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The map label for this gene is hflC [H]

Identifier: 158424194

GI number: 158424194

Start: 2895172

End: 2896104

Strand: Direct

Name: hflC [H]

Synonym: AZC_2570

Alternate gene names: 158424194

Gene position: 2895172-2896104 (Clockwise)

Preceding gene: 158424193

Following gene: 158424195

Centisome position: 53.92

GC content: 67.85

Gene sequence:

>933_bases
ATGAAAAACTCTTTCCTCGGCGGCGGCATCCTCGTCGTCTTCCTCATCGTGGTGATCGGCCTCTATTCCTCGGCCTTCAC
CGTGACCCAGAACCAGCAGGCGCTGGTGCTGCGCCTCGGCAATCCGCGGCCGCCCATCACGACGCCGGGCCTGCACTGGA
AGGTGCCGTTCATCGACACGGTGGTCTATCTGGACAAGCGCATCCTCGACCTCGAGAACCCCTCGCAGGAAGTGATCGCC
TCGGACCAGAAGCGCCTCGTGGTGGATGCCTTCGCGCGCTACCGCATCTCCGATCCGCTCAAGTACTATCAGGCGGTCGG
CACGGTTGAGGGCGCCAACTCCCGCCTCGCCACCGTCCTCAACTCGGCCCTGCGCCGCGTGCTGGGCGAAAGCACGTTCA
CCCAGGTGGTGCGCGATGAGCGCGAGGGCCTGATGGCCCGCATCAAGGAGCAGGTGAACCGCGAGGCCTCCAACTTCGGC
ATCACGGTGGTGGATGTGCGCATCCGCCGCGCGGACCTGCCGGACGCCAACAGCCAGGCGGTGTTCCAGCGCATGCAGAC
GGAACGCCAGCGTGAGGCCGCCGAGATCCGCGCCCAGGGCGGCGAGGCAGCCCAGCGCACCCGCTCGCGTGCCGACCGCG
AGGTGACGATCCTGCTCGCCGAAGCCAACTCCCGGGGCGAGGCCGTGCGCGGCCAGGGCGATGCGGAACGCAACCAGATC
TTCGCCCAGGCCTATGGGCGCGATCCGGAGTTCTTCACCTTCTATCGTTCGCTCCAGGCCTACGAGCAGTCGATCAAGGC
TTCCGACACCCGTCTCGTGTTGAGCCCGGAGGCGGACTTCTTCCGCTTCCTGCGCAACCCGCAAGGCACACGGGGCCCGG
TCGGCGCGGCCCCGGCGGACAGCGTCACGCCCGTTCCCGTTCCGGCCCGCTGA

Upstream 100 bases:

>100_bases
ACGCCAGCCGCAGCGGCGGCGTGGTGCCCGTGCTGCCGCTCAACGAGCCGGCCCGCCGCGCCCCCGCCCCCACCGGCCCG
CAGACCCAGGGAGCCGCCCG

Downstream 100 bases:

>100_bases
AGGTCCGGGAAACGTGCGCGATCTCGTCGCCGCCCTCGGGCTCGTGCTGGTCATCGAGGGCCTCAGCCTCGCGGCGTTCC
CCGCCGCGTGGCGCCGCGCC

Product: HflC protein precursor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MKNSFLGGGILVVFLIVVIGLYSSAFTVTQNQQALVLRLGNPRPPITTPGLHWKVPFIDTVVYLDKRILDLENPSQEVIA
SDQKRLVVDAFARYRISDPLKYYQAVGTVEGANSRLATVLNSALRRVLGESTFTQVVRDEREGLMARIKEQVNREASNFG
ITVVDVRIRRADLPDANSQAVFQRMQTERQREAAEIRAQGGEAAQRTRSRADREVTILLAEANSRGEAVRGQGDAERNQI
FAQAYGRDPEFFTFYRSLQAYEQSIKASDTRLVLSPEADFFRFLRNPQGTRGPVGAAPADSVTPVPVPAR

Sequences:

