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The map label for this gene is mutA [H]

Identifier: 158423397

GI number: 158423397

Start: 2026081

End: 2027913

Strand: Reverse

Name: mutA [H]

Synonym: AZC_1773

Alternate gene names: 158423397

Gene position: 2027913-2026081 (Counterclockwise)

Preceding gene: 158423398

Following gene: 158423396

Centisome position: 37.77

GC content: 72.01

Gene sequence:

>1833_bases
ATGACCGCAACCCTGCCCTTCGTGACGCAGGCGGGCCCGGTAACCCGGGCGGACTGGCTGTCGCTGGTGGAAGGCGTGCT
GAAAGGCGCGCCCTATGACAAGCGCCTCGTGACCCGCACCTCTGAGGGCCTTGCGCTGGACGCCCTCCCACCGCGCAGGG
AAGAGGCCGTCCCCATCGCCGGACGGGCGGCAGGTGCGCCGTGGACGATCAGCGCGCGCGTCGACCAGCCGGACCTTGCC
GCCGCCAATGCCCAGATCCTCGATGATCTGGAAAATGGCGCCTCCGGCCTCACCCTCGTCTATGCCTCGTCTCCCTCCGC
CCACGGCTTCGGCCTGCCGGACGGCGCGGCGCTGGAGACGCTGCTCGCCAGCGTGATGCCGGACCTCATCGAGACGCGGC
TGGAGAGCGGAGCCTTCAAGGGCCGCGAGAATGCCCTCGCCTTCGCTGATTTCATCGCGGCACGCGGGCTCGATCCGGCG
CGTGTGAGCGTTTCCTTCGGCCTTGATCCGCTCGCGGACATGGCCGCGCGCGGCAGCGCACCCATGCCTTGGCCGGGCCT
TGCCGAGCGGGTGGCGGAAAGCGCCGCTATCCTCAAGGCGCGCGGCTTCACCGGGCCGCTGCTGCGGGCGGACGGCGCCA
TCCACCATGCGGCCGGTGCCAGCGATGCGCAGGAGCTGGCGGCGGTGCTGGCGGCGGCTGTCGCCTATCTGCGGGCGCTG
GAGAAGGCCGGCTTCTCGCTGGAGGAGGCCGCCGGCCGTATCGAGGTGGCGCTGACGGCGGACGTGAACCAGACCGCAAC
GCTCGCGAAAGTCCGCGCCATCCGCCTGCTGTGGGGCGCGGTGCTGCGGGAGGCCGGCATCGGGGCCGGGCCGCTGAAGG
TCCACGCCACCACGGCGTGGCGCTCGCTCACCCGGCGCGATCCCTATGTGAACCTGCTGCGCGCCACCATCGCCGCCTTC
GCGGCCGGCGTGGGCGGAGCGGACGGCCTCACCGTCCTGCCCTTCACGCAGGCCCTCGGCCTGCCGGATGCTCAGGCGCG
GCGGCTCGCCCGCAACACGCAGCTCATCCTGCTGGAGGAAAGCCAGCTCCACCGCGTGGCCGATCCCGGTGCCGGCGCGG
GCGCGGTAGAAGCGCATACGGATGGCCTTGCGGCTGCCGCGTGGGATCTCTTCCGCGCCATCGAAGGCAAGGGTGGGCTC
GCCGAGGCGCTGGCCTCCGGCTGGTGGCAGGGCGAGTTGGCGGCGACCCGCGCCAAGCGGGCGAAGGATATCGCCACACG
CAGGGAGCCGCTCACCGGCACGTCGGAATTCCCCATCCTCGGCCAGAGCGTGCCGGAGGTGCTCGCCCCCGTCCCCGCGC
GGGAAGAAGCGCCGAACGATCTCGCCCTCGCGCCCCAGCGGCTCGCGGAGCCTTTCGAGGCGCTCCGCGATGCGGCCGAG
GCGACGGGTACGCCTCAGGTGTTCCTCGCGACCCTCGGACCCATCGCCGCCTTCACCGCCCGCGCCACTTTCGCCAAGGC
GCTGTTCGAGGCTGGCGGCCTCGCCGTGACCGTGACCGACGGTTATGCGGATTTCGATGCTCTCATCGCCGCGTTCAAGG
CTTCCGGCACGGCCATCGCCTGCATCGCCTCCTCCGACGAGATCTACGAAGCGGAGGCCGCCACCATCGCGGCCGCGCTA
AAGGCCGCGGGCGCCCGGCAGGTGTGGCTCGCGGGCCGGGGCGGCGATCTTGAGGCGACGTGGCGCGCAGCGGGCGTGGA
CGACTTCATCTTCGCCGGCTGCGACGTGCTGTCGGTACTGAAGAAAGCACACGGGGCGCTGGGGATCGGGTGA

Upstream 100 bases:

>100_bases
GGCGTCATCAAAGCCGTCCACGCCAAGGCCGGCGACAGTCTCGCCGTGGACGCGGTGATCCTCGAATTCGCGTGACGACG
AAACACGGAAGGGCCGCACA

Downstream 100 bases:

>100_bases
AATCTGGCAAAGCCCTCCCCCCTTGTGGGGGAGGGTTGGGAGGGGGGTAATGCCCTCTCCGAAAGGGCACGCTGGGGAAC
GGGGAAAATCAAGGGCTGCC

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM-beta [H]

Number of amino acids: Translated: 610; Mature: 609

Protein sequence:

>610_residues
MTATLPFVTQAGPVTRADWLSLVEGVLKGAPYDKRLVTRTSEGLALDALPPRREEAVPIAGRAAGAPWTISARVDQPDLA
AANAQILDDLENGASGLTLVYASSPSAHGFGLPDGAALETLLASVMPDLIETRLESGAFKGRENALAFADFIAARGLDPA
RVSVSFGLDPLADMAARGSAPMPWPGLAERVAESAAILKARGFTGPLLRADGAIHHAAGASDAQELAAVLAAAVAYLRAL
EKAGFSLEEAAGRIEVALTADVNQTATLAKVRAIRLLWGAVLREAGIGAGPLKVHATTAWRSLTRRDPYVNLLRATIAAF
AAGVGGADGLTVLPFTQALGLPDAQARRLARNTQLILLEESQLHRVADPGAGAGAVEAHTDGLAAAAWDLFRAIEGKGGL
AEALASGWWQGELAATRAKRAKDIATRREPLTGTSEFPILGQSVPEVLAPVPAREEAPNDLALAPQRLAEPFEALRDAAE
ATGTPQVFLATLGPIAAFTARATFAKALFEAGGLAVTVTDGYADFDALIAAFKASGTAIACIASSDEIYEAEAATIAAAL
KAAGARQVWLAGRGGDLEATWRAAGVDDFIFAGCDVLSVLKKAHGALGIG

Sequences:

>Translated_610_residues
MTATLPFVTQAGPVTRADWLSLVEGVLKGAPYDKRLVTRTSEGLALDALPPRREEAVPIAGRAAGAPWTISARVDQPDLA
AANAQILDDLENGASGLTLVYASSPSAHGFGLPDGAALETLLASVMPDLIETRLESGAFKGRENALAFADFIAARGLDPA
RVSVSFGLDPLADMAARGSAPMPWPGLAERVAESAAILKARGFTGPLLRADGAIHHAAGASDAQELAAVLAAAVAYLRAL
EKAGFSLEEAAGRIEVALTADVNQTATLAKVRAIRLLWGAVLREAGIGAGPLKVHATTAWRSLTRRDPYVNLLRATIAAF
AAGVGGADGLTVLPFTQALGLPDAQARRLARNTQLILLEESQLHRVADPGAGAGAVEAHTDGLAAAAWDLFRAIEGKGGL
AEALASGWWQGELAATRAKRAKDIATRREPLTGTSEFPILGQSVPEVLAPVPAREEAPNDLALAPQRLAEPFEALRDAAE
ATGTPQVFLATLGPIAAFTARATFAKALFEAGGLAVTVTDGYADFDALIAAFKASGTAIACIASSDEIYEAEAATIAAAL
KAAGARQVWLAGRGGDLEATWRAAGVDDFIFAGCDVLSVLKKAHGALGIG
>Mature_609_residues
TATLPFVTQAGPVTRADWLSLVEGVLKGAPYDKRLVTRTSEGLALDALPPRREEAVPIAGRAAGAPWTISARVDQPDLAA
ANAQILDDLENGASGLTLVYASSPSAHGFGLPDGAALETLLASVMPDLIETRLESGAFKGRENALAFADFIAARGLDPAR
VSVSFGLDPLADMAARGSAPMPWPGLAERVAESAAILKARGFTGPLLRADGAIHHAAGASDAQELAAVLAAAVAYLRALE
KAGFSLEEAAGRIEVALTADVNQTATLAKVRAIRLLWGAVLREAGIGAGPLKVHATTAWRSLTRRDPYVNLLRATIAAFA
AGVGGADGLTVLPFTQALGLPDAQARRLARNTQLILLEESQLHRVADPGAGAGAVEAHTDGLAAAAWDLFRAIEGKGGLA
EALASGWWQGELAATRAKRAKDIATRREPLTGTSEFPILGQSVPEVLAPVPAREEAPNDLALAPQRLAEPFEALRDAAEA
TGTPQVFLATLGPIAAFTARATFAKALFEAGGLAVTVTDGYADFDALIAAFKASGTAIACIASSDEIYEAEAATIAAALK
AAGARQVWLAGRGGDLEATWRAAGVDDFIFAGCDVLSVLKKAHGALGIG

