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The map label for this gene is lysR [H]

Identifier: 158423665

GI number: 158423665

Start: 2353511

End: 2354467

Strand: Reverse

Name: lysR [H]

Synonym: AZC_2041

Alternate gene names: 158423665

Gene position: 2354467-2353511 (Counterclockwise)

Preceding gene: 158423667

Following gene: 158423664

Centisome position: 43.85

GC content: 67.71

Gene sequence:

>957_bases
ATGAGCCTCTCCCTCCGACAGGTGCGCTATGTGGTCGAAGTCGCGCGCCTCGGCTCCATCCAGGCGGCGTCCCGCGAACT
CTCCATTTCGCAGTCCTCCATCCTCGCCGCCATCGATCTCGCGGAGGCCGACATCGGAGCGCGCATGTTCATGCGACGCC
CGTCCCAGGGCATGCGTACCACGCCGGCTGGCGAACGTTTCATTGCCGCAGCGCGGGGCCTGCTGGCCGCGGAAACGGAG
TTCGTGCGGGAGATCGGCTCGCTGGCGGATCGCCCGCCCCGCCTGATCCGCATCGGTTGCTTCCTGCCCTTCGGGCCGCT
GTTCATGCCGGAGGTGCTACGCCGCCTGGTGGCCCGCACGGGCTCCATCGACATCAGCGTGATGGAAGCCGACCAACTGC
AACTGCGCGACTGGCTCGACACCGGTCATATCGATGCCGCCGTCACATACGAGATGGGGCCGCCCTTTGCCGGCGAGATC
ACGCGGATCTGCAAGGTGCCGGCGCATGTGCTGATGCGCGCGGACGATCCGCTGGCGCGGCTCGACGCGGTGCCGCTGGC
AGCCCTTGCCGAGCGCCCGCACATCCTGCTCGATCTGCCGCAGACCGGCGCCTATCTCACCTCCATCGTGGACATGTCTG
GCCTGGGGCGGCGCATCAGTTTCCGCACCCGATCCTACGACACCGTGCGCGCGGCGGTGGAGGCGGGTTTCGGCCTCACC
ATCCTGAATCTGCGCCCCATGACCCGCGTCGCGGCGGACACGCCCGATCTCTGCCGCCGCCCCATCGCCGATCCCCTGCC
GCCGCCGAACCTGATCGTGATCGACCCCTATGGCGATCGCAAACCGCGCTTCCTCAAGGAATTCATCGCGGAGATGCACG
CCATGTTCCGCGAACTCGGGCCGCGCCGCTTCGCGGTAGCCAAACCGGAAGAGGAAAACGAACTCCTTCCCGCCTGA

Upstream 100 bases:

>100_bases
CAAAATTTCCGCTGCACCTTTGAAAGGCAGAATGACCTTCCCGAGGCCTCCCACAAAATGTATTATTCGGAGAACATTCT
TCTATTTTCTGGATGATTGG

Downstream 100 bases:

>100_bases
TGGGTTGTGACGTTCGAGGACCCGCGCAGCACCTCCCGGAATGGAGCCAAGCCGCATTTTTCGTATGACAGAGGCAAACG
GGACAGTTCTCAGCGCGGAG

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MSLSLRQVRYVVEVARLGSIQAASRELSISQSSILAAIDLAEADIGARMFMRRPSQGMRTTPAGERFIAAARGLLAAETE
FVREIGSLADRPPRLIRIGCFLPFGPLFMPEVLRRLVARTGSIDISVMEADQLQLRDWLDTGHIDAAVTYEMGPPFAGEI
TRICKVPAHVLMRADDPLARLDAVPLAALAERPHILLDLPQTGAYLTSIVDMSGLGRRISFRTRSYDTVRAAVEAGFGLT
ILNLRPMTRVAADTPDLCRRPIADPLPPPNLIVIDPYGDRKPRFLKEFIAEMHAMFRELGPRRFAVAKPEEENELLPA

