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The map label for this gene is moaA [H]

Identifier: 158423054

GI number: 158423054

Start: 1631368

End: 1632369

Strand: Direct

Name: moaA [H]

Synonym: AZC_1430

Alternate gene names: 158423054

Gene position: 1631368-1632369 (Clockwise)

Preceding gene: 158423053

Following gene: 158423055

Centisome position: 30.38

GC content: 68.86

Gene sequence:

>1002_bases
ATGACCCGCTGCGGGCTTGTCGATCTCTTCGGCCGGCGGGTTTCCTATCTCAGGCTGTCGGTGACGGACCGGTGCGACCT
GCGCTGTGTCTATTGCATGGCCGAGGACATGGCCTTCGTGCCGCGCAACCAGTTGCTCACGCTGGAGGAACTGGATCGTC
TCGCTTCCGCCTTCGTGGCGCGGGGCGTTGCGAAGATCCGCCTCACGGGTGGGGAGCCGCTGGTGCGCAAGGGCTTGATG
GAGCTAGTCTCCAGCCTGTCGCGTCACCTCGCCGCCCGCCGGCTCAAGGAACTGACGCTCACCACGAACGGGAGCCTGCT
CGCCCGCCATGCGGACGGGCTCGCCCGTGCCGGTGTGCGCCGGGTCAATGTGTCGCTCGACACGCTTGATGCGTCCCGCT
TTCGCGCGCTGACCCGGCGGGGCACGCTCGGTGTTGTCATGGAGGGGCTCTTGGCGGCGCAGGAGGCCGGGTTGAAGGTG
AAGCTCAATGCGGTGGCGCTGAAGGGCAGCACGGAAGACGAGATCCACGATCTCATCGCCTTCGCCCATGGCCGGGGCAT
GGACCTCACCCTCATCGAGACCATGCCGCTCGGCGATGTGGGCGCGGACCGGACGGACCAGTATTTATCCCTCGCCACGC
TGCGCCGGACCATCGAGACCCGCTGGACGCTGACCGACACCGCCGACCGCAGCGGCGGCCCTGCGCGCTATGCGCGGGTG
GCGGAGACCGGCGGGCGCATCGGCTTCATCACGCCGCTGACCCATAGCTTCTGCGAGACCTGCAACCGCGTGCGGGTGAG
CGCGACGGGCGTCCTCTACACCTGCCTCGGGCAGGAGGATCAGGTGGACCTGCGCGCGCCGCTGCGGGCCTGCGAGGGGG
ACGAGGCGCTCCACGCCGCCATTGATGCGGGCATCCGAGCGAAGCCCCGCGGCCATGATTTCGCGATTGCCCGCAATGGC
GCGCCCGCGCTGGCGCGGCACATGTCTGTGCTGGGAGGTTGA

Upstream 100 bases:

>100_bases
ATCATTTCGTCCAGCTCATGGGCATCATGAACCAGGCCAAAGATCCCGGCCTTGCCGCCGTGAAGGCCATCCTCGCCGCC
ACCTTGCCGGAGGGCGTCGC

Downstream 100 bases:

>100_bases
ACCATGGTGCGCATCGGTCTTCTCACGATTTCGGATCGCGCGAGCCGGGGCGATTATGTGGACCGCTCCGGCCCCGCCAT
GGAGGAATGGCTGGCACTGG

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MTRCGLVDLFGRRVSYLRLSVTDRCDLRCVYCMAEDMAFVPRNQLLTLEELDRLASAFVARGVAKIRLTGGEPLVRKGLM
ELVSSLSRHLAARRLKELTLTTNGSLLARHADGLARAGVRRVNVSLDTLDASRFRALTRRGTLGVVMEGLLAAQEAGLKV
KLNAVALKGSTEDEIHDLIAFAHGRGMDLTLIETMPLGDVGADRTDQYLSLATLRRTIETRWTLTDTADRSGGPARYARV
AETGGRIGFITPLTHSFCETCNRVRVSATGVLYTCLGQEDQVDLRAPLRACEGDEALHAAIDAGIRAKPRGHDFAIARNG
APALARHMSVLGG

Sequences:

>Translated_333_residues
MTRCGLVDLFGRRVSYLRLSVTDRCDLRCVYCMAEDMAFVPRNQLLTLEELDRLASAFVARGVAKIRLTGGEPLVRKGLM
ELVSSLSRHLAARRLKELTLTTNGSLLARHADGLARAGVRRVNVSLDTLDASRFRALTRRGTLGVVMEGLLAAQEAGLKV
KLNAVALKGSTEDEIHDLIAFAHGRGMDLTLIETMPLGDVGADRTDQYLSLATLRRTIETRWTLTDTADRSGGPARYARV
AETGGRIGFITPLTHSFCETCNRVRVSATGVLYTCLGQEDQVDLRAPLRACEGDEALHAAIDAGIRAKPRGHDFAIARNG
APALARHMSVLGG
>Mature_332_residues
TRCGLVDLFGRRVSYLRLSVTDRCDLRCVYCMAEDMAFVPRNQLLTLEELDRLASAFVARGVAKIRLTGGEPLVRKGLME
LVSSLSRHLAARRLKELTLTTNGSLLARHADGLARAGVRRVNVSLDTLDASRFRALTRRGTLGVVMEGLLAAQEAGLKVK
LNAVALKGSTEDEIHDLIAFAHGRGMDLTLIETMPLGDVGADRTDQYLSLATLRRTIETRWTLTDTADRSGGPARYARVA
ETGGRIGFITPLTHSFCETCNRVRVSATGVLYTCLGQEDQVDLRAPLRACEGDEALHAAIDAGIRAKPRGHDFAIARNGA
PALARHMSVLGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=333, Percent_Identity=38.4384384384384, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI22027536, Length=333, Percent_Identity=38.4384384384384, Blast_Score=212, Evalue=3e-55,
Organism=Escherichia coli, GI1786999, Length=331, Percent_Identity=34.7432024169184, Blast_Score=189, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17561210, Length=331, Percent_Identity=34.7432024169184, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI32566331, Length=333, Percent_Identity=34.5345345345345, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI32566329, Length=331, Percent_Identity=34.1389728096677, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI28574490, Length=328, Percent_Identity=39.0243902439024, Blast_Score=208, Evalue=5e-54,
Organism=Drosophila melanogaster, GI28574488, Length=333, Percent_Identity=39.039039039039, Blast_Score=207, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 36149; Mature: 36018

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRCGLVDLFGRRVSYLRLSVTDRCDLRCVYCMAEDMAFVPRNQLLTLEELDRLASAFVA
CCCCCHHHHHHHHEEEEEEEECCCCCCEEEEEEHHCHHCCCCCCEEEHHHHHHHHHHHHH
RGVAKIRLTGGEPLVRKGLMELVSSLSRHLAARRLKELTLTTNGSLLARHADGLARAGVR
CCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEHHCHHHHCCEE
RVNVSLDTLDASRFRALTRRGTLGVVMEGLLAAQEAGLKVKLNAVALKGSTEDEIHDLIA
EEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHH
FAHGRGMDLTLIETMPLGDVGADRTDQYLSLATLRRTIETRWTLTDTADRSGGPARYARV
HHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHH
AETGGRIGFITPLTHSFCETCNRVRVSATGVLYTCLGQEDQVDLRAPLRACEGDEALHAA
HHCCCCEEEECHHHHHHHHHHCCEEEEECEEEEEECCCCCCCHHHHHHHHCCCCHHHHHH
IDAGIRAKPRGHDFAIARNGAPALARHMSVLGG
HHCCCCCCCCCCCEEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TRCGLVDLFGRRVSYLRLSVTDRCDLRCVYCMAEDMAFVPRNQLLTLEELDRLASAFVA
CCCCHHHHHHHHEEEEEEEECCCCCCEEEEEEHHCHHCCCCCCEEEHHHHHHHHHHHHH
RGVAKIRLTGGEPLVRKGLMELVSSLSRHLAARRLKELTLTTNGSLLARHADGLARAGVR
CCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEHHCHHHHCCEE
RVNVSLDTLDASRFRALTRRGTLGVVMEGLLAAQEAGLKVKLNAVALKGSTEDEIHDLIA
EEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHH
FAHGRGMDLTLIETMPLGDVGADRTDQYLSLATLRRTIETRWTLTDTADRSGGPARYARV
HHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHH
AETGGRIGFITPLTHSFCETCNRVRVSATGVLYTCLGQEDQVDLRAPLRACEGDEALHAA
HHCCCCEEEECHHHHHHHHHHCCEEEEECEEEEEECCCCCCCHHHHHHHHCCCCHHHHHH
IDAGIRAKPRGHDFAIARNGAPALARHMSVLGG
HHCCCCCCCCCCCEEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]