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The map label for this gene is moaB [H]

Identifier: 158424024

GI number: 158424024

Start: 2727474

End: 2728037

Strand: Direct

Name: moaB [H]

Synonym: AZC_2400

Alternate gene names: 158424024

Gene position: 2727474-2728037 (Clockwise)

Preceding gene: 158424023

Following gene: 158424026

Centisome position: 50.79

GC content: 67.91

Gene sequence:

>564_bases
ATGCCCGGCATCGACGAGAGCCGCCCGTTCGTGGCGCTGAACATCGCCGTCCTGACCATCTCCGACACGCGGGTGATGGA
GGATGACCGCTCCGGCAGCCTGCTGGTGGAGCGCCTCACCCTCGCCGGCCACAGGCTGGCGGACCGGCGCATTGTCACCG
ACGACGTGGAGGAGATCCGTGGCGCGGTCAGTGCCTGGATCGCCGATCCGACGGTGGACGTGGTCATCACCACCGGCGGA
ACCGGCTTCACCGGCCGCGATGTCACGCCGGAGGCCGTGGAGCCGCTGTTCGAGAAGCGGATGGAGGGCTTCTCCACCGT
CTTCCACATGATCTCCTTCCCCAAGATCGGCACCTCGACGCTCCAGAGCCGGGCGACGGCCGGGGTCGCGAACGCCACCT
ATATCTTCTGTCTGCCGGGCTCGCCGGGGGCATGCCGGGACGGCTGGGACGAGATCCTCGCCAACCAGCTCGACGTGCGC
TTCCGCCCCTGCAATTTCGTGGAAATCCTGCCCCGCCTCGACGAGCATCTGAAGCGCGCCAAGGCGAAGGGTGCCACCGT
CTGA

Upstream 100 bases:

>100_bases
ACTTCACCCACGGCTCCTCCCAGCAGCGCGTCACCTGGTTCATGCGTGGACTGAAGGCCGGAAACATGAACCAGTGCAAC
ACCTTGCAGGGAACGCCCTG

Downstream 100 bases:

>100_bases
GCCCTATTCCACCTCGGCGCGCTGCGGCTTCGGCCGGGGCGCGCTGCGCCGGCGCGGCTGCTGCGGCGCGGGCGGCGGTG
GGGGCGGCGCCATCAGGCGG

Product: molybdopterin biosynthesis protein B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 187; Mature: 186

Protein sequence:

>187_residues
MPGIDESRPFVALNIAVLTISDTRVMEDDRSGSLLVERLTLAGHRLADRRIVTDDVEEIRGAVSAWIADPTVDVVITTGG
TGFTGRDVTPEAVEPLFEKRMEGFSTVFHMISFPKIGTSTLQSRATAGVANATYIFCLPGSPGACRDGWDEILANQLDVR
FRPCNFVEILPRLDEHLKRAKAKGATV

Sequences:

>Translated_187_residues
MPGIDESRPFVALNIAVLTISDTRVMEDDRSGSLLVERLTLAGHRLADRRIVTDDVEEIRGAVSAWIADPTVDVVITTGG
TGFTGRDVTPEAVEPLFEKRMEGFSTVFHMISFPKIGTSTLQSRATAGVANATYIFCLPGSPGACRDGWDEILANQLDVR
FRPCNFVEILPRLDEHLKRAKAKGATV
>Mature_186_residues
PGIDESRPFVALNIAVLTISDTRVMEDDRSGSLLVERLTLAGHRLADRRIVTDDVEEIRGAVSAWIADPTVDVVITTGGT
GFTGRDVTPEAVEPLFEKRMEGFSTVFHMISFPKIGTSTLQSRATAGVANATYIFCLPGSPGACRDGWDEILANQLDVRF
RPCNFVEILPRLDEHLKRAKAKGATV

Specific function: Maybe involved in the biosynthesis of molybdopterin. Can bind GTP and has low GTPase activity. Can bind MPT, but has no MPT adenylyl transferase activity [H]

COG id: COG0521

COG function: function code H; Molybdopterin biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaB/mog family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=146, Percent_Identity=34.2465753424658, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI66932975, Length=146, Percent_Identity=34.2465753424658, Blast_Score=82, Evalue=4e-16,
Organism=Escherichia coli, GI1787000, Length=160, Percent_Identity=55, Blast_Score=176, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17564954, Length=147, Percent_Identity=35.3741496598639, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17136978, Length=149, Percent_Identity=36.9127516778523, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24638841, Length=149, Percent_Identity=36.9127516778523, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR012245
- InterPro:   IPR013484
- InterPro:   IPR008284
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth [H]

EC number: NA

Molecular weight: Translated: 20402; Mature: 20270

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS01078 MOCF_BIOSYNTHESIS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGIDESRPFVALNIAVLTISDTRVMEDDRSGSLLVERLTLAGHRLADRRIVTDDVEEIR
CCCCCCCCCEEEEEEEEEEEECCEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHH
GAVSAWIADPTVDVVITTGGTGFTGRDVTPEAVEPLFEKRMEGFSTVFHMISFPKIGTST
HHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LQSRATAGVANATYIFCLPGSPGACRDGWDEILANQLDVRFRPCNFVEILPRLDEHLKRA
HHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHH
KAKGATV
HCCCCCC
>Mature Secondary Structure 
PGIDESRPFVALNIAVLTISDTRVMEDDRSGSLLVERLTLAGHRLADRRIVTDDVEEIR
CCCCCCCCEEEEEEEEEEEECCEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHH
GAVSAWIADPTVDVVITTGGTGFTGRDVTPEAVEPLFEKRMEGFSTVFHMISFPKIGTST
HHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LQSRATAGVANATYIFCLPGSPGACRDGWDEILANQLDVRFRPCNFVEILPRLDEHLKRA
HHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHH
KAKGATV
HCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin precursor biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]