Sequences:

>Translated_318_residues
MSLSLRQVRYVVEVARLGSIQAASRELSISQSSILAAIDLAEADIGARMFMRRPSQGMRTTPAGERFIAAARGLLAAETE
FVREIGSLADRPPRLIRIGCFLPFGPLFMPEVLRRLVARTGSIDISVMEADQLQLRDWLDTGHIDAAVTYEMGPPFAGEI
TRICKVPAHVLMRADDPLARLDAVPLAALAERPHILLDLPQTGAYLTSIVDMSGLGRRISFRTRSYDTVRAAVEAGFGLT
ILNLRPMTRVAADTPDLCRRPIADPLPPPNLIVIDPYGDRKPRFLKEFIAEMHAMFRELGPRRFAVAKPEEENELLPA
>Mature_317_residues
SLSLRQVRYVVEVARLGSIQAASRELSISQSSILAAIDLAEADIGARMFMRRPSQGMRTTPAGERFIAAARGLLAAETEF
VREIGSLADRPPRLIRIGCFLPFGPLFMPEVLRRLVARTGSIDISVMEADQLQLRDWLDTGHIDAAVTYEMGPPFAGEIT
RICKVPAHVLMRADDPLARLDAVPLAALAERPHILLDLPQTGAYLTSIVDMSGLGRRISFRTRSYDTVRAAVEAGFGLTI
LNLRPMTRVAADTPDLCRRPIADPLPPPNLIVIDPYGDRKPRFLKEFIAEMHAMFRELGPRRFAVAKPEEENELLPA

Specific function: This Protein Is A Positive Regulator Of Gene Expression For The Cysteine Regulon, A System Of 10 Or More Loci Involved In The Biosynthesis Of L-Cysteine From Inorganic Sulfate. The Inducer For Cysb Is N-Acetylserine. Cysb Inhibits Its Own Transcription.

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787530, Length=298, Percent_Identity=22.8187919463087, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787601, Length=159, Percent_Identity=32.7044025157233, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1790399, Length=248, Percent_Identity=25.4032258064516, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35161; Mature: 35029

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSLRQVRYVVEVARLGSIQAASRELSISQSSILAAIDLAEADIGARMFMRRPSQGMRT
CCCHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TPAGERFIAAARGLLAAETEFVREIGSLADRPPRLIRIGCFLPFGPLFMPEVLRRLVART
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHC
GSIDISVMEADQLQLRDWLDTGHIDAAVTYEMGPPFAGEITRICKVPAHVLMRADDPLAR
CCCEEEEECCHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCHHH
LDAVPLAALAERPHILLDLPQTGAYLTSIVDMSGLGRRISFRTRSYDTVRAAVEAGFGLT
HHCCHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCEE
ILNLRPMTRVAADTPDLCRRPIADPLPPPNLIVIDPYGDRKPRFLKEFIAEMHAMFRELG
EEECCCHHHHHCCCHHHHHCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCC
PRRFAVAKPEEENELLPA
CCEEEECCCCCCCCCCCC
>Mature Secondary Structure 
SLSLRQVRYVVEVARLGSIQAASRELSISQSSILAAIDLAEADIGARMFMRRPSQGMRT
CCHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TPAGERFIAAARGLLAAETEFVREIGSLADRPPRLIRIGCFLPFGPLFMPEVLRRLVART
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHC
GSIDISVMEADQLQLRDWLDTGHIDAAVTYEMGPPFAGEITRICKVPAHVLMRADDPLAR
CCCEEEEECCHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCHHH
LDAVPLAALAERPHILLDLPQTGAYLTSIVDMSGLGRRISFRTRSYDTVRAAVEAGFGLT
HHCCHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCEE
ILNLRPMTRVAADTPDLCRRPIADPLPPPNLIVIDPYGDRKPRFLKEFIAEMHAMFRELG
EEECCCHHHHHCCCHHHHHCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCC
PRRFAVAKPEEENELLPA
CCEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]