>Translated_310_residues
MKNSFLGGGILVVFLIVVIGLYSSAFTVTQNQQALVLRLGNPRPPITTPGLHWKVPFIDTVVYLDKRILDLENPSQEVIA
SDQKRLVVDAFARYRISDPLKYYQAVGTVEGANSRLATVLNSALRRVLGESTFTQVVRDEREGLMARIKEQVNREASNFG
ITVVDVRIRRADLPDANSQAVFQRMQTERQREAAEIRAQGGEAAQRTRSRADREVTILLAEANSRGEAVRGQGDAERNQI
FAQAYGRDPEFFTFYRSLQAYEQSIKASDTRLVLSPEADFFRFLRNPQGTRGPVGAAPADSVTPVPVPAR
>Mature_310_residues
MKNSFLGGGILVVFLIVVIGLYSSAFTVTQNQQALVLRLGNPRPPITTPGLHWKVPFIDTVVYLDKRILDLENPSQEVIA
SDQKRLVVDAFARYRISDPLKYYQAVGTVEGANSRLATVLNSALRRVLGESTFTQVVRDEREGLMARIKEQVNREASNFG
ITVVDVRIRRADLPDANSQAVFQRMQTERQREAAEIRAQGGEAAQRTRSRADREVTILLAEANSRGEAVRGQGDAERNQI
FAQAYGRDPEFFTFYRSLQAYEQSIKASDTRLVLSPEADFFRFLRNPQGTRGPVGAAPADSVTPVPVPAR

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Homo sapiens, GI38016911, Length=222, Percent_Identity=25.6756756756757, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1790617, Length=313, Percent_Identity=33.8658146964856, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI1786697, Length=281, Percent_Identity=25.2669039145907, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17569493, Length=190, Percent_Identity=28.9473684210526, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI193209764, Length=190, Percent_Identity=28.9473684210526, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17569497, Length=209, Percent_Identity=27.7511961722488, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71987621, Length=232, Percent_Identity=28.8793103448276, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25153583, Length=232, Percent_Identity=28.8793103448276, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71987612, Length=165, Percent_Identity=28.4848484848485, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI32564147, Length=210, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71989955, Length=156, Percent_Identity=30.7692307692308, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71989948, Length=156, Percent_Identity=30.7692307692308, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI32566490, Length=176, Percent_Identity=27.2727272727273, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI45556022, Length=217, Percent_Identity=28.110599078341, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45550506, Length=208, Percent_Identity=28.8461538461538, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI18860517, Length=166, Percent_Identity=27.1084337349398, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573263, Length=200, Percent_Identity=27.5, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 34510; Mature: 34510

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNSFLGGGILVVFLIVVIGLYSSAFTVTQNQQALVLRLGNPRPPITTPGLHWKVPFIDT
CCCCCCCHHHHHHHHHHHHHHHHCCEEEECCCCEEEEEECCCCCCCCCCCCEEECHHHHH
VVYLDKRILDLENPSQEVIASDQKRLVVDAFARYRISDPLKYYQAVGTVEGANSRLATVL
HHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHH
NSALRRVLGESTFTQVVRDEREGLMARIKEQVNREASNFGITVVDVRIRRADLPDANSQA
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCEEEEEEEEEECCCCCCCHHH
VFQRMQTERQREAAEIRAQGGEAAQRTRSRADREVTILLAEANSRGEAVRGQGDAERNQI
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCHHHHHH
FAQAYGRDPEFFTFYRSLQAYEQSIKASDTRLVLSPEADFFRFLRNPQGTRGPVGAAPAD
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCCCCCCCCCCCCCC
SVTPVPVPAR
CCCCCCCCCC
>Mature Secondary Structure
MKNSFLGGGILVVFLIVVIGLYSSAFTVTQNQQALVLRLGNPRPPITTPGLHWKVPFIDT
CCCCCCCHHHHHHHHHHHHHHHHCCEEEECCCCEEEEEECCCCCCCCCCCCEEECHHHHH
VVYLDKRILDLENPSQEVIASDQKRLVVDAFARYRISDPLKYYQAVGTVEGANSRLATVL
HHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHH
NSALRRVLGESTFTQVVRDEREGLMARIKEQVNREASNFGITVVDVRIRRADLPDANSQA
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCEEEEEEEEEECCCCCCCHHH
VFQRMQTERQREAAEIRAQGGEAAQRTRSRADREVTILLAEANSRGEAVRGQGDAERNQI
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCHHHHHH
FAQAYGRDPEFFTFYRSLQAYEQSIKASDTRLVLSPEADFFRFLRNPQGTRGPVGAAPAD
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCCCCCCCCCCCCCC
SVTPVPVPAR
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]