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The map label for this gene is adk

Identifier: 158424157

GI number: 158424157

Start: 2869537

End: 2870121

Strand: Reverse

Name: adk

Synonym: AZC_2533

Alternate gene names: 158424157

Gene position: 2870121-2869537 (Counterclockwise)

Preceding gene: 158424158

Following gene: 158424156

Centisome position: 53.45

GC content: 67.01

Gene sequence:

>585_bases
ATGAGGTTGGTACTGCTTGGTCCTCCCGGTGCCGGCAAGGGCACGCAGGCGCTGCGTCTCGTCCAGCGTCACGGGATCGT
CCAGCTCTCCACCGGCGACATGCTGCGGGCGGCGGTCGCCGCCGGCACGCCGGTGGGCCTCAAGGCCAAGGCGGTGATGG
AATCGGGCGGCCTCGTCTCGGATGAGATCGTCATCGGCATCATCGCCGAGCGGCTCGATCAGCCGGATGCCCGCAAGGGC
TTCATTCTCGACGGCTTCCCGCGCACGGTCGCGCAGGCGGACGCCCTCGACAAGCTGCTGGCGGACAAGGGCCTCAAGCT
CGATGCCGTCATCGAGCTGAAGGTGGATCAGGCCAAGCTCCTCGATCGCATCCTCAACCGCGCTGCCGAGGCCAAGGCCA
AGGGCGAGCCGGTGCGCAAGGATGACGATCCGGAGGTGTTCAAGACCCGCCTCGAGGCCTACAACCGCGATACCGCGGTC
GTGGCGCCCTATTATTCGGCCCGGGGCCAGCTTCAGCAGATCGACGGCATGGCGCCGATCGAGAAGGTGACGCAGGCCAT
CGACTCGATTCTCGAGACGGCCTGA

Upstream 100 bases:

>100_bases
GCGTGACCATGGATACGGTCTCGCAGATCCAGGGACATCTGCTGGCGCATCAATATGAGGGCTTGGTCAAGAAGTCCAAG
CTGCGCGGGGGGAAACGGAA

Downstream 100 bases:

>100_bases
GCATCCCTCGCGCTCCGTGACAGCGCCTGGAGGCGTTGCGGGGCGTTGACAGAATCCGAAAAAGCGCGTAATGGCGCTCC
TTCCTTTTCGAGATCCGTGC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MRLVLLGPPGAGKGTQALRLVQRHGIVQLSTGDMLRAAVAAGTPVGLKAKAVMESGGLVSDEIVIGIIAERLDQPDARKG
FILDGFPRTVAQADALDKLLADKGLKLDAVIELKVDQAKLLDRILNRAAEAKAKGEPVRKDDDPEVFKTRLEAYNRDTAV
VAPYYSARGQLQQIDGMAPIEKVTQAIDSILETA

Sequences:

