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The map label for this gene is nqo12 [H]

Identifier: 158423303

GI number: 158423303

Start: 1919472

End: 1921397

Strand: Direct

Name: nqo12 [H]

Synonym: AZC_1679

Alternate gene names: 158423303

Gene position: 1919472-1921397 (Clockwise)

Preceding gene: 158423302

Following gene: 158423304

Centisome position: 35.75

GC content: 63.97

Gene sequence:

>1926_bases
ATGTATCAGGCCATCGTCTTCCTGCCGCTCATCGGCTTCCTGATCGCCGGTCTTTTCGGCCGCGTTCTGGGTCCGCGCCC
GTCGGAACTCATCACCACGGCGCTGCTGTTCATCGCCTGCCTGTTCGCCTGGATCACCTTCATCAAGGTCGGCTTCGCGG
GCTTCGACACCCGCGTGCAGGTGATGCACTGGATCTATGTGGGCGACCTCAAGATCGACTGGGCGCTGCGCATCGACACC
ATGACCGCGATCATGCTGATCGTCGTCACCTCCGTGTCCTCGCTGGTTCACCTCTATTCCATCGGCTACATGCACGAGGA
TCCGAGCCGGCCGCGCTTCTTCGCCTATCTCTCGCTCTTCACCTTCGCCATGCTGATGCTGGTGACGGCCGACAACCTCG
TCCAGCTGTTCTTCGGCTGGGAAGGCGTGGGCCTCGCCTCCTACCTGCTCATCGGCTTCTGGTTCGAGAAGCCCTCGGCG
AACGCGGCGGCCATGAAGGCCTTCGTGGTCAACCGCGTGGGTGACTTCGGCTTCATGCTCGGCATCTTCGCCGTGTTCGT
GATGACCGGCTCGGTGAGCTTCGACACCATCTTCGCCCAGGCCCCGAGCCTGGCCGGCAAGACGATCACCTTCCTCGGCC
ACCATTGGGATGCGCCGACGGTGATCGCCCTGCTGCTGTTCATCGGCGCCATGGGCAAGTCGGCCCAGTTCCTGCTGCAT
ACCTGGCTCCCGGACGCCATGGAAGGCCCGACCCCGGTCTCGGCCCTCATCCATGCCGCGACCATGGTGACCGCCGGCGT
GTTCATGGTGGCGCGCATGTCGCCCATCTTCGAGCTGTCGCCGTCCGCTCTCGACGTGGTGACAATCGTGGGCGCCACCA
CGGCCATGTTCGCGGCGACCGTCGCGCTGGTGCAGAACGACATCAAGAAGGTCATCGCCTACTCGACCTGCTCGCAGCTC
GGCTACATGTTCGTGGCCATGGGCGCGGGCGCCTATTCGGTCGGCGTGTTCCACCTCTTCACGCACGCCTTCTTCAAGGC
GCTGCTGTTCCTCGGGGCCGGCTCGGTCATCCACGCGATGCACCACGAGCAGGACATGCGCCACATGGGCGGGCTCTATA
AGAAGATCCCCTTCACCTATGGCGCCATGATGATCGGGACGCTGGCCATCACCGGCTTCCCCTTCCTCGCCGGCTACTAC
TCCAAGGACGCCATCATCGAGGCGGCCTATGCCAGCCACTCGCACTTCCGGGTCTATGCCTACTGGATGACGGTGCTGGC
GGCGGCGCTCACCTCCTTCTACTCGTGGCGCCTCGTGTTCCTGACCTTCCACGGTCATCCGCACGACCACCACCATTACG
ACCACGCGCACGAGAGCCCGCTGGTGATGACCATCCCGCTCGCCGTGCTCAGCGTCGGCGCGGTGATCGCGGGATTCGTC
TGCTACAACCTCTTCGTCGGCCACGACGTGGAGCACTTCTTCCGCAGCTCCATCTTCATGGGTCCGGACAACCACATCCT
CCACGCCATGCATGAGGTGCCCGGCTGGGCCGCCTACATGCCCACCGTGATGATGGTGCTGGGCTTCGTGGTGGCCTACT
GGTTCTACATGGTGGACCGCCGGGTGCCGGCCGCCCTCGCCAAGAGCCAGGACGCGCTGTACCAGTTCCTGCTGAACAAG
TGGTACATCGACGAGCTGTACAACTTCCTGTTCGTGCGTCCGGCGCTCTGCCTCGGCCGCATCCTCTGGAAGAAGGGTGA
CGGCGCCATCATCGACGGCCTCGGCCCGAACGGCATCTCCGCCCGCGTGCTGGATGTCACCGGACAGCTGGTCCGGCTGC
AGACCGGCTACCTCTACCACTATGCGTTCGTGATGCTGGTCGGCGTTGCCGCCATCATCACCTGGTTCATGTTCGCCGGA
GTGTGA

Upstream 100 bases:

>100_bases
GCCGCCGAGGCGGCCATCGGCCTCGCCATCCTCGTGGTGTTCTTCCGCAACCGCGGATCGATCGCCGTCGAGGACATCAA
TGCCATGAAGGGCTGAGGGC

Downstream 100 bases:

>100_bases
CGATGTCCAACTGGCCGATCCTCTCCGTCGTCACCTTCCTGCCGCTGGTGGGTGCGCTGTTCATCTTCGTCGTGCGCGGC
GAGGATGAGGTCGCGGCGCG

Product: NADH-plastoquinone oxidoreductase chain 5 protein

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 12; NDH-1, chain 12 [H]

Number of amino acids: Translated: 641; Mature: 641

Protein sequence:

>641_residues
MYQAIVFLPLIGFLIAGLFGRVLGPRPSELITTALLFIACLFAWITFIKVGFAGFDTRVQVMHWIYVGDLKIDWALRIDT
MTAIMLIVVTSVSSLVHLYSIGYMHEDPSRPRFFAYLSLFTFAMLMLVTADNLVQLFFGWEGVGLASYLLIGFWFEKPSA
NAAAMKAFVVNRVGDFGFMLGIFAVFVMTGSVSFDTIFAQAPSLAGKTITFLGHHWDAPTVIALLLFIGAMGKSAQFLLH
TWLPDAMEGPTPVSALIHAATMVTAGVFMVARMSPIFELSPSALDVVTIVGATTAMFAATVALVQNDIKKVIAYSTCSQL
GYMFVAMGAGAYSVGVFHLFTHAFFKALLFLGAGSVIHAMHHEQDMRHMGGLYKKIPFTYGAMMIGTLAITGFPFLAGYY
SKDAIIEAAYASHSHFRVYAYWMTVLAAALTSFYSWRLVFLTFHGHPHDHHHYDHAHESPLVMTIPLAVLSVGAVIAGFV
CYNLFVGHDVEHFFRSSIFMGPDNHILHAMHEVPGWAAYMPTVMMVLGFVVAYWFYMVDRRVPAALAKSQDALYQFLLNK
WYIDELYNFLFVRPALCLGRILWKKGDGAIIDGLGPNGISARVLDVTGQLVRLQTGYLYHYAFVMLVGVAAIITWFMFAG
V

Sequences:

>Translated_641_residues
MYQAIVFLPLIGFLIAGLFGRVLGPRPSELITTALLFIACLFAWITFIKVGFAGFDTRVQVMHWIYVGDLKIDWALRIDT
MTAIMLIVVTSVSSLVHLYSIGYMHEDPSRPRFFAYLSLFTFAMLMLVTADNLVQLFFGWEGVGLASYLLIGFWFEKPSA
NAAAMKAFVVNRVGDFGFMLGIFAVFVMTGSVSFDTIFAQAPSLAGKTITFLGHHWDAPTVIALLLFIGAMGKSAQFLLH
TWLPDAMEGPTPVSALIHAATMVTAGVFMVARMSPIFELSPSALDVVTIVGATTAMFAATVALVQNDIKKVIAYSTCSQL
GYMFVAMGAGAYSVGVFHLFTHAFFKALLFLGAGSVIHAMHHEQDMRHMGGLYKKIPFTYGAMMIGTLAITGFPFLAGYY
SKDAIIEAAYASHSHFRVYAYWMTVLAAALTSFYSWRLVFLTFHGHPHDHHHYDHAHESPLVMTIPLAVLSVGAVIAGFV
CYNLFVGHDVEHFFRSSIFMGPDNHILHAMHEVPGWAAYMPTVMMVLGFVVAYWFYMVDRRVPAALAKSQDALYQFLLNK
WYIDELYNFLFVRPALCLGRILWKKGDGAIIDGLGPNGISARVLDVTGQLVRLQTGYLYHYAFVMLVGVAAIITWFMFAG
V
>Mature_641_residues
MYQAIVFLPLIGFLIAGLFGRVLGPRPSELITTALLFIACLFAWITFIKVGFAGFDTRVQVMHWIYVGDLKIDWALRIDT
MTAIMLIVVTSVSSLVHLYSIGYMHEDPSRPRFFAYLSLFTFAMLMLVTADNLVQLFFGWEGVGLASYLLIGFWFEKPSA
NAAAMKAFVVNRVGDFGFMLGIFAVFVMTGSVSFDTIFAQAPSLAGKTITFLGHHWDAPTVIALLLFIGAMGKSAQFLLH
TWLPDAMEGPTPVSALIHAATMVTAGVFMVARMSPIFELSPSALDVVTIVGATTAMFAATVALVQNDIKKVIAYSTCSQL
GYMFVAMGAGAYSVGVFHLFTHAFFKALLFLGAGSVIHAMHHEQDMRHMGGLYKKIPFTYGAMMIGTLAITGFPFLAGYY
SKDAIIEAAYASHSHFRVYAYWMTVLAAALTSFYSWRLVFLTFHGHPHDHHHYDHAHESPLVMTIPLAVLSVGAVIAGFV
CYNLFVGHDVEHFFRSSIFMGPDNHILHAMHEVPGWAAYMPTVMMVLGFVVAYWFYMVDRRVPAALAKSQDALYQFLLNK
WYIDELYNFLFVRPALCLGRILWKKGDGAIIDGLGPNGISARVLDVTGQLVRLQTGYLYHYAFVMLVGVAAIITWFMFAG
V

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=452, Percent_Identity=41.3716814159292, Blast_Score=327, Evalue=2e-89,
Organism=Escherichia coli, GI1788614, Length=645, Percent_Identity=38.1395348837209, Blast_Score=367, Evalue=1e-102,
Organism=Escherichia coli, GI1788829, Length=441, Percent_Identity=28.3446712018141, Blast_Score=145, Evalue=1e-35,
Organism=Escherichia coli, GI1788827, Length=435, Percent_Identity=27.3563218390805, Blast_Score=132, Evalue=8e-32,
Organism=Escherichia coli, GI1788831, Length=356, Percent_Identity=30.0561797752809, Blast_Score=119, Evalue=8e-28,
Organism=Escherichia coli, GI2367154, Length=211, Percent_Identity=28.436018957346, Blast_Score=90, Evalue=5e-19,
Organism=Escherichia coli, GI145693160, Length=409, Percent_Identity=22.7383863080685, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788613, Length=410, Percent_Identity=25.1219512195122, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 70997; Mature: 70997

Theoretical pI: Translated: 7.52; Mature: 7.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQAIVFLPLIGFLIAGLFGRVLGPRPSELITTALLFIACLFAWITFIKVGFAGFDTRVQ
CCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEE
VMHWIYVGDLKIDWALRIDTMTAIMLIVVTSVSSLVHLYSIGYMHEDPSRPRFFAYLSLF
EEEEEEEECEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
TFAMLMLVTADNLVQLFFGWEGVGLASYLLIGFWFEKPSANAAAMKAFVVNRVGDFGFML
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHH
GIFAVFVMTGSVSFDTIFAQAPSLAGKTITFLGHHWDAPTVIALLLFIGAMGKSAQFLLH
HHHHHHHHHCCCCHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHH
TWLPDAMEGPTPVSALIHAATMVTAGVFMVARMSPIFELSPSALDVVTIVGATTAMFAAT
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHH
VALVQNDIKKVIAYSTCSQLGYMFVAMGAGAYSVGVFHLFTHAFFKALLFLGAGSVIHAM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
HHEQDMRHMGGLYKKIPFTYGAMMIGTLAITGFPFLAGYYSKDAIIEAAYASHSHFRVYA
HHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHH
YWMTVLAAALTSFYSWRLVFLTFHGHPHDHHHYDHAHESPLVMTIPLAVLSVGAVIAGFV
HHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHH
CYNLFVGHDVEHFFRSSIFMGPDNHILHAMHEVPGWAAYMPTVMMVLGFVVAYWFYMVDR
HHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RVPAALAKSQDALYQFLLNKWYIDELYNFLFVRPALCLGRILWKKGDGAIIDGLGPNGIS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCC
ARVLDVTGQLVRLQTGYLYHYAFVMLVGVAAIITWFMFAGV
EEEEECCCCHHHHEHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYQAIVFLPLIGFLIAGLFGRVLGPRPSELITTALLFIACLFAWITFIKVGFAGFDTRVQ
CCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEE
VMHWIYVGDLKIDWALRIDTMTAIMLIVVTSVSSLVHLYSIGYMHEDPSRPRFFAYLSLF
EEEEEEEECEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
TFAMLMLVTADNLVQLFFGWEGVGLASYLLIGFWFEKPSANAAAMKAFVVNRVGDFGFML
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHH
GIFAVFVMTGSVSFDTIFAQAPSLAGKTITFLGHHWDAPTVIALLLFIGAMGKSAQFLLH
HHHHHHHHHCCCCHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHH
TWLPDAMEGPTPVSALIHAATMVTAGVFMVARMSPIFELSPSALDVVTIVGATTAMFAAT
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHH
VALVQNDIKKVIAYSTCSQLGYMFVAMGAGAYSVGVFHLFTHAFFKALLFLGAGSVIHAM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
HHEQDMRHMGGLYKKIPFTYGAMMIGTLAITGFPFLAGYYSKDAIIEAAYASHSHFRVYA
HHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHH
YWMTVLAAALTSFYSWRLVFLTFHGHPHDHHHYDHAHESPLVMTIPLAVLSVGAVIAGFV
HHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHH
CYNLFVGHDVEHFFRSSIFMGPDNHILHAMHEVPGWAAYMPTVMMVLGFVVAYWFYMVDR
HHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RVPAALAKSQDALYQFLLNKWYIDELYNFLFVRPALCLGRILWKKGDGAIIDGLGPNGIS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCC
ARVLDVTGQLVRLQTGYLYHYAFVMLVGVAAIITWFMFAGV
EEEEECCCCHHHHEHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8422400 [H]