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthes

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=470, Percent_Identity=27.6595744680851, Blast_Score=136, Evalue=6e-32,
Organism=Escherichia coli, GI1789284, Length=450, Percent_Identity=27.1111111111111, Blast_Score=127, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI25144500, Length=241, Percent_Identity=32.7800829875519, Blast_Score=125, Evalue=7e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 62826; Mature: 62695

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATLPFVTQAGPVTRADWLSLVEGVLKGAPYDKRLVTRTSEGLALDALPPRREEAVPIA
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCCEECCCCCCCCCCCCCC
GRAAGAPWTISARVDQPDLAAANAQILDDLENGASGLTLVYASSPSAHGFGLPDGAALET
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCHHHHHH
LLASVMPDLIETRLESGAFKGRENALAFADFIAARGLDPARVSVSFGLDPLADMAARGSA
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHEEEEECCCCHHHHHHHCCCC
PMPWPGLAERVAESAAILKARGFTGPLLRADGAIHHAAGASDAQELAAVLAAAVAYLRAL
CCCCCHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
EKAGFSLEEAAGRIEVALTADVNQTATLAKVRAIRLLWGAVLREAGIGAGPLKVHATTAW
HHCCCCHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHH
RSLTRRDPYVNLLRATIAAFAAGVGGADGLTVLPFTQALGLPDAQARRLARNTQLILLEE
HHHHHCCHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHCCCCCHHHHHHHCCCEEEEEEH
SQLHRVADPGAGAGAVEAHTDGLAAAAWDLFRAIEGKGGLAEALASGWWQGELAATRAKR
HHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHH
AKDIATRREPLTGTSEFPILGQSVPEVLAPVPAREEAPNDLALAPQRLAEPFEALRDAAE
HHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
ATGTPQVFLATLGPIAAFTARATFAKALFEAGGLAVTVTDGYADFDALIAAFKASGTAIA
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCEEE
CIASSDEIYEAEAATIAAALKAAGARQVWLAGRGGDLEATWRAAGVDDFIFAGCDVLSVL
EEECCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHH
KKAHGALGIG
HHHCCCCCCC
>Mature Secondary Structure 
TATLPFVTQAGPVTRADWLSLVEGVLKGAPYDKRLVTRTSEGLALDALPPRREEAVPIA
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCCEECCCCCCCCCCCCCC
GRAAGAPWTISARVDQPDLAAANAQILDDLENGASGLTLVYASSPSAHGFGLPDGAALET
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCHHHHHH
LLASVMPDLIETRLESGAFKGRENALAFADFIAARGLDPARVSVSFGLDPLADMAARGSA
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHEEEEECCCCHHHHHHHCCCC
PMPWPGLAERVAESAAILKARGFTGPLLRADGAIHHAAGASDAQELAAVLAAAVAYLRAL
CCCCCHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
EKAGFSLEEAAGRIEVALTADVNQTATLAKVRAIRLLWGAVLREAGIGAGPLKVHATTAW
HHCCCCHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHH
RSLTRRDPYVNLLRATIAAFAAGVGGADGLTVLPFTQALGLPDAQARRLARNTQLILLEE
HHHHHCCHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHCCCCCHHHHHHHCCCEEEEEEH
SQLHRVADPGAGAGAVEAHTDGLAAAAWDLFRAIEGKGGLAEALASGWWQGELAATRAKR
HHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHH
AKDIATRREPLTGTSEFPILGQSVPEVLAPVPAREEAPNDLALAPQRLAEPFEALRDAAE
HHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
ATGTPQVFLATLGPIAAFTARATFAKALFEAGGLAVTVTDGYADFDALIAAFKASGTAIA
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCEEE
CIASSDEIYEAEAATIAAALKAAGARQVWLAGRGGDLEATWRAAGVDDFIFAGCDVLSVL
EEECCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHH
KKAHGALGIG
HHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8099072 [H]