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The map label for this gene is hlyD [H]

Identifier: 158422701

GI number: 158422701

Start: 1204491

End: 1205417

Strand: Direct

Name: hlyD [H]

Synonym: AZC_1077

Alternate gene names: 158422701

Gene position: 1204491-1205417 (Clockwise)

Preceding gene: 158422700

Following gene: 158422702

Centisome position: 22.43

GC content: 70.44

Gene sequence:

>927_bases
ATGAAACGGATGCTCGCCACCGCCGGGCGCATCGGCGTCACCCTCACCGCCCTCGTTCTGGCGGTGCTCACCGGCCACTA
TCTGTGGTCCTATTACATGGAGGAGCCCTGGACCCGCGACGCGAAGATCCGCGCCGCCGTCGTGGAGGTGGCCCCCGATG
TCTCCGGCCTCGTCTCCGAGGTGCTGGTGGACGACAATGCGGCGGTCCGCAAGGGCGACCCGATCCTGCGCATCGATCCG
CAGCGCTTCCAGATCGCGCTGGAACAGGCGGACGCCGCGCTCGCCAGCCGGAAGGCGGCCCTCGTGCAGGCGCAGCGGGA
CTATGATCGTGCCCAGCAGCTGAGCGAGATGGCGGTCTCCCGCCAGGCCCGCGAGCAGGCGGAGACGACGCTGGCGCAGG
ACAAGGCCGCGCTGGCGCAGGCCCAGAGCGACCGCGATCTTGCCGCCCTCAATCTGGAGCGCTCCACCCTGCGGGCGCCC
GTGGATGGCATCATCACCAATTTCGAACTGCGGCCGGGCAAATACGTCTCGGCCGGATCGGGCGTCGCCGCGCTGGTCGA
CACCGGCTCCTATTATGTGGCGGGCTATTTCGAAGAAACGAAGCTGCCCCGCATCGCGCCCGGCGACCGCGTGAAGATCT
CGCTCATGGGATCGGATGCGGTCCTCTCCGGACGCGTGCGCAGCATCGATGCGGCGATCGAGGACCGTGAGCGCTCCGAC
GGCTCGAGCCTCATCGCCAATGTGACGCCCACCTTCAGCTGGGTGCGTCTCGCCCAGCGCGTGCCGGTGCGCATCGCGCT
CGATCCGGTGCCCGAGGGCACGCGCCTCGTGGCCGGCCGCACGGCGACGGTGGAGGTGTTGCCCGGCACCGCGTCCGGGA
CGGCGCAGGCGGACGCGCGGGGCGAGGCGCCGACGCTGACGCGCTGA

Upstream 100 bases:

>100_bases
ACCTCTATCGCCTCGTGTGGCACCGCGCGCTGTTCGACGTGTGCCTCTACGTCCTCGTCCTGGGCGGTTTCGTCGCCCTC
TCGCTGCAATGGTCGCAATC

Downstream 100 bases:

>100_bases
ACGTCGATCCCGTCCGGCCGGAGCGTTGGCCTGCTCCGGCCTTCAGTCTTCCCCTACGTCTCGTCGCCATGCCGGAGGTT
TCGGCCGTTGGGGAAGTCGC

Product: secretion protein

Products: NA

Alternate protein names: pHBA efflux pump protein A [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MKRMLATAGRIGVTLTALVLAVLTGHYLWSYYMEEPWTRDAKIRAAVVEVAPDVSGLVSEVLVDDNAAVRKGDPILRIDP
QRFQIALEQADAALASRKAALVQAQRDYDRAQQLSEMAVSRQAREQAETTLAQDKAALAQAQSDRDLAALNLERSTLRAP
VDGIITNFELRPGKYVSAGSGVAALVDTGSYYVAGYFEETKLPRIAPGDRVKISLMGSDAVLSGRVRSIDAAIEDRERSD
GSSLIANVTPTFSWVRLAQRVPVRIALDPVPEGTRLVAGRTATVEVLPGTASGTAQADARGEAPTLTR

Sequences:

>Translated_308_residues
MKRMLATAGRIGVTLTALVLAVLTGHYLWSYYMEEPWTRDAKIRAAVVEVAPDVSGLVSEVLVDDNAAVRKGDPILRIDP
QRFQIALEQADAALASRKAALVQAQRDYDRAQQLSEMAVSRQAREQAETTLAQDKAALAQAQSDRDLAALNLERSTLRAP
VDGIITNFELRPGKYVSAGSGVAALVDTGSYYVAGYFEETKLPRIAPGDRVKISLMGSDAVLSGRVRSIDAAIEDRERSD
GSSLIANVTPTFSWVRLAQRVPVRIALDPVPEGTRLVAGRTATVEVLPGTASGTAQADARGEAPTLTR
>Mature_308_residues
MKRMLATAGRIGVTLTALVLAVLTGHYLWSYYMEEPWTRDAKIRAAVVEVAPDVSGLVSEVLVDDNAAVRKGDPILRIDP
QRFQIALEQADAALASRKAALVQAQRDYDRAQQLSEMAVSRQAREQAETTLAQDKAALAQAQSDRDLAALNLERSTLRAP
VDGIITNFELRPGKYVSAGSGVAALVDTGSYYVAGYFEETKLPRIAPGDRVKISLMGSDAVLSGRVRSIDAAIEDRERSD
GSSLIANVTPTFSWVRLAQRVPVRIALDPVPEGTRLVAGRTATVEVLPGTASGTAQADARGEAPTLTR

Specific function: Unknown

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081951, Length=273, Percent_Identity=43.5897435897436, Blast_Score=217, Evalue=9e-58,
Organism=Escherichia coli, GI1789637, Length=286, Percent_Identity=41.958041958042, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1790519, Length=309, Percent_Identity=32.6860841423948, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1789041, Length=300, Percent_Identity=26.3333333333333, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1788711, Length=331, Percent_Identity=27.7945619335347, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790024, Length=278, Percent_Identity=26.978417266187, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI87082036, Length=161, Percent_Identity=32.9192546583851, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022871
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 33098; Mature: 33098

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRMLATAGRIGVTLTALVLAVLTGHYLWSYYMEEPWTRDAKIRAAVVEVAPDVSGLVSE
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEEEEEECCCCHHHHHHH
VLVDDNAAVRKGDPILRIDPQRFQIALEQADAALASRKAALVQAQRDYDRAQQLSEMAVS
HHHCCCCCEECCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQAREQAETTLAQDKAALAQAQSDRDLAALNLERSTLRAPVDGIITNFELRPGKYVSAGS
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHCCHHHHEEEEEECCCCEEECCC
GVAALVDTGSYYVAGYFEETKLPRIAPGDRVKISLMGSDAVLSGRVRSIDAAIEDRERSD
CEEEEEECCCEEEEEEECCCCCCCCCCCCEEEEEEECCCCEECCCHHHHHHHHHHCCCCC
GSSLIANVTPTFSWVRLAQRVPVRIALDPVPEGTRLVAGRTATVEVLPGTASGTAQADAR
CCEEEEECCCHHHHHHHHHHCCEEEEECCCCCCCEEEECCCEEEEEECCCCCCCCCCCCC
GEAPTLTR
CCCCCCCC
>Mature Secondary Structure
MKRMLATAGRIGVTLTALVLAVLTGHYLWSYYMEEPWTRDAKIRAAVVEVAPDVSGLVSE
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEEEEEECCCCHHHHHHH
VLVDDNAAVRKGDPILRIDPQRFQIALEQADAALASRKAALVQAQRDYDRAQQLSEMAVS
HHHCCCCCEECCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQAREQAETTLAQDKAