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The map label for this gene is lpxK

Identifier: 158424007

GI number: 158424007

Start: 2708966

End: 2709982

Strand: Direct

Name: lpxK

Synonym: AZC_2383

Alternate gene names: 158424007

Gene position: 2708966-2709982 (Clockwise)

Preceding gene: 158424006

Following gene: 158424010

Centisome position: 50.45

GC content: 71.88

Gene sequence:

>1017_bases
ATGATCGGGCAGGCGCCCGCCTTCTGGTCCCGCCGCAACAGCCTCATGGGCTGGGTGCTCTCGCCGATCGGCGCGCTTGT
CGGCGCCCTCACCCTGAAGCGGATGGCCGGCCCCTCGACGGGCGTCCCGGTCCCCGTCATCTGCATCGGCAATCCCACCG
TCGGCGGCTCCGGCAAGACACCAACCGCCCTCATGGTCCTGGCGCGCCTGCAAGAGCAGGGCGCACGCCCCTTCGCCCTG
CTGCGCGGCCATGGCGGGCGCCTCGCAGGTCCGGTCCTCGTCGATCCGCAGACCCATACGGCGGCTGACGTGGGCGACGA
AGCCCTGCTGCTTGCGCAGGCGACACCCACCGTCGTGTCCCGCGACCGCCCCGCCGGCGCCGCCCATGCGGTGGCCCTCG
GCGCCAGCCATGTGGTGATGGACGACGGCTTCCAGAACCCGTCGCTCGCCAAGGACGTGAGCCTGCTGGTCATTGATGGT
GAGGCTGGCGTCGGCAACGGGCGCGTGCTGCCAGCCGGGCCTTTGCGCGCACCGCTGGCGCCGCAACTCGATCGCGCCGA
TGCGCTGCTGGTGGCCGGTGGCGGGCGCTGTGCCGACGCGCTCGGAAGGCTTGCCCACAGCCATGGCAAGGTGGTGCTGA
GGGGGCAGGTCCGGCCCGATCCGTCGGTCATCGCCACGCTCGAAGCCGGGACCGTGCTTGCCTTCGCGGGCATCGGCCGA
CCGCAGAAGCTCGCCGACACGCTGGCGGCAGCGGGCGTGCGGATCGGGCGGCTCCAGCCCTTTCCCGATCATCATCCCTA
CCAGCCGTCGGACATCGCTCCGCTCATCGCGGAGGCCGCGCGCGAACGGTGGCAGCTCGTCACCACCACGAAGGACCATG
TGCGGCTGGCAGATCGGCGCTTTGCCGACATGGCCGGCGCCATCACGGCCCTGCCGGTGACCATGCAGTTGGATGCGCCC
GAGGCCCTGGATGACATTCTGCGGCTGGCAGAGGCACGGGCCGCGGCCCGGAGCTGA

Upstream 100 bases:

>100_bases
CCCACGCCGCCTGGCAGACGGTGGAAAACCTCAGCGGTGCGCTGCCGCGCACGCTGGCGGCCATCGAGCCCTATCTCCTG
CAGATCCGGCTGGAAGGGAA

Downstream 100 bases:

>100_bases
AGCCGCTAGGGCTCAGTCCTCGTCGTCGGCCGCTTCGATCTTGGTCGGGCCGAGCACCCGCGTCAGGACAGCCTGCGGGT
CCGCATAGGCCTCCTGCAGA

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MIGQAPAFWSRRNSLMGWVLSPIGALVGALTLKRMAGPSTGVPVPVICIGNPTVGGSGKTPTALMVLARLQEQGARPFAL
LRGHGGRLAGPVLVDPQTHTAADVGDEALLLAQATPTVVSRDRPAGAAHAVALGASHVVMDDGFQNPSLAKDVSLLVIDG
EAGVGNGRVLPAGPLRAPLAPQLDRADALLVAGGGRCADALGRLAHSHGKVVLRGQVRPDPSVIATLEAGTVLAFAGIGR
PQKLADTLAAAGVRIGRLQPFPDHHPYQPSDIAPLIAEAARERWQLVTTTKDHVRLADRRFADMAGAITALPVTMQLDAP
EALDDILRLAEARAAARS

Sequences:

>Translated_338_residues
MIGQAPAFWSRRNSLMGWVLSPIGALVGALTLKRMAGPSTGVPVPVICIGNPTVGGSGKTPTALMVLARLQEQGARPFAL
LRGHGGRLAGPVLVDPQTHTAADVGDEALLLAQATPTVVSRDRPAGAAHAVALGASHVVMDDGFQNPSLAKDVSLLVIDG
EAGVGNGRVLPAGPLRAPLAPQLDRADALLVAGGGRCADALGRLAHSHGKVVLRGQVRPDPSVIATLEAGTVLAFAGIGR
PQKLADTLAAAGVRIGRLQPFPDHHPYQPSDIAPLIAEAARERWQLVTTTKDHVRLADRRFADMAGAITALPVTMQLDAP
EALDDILRLAEARAAARS
>Mature_338_residues
MIGQAPAFWSRRNSLMGWVLSPIGALVGALTLKRMAGPSTGVPVPVICIGNPTVGGSGKTPTALMVLARLQEQGARPFAL
LRGHGGRLAGPVLVDPQTHTAADVGDEALLLAQATPTVVSRDRPAGAAHAVALGASHVVMDDGFQNPSLAKDVSLLVIDG
EAGVGNGRVLPAGPLRAPLAPQLDRADALLVAGGGRCADALGRLAHSHGKVVLRGQVRPDPSVIATLEAGTVLAFAGIGR
PQKLADTLAAAGVRIGRLQPFPDHHPYQPSDIAPLIAEAARERWQLVTTTKDHVRLADRRFADMAGAITALPVTMQLDAP
EALDDILRLAEARAAARS

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=304, Percent_Identity=36.8421052631579, Blast_Score=129, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_AZOC5 (A8I6A3)

Other databases:

- EMBL:   AP009384
- RefSeq:   YP_001525299.1
- GeneID:   5688609
- GenomeReviews:   AP009384_GR
- KEGG:   azc:AZC_2383
- HOGENOM:   HBG663914
- OMA:   VILMDDG
- ProtClustDB:   PRK00652
- BioCyc:   ACAU438753:AZC_2383-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 34920; Mature: 34920

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGQAPAFWSRRNSLMGWVLSPIGALVGALTLKRMAGPSTGVPVPVICIGNPTVGGSGKT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCC
PTALMVLARLQEQGARPFALLRGHGGRLAGPVLVDPQTHTAADVGDEALLLAQATPTVVS
HHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEECCCCCCHHCCCCCEEEEEECCCHHHC
RDRPAGAAHAVALGASHVVMDDGFQNPSLAKDVSLLVIDGEAGVGNGRVLPAGPLRAPLA
CCCCCCCHHHHHHCCCEEEEECCCCCCCCCCCEEEEEEECCCCCCCCEEECCCCCCCCCC
PQLDRADALLVAGGGRCADALGRLAHSHGKVVLRGQVRPDPSVIATLEAGTVLAFAGIGR
CCCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEECCCCEEEEECCCC
PQKLADTLAAAGVRIGRLQPFPDHHPYQPSDIAPLIAEAARERWQLVTTTKDHVRLADRR
HHHHHHHHHHCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEECCHHHHHHHHHH
FADMAGAITALPVTMQLDAPEALDDILRLAEARAAARS
HHHHHCCHHHEEEEEEECCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIGQAPAFWSRRNSLMGWVLSPIGALVGALTLKRMAGPSTGVPVPVICIGNPTVGGSGKT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCC
PTALMVLARLQEQGARPFALLRGHGGRLAGPVLVDPQTHTAADVGDEALLLAQATPTVVS
HHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEECCCCCCHHCCCCCEEEEEECCCHHHC
RDRPAGAAHAVALGASHVVMDDGFQNPSLAKDVSLLVIDGEAGVGNGRVLPAGPLRAPLA
CCCCCCCHHHHHHCCCEEEEECCCCCCCCCCCEEEEEEECCCCCCCCEEECCCCCCCCCC
PQLDRADALLVAGGGRCADALGRLAHSHGKVVLRGQVRPDPSVIATLEAGTVLAFAGIGR
CCCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEECCCCEEEEECCCC
PQKLADTLAAAGVRIGRLQPFPDHHPYQPSDIAPLIAEAARERWQLVTTTKDHVRLADRR
HHHHHHHHHHCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEECCHHHHHHHHHH
FADMAGAITALPVTMQLDAPEALDDILRLAEARAAARS
HHHHHCCHHHEEEEEEECCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA