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The map label for this gene is lldD [H]

Identifier: 158423243

GI number: 158423243

Start: 1848179

End: 1849315

Strand: Reverse

Name: lldD [H]

Synonym: AZC_1619

Alternate gene names: 158423243

Gene position: 1849315-1848179 (Counterclockwise)

Preceding gene: 158423244

Following gene: 158423242

Centisome position: 34.44

GC content: 71.77

Gene sequence:

>1137_bases
TTGTCCTTTCCTGCTCCCGCGCCTGGCGAAAATCCCATGCAGCTGCATCTGCCGGAAGCCTATGACCTGAGCGACTACGA
GGCTCTGGCGCGCGAGCGCGTGCCGGCGGCGAGCTGGGCCTACCTCGCCGCCGCCGCGGGGGACGGCCTGACCAACGCCG
CCAACCGCGCCGCCTATGACCGGCTGCGCCTGCTGCCGCGCGTGCTCAGCGACCTGTCCAAGGCCACGACGCGCATCAAC
CTGATGGGGTTTGCGCTGGAGCACCCCATCCTGCTGGCGCCGGTCGCCTACCATCGCCTGTTCCATCCCGATGGAGAGCT
GGCGACCGCCCAGGGTGCCGCCATCGCGCAGGCGCCGCTGGTGGTGAGCACGCAGGCCAGCACCAGCCTCGAGGAGGTGC
GGGCGGCGAGCCGGGGGCAGCTCTGGTTCCAGCTCTACATCCAGCCGGACTGGGGTTTCACCGTGAACCTGCTGCGGCGG
GCGGAGGCCGCCGGCTACAGCGCCGTGGTGCTGACGGTGGACGCGCCGGTGAGCCTGCGCACGCAGGAGCGGCGGGCCGG
CTTTTCCCTGCCGCCGGGTGTCGAGGCGGTGAATCTCGCCGGCCTGAAGCCGCGCCCCCTGCACAGCGGCGGCATCGGAT
CGAGCCCGCTGTTCGGCACCGCCCTGCCCCATACGCCGCTCTGGGGCGACGTGGCGCGGCTGCGCAGCCTGACCCGCCTG
CCCATCCTGCTGAAGGGCGTGCTCGCGCCGGACGATGCGTCCCGCGCCCTTGCGGAGGGCGTGGACGGCATCATCGTCTC
CAACCACGGCGGACGGGTCCTCGACAGCCTCCCGGCCTCCATCGAGGCCCTGCCGCGCATCGTGGAGACGCTGGAAGGGC
GCATTCCCGTTCTGGTGGACGGCGGCATCCGCCGGGGCACCGACATCCTCAAGGCCATGGCGCTGGGCGCCAATGCGGTG
ATGATCGGGCGGCCCTATATCCACGCCTTGGCGGTGGCCGGGGCGGCGGGTGTCGCCCATGCCATGCATGTGCTGCGGGC
GGAGCTGGAAGTGGCCATGGCGCTCACCGGACGGCCGACGCTGGATACGGTGAACCGCAGCATCCTGTTCGATCCACCGG
CGCCTCCCGCCCCCTAA

Upstream 100 bases:

>100_bases
CAGCGCCGTCCGCGAGAAGGTGACGGAGGCCGTTTTCGTGATGGTGGCGCTTGATGCCGAGGGGCGCCCGCGTCCGGTGT
CTCCGGCCTGAGACGGCGGT

Downstream 100 bases:

>100_bases
GGCCCGCGGCCCCGCGTCTTCGCAACCACTCCGTAATCTCACGGGCTGGCGGGCAGCGCCCCATGCGCCAGAATGGCGTA
TTCGTGCGTGGAGCCCGCAA

Product: FMN-dependent alpha-hydroxy acid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 377

Protein sequence:

>378_residues
MSFPAPAPGENPMQLHLPEAYDLSDYEALARERVPAASWAYLAAAAGDGLTNAANRAAYDRLRLLPRVLSDLSKATTRIN
LMGFALEHPILLAPVAYHRLFHPDGELATAQGAAIAQAPLVVSTQASTSLEEVRAASRGQLWFQLYIQPDWGFTVNLLRR
AEAAGYSAVVLTVDAPVSLRTQERRAGFSLPPGVEAVNLAGLKPRPLHSGGIGSSPLFGTALPHTPLWGDVARLRSLTRL
PILLKGVLAPDDASRALAEGVDGIIVSNHGGRVLDSLPASIEALPRIVETLEGRIPVLVDGGIRRGTDILKAMALGANAV
MIGRPYIHALAVAGAAGVAHAMHVLRAELEVAMALTGRPTLDTVNRSILFDPPAPPAP

Sequences:

>Translated_378_residues
MSFPAPAPGENPMQLHLPEAYDLSDYEALARERVPAASWAYLAAAAGDGLTNAANRAAYDRLRLLPRVLSDLSKATTRIN
LMGFALEHPILLAPVAYHRLFHPDGELATAQGAAIAQAPLVVSTQASTSLEEVRAASRGQLWFQLYIQPDWGFTVNLLRR
AEAAGYSAVVLTVDAPVSLRTQERRAGFSLPPGVEAVNLAGLKPRPLHSGGIGSSPLFGTALPHTPLWGDVARLRSLTRL
PILLKGVLAPDDASRALAEGVDGIIVSNHGGRVLDSLPASIEALPRIVETLEGRIPVLVDGGIRRGTDILKAMALGANAV
MIGRPYIHALAVAGAAGVAHAMHVLRAELEVAMALTGRPTLDTVNRSILFDPPAPPAP
>Mature_377_residues
SFPAPAPGENPMQLHLPEAYDLSDYEALARERVPAASWAYLAAAAGDGLTNAANRAAYDRLRLLPRVLSDLSKATTRINL
MGFALEHPILLAPVAYHRLFHPDGELATAQGAAIAQAPLVVSTQASTSLEEVRAASRGQLWFQLYIQPDWGFTVNLLRRA
EAAGYSAVVLTVDAPVSLRTQERRAGFSLPPGVEAVNLAGLKPRPLHSGGIGSSPLFGTALPHTPLWGDVARLRSLTRLP
ILLKGVLAPDDASRALAEGVDGIIVSNHGGRVLDSLPASIEALPRIVETLEGRIPVLVDGGIRRGTDILKAMALGANAVM
IGRPYIHALAVAGAAGVAHAMHVLRAELEVAMALTGRPTLDTVNRSILFDPPAPPAP

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI54234014, Length=362, Percent_Identity=40.0552486187845, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI7705393, Length=362, Percent_Identity=40.0552486187845, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI11068137, Length=363, Percent_Identity=38.0165289256198, Blast_Score=254, Evalue=1e-67,
Organism=Escherichia coli, GI1790033, Length=369, Percent_Identity=34.6883468834688, Blast_Score=201, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI193208036, Length=348, Percent_Identity=36.7816091954023, Blast_Score=225, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI32566217, Length=267, Percent_Identity=33.7078651685393, Blast_Score=151, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6323587, Length=357, Percent_Identity=34.733893557423, Blast_Score=209, Evalue=5e-55,
Organism=Drosophila melanogaster, GI281363140, Length=352, Percent_Identity=39.4886363636364, Blast_Score=236, Evalue=1e-62,
Organism=Drosophila melanogaster, GI78707190, Length=352, Percent_Identity=39.4886363636364, Blast_Score=236, Evalue=1e-62,
Organism=Drosophila melanogaster, GI78707188, Length=352, Percent_Identity=39.4886363636364, Blast_Score=236, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 39912; Mature: 39781

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFPAPAPGENPMQLHLPEAYDLSDYEALARERVPAASWAYLAAAAGDGLTNAANRAAYD
CCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHH
RLRLLPRVLSDLSKATTRINLMGFALEHPILLAPVAYHRLFHPDGELATAQGAAIAQAPL
HHHHHHHHHHHHHHHHHEEEEEEEECCCCEEEEHHHHHHHCCCCCCEEECCCCHHHHCCE
VVSTQASTSLEEVRAASRGQLWFQLYIQPDWGFTVNLLRRAEAAGYSAVVLTVDAPVSLR
EEECCCHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCCCC
TQERRAGFSLPPGVEAVNLAGLKPRPLHSGGIGSSPLFGTALPHTPLWGDVARLRSLTRL
CHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
PILLKGVLAPDDASRALAEGVDGIIVSNHGGRVLDSLPASIEALPRIVETLEGRIPVLVD
HHHHHHCCCCCHHHHHHHCCCCEEEEECCCCHHHHHCCHHHHHHHHHHHHHCCCCCEEEC
GGIRRGTDILKAMALGANAVMIGRPYIHALAVAGAAGVAHAMHVLRAELEVAMALTGRPT
CCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCC
LDTVNRSILFDPPAPPAP
HHHCCCEEEECCCCCCCC
>Mature Secondary Structure 
SFPAPAPGENPMQLHLPEAYDLSDYEALARERVPAASWAYLAAAAGDGLTNAANRAAYD
CCCCCCCCCCCEEEECCCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHH
RLRLLPRVLSDLSKATTRINLMGFALEHPILLAPVAYHRLFHPDGELATAQGAAIAQAPL
HHHHHHHHHHHHHHHHHEEEEEEEECCCCEEEEHHHHHHHCCCCCCEEECCCCHHHHCCE
VVSTQASTSLEEVRAASRGQLWFQLYIQPDWGFTVNLLRRAEAAGYSAVVLTVDAPVSLR
EEECCCHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCCCC
TQERRAGFSLPPGVEAVNLAGLKPRPLHSGGIGSSPLFGTALPHTPLWGDVARLRSLTRL
CHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
PILLKGVLAPDDASRALAEGVDGIIVSNHGGRVLDSLPASIEALPRIVETLEGRIPVLVD
HHHHHHCCCCCHHHHHHHCCCCEEEEECCCCHHHHHCCHHHHHHHHHHHHHCCCCCEEEC
GGIRRGTDILKAMALGANAVMIGRPYIHALAVAGAAGVAHAMHVLRAELEVAMALTGRPT
CCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCC
LDTVNRSILFDPPAPPAP
HHHCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA