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The map label for this gene is atsA [H]

Identifier: 158424485

GI number: 158424485

Start: 3258672

End: 3260144

Strand: Direct

Name: atsA [H]

Synonym: AZC_2861

Alternate gene names: 158424485

Gene position: 3258672-3260144 (Clockwise)

Preceding gene: 158424484

Following gene: 158424486

Centisome position: 60.69

GC content: 69.04

Gene sequence:

>1473_bases
ATGACGGATACGCACCGCAACGAGACCGAGGCCGGCCCCAGCCGGCGCGACGTGCTGGCCGGGACGGCCGGTTTCATGGC
CGCCGTGGCGGGCCTATCGGCCCTCGCCAGCCCGGCACGCGCGCAGGCCGCGCCGCGCCCGCACATCCTCTACATCCTGG
CGGATGATTTGGGCTTCGCCGACGTCGGCTTCCACGGGTCGGACATCAAGACGCCGAACCTCGACAAGCTTGCCGCCACC
GGCGCGACGCTCGGCCAGTTCTACACTCAGCCCATGTGCACACCGACGCGTGCGGCCCTCATGACCGGCCGCTACCCGCT
GCGCTACGGCCTCCAGACCGGCGTGATTCCCTCGGGGGCGAGCTATGGCCTCGCCACCGACGAATTCCTGCTGCCGCAGG
CGCTGAAGAGCGTGGGCTACAGCACGGCGCTGATCGGCAAGTGGCACCTCGGCCATGCCAAGCAGGACTTCTGGCCCCGC
CAGCGCGGCTTCGATTATTTCTACGGGCCGCTGGTGGGCGAGATCGACCATTACAAGCACGAAGCCCATGGCGTCGTGGA
CTGGTATCGCGACAACAAGCAGGTGGTCGAGGAGGGCTACGACACCGAGCTGTTCGGCACCGACGCGGCGCGGCTGATCG
GGGCGCACGATCCCAAGACGCCGCTGTTCCTCTACCTCGCGTTCACCGCGCCCCACACGCCCTTCCAGGCACCACAGGCC
TACGTGGACCGCTACCCGAACATCACCGATCCGGCGCGGCGCCTCTATGCGGCGATGATTTCCGCCATGGACGACCAGAT
CGGCAAGGTGGTGGCGGCGCTGGAGCAGCGCGGCATGCGCGAGAACACGCTCATCGTGTTCCACAGCGACAATGGCGGCA
CGCGCTCCAAGATGTTCGTGGGCGAAGGCGCCTTCCATGGCGAACTGCCGGCCAGCAACGCGCCTTATCGCGACGGCAAG
GGCACGCTCTACGAGGGTGGCACGCGTGTTGCGGCGCTGGCCAACTGGCCGGGCCGCATCACGCCCGGCGCGGCGGATGG
CGTCATGCACGTGGTTGACATGATGCCGACCCTCGCCCGGCTGGCCGGCGCGAACCTCGACCGCTCCAAGCCGCTGGACG
GCGTGGACGTGTGGTCGGCCCTGTCCAGCGCGCGCACCTCGCCGCGCGACGGCGTCGTCTACAATGTGGAGCCGACACAG
GGCGCGGTGCGCGAGGGCAACTGGAAGCTCTACTGGCACGCTCTGCTGCCGCCGAAGGTCGAGCTCTACGATCTCGCGAA
GGACCCCTCCGAGACCACGGACGTCGCCGCCCAGCATCCCGAGAAGGTCGCGGCCCTGCAGGCGCACGTGGTCGACCTTG
CCCGCACCATGGCGCCCCCGCTCTTCTATGCGGCAGCCCTGAAGGCGGCGCTCTCCGCCCCCCTCTCGACGCCCACCGGC
GCCCTCTATGGCCTCGGGATGGAAGACGATTGA

Upstream 100 bases:

>100_bases
AGCGCTACCGCCCCGCTGCGCGCTCCCCCCAGACCATTGACACCGCCTCGGGACACATCGGCTTCCGCTGTGTCCGGCGT
GGTCCCAAGCAGGAAACGAA

Downstream 100 bases:

