNTHRYDPPLVPRNLTRGVAERTDMFGKVVIPLRE
ETARAAARDLIAADVEGIVISLLHSYKNPAHERRVRDIVLEEIAKSGKAIPVFASADYYPVRKETHRTNTTILEGYAAEP
SRQTLKKISDAFKEHGTKFDFRVMATHGGTISWKAKELARTIVSGPIGGVIGAKYLGEVLGYNNIACSDIGGTSFDVALI
TQGELTIKNDPDMARLVLSLPLVAMDSVGAGAGSFIRLDPYTKAIKLGPDSAGYRVGVCWKESGIETVTISDCHMVLGYL
NPDNFLGGAVKLDRQRSVDAIKAQVADPLGLSVEDAAAGVIELLDSDLRDYLRSMISAKGYSPQSFVCFSYGGAGPVHTY
GYTEGLGFEDVIVPAWAAGFSAFGCAAADFEYRYDKSLDINLAPDAPDDLSEKAARTLQGAWDELTRNVLEEFKLNGYEA
DQVTLQPGYRMQYRGQLNDLEIESPLASADSAQDWAKLVEAFNATYGRVYAASARSPELGYSVTGAIMRGSVPIQKPKIP
KEPLEGETPPADAFLGTRKFYRKKRWVDAQLYRMESLRPGNRVAGPAIIESDATTFVVPDGFETFLDGHRLFHLKEI
>Mature_717_residues
MNIQARHVRSVQVLGIDAGGTMTDTFFVDSEGDFVVGKAQSTPQNEALGLIASSEDGLGSWGLSLADGLKHLQTGVYSGT
AMLNRVVQRKGLKCGLIVNSGLEDFHRMGRAIQCYLGYAYEDRIHLNTHRYDPPLVPRNLTRGVAERTDMFGKVVIPLRE
ETARAAARDLIAADVEGIVISLLHSYKNPAHERRVRDIVLEEIAKSGKAIPVFASADYYPVRKETHRTNTTILEGYAAEP
SRQTLKKISDAFKEHGTKFDFRVMATHGGTISWKAKELARTIVSGPIGGVIGAKYLGEVLGYNNIACSDIGGTSFDVALI
TQGELTIKNDPDMARLVLSLPLVAMDSVGAGAGSFIRLDPYTKAIKLGPDSAGYRVGVCWKESGIETVTISDCHMVLGYL
NPDNFLGGAVKLDRQRSVDAIKAQVADPLGLSVEDAAAGVIELLDSDLRDYLRSMISAKGYSPQSFVCFSYGGAGPVHTY
GYTEGLGFEDVIVPAWAAGFSAFGCAAADFEYRYDKSLDINLAPDAPDDLSEKAARTLQGAWDELTRNVLEEFKLNGYEA
DQVTLQPGYRMQYRGQLNDLEIESPLASADSAQDWAKLVEAFNATYGRVYAASARSPELGYSVTGAIMRGSVPIQKPKIP
KEPLEGETPPADAFLGTRKFYRKKRWVDAQLYRMESLRPGNRVAGPAIIESDATTFVVPDGFETFLDGHRLFHLKEI

Specific function: Catalyzes the carboxylation of acetone to form acetoacetate. Has a reduced activity on butanone, and no activity on 2-pentatone, 3-pentatone, 2-hexanone, chloroacetone, pyruvate, phosphoenolpyruvate, acetaldehyde, propionaldehyde and propylene oxide [H]

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=734, Percent_Identity=23.5694822888283, Blast_Score=115, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI133901900, Length=715, Percent_Identity=22.2377622377622, Blast_Score=92, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6322634, Length=678, Percent_Identity=23.1563421828909, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI45550492, Length=740, Percent_Identity=24.1891891891892, Blast_Score=146, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: =6.4.1.6 [H]

Molecular weight: Translated: 78136; Mature: 78136

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIQARHVRSVQVLGIDAGGTMTDTFFVDSEGDFVVGKAQSTPQNEALGLIASSEDGLGS
CCCCCCEECEEEEEEEECCCCEEEEEEEECCCCEEEECCCCCCCCCCEEEEECCCCCCCC
WGLSLADGLKHLQTGVYSGTAMLNRVVQRKGLKCGLIVNSGLEDFHRMGRAIQCYLGYAY
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHCHHEEEEEEEEE
EDRIHLNTHRYDPPLVPRNLTRGVAERTDMFGKVVIPLREETARAAARDLIAADVEGIVI
ECEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHH
SLLHSYKNPAHERRVRDIVLEEIAKSGKAIPVFASADYYPVRKETHRTNTTILEGYAAEP
HHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHCCCCCEEEECCCCCC
SRQTLKKISDAFKEHGTKFDFRVMATHGGTISWKAKELARTIVSGPIGGVIGAKYLGEVL
HHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHH
GYNNIACSDIGGTSFDVALITQGELTIKNDPDMARLVLSLPLVAMDSVGAGAGSFIRLDP
CCCCEEEECCCCCEEEEEEEECCCEEECCCCHHHHHHHHCCHHHHHCCCCCCCCEEEECC
YTKAIKLGPDSAGYRVGVCWKESGIETVTISDCHMVLGYLNPDNFLGGAVKLDRQRSVDA
CCEEEEECCCCCCCEEEEEEECCCCCEEEECCCEEEEEECCCCCCCCCEEEECCHHCHHH
IKAQVADPLGLSVEDAAAGVIELLDSDLRDYLRSMISAKGYSPQSFVCFSYGGAGPVHTY
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCC
GYTEGLGFEDVIVPAWAAGFSAFGCAAADFEYRYDKSLDINLAPDAPDDLSEKAARTLQG
CCCCCCCCCHHHHHHHHHHHHHHCCEECCCCEECCCCEEEEECCCCCHHHHHHHHHHHHH
AWDELTRNVLEEFKLNGYEADQVTLQPGYRMQYRGQLNDLEIESPLASADSAQDWAKLVE
HHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEECCCCCCEEECCCCCCCCCHHHHHHHHH
AFNATYGRVYAASARSPELGYSVTGAIMRGSVPIQKPKIPKEPLEGETPPADAFLGTRKF
HHCCCCCEEEEECCCCCCCCCEEEHHHEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
YRKKRWVDAQLYRMESLRPGNRVAGPAIIESDATTFVVPDGFETFLDGHRLFHLKEI
HHHHHCCHHHHHHHHHCCCCCCCCCCEEEECCCEEEEECCCHHHHHCCCEEEEEECC
>Mature Secondary Structure
MNIQARHVRSVQVLGIDAGGTMTDTFFVDSEGDFVVGKAQSTPQNEALGLIASSEDGLGS
CCCCCCEECEEEEEEEECCCCEEEEEEEECCCCEEEECCCCCCCCCCEEEEECCCCCCCC
WGLSLADGLKHLQTGVYSGTAMLNRVVQRKGLKCGLIVNSGLEDFHRMGRAIQCYLGYAY
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHCHHEEEEEEEEE
EDRIHLNTHRYDPPLVPRNLTRGVAERTDMFGKVVIPLREETARAAARDLIAADVEGIVI
ECEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHH
SLLHSYKNPAHERRVRDIVLEEIAKSGKAIPVFASADYYPVRKETHRTNTTILEGYAAEP
HHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHCCCCCEEEECCCCCC
SRQTLKKISDAFKEHGTKFDFRVMATHGGTISWKAKELARTIVSGPIGGVIGAKYLGEVL
HHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHH
GYNNIACSDIGGTSFDVALITQGELTIKNDPDMARLVLSLPLVAMDSVGAGAGSFIRLDP
CCCCEEEECCCCCEEEEEEEECCCEEECCCCHHHHHHHHCCHHHHHCCCCCCCCEEEECC
YTKAIKLGPDSAGYRVGVCWKESGIETVTISDCHMVLGYLNPDNFLGGAVKLDRQRSVDA
CCEEEEECCCCCCCEEEEEEECCCCCEEEECCCEEEEEECCCCCCCCCEEEECCHHCHHH
IKAQVADPLGLSVEDAAAGVIELLDSDLRDYLRSMISAKGYSPQSFVCFSYGGAGPVHTY
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCC
GYTEGLGFEDVIVPAWAAGFSAFGCAAADFEYRYDKSLDINLAPDAPDDLSEKAARTLQG
CCCCCCCCCHHHHHHHHHHHHHHCCEECCCCEECCCCEEEEECCCCCHHHHHHHHHHHHH
AWDELTRNVLEEFKLNGYEADQVTLQPGYRMQYRGQLNDLEIESPLASADSAQDWAKLVE
HHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEECCCCCCEEECCCCCCCCCHHHHHHHHH
AFNATYGRVYAASARSPELGYSVTGAIMRGSVPIQKPKIPKEPLEGETPPADAFLGTRKF
HHCCCCCEEEEECCCCCCCCCEEEHHHEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
YRKKRWVDAQLYRMESLRPGNRVAGPAIIESDATTFVVPDGFETFLDGHRLFHLKEI
HHHHHCCHHHHHHHHHCCCCCCCCCCEEEECCCEEEEECCCHHHHHCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12003937 [H]