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The map label for this gene is mutB [H]

Identifier: 158423396

GI number: 158423396

Start: 2023455

End: 2025620

Strand: Reverse

Name: mutB [H]

Synonym: AZC_1772

Alternate gene names: 158423396

Gene position: 2025620-2023455 (Counterclockwise)

Preceding gene: 158423397

Following gene: 158423395

Centisome position: 37.72

GC content: 67.96

Gene sequence:

>2166_bases
ATGACCGCCATGAGCCGCTTGCCCGCCTTTGCCGACATCGAATGGCGCGCGCCGGAGCTTGCCCCGCCGGCGGATGCGCC
CGCGCCCTGGCTGACGCCGGAAGGCATTCCGGTGAAGGGTCTCTATGGTCCGGCGGACATCGCGGGCCTCTCCTTCATCG
ACACCTATCCCGGCATCGCGCCCTTCCTGCGCGGGCCCTACCCCACCATGTATGCGACCCAGCCCTGGACCATCCGGCAA
TATGCCGGCTTCTCCACGGCGGAGGATTCCAACGCCTTCTACCGCCGCAACCTCGCGGCCGGGCAGAAGGGCCTGTCGGT
CGCCTTCGATCTCGCCACCCATCGCGGCTATGACTCGGACCATCCGCGCGTCGCCGGCGACGTCGGCATGGCGGGGGTCG
CCATCGACAGCATCTATGACATGCGCACGCTCTTCTCCGGCATTCCGCTGGACCAGATGAGCGTCTCCATGACCATGAAT
GGCGCGGTGCTGCCCATTCTGGCTCTGTTCGTGGTGGCGGCGGAAGAACAGGGCGTGCCGGCGGCCAAGCTCTCCGGCAC
CATCCAGAACGACATTCTCAAAGAATTCATGGTGCGGAACACCTATATCTATCCGCCCGCACCCTCCATGCGCATCATTT
CCGACATCTTCGCCTTGACATCCAAGGAGATGCCGCGCTTCAACTCCATCTCCATTTCCGGCTACCACATGCAGGAAGCC
GGGGCGACGCAGGACCTGGAGCTCGCCTATACGCTCGCGGACGGCGTCGAATATGTGCGCGCGGGCGCCAAAGCCGGCCT
GCCCATCGACGCCTTCGCGCCGCGCCTTTCGTTCTTCTGGGCCATCGGCATGAACTTCTTCATGGAGGTGGCGAAGCTGC
GCGCCGCGCGCCTCCTGTGGACGCGGCTGATGAGCGATCTCGGGGCCAAGAACCCCAAGTCCCTGCCCCTGCGCACCCAT
TCGCAGACCTCCGGCTGGAGCCTCACGGCGCAGGACGTGTTCAACAACGTCATCCGCACCATGGTGGAAGCCATGGCGGC
AACGCAGGGCCACACCCAGTCGCTGCACACCAATGCGCTGGACGAGGCGCTGGCCCTGCCCACCGACTTCTCCGCCCGCA
TCGCCCGCAACACGCAGATCCTGCTGCAGCAGGAGAGCGGCACCACCCGCCAGATCGACCCCTGGGGCGGCTCCTTCTTC
GTGGAGCGCCTCACCGCCGACCTCGCCGCCAAGGCGTGGGACCATATTCAGGAGGTGGAAGCACTGGGCGGCATGGCGAA
GGCCATCGAGGCCGGCATCCCCAAGCTGCGCATCGAGGAAGCCGCCGCCACCACGCAGGCCCGCATCGACGGCGGCGCGC
AGATCGTGGTGGGCGTCAACAAGTTCAAGCCCGAGCGCGAGACGCCCATCGACGTGCTGAAGGTGGACAATTCCGCCGTC
CGCGCCGCGCAGATCGAGAAGCTGCGCCGCCTGAAGGCGGAGCGCGACCCGCAGGGCGTGGCCGCCGCGCTGGAGGCGCT
GACCAATGGAGCGCGGGGCAACGGCAACCTGCTGGCGCTCGCCATCGACGCCGCCCGCGCCAAGGCGACAGTGGGCGAGA
TTTCGGATGCGCTCGAAGCCGTCTTTGGTCGCCACCGGGCGGAAATCCGCGCCATTTCGGGCGTCTACAAGAGGGAGGCC
GGCGCCATGACCGACAAGGTGGCGCAGGTGCAGCGCCTCACAGAAGCCTTCGAGCACAATGAGGGCCGCCGCCCGCGCAT
CCTCGTCGCCAAGGTGGGACAGGACGGGCACGACCGGGGCCAGAAGGTGATCGCCTCCGCCTTCGCCGATCTCGGCTTCG
ACGTGGACATCGGCCCCCTCTTCGCCACGCCCGAGGAAGCCGCCCGGCAGGCGGTGGAGAATGACGTCCATGTGGTGGGC
ATCTCTTCGCTCGCCGCCGGCCACCTGACGCTCGTGCCCGCGCTCAAGGCGGCGCTGGAGGCGGAGGGGCGCGGCGACAT
CATGGTGGTGGTGGGCGGCGTCGTGCCGCCGCAGGATTATGAGGCGCTGAAAGCCGCCGGCGCGGAAGCCATCTTCCCCC
CCGGCACCGTCATCGCCGACGCCGCCCGCGACCTGCTGGCAACACTCTCCACCCGCCTCGGCCACGCGCAGGAGGCGGCG
GAATAA

Upstream 100 bases:

>100_bases
GCCGCGACAGGAAAACAGGGCCGCGCCCCAACAAGAGCCGCGAAGGCCAATGGAACGGGATGGAACGGGCCGCGCCAACG
CGCACCCGAAATGAGGTAGG

Downstream 100 bases:

>100_bases
GCGCCGAAACCTAGGAAAATGAATAGCGCTCAAATTGACGATGAAGCCCTCCCTTACATCATAGGAACAACAGACAAGCA
ACTATTTGATTCCGGAATGG

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM-alpha [H]

Number of amino acids: Translated: 721; Mature: 720

Protein sequence:

>721_residues
MTAMSRLPAFADIEWRAPELAPPADAPAPWLTPEGIPVKGLYGPADIAGLSFIDTYPGIAPFLRGPYPTMYATQPWTIRQ
YAGFSTAEDSNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVAGDVGMAGVAIDSIYDMRTLFSGIPLDQMSVSMTMN
GAVLPILALFVVAAEEQGVPAAKLSGTIQNDILKEFMVRNTYIYPPAPSMRIISDIFALTSKEMPRFNSISISGYHMQEA
GATQDLELAYTLADGVEYVRAGAKAGLPIDAFAPRLSFFWAIGMNFFMEVAKLRAARLLWTRLMSDLGAKNPKSLPLRTH
SQTSGWSLTAQDVFNNVIRTMVEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQILLQQESGTTRQIDPWGGSFF
VERLTADLAAKAWDHIQEVEALGGMAKAIEAGIPKLRIEEAAATTQARIDGGAQIVVGVNKFKPERETPIDVLKVDNSAV
RAAQIEKLRRLKAERDPQGVAAALEALTNGARGNGNLLALAIDAARAKATVGEISDALEAVFGRHRAEIRAISGVYKREA
GAMTDKVAQVQRLTEAFEHNEGRRPRILVAKVGQDGHDRGQKVIASAFADLGFDVDIGPLFATPEEAARQAVENDVHVVG
ISSLAAGHLTLVPALKAALEAEGRGDIMVVVGGVVPPQDYEALKAAGAEAIFPPGTVIADAARDLLATLSTRLGHAQEAA
E

Sequences:

>Translated_721_residues
MTAMSRLPAFADIEWRAPELAPPADAPAPWLTPEGIPVKGLYGPADIAGLSFIDTYPGIAPFLRGPYPTMYATQPWTIRQ
YAGFSTAEDSNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVAGDVGMAGVAIDSIYDMRTLFSGIPLDQMSVSMTMN
GAVLPILALFVVAAEEQGVPAAKLSGTIQNDILKEFMVRNTYIYPPAPSMRIISDIFALTSKEMPRFNSISISGYHMQEA
GATQDLELAYTLADGVEYVRAGAKAGLPIDAFAPRLSFFWAIGMNFFMEVAKLRAARLLWTRLMSDLGAKNPKSLPLRTH
SQTSGWSLTAQDVFNNVIRTMVEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQILLQQESGTTRQIDPWGGSFF
VERLTADLAAKAWDHIQEVEALGGMAKAIEAGIPKLRIEEAAATTQARIDGGAQIVVGVNKFKPERETPIDVLKVDNSAV
RAAQIEKLRRLKAERDPQGVAAALEALTNGARGNGNLLALAIDAARAKATVGEISDALEAVFGRHRAEIRAISGVYKREA
GAMTDKVAQVQRLTEAFEHNEGRRPRILVAKVGQDGHDRGQKVIASAFADLGFDVDIGPLFATPEEAARQAVENDVHVVG
ISSLAAGHLTLVPALKAALEAEGRGDIMVVVGGVVPPQDYEALKAAGAEAIFPPGTVIADAARDLLATLSTRLGHAQEAA
E
>Mature_720_residues
TAMSRLPAFADIEWRAPELAPPADAPAPWLTPEGIPVKGLYGPADIAGLSFIDTYPGIAPFLRGPYPTMYATQPWTIRQY
AGFSTAEDSNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVAGDVGMAGVAIDSIYDMRTLFSGIPLDQMSVSMTMNG
AVLPILALFVVAAEEQGVPAAKLSGTIQNDILKEFMVRNTYIYPPAPSMRIISDIFALTSKEMPRFNSISISGYHMQEAG
ATQDLELAYTLADGVEYVRAGAKAGLPIDAFAPRLSFFWAIGMNFFMEVAKLRAARLLWTRLMSDLGAKNPKSLPLRTHS
QTSGWSLTAQDVFNNVIRTMVEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQILLQQESGTTRQIDPWGGSFFV
ERLTADLAAKAWDHIQEVEALGGMAKAIEAGIPKLRIEEAAATTQARIDGGAQIVVGVNKFKPERETPIDVLKVDNSAVR
AAQIEKLRRLKAERDPQGVAAALEALTNGARGNGNLLALAIDAARAKATVGEISDALEAVFGRHRAEIRAISGVYKREAG
AMTDKVAQVQRLTEAFEHNEGRRPRILVAKVGQDGHDRGQKVIASAFADLGFDVDIGPLFATPEEAARQAVENDVHVVGI
SSLAAGHLTLVPALKAALEAEGRGDIMVVVGGVVPPQDYEALKAAGAEAIFPPGTVIADAARDLLATLSTRLGHAQEAAE

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthes

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=692, Percent_Identity=62.8612716763006, Blast_Score=895, Evalue=0.0,
Organism=Escherichia coli, GI1789284, Length=683, Percent_Identity=63.3967789165447, Blast_Score=854, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144500, Length=690, Percent_Identity=63.3333333333333, Blast_Score=897, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 77266; Mature: 77135

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00544 METMALONYL_COA_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAMSRLPAFADIEWRAPELAPPADAPAPWLTPEGIPVKGLYGPADIAGLSFIDTYPGIA
CCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHCCCCHH
PFLRGPYPTMYATQPWTIRQYAGFSTAEDSNAFYRRNLAAGQKGLSVAFDLATHRGYDSD
HHHCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHCCCCCCEEEEEHHHHCCCCCC
HPRVAGDVGMAGVAIDSIYDMRTLFSGIPLDQMSVSMTMNGAVLPILALFVVAAEEQGVP
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCC
AAKLSGTIQNDILKEFMVRNTYIYPPAPSMRIISDIFALTSKEMPRFNSISISGYHMQEA
HHHHCCHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHCCCCCCCCEEECCEEECCC
GATQDLELAYTLADGVEYVRAGAKAGLPIDAFAPRLSFFWAIGMNFFMEVAKLRAARLLW
CCCCCHHEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRLMSDLGAKNPKSLPLRTHSQTSGWSLTAQDVFNNVIRTMVEAMAATQGHTQSLHTNAL
HHHHHHHCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
DEALALPTDFSARIARNTQILLQQESGTTRQIDPWGGSFFVERLTADLAAKAWDHIQEVE
HHHHCCCCCCHHHHHCCEEEEEEECCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
ALGGMAKAIEAGIPKLRIEEAAATTQARIDGGAQIVVGVNKFKPERETPIDVLKVDNSAV
HHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCEEEEECCHHH
RAAQIEKLRRLKAERDPQGVAAALEALTNGARGNGNLLALAIDAARAKATVGEISDALEA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHH
VFGRHRAEIRAISGVYKREAGAMTDKVAQVQRLTEAFEHNEGRRPRILVAKVGQDGHDRG
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHH
QKVIASAFADLGFDVDIGPLFATPEEAARQAVENDVHVVGISSLAAGHLTLVPALKAALE
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEEHHHCCCHHHHHHHHHHHHH
AEGRGDIMVVVGGVVPPQDYEALKAAGAEAIFPPGTVIADAARDLLATLSTRLGHAQEAA
CCCCCCEEEEECCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHC
E
C
>Mature Secondary Structure 
TAMSRLPAFADIEWRAPELAPPADAPAPWLTPEGIPVKGLYGPADIAGLSFIDTYPGIA
CCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHCCCCHH
PFLRGPYPTMYATQPWTIRQYAGFSTAEDSNAFYRRNLAAGQKGLSVAFDLATHRGYDSD
HHHCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHCCCCCCEEEEEHHHHCCCCCC
HPRVAGDVGMAGVAIDSIYDMRTLFSGIPLDQMSVSMTMNGAVLPILALFVVAAEEQGVP
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCC
AAKLSGTIQNDILKEFMVRNTYIYPPAPSMRIISDIFALTSKEMPRFNSISISGYHMQEA
HHHHCCHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHCCCCCCCCEEECCEEECCC
GATQDLELAYTLADGVEYVRAGAKAGLPIDAFAPRLSFFWAIGMNFFMEVAKLRAARLLW
CCCCCHHEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRLMSDLGAKNPKSLPLRTHSQTSGWSLTAQDVFNNVIRTMVEAMAATQGHTQSLHTNAL
HHHHHHHCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
DEALALPTDFSARIARNTQILLQQESGTTRQIDPWGGSFFVERLTADLAAKAWDHIQEVE
HHHHCCCCCCHHHHHCCEEEEEEECCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
ALGGMAKAIEAGIPKLRIEEAAATTQARIDGGAQIVVGVNKFKPERETPIDVLKVDNSAV
HHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCEEEEECCHHH
RAAQIEKLRRLKAERDPQGVAAALEALTNGARGNGNLLALAIDAARAKATVGEISDALEA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHH
VFGRHRAEIRAISGVYKREAGAMTDKVAQVQRLTEAFEHNEGRRPRILVAKVGQDGHDRG
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHH
QKVIASAFADLGFDVDIGPLFATPEEAARQAVENDVHVVGISSLAAGHLTLVPALKAALE
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEEHHHCCCHHHHHHHHHHHHH
AEGRGDIMVVVGGVVPPQDYEALKAAGAEAIFPPGTVIADAARDLLATLSTRLGHAQEAA
CCCCCCEEEEECCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHC
E
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8099072 [H]