>Translated_194_residues
MRLVLLGPPGAGKGTQALRLVQRHGIVQLSTGDMLRAAVAAGTPVGLKAKAVMESGGLVSDEIVIGIIAERLDQPDARKG
FILDGFPRTVAQADALDKLLADKGLKLDAVIELKVDQAKLLDRILNRAAEAKAKGEPVRKDDDPEVFKTRLEAYNRDTAV
VAPYYSARGQLQQIDGMAPIEKVTQAIDSILETA
>Mature_194_residues
MRLVLLGPPGAGKGTQALRLVQRHGIVQLSTGDMLRAAVAAGTPVGLKAKAVMESGGLVSDEIVIGIIAERLDQPDARKG
FILDGFPRTVAQADALDKLLADKGLKLDAVIELKVDQAKLLDRILNRAAEAKAKGEPVRKDDDPEVFKTRLEAYNRDTAV
VAPYYSARGQLQQIDGMAPIEKVTQAIDSILETA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=197, Percent_Identity=44.1624365482233, Blast_Score=157, Evalue=4e-39,
Organism=Homo sapiens, GI7524346, Length=196, Percent_Identity=44.3877551020408, Blast_Score=157, Evalue=4e-39,
Organism=Homo sapiens, GI310110345, Length=199, Percent_Identity=35.1758793969849, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI53832003, Length=199, Percent_Identity=35.1758793969849, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI8051579, Length=199, Percent_Identity=35.1758793969849, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI53832001, Length=199, Percent_Identity=35.1758793969849, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI4502011, Length=191, Percent_Identity=30.3664921465969, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI19923437, Length=214, Percent_Identity=31.3084112149533, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI28144897, Length=195, Percent_Identity=33.8461538461538, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI28144899, Length=195, Percent_Identity=33.8461538461538, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI7706497, Length=195, Percent_Identity=27.6923076923077, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI22749187, Length=127, Percent_Identity=34.6456692913386, Blast_Score=75, Evalue=4e-14,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=40.5529953917051, Blast_Score=154, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17552384, Length=212, Percent_Identity=36.7924528301887, Blast_Score=144, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17567503, Length=194, Percent_Identity=32.9896907216495, Blast_Score=113, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17533833, Length=193, Percent_Identity=27.979274611399, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17550688, Length=193, Percent_Identity=27.979274611399, Blast_Score=90, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17537943, Length=200, Percent_Identity=31, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320432, Length=201, Percent_Identity=41.2935323383085, Blast_Score=149, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6321018, Length=197, Percent_Identity=35.0253807106599, Blast_Score=106, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6322828, Length=188, Percent_Identity=29.2553191489362, Blast_Score=82, Evalue=5e-17,
Organism=Drosophila melanogaster, GI22026816, Length=210, Percent_Identity=41.9047619047619, Blast_Score=162, Evalue=1e-40,
Organism=Drosophila melanogaster, GI17737899, Length=213, Percent_Identity=34.7417840375587, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24645822, Length=213, Percent_Identity=34.7417840375587, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI17647141, Length=195, Percent_Identity=31.7948717948718, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24663208, Length=195, Percent_Identity=31.7948717948718, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI221459597, Length=190, Percent_Identity=27.3684210526316, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21356893, Length=190, Percent_Identity=27.3684210526316, Blast_Score=87, Evalue=7e-18,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_AZOC5 (A8IAP0)

Other databases:

- EMBL:   AP009384
- RefSeq:   YP_001525449.1
- ProteinModelPortal:   A8IAP0
- SMR:   A8IAP0
- GeneID:   5688958
- GenomeReviews:   AP009384_GR
- KEGG:   azc:AZC_2533
- HOGENOM:   HBG630208
- OMA:   MVLIGPP
- ProtClustDB:   PRK00279
- BioCyc:   ACAU438753:AZC_2533-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 20747; Mature: 20747

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVLLGPPGAGKGTQALRLVQRHGIVQLSTGDMLRAAVAAGTPVGLKAKAVMESGGLVS
CEEEEECCCCCCCHHHHHHHHHHCCEEEECCCHHHHHHHHCCCCCCCHHHHHHHCCCCCC
DEIVIGIIAERLDQPDARKGFILDGFPRTVAQADALDKLLADKGLKLDAVIELKVDQAKL
HHHHHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCHHHH
LDRILNRAAEAKAKGEPVRKDDDPEVFKTRLEAYNRDTAVVAPYYSARGQLQQIDGMAPI
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCHHHCCCHHHHCCCCHH
EKVTQAIDSILETA
HHHHHHHHHHHHCC
>Mature Secondary Structure
MRLVLLGPPGAGKGTQALRLVQRHGIVQLSTGDMLRAAVAAGTPVGLKAKAVMESGGLVS
CEEEEECCCCCCCHHHHHHHHHHCCEEEECCCHHHHHHHHCCCCCCCHHHHHHHCCCCCC
DEIVIGIIAERLDQPDARKGFILDGFPRTVAQADALDKLLADKGLKLDAVIELKVDQAKL
HHHHHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCHHHH
LDRILNRAAEAKAKGEPVRKDDDPEVFKTRLEAYNRDTAVVAPYYSARGQLQQIDGMAPI
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCHHHCCCHHHHCCCCHH
EKVTQAIDSILETA
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA