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The map label for this gene is iclR [H]

Identifier: 158424103

GI number: 158424103

Start: 2816766

End: 2817707

Strand: Direct

Name: iclR [H]

Synonym: AZC_2479

Alternate gene names: 158424103

Gene position: 2816766-2817707 (Clockwise)

Preceding gene: 158424102

Following gene: 158424108

Centisome position: 52.46

GC content: 66.77

Gene sequence:

>942_bases
TTGTGCATCTGCATTGCCATTGACGGCCGCGCGGCGAACCCGAAATTTAAAGGCATCATGCGCAAGCCCAGCCGGACCTC
CCTCCGCCCAGCCAGTGCCAAGCCCGCCGCTCCCTCCCCCGTCCGTACGGAACGCGCGGATGCCGGCGCGGCGGTCGCCG
AGAAGAAGCGCTCCTCGCTCTTCGTCGGCTCGACGGAGAAGGCCTTCCAGGTGCTGCATGCCTTCGACGGGCCGCTGCGC
TTCATGACGCTGGCCGACATCGCGCGCGCCTCCGGCCTCGACCGGAGCGCCGCGCAGCGGCTCGTGCACACGCTCGAAAC
GCTAGGCTACATCCGCCGCGTGCCGGACACGCGCAATTATGCCCTCACCTCCAAGGTGCTCCAGTTCTCCTACAGCTACA
TCCGCGCCAATGAGCTGATCGACAAGGCCTCGCCCTATCTGCTCGACATCAGCCGCCGGCTCGGGGAGACCACCAACCTG
CATGAGCTGGACGGGCCGGAGGTGGTGTTCGTCGCCCGATTCCCCGGCCAGCACATGAACAATATCGACATCGTGGTCGG
CAGCCGCCTGCCCACCTTCTTCACCTCCTCGGGGACCGCCATGCTGTCGCAGCTGAGCGAAGAGGAGCAGCGGGAGATTC
TCGCCCGCACGAATCTCTCGCCCCGCACGCCCTTCACGGTGACGGATCCCGAGGCGCTTCTGGCGCGTGTGAGGCAGGCG
GGAGAGCGCGGCTATGCGATGATCGTGAACGAGACGGTGATGGGCGACATCTCCATCTCCGCCCCCATCACCGACGAGCA
CGGCCGCCCGGTCGCGGGCATCAACATCTCAGTGCCCACCAGCCGCTGGACCCCGGAGCGCGCCGAGGCGGAGCTGGCGC
AGGAAATCCAGGTGGCCGCGACCTCCATCTCCAAGCCGAAACTCACCCGTGTTTCAAGCTGA

Upstream 100 bases:

>100_bases
CTCGCCGCGCGGCTGAGGAAGGAACTTCAACCGCTGTTGCAGGAATTCGAATGCGTTCCGCACGCCCTCGCCTCCTGAAC
CCGAAGGCCGCGCGGCCGTA

Downstream 100 bases:

>100_bases
GGTGCGCGGCTCAGCGGCGGGCGATCTCCACACCGCCGGACGGAGCGCGTGAAATGCCGCCGCACAGCCGGGCATTCGCC
AGACGGGGAGCATCGGCCAC

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MCICIAIDGRAANPKFKGIMRKPSRTSLRPASAKPAAPSPVRTERADAGAAVAEKKRSSLFVGSTEKAFQVLHAFDGPLR
FMTLADIARASGLDRSAAQRLVHTLETLGYIRRVPDTRNYALTSKVLQFSYSYIRANELIDKASPYLLDISRRLGETTNL
HELDGPEVVFVARFPGQHMNNIDIVVGSRLPTFFTSSGTAMLSQLSEEEQREILARTNLSPRTPFTVTDPEALLARVRQA
GERGYAMIVNETVMGDISISAPITDEHGRPVAGINISVPTSRWTPERAEAELAQEIQVAATSISKPKLTRVSS

Sequences:

>Translated_313_residues
MCICIAIDGRAANPKFKGIMRKPSRTSLRPASAKPAAPSPVRTERADAGAAVAEKKRSSLFVGSTEKAFQVLHAFDGPLR
FMTLADIARASGLDRSAAQRLVHTLETLGYIRRVPDTRNYALTSKVLQFSYSYIRANELIDKASPYLLDISRRLGETTNL
HELDGPEVVFVARFPGQHMNNIDIVVGSRLPTFFTSSGTAMLSQLSEEEQREILARTNLSPRTPFTVTDPEALLARVRQA
GERGYAMIVNETVMGDISISAPITDEHGRPVAGINISVPTSRWTPERAEAELAQEIQVAATSISKPKLTRVSS
>Mature_313_residues
MCICIAIDGRAANPKFKGIMRKPSRTSLRPASAKPAAPSPVRTERADAGAAVAEKKRSSLFVGSTEKAFQVLHAFDGPLR
FMTLADIARASGLDRSAAQRLVHTLETLGYIRRVPDTRNYALTSKVLQFSYSYIRANELIDKASPYLLDISRRLGETTNL
HELDGPEVVFVARFPGQHMNNIDIVVGSRLPTFFTSSGTAMLSQLSEEEQREILARTNLSPRTPFTVTDPEALLARVRQA
GERGYAMIVNETVMGDISISAPITDEHGRPVAGINISVPTSRWTPERAEAELAQEIQVAATSISKPKLTRVSS

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1786468, Length=248, Percent_Identity=29.8387096774194, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87082359, Length=208, Percent_Identity=30.2884615384615, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1788131, Length=243, Percent_Identity=28.8065843621399, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786715, Length=246, Percent_Identity=28.8617886178862, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789999, Length=231, Percent_Identity=25.5411255411255, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI145693096, Length=227, Percent_Identity=29.0748898678414, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 34234; Mature: 34234

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCICIAIDGRAANPKFKGIMRKPSRTSLRPASAKPAAPSPVRTERADAGAAVAEKKRSSL
CEEEEEECCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCEE
FVGSTEKAFQVLHAFDGPLRFMTLADIARASGLDRSAAQRLVHTLETLGYIRRVPDTRNY
EECCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCH
ALTSKVLQFSYSYIRANELIDKASPYLLDISRRLGETTNLHELDGPEVVFVARFPGQHMN
HHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHCCCCCCEECCCCCEEEEEECCCCCCC
NIDIVVGSRLPTFFTSSGTAMLSQLSEEEQREILARTNLSPRTPFTVTDPEALLARVRQA
CEEEEECCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHC
GERGYAMIVNETVMGDISISAPITDEHGRPVAGINISVPTSRWTPERAEAELAQEIQVAA
CCCCEEEEEECEEEEEEEEECCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHH
TSISKPKLTRVSS
HHCCCCCCCCCCC
>Mature Secondary Structure
MCICIAIDGRAANPKFKGIMRKPSRTSLRPASAKPAAPSPVRTERADAGAAVAEKKRSSL
CEEEEEECCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCEE
FVGSTEKAFQVLHAFDGPLRFMTLADIARASGLDRSAAQRLVHTLETLGYIRRVPDTRNY
EECCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCH
ALTSKVLQFSYSYIRANELIDKASPYLLDISRRLGETTNLHELDGPEVVFVARFPGQHMN
HHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHCCCCCCEECCCCCEEEEEECCCCCCC
NIDIVVGSRLPTFFTSSGTAMLSQLSEEEQREILARTNLSPRTPFTVTDPEALLARVRQA
CEEEEECCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHC
GERGYAMIVNETVMGDISISAPITDEHGRPVAGINISVPTSRWTPERAEAELAQEIQVAA
CCCCEEEEEECEEEEEEEEECCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHH
TSISKPKLTRVSS
HHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]