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The map label for this gene is nadC [H]

Identifier: 158424092

GI number: 158424092

Start: 2804921

End: 2805757

Strand: Reverse

Name: nadC [H]

Synonym: AZC_2468

Alternate gene names: 158424092

Gene position: 2805757-2804921 (Counterclockwise)

Preceding gene: 158424093

Following gene: 158424091

Centisome position: 52.25

GC content: 65.83

Gene sequence:

>837_bases
ATGTATGATCCCTTCCAGATTGACCGGCTGATCGACCTCTGGCTTGCCGAGGACATCGGCTATTGCGACCTCACCGTGCA
GGTGATGATCGAGCCGGACGAGCAGGGCCATTTCTACATGAATGCCCGCGAGCCCATGACCATTTCCGGCATCGAGATCG
CGGCCGCCATCTTCCGGCGCTACGACAAGCGGCTCGACGTGGAAGTGAAGGTGAAGGACGGCGATGTGGTGGAAAAGGGC
GCGGTGCTGCTCACCGTGCGCGGCCCGGCGCGGGGCATCCTCACCGCCGAGCGCACGGCCCTCAATATTGTCCAGCGCAT
GAGCGGCATCGCCACCGAGACGGCGAAATATGTGGCGGCGGTTGCCGGCACCAAGGCGCGCCTCATCGACACCCGCAAGA
CCACGCCCGGCCTGCGCATGATCGAGAAGCATGCCGTCACATCCGGCGGCGGCCTCAACCATCGCCTCGGCCTCGATAAC
GGCGTGATGATCAAGGACAACCACATCGCCGTGTGCGGCGGCATCGGCCCGGCTGTCGCCCGCGCCCGGAAAAGCCTGCC
GACCCTCACCAAGATCGAGGTGGAATGCGACCGCCTCGATCAGGTGGGCGAGGCGCTCGCAGCGGGTGCGGACGTGATCA
TGCTCGACAACATGTCCATCCCGGACATGAAGGCGGCGGTGGAGCTGGTGGCCGGGCGCGTGCCGCTGGAAGCCTCCGGC
GGGATCCGGCTCGACACCATCGGCCCGATCGCGCAGACGGGGGTGAACTACATTTCCACCAGCAAGATCACCCAGTCGGC
GCCAGCCGTCGACATCGGCCTCGACGAGGCGGAGTGA

Upstream 100 bases:

>100_bases
TGATCGCTCTGAAATTCTGTCCCGCCGGGCCGCCACGACGGCCTCCCGGCGCCGGCGGCAACACGCCTGAATTCAATGCG
CCTTCCTCGGGAGAAGCCCC

Downstream 100 bases:

>100_bases
GCGTCATGGGATCGGGACTCTTCTTCTTCGTGGTCGGGCCGAGCGGCTCGGGCAAGGACACCCTCATCGAGGGGGCGAAG
GCGGCTCTCGGTCCCACCGG

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MYDPFQIDRLIDLWLAEDIGYCDLTVQVMIEPDEQGHFYMNAREPMTISGIEIAAAIFRRYDKRLDVEVKVKDGDVVEKG
AVLLTVRGPARGILTAERTALNIVQRMSGIATETAKYVAAVAGTKARLIDTRKTTPGLRMIEKHAVTSGGGLNHRLGLDN
GVMIKDNHIAVCGGIGPAVARARKSLPTLTKIEVECDRLDQVGEALAAGADVIMLDNMSIPDMKAAVELVAGRVPLEASG
GIRLDTIGPIAQTGVNYISTSKITQSAPAVDIGLDEAE

Sequences:

>Translated_278_residues
MYDPFQIDRLIDLWLAEDIGYCDLTVQVMIEPDEQGHFYMNAREPMTISGIEIAAAIFRRYDKRLDVEVKVKDGDVVEKG
AVLLTVRGPARGILTAERTALNIVQRMSGIATETAKYVAAVAGTKARLIDTRKTTPGLRMIEKHAVTSGGGLNHRLGLDN
GVMIKDNHIAVCGGIGPAVARARKSLPTLTKIEVECDRLDQVGEALAAGADVIMLDNMSIPDMKAAVELVAGRVPLEASG
GIRLDTIGPIAQTGVNYISTSKITQSAPAVDIGLDEAE
>Mature_278_residues
MYDPFQIDRLIDLWLAEDIGYCDLTVQVMIEPDEQGHFYMNAREPMTISGIEIAAAIFRRYDKRLDVEVKVKDGDVVEKG
AVLLTVRGPARGILTAERTALNIVQRMSGIATETAKYVAAVAGTKARLIDTRKTTPGLRMIEKHAVTSGGGLNHRLGLDN
GVMIKDNHIAVCGGIGPAVARARKSLPTLTKIEVECDRLDQVGEALAAGADVIMLDNMSIPDMKAAVELVAGRVPLEASG
GIRLDTIGPIAQTGVNYISTSKITQSAPAVDIGLDEAE

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=279, Percent_Identity=34.7670250896057, Blast_Score=149, Evalue=2e-36,
Organism=Escherichia coli, GI1786299, Length=267, Percent_Identity=39.7003745318352, Blast_Score=165, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6321162, Length=279, Percent_Identity=37.6344086021505, Blast_Score=162, Evalue=7e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 29821; Mature: 29821

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYDPFQIDRLIDLWLAEDIGYCDLTVQVMIEPDEQGHFYMNAREPMTISGIEIAAAIFRR
CCCCHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCEEEECCCCEEECHHHHHHHHHHH
YDKRLDVEVKVKDGDVVEKGAVLLTVRGPARGILTAERTALNIVQRMSGIATETAKYVAA
HHHCCCEEEEECCCCEEECCEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
VAGTKARLIDTRKTTPGLRMIEKHAVTSGGGLNHRLGLDNGVMIKDNHIAVCGGIGPAVA
HCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCEEECCCCCEEEECCCEEEECCCCHHHH
RARKSLPTLTKIEVECDRLDQVGEALAAGADVIMLDNMSIPDMKAAVELVAGRVPLEASG
HHHHCCCCEEEEEEEHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCCEECCC
GIRLDTIGPIAQTGVNYISTSKITQSAPAVDIGLDEAE
CEEEECCCCHHHHCCCCEECCCHHCCCCEEEECCCCCC
>Mature Secondary Structure
MYDPFQIDRLIDLWLAEDIGYCDLTVQVMIEPDEQGHFYMNAREPMTISGIEIAAAIFRR
CCCCHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCEEEECCCCEEECHHHHHHHHHHH
YDKRLDVEVKVKDGDVVEKGAVLLTVRGPARGILTAERTALNIVQRMSGIATETAKYVAA
HHHCCCEEEEECCCCEEECCEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
VAGTKARLIDTRKTTPGLRMIEKHAVTSGGGLNHRLGLDNGVMIKDNHIAVCGGIGPAVA
HCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCEEECCCCCEEEECCCEEEECCCCHHHH
RARKSLPTLTKIEVECDRLDQVGEALAAGADVIMLDNMSIPDMKAAVELVAGRVPLEASG
HHHHCCCCEEEEEEEHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCCEECCC
GIRLDTIGPIAQTGVNYISTSKITQSAPAVDIGLDEAE
CEEEECCCCHHHHCCCCEECCCHHCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]