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The map label for this gene is galE [C]

Identifier: 158423146

GI number: 158423146

Start: 1732203

End: 1733165

Strand: Direct

Name: galE [C]

Synonym: AZC_1522

Alternate gene names: 158423146

Gene position: 1732203-1733165 (Clockwise)

Preceding gene: 158423145

Following gene: 158423148

Centisome position: 32.26

GC content: 65.21

Gene sequence:

>963_bases
ATGGTCGAGCACCATCTCATTCTGGGGGGCTGTGGCTTTATCGGACGCCATGTGGCGATCCTGCTGGCACGGGCGGGACA
TAAGGTCATCCTGGCGGACCGGGTGCCGCTGTCCTTCGGATTTGATGACGATGTGGCCGGCTCCATCGCTTGGAGTCCGT
TCGATCTTGCCACCGCAGACTGGGATGACCTGATCGCCGGCATCGACGTCATCCATCATTATGCCTGGGCGTCGATCCCG
TCTTCCGCCAATGCCGATCCCGGCGCCGACATGAAGGGCAACGTACTGCCGACCATCGCCCTGCTGGATGCGATGCGGGC
CCGTCAGGAAGAGCGGAAGCGGCGCCTCGTTTTCTCGTCGTCGGGTGGCACGGTCTACGGGCGTCTGCACCGCGTGCCGG
TGCGAGAGGATCATGCGCTCAGTCCGCTGAACGCCTATGGTGCCGGCAAGGCTGCCGCCGAGCTGTATATCTCCACCTAC
AGCAATCTCCATGGGCTCGACACGCGCATCGCCCGCCTCTCCAATCCATTCGGTGCGGGTCAGAACCTGGCGCGCGGGCA
GGGGGCGGCGACCACCTTTCTGGCTCGGGCCATCAATAATGAGCAGATCGTCATCTGGGGTGATGGCGAGGTGGTGCGCG
ATTATGTCCACATCGCCGACGCTGCGGCGGGGCTGGTGGCGCTGGCCTGCGCCAACAGTGTTGGCGCGTCGCACACCTTC
AACATCGGCTCGGGGCAAGGCGTGACCCTCAACGCGATCATCGCGGAACTGGAGACGGAACTCGGCCGGCCGCTGGATGT
GCGCTACGAGCCGGCACGCCCCTACGACGTGCCGGTCAGCGTTCTGGATATCTCCGCCGCGCACGCCGCCCTCGGTTGGC
GGCCGCGGCTCAGCTTTGCGGAAGGGATCAGGCTCACCCTCGCCGATCTGGCGGCGGGTCACGCCTTCTCTTCATTGCGG
TGA

Upstream 100 bases:

>100_bases
CTGCCGTGGCCCGACGCCATCATCGGGTTGGGACGCTCTCCGGCTTCCTGACGTCTTCCGCCGGCGCCCACCCTGAACAA
TTACGACGGATTACCAAGAC

Downstream 100 bases:

>100_bases
AAAGGGGGGGGCATGCTGCCCCTCTCCGTCTCACTCCACTGAGGCAACATACGACCGGAAGCTGCCGAAGGCGGTGATGT
CCGGGCAGCCGTGCGTGGCG

Product: NAD-dependent epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MVEHHLILGGCGFIGRHVAILLARAGHKVILADRVPLSFGFDDDVAGSIAWSPFDLATADWDDLIAGIDVIHHYAWASIP
SSANADPGADMKGNVLPTIALLDAMRARQEERKRRLVFSSSGGTVYGRLHRVPVREDHALSPLNAYGAGKAAAELYISTY
SNLHGLDTRIARLSNPFGAGQNLARGQGAATTFLARAINNEQIVIWGDGEVVRDYVHIADAAAGLVALACANSVGASHTF
NIGSGQGVTLNAIIAELETELGRPLDVRYEPARPYDVPVSVLDISAAHAALGWRPRLSFAEGIRLTLADLAAGHAFSSLR

Sequences:

>Translated_320_residues
MVEHHLILGGCGFIGRHVAILLARAGHKVILADRVPLSFGFDDDVAGSIAWSPFDLATADWDDLIAGIDVIHHYAWASIP
SSANADPGADMKGNVLPTIALLDAMRARQEERKRRLVFSSSGGTVYGRLHRVPVREDHALSPLNAYGAGKAAAELYISTY
SNLHGLDTRIARLSNPFGAGQNLARGQGAATTFLARAINNEQIVIWGDGEVVRDYVHIADAAAGLVALACANSVGASHTF
NIGSGQGVTLNAIIAELETELGRPLDVRYEPARPYDVPVSVLDISAAHAALGWRPRLSFAEGIRLTLADLAAGHAFSSLR
>Mature_320_residues
MVEHHLILGGCGFIGRHVAILLARAGHKVILADRVPLSFGFDDDVAGSIAWSPFDLATADWDDLIAGIDVIHHYAWASIP
SSANADPGADMKGNVLPTIALLDAMRARQEERKRRLVFSSSGGTVYGRLHRVPVREDHALSPLNAYGAGKAAAELYISTY
SNLHGLDTRIARLSNPFGAGQNLARGQGAATTFLARAINNEQIVIWGDGEVVRDYVHIADAAAGLVALACANSVGASHTF
NIGSGQGVTLNAIIAELETELGRPLDVRYEPARPYDVPVSVLDISAAHAALGWRPRLSFAEGIRLTLADLAAGHAFSSLR

Specific function: Galactose metabolism; third step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=307, Percent_Identity=27.3615635179153, Blast_Score=104, Evalue=9e-23,
Organism=Homo sapiens, GI56237023, Length=325, Percent_Identity=26.4615384615385, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI56118217, Length=325, Percent_Identity=26.4615384615385, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI189083684, Length=325, Percent_Identity=26.4615384615385, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI1786974, Length=315, Percent_Identity=26.984126984127, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI48994969, Length=329, Percent_Identity=25.8358662613982, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1788353, Length=334, Percent_Identity=24.251497005988, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788365, Length=215, Percent_Identity=25.5813953488372, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17539532, Length=319, Percent_Identity=25.705329153605, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI115532424, Length=331, Percent_Identity=27.4924471299094, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17568069, Length=322, Percent_Identity=23.6024844720497, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71982038, Length=337, Percent_Identity=26.7062314540059, Blast_Score=74, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6319493, Length=337, Percent_Identity=27.0029673590504, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21356223, Length=309, Percent_Identity=25.8899676375405, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 34007; Mature: 34007

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00061 ADH_SHORT ; PS00435 PEROXIDASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEHHLILGGCGFIGRHVAILLARAGHKVILADRVPLSFGFDDDVAGSIAWSPFDLATAD
CCCCEEEEECCHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCCEECCCCCCCCCC
WDDLIAGIDVIHHYAWASIPSSANADPGADMKGNVLPTIALLDAMRARQEERKRRLVFSS
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEC
SGGTVYGRLHRVPVREDHALSPLNAYGAGKAAAELYISTYSNLHGLDTRIARLSNPFGAG
CCCEEEEEEEECCCCCCCCCCCCHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCC
QNLARGQGAATTFLARAINNEQIVIWGDGEVVRDYVHIADAAAGLVALACANSVGASHTF
CCCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
NIGSGQGVTLNAIIAELETELGRPLDVRYEPARPYDVPVSVLDISAAHAALGWRPRLSFA
ECCCCCCEEHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEEHHHHHHCCCCCCCHHH
EGIRLTLADLAAGHAFSSLR
CCCEEEEHHHHHCCHHHCCC
>Mature Secondary Structure
MVEHHLILGGCGFIGRHVAILLARAGHKVILADRVPLSFGFDDDVAGSIAWSPFDLATAD
CCCCEEEEECCHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCCEECCCCCCCCCC
WDDLIAGIDVIHHYAWASIPSSANADPGADMKGNVLPTIALLDAMRARQEERKRRLVFSS
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEC
SGGTVYGRLHRVPVREDHALSPLNAYGAGKAAAELYISTYSNLHGLDTRIARLSNPFGAG
CCCEEEEEEEECCCCCCCCCCCCHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCC
QNLARGQGAATTFLARAINNEQIVIWGDGEVVRDYVHIADAAAGLVALACANSVGASHTF
CCCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
NIGSGQGVTLNAIIAELETELGRPLDVRYEPARPYDVPVSVLDISAAHAALGWRPRLSFA
ECCCCCCEEHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEEHHHHHHCCCCCCCHHH
EGIRLTLADLAAGHAFSSLR
CCCEEEEHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]