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The map label for this gene is hyi [H]

Identifier: 158424400

GI number: 158424400

Start: 3157016

End: 3157810

Strand: Reverse

Name: hyi [H]

Synonym: AZC_2776

Alternate gene names: 158424400

Gene position: 3157810-3157016 (Counterclockwise)

Preceding gene: 158424401

Following gene: 158424399

Centisome position: 58.81

GC content: 66.29

Gene sequence:

>795_bases
ATGATCCGTTTCGCTGCGAACCTCCATTCGCTCTTTACGGAATTGCCGTTTCTCGACCGCTTCGCGCCCGCCGCCGAGGC
CGGCTTTGCCGCCGTGGAATTCACCTTCCCTTATGACGTGCCGGCGGACCGGATCTCCGAGCGCCTTCAGCGTCATGGTC
TCAAGGCGGCGATGCTGCATCTGCCCGCCGGGGACTGGGCGGCGGGGGACCGCGGCCTTGCCTGCCAGGCAGAGCGGTTC
GACGAATTCCGGGCGACGCTGGAGCAGGGCGTCGCCTACGCCCGGACGATCGGTGCCGGCAAGCTCGTCATGATGGCGGG
CCTCGGCTCGCGGCAGGATCCGCAGGCGGAGGCGAGCTTCCGCCGGGCGGTGGCCTTCGCCGGTGAAAGACTGGAGCGGG
AGGGGCTCTGCCTGCTGCTCAAGCCGCTCGATCCGCGCGAGATCCCTGGCTATTTCCTCACCGATTTCTGCCATGTGGCC
GATCTGGTGGCCGAACTCGGCGTGCCGCACGTGAAGATGCTGTTCGACGTCTATCAGCGCCAGCTCGCGCGCGGAGATGT
GGCCATGGCGCTGCGCCGCCGCATCAAGCAGATCGGCCATGTGCAGGTCGCTGCCGTGCCCGACCGGGGTGAGCCCGATG
ACGGCGAACTCAACTATGCCTATATCCTGCGCCGGCTCGAATGCCTCGGCTATGACGGATATATCGGCTGCGATTATCGT
CCCCGCGGGCGTTCCACCCTTGCGGGTCTCGGCTGGATGAAGCCTTATCTTCCTCGCGTTCGGGCCATCGCATGA

Upstream 100 bases:

>100_bases
GGGCAGCGGGTGCCGGGATGGGCCGGGATGACGATTCTTCGCTCGCACGTCTTTATGCCGGCCTGTCCGGGGTGACATTG
CCAAAGGGGGAGAGCGTTTC

Downstream 100 bases:

>100_bases
CCCTTCTTCTTGGCTGTATCGCCGACGACTATACCGGTGCCTCGGATCTCGCCAACACCCTGACCAAAGCGGGCCTGCGC
ACCGTGCAGACCATCGGCGT

Product: hydroxypyruvate isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MIRFAANLHSLFTELPFLDRFAPAAEAGFAAVEFTFPYDVPADRISERLQRHGLKAAMLHLPAGDWAAGDRGLACQAERF
DEFRATLEQGVAYARTIGAGKLVMMAGLGSRQDPQAEASFRRAVAFAGERLEREGLCLLLKPLDPREIPGYFLTDFCHVA
DLVAELGVPHVKMLFDVYQRQLARGDVAMALRRRIKQIGHVQVAAVPDRGEPDDGELNYAYILRRLECLGYDGYIGCDYR
PRGRSTLAGLGWMKPYLPRVRAIA

Sequences:

>Translated_264_residues
MIRFAANLHSLFTELPFLDRFAPAAEAGFAAVEFTFPYDVPADRISERLQRHGLKAAMLHLPAGDWAAGDRGLACQAERF
DEFRATLEQGVAYARTIGAGKLVMMAGLGSRQDPQAEASFRRAVAFAGERLEREGLCLLLKPLDPREIPGYFLTDFCHVA
DLVAELGVPHVKMLFDVYQRQLARGDVAMALRRRIKQIGHVQVAAVPDRGEPDDGELNYAYILRRLECLGYDGYIGCDYR
PRGRSTLAGLGWMKPYLPRVRAIA
>Mature_264_residues
MIRFAANLHSLFTELPFLDRFAPAAEAGFAAVEFTFPYDVPADRISERLQRHGLKAAMLHLPAGDWAAGDRGLACQAERF
DEFRATLEQGVAYARTIGAGKLVMMAGLGSRQDPQAEASFRRAVAFAGERLEREGLCLLLKPLDPREIPGYFLTDFCHVA
DLVAELGVPHVKMLFDVYQRQLARGDVAMALRRRIKQIGHVQVAAVPDRGEPDDGELNYAYILRRLECLGYDGYIGCDYR
PRGRSTLAGLGWMKPYLPRVRAIA

Specific function: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) [H]

COG id: COG3622

COG function: function code G; Hydroxypyruvate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hyi family [H]

Homologues:

Organism=Homo sapiens, GI300068962, Length=267, Percent_Identity=35.9550561797753, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI300068964, Length=248, Percent_Identity=35.0806451612903, Blast_Score=131, Evalue=7e-31,
Organism=Escherichia coli, GI1786718, Length=258, Percent_Identity=38.3720930232558, Blast_Score=199, Evalue=1e-52,
Organism=Escherichia coli, GI1789095, Length=258, Percent_Identity=35.6589147286822, Blast_Score=168, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17552022, Length=240, Percent_Identity=33.75, Blast_Score=158, Evalue=2e-39,
Organism=Drosophila melanogaster, GI17530883, Length=259, Percent_Identity=30.8880308880309, Blast_Score=140, Evalue=8e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017643
- InterPro:   IPR013022
- InterPro:   IPR012307 [H]

Pfam domain/function: PF01261 AP_endonuc_2 [H]

EC number: =5.3.1.22 [H]

Molecular weight: Translated: 29397; Mature: 29397

Theoretical pI: Translated: 7.90; Mature: 7.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRFAANLHSLFTELPFLDRFAPAAEAGFAAVEFTFPYDVPADRISERLQRHGLKAAMLH
CEEEHHHHHHHHHHCCHHHHHCCHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEE
LPAGDWAAGDRGLACQAERFDEFRATLEQGVAYARTIGAGKLVMMAGLGSRQDPQAEASF
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHH
RRAVAFAGERLEREGLCLLLKPLDPREIPGYFLTDFCHVADLVAELGVPHVKMLFDVYQR
HHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
QLARGDVAMALRRRIKQIGHVQVAAVPDRGEPDDGELNYAYILRRLECLGYDGYIGCDYR
HHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEECCCCC
PRGRSTLAGLGWMKPYLPRVRAIA
CCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIRFAANLHSLFTELPFLDRFAPAAEAGFAAVEFTFPYDVPADRISERLQRHGLKAAMLH
CEEEHHHHHHHHHHCCHHHHHCCHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEE
LPAGDWAAGDRGLACQAERFDEFRATLEQGVAYARTIGAGKLVMMAGLGSRQDPQAEASF
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHH
RRAVAFAGERLEREGLCLLLKPLDPREIPGYFLTDFCHVADLVAELGVPHVKMLFDVYQR
HHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
QLARGDVAMALRRRIKQIGHVQVAAVPDRGEPDDGELNYAYILRRLECLGYDGYIGCDYR
HHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEECCCCC
PRGRSTLAGLGWMKPYLPRVRAIA
CCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8440684; 10561547; 9278503 [H]