>100_bases
TGGCCCGCCTTCTCTCGTCCGCCTCCCCCATCGCCCTTGTCCTGACGATCGCAGCGGCCTTCCCGGCCGCCGCGGCGGAT
CTCACGCCGGCGGCGCCCCA

Product: twin-arginine translocation pathway signal precursor

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MTDTHRNETEAGPSRRDVLAGTAGFMAAVAGLSALASPARAQAAPRPHILYILADDLGFADVGFHGSDIKTPNLDKLAAT
GATLGQFYTQPMCTPTRAALMTGRYPLRYGLQTGVIPSGASYGLATDEFLLPQALKSVGYSTALIGKWHLGHAKQDFWPR
QRGFDYFYGPLVGEIDHYKHEAHGVVDWYRDNKQVVEEGYDTELFGTDAARLIGAHDPKTPLFLYLAFTAPHTPFQAPQA
YVDRYPNITDPARRLYAAMISAMDDQIGKVVAALEQRGMRENTLIVFHSDNGGTRSKMFVGEGAFHGELPASNAPYRDGK
GTLYEGGTRVAALANWPGRITPGAADGVMHVVDMMPTLARLAGANLDRSKPLDGVDVWSALSSARTSPRDGVVYNVEPTQ
GAVREGNWKLYWHALLPPKVELYDLAKDPSETTDVAAQHPEKVAALQAHVVDLARTMAPPLFYAAALKAALSAPLSTPTG
ALYGLGMEDD

Sequences:

>Translated_490_residues
MTDTHRNETEAGPSRRDVLAGTAGFMAAVAGLSALASPARAQAAPRPHILYILADDLGFADVGFHGSDIKTPNLDKLAAT
GATLGQFYTQPMCTPTRAALMTGRYPLRYGLQTGVIPSGASYGLATDEFLLPQALKSVGYSTALIGKWHLGHAKQDFWPR
QRGFDYFYGPLVGEIDHYKHEAHGVVDWYRDNKQVVEEGYDTELFGTDAARLIGAHDPKTPLFLYLAFTAPHTPFQAPQA
YVDRYPNITDPARRLYAAMISAMDDQIGKVVAALEQRGMRENTLIVFHSDNGGTRSKMFVGEGAFHGELPASNAPYRDGK
GTLYEGGTRVAALANWPGRITPGAADGVMHVVDMMPTLARLAGANLDRSKPLDGVDVWSALSSARTSPRDGVVYNVEPTQ
GAVREGNWKLYWHALLPPKVELYDLAKDPSETTDVAAQHPEKVAALQAHVVDLARTMAPPLFYAAALKAALSAPLSTPTG
ALYGLGMEDD
>Mature_489_residues
TDTHRNETEAGPSRRDVLAGTAGFMAAVAGLSALASPARAQAAPRPHILYILADDLGFADVGFHGSDIKTPNLDKLAATG
ATLGQFYTQPMCTPTRAALMTGRYPLRYGLQTGVIPSGASYGLATDEFLLPQALKSVGYSTALIGKWHLGHAKQDFWPRQ
RGFDYFYGPLVGEIDHYKHEAHGVVDWYRDNKQVVEEGYDTELFGTDAARLIGAHDPKTPLFLYLAFTAPHTPFQAPQAY
VDRYPNITDPARRLYAAMISAMDDQIGKVVAALEQRGMRENTLIVFHSDNGGTRSKMFVGEGAFHGELPASNAPYRDGKG
TLYEGGTRVAALANWPGRITPGAADGVMHVVDMMPTLARLAGANLDRSKPLDGVDVWSALSSARTSPRDGVVYNVEPTQG
AVREGNWKLYWHALLPPKVELYDLAKDPSETTDVAAQHPEKVAALQAHVVDLARTMAPPLFYAAALKAALSAPLSTPTGA
LYGLGMEDD

Specific function: Plays an important role in the mineralization of sulfates [H]

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI59797060, Length=466, Percent_Identity=37.3390557939914, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI38569405, Length=499, Percent_Identity=35.8717434869739, Blast_Score=301, Evalue=7e-82,
Organism=Homo sapiens, GI109389362, Length=470, Percent_Identity=34.8936170212766, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI38569407, Length=378, Percent_Identity=41.2698412698413, Blast_Score=292, Evalue=6e-79,
Organism=Homo sapiens, GI4503899, Length=377, Percent_Identity=33.42175066313, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI146229331, Length=456, Percent_Identity=33.5526315789474, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI146229329, Length=456, Percent_Identity=33.5526315789474, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI6005990, Length=456, Percent_Identity=33.5526315789474, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI146229324, Length=456, Percent_Identity=33.5526315789474, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI45430057, Length=433, Percent_Identity=31.6397228637413, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI53831991, Length=143, Percent_Identity=51.7482517482517, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI146229327, Length=381, Percent_Identity=30.1837270341207, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI157266309, Length=159, Percent_Identity=43.3962264150943, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI58743319, Length=137, Percent_Identity=43.7956204379562, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI31742482, Length=157, Percent_Identity=40.1273885350318, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI71852586, Length=138, Percent_Identity=41.304347826087, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI71852584, Length=138, Percent_Identity=41.304347826087, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4506919, Length=358, Percent_Identity=25.6983240223464, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1790233, Length=426, Percent_Identity=30.0469483568075, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI87081924, Length=402, Percent_Identity=25.6218905472637, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1790112, Length=453, Percent_Identity=25.3863134657837, Blast_Score=90, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI115533416, Length=449, Percent_Identity=33.8530066815145, Blast_Score=237, Evalue=8e-63,
Organism=Caenorhabditis elegans, GI115533418, Length=439, Percent_Identity=33.7129840546697, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17559078, Length=134, Percent_Identity=35.0746268656716, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI281363223, Length=406, Percent_Identity=37.9310344827586, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24666175, Length=378, Percent_Identity=39.1534391534392, Blast_Score=260, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24666109, Length=364, Percent_Identity=39.8351648351648, Blast_Score=251, Evalue=9e-67,
Organism=Drosophila melanogaster, GI281366397, Length=412, Percent_Identity=35.4368932038835, Blast_Score=225, Evalue=6e-59,
Organism=Drosophila melanogaster, GI281366395, Length=412, Percent_Identity=35.4368932038835, Blast_Score=225, Evalue=6e-59,
Organism=Drosophila melanogaster, GI24666163, Length=412, Percent_Identity=35.4368932038835, Blast_Score=225, Evalue=6e-59,
Organism=Drosophila melanogaster, GI24653364, Length=395, Percent_Identity=27.3417721518987, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19922168, Length=395, Percent_Identity=27.0886075949367, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 52907; Mature: 52776

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00523 SULFATASE_1 ; PS00149 SULFATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTHRNETEAGPSRRDVLAGTAGFMAAVAGLSALASPARAQAAPRPHILYILADDLGFA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCEEEEEEECCCCCE
DVGFHGSDIKTPNLDKLAATGATLGQFYTQPMCTPTRAALMTGRYPLRYGLQTGVIPSGA
ECCCCCCCCCCCCHHHHHHCCHHHHHHHCCCCCCCHHHHHHCCCCCCEECCCCCCCCCCC
SYGLATDEFLLPQALKSVGYSTALIGKWHLGHAKQDFWPRQRGFDYFYGPLVGEIDHYKH
CCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCHHCCCHHCCCCEEECCHHHHHHHHHH
EAHGVVDWYRDNKQVVEEGYDTELFGTDAARLIGAHDPKTPLFLYLAFTAPHTPFQAPQA
HHCCCHHHHHCCHHHHHCCCCCEEECCCHHHHHCCCCCCCCEEEEEEEECCCCCCCCCHH
YVDRYPNITDPARRLYAAMISAMDDQIGKVVAALEQRGMRENTLIVFHSDNGGTRSKMFV
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEE
GEGAFHGELPASNAPYRDGKGTLYEGGTRVAALANWPGRITPGAADGVMHVVDMMPTLAR
ECCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
LAGANLDRSKPLDGVDVWSALSSARTSPRDGVVYNVEPTQGAVREGNWKLYWHALLPPKV
HHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEEEEEEECCCCE
ELYDLAKDPSETTDVAAQHPEKVAALQAHVVDLARTMAPPLFYAAALKAALSAPLSTPTG
EEEECCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCC
ALYGLGMEDD
CEEECCCCCC
>Mature Secondary Structure 
TDTHRNETEAGPSRRDVLAGTAGFMAAVAGLSALASPARAQAAPRPHILYILADDLGFA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCEEEEEEECCCCCE
DVGFHGSDIKTPNLDKLAATGATLGQFYTQPMCTPTRAALMTGRYPLRYGLQTGVIPSGA
ECCCCCCCCCCCCHHHHHHCCHHHHHHHCCCCCCCHHHHHHCCCCCCEECCCCCCCCCCC
SYGLATDEFLLPQALKSVGYSTALIGKWHLGHAKQDFWPRQRGFDYFYGPLVGEIDHYKH
CCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCHHCCCHHCCCCEEECCHHHHHHHHHH
EAHGVVDWYRDNKQVVEEGYDTELFGTDAARLIGAHDPKTPLFLYLAFTAPHTPFQAPQA
HHCCCHHHHHCCHHHHHCCCCCEEECCCHHHHHCCCCCCCCEEEEEEEECCCCCCCCCHH
YVDRYPNITDPARRLYAAMISAMDDQIGKVVAALEQRGMRENTLIVFHSDNGGTRSKMFV
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEE
GEGAFHGELPASNAPYRDGKGTLYEGGTRVAALANWPGRITPGAADGVMHVVDMMPTLAR
ECCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
LAGANLDRSKPLDGVDVWSALSSARTSPRDGVVYNVEPTQGAVREGNWKLYWHALLPPKV
HHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEEEEEEECCCCE
ELYDLAKDPSETTDVAAQHPEKVAALQAHVVDLARTMAPPLFYAAALKAALSAPLSTPTG
EEEECCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCC
ALYGLGMEDD
CEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10336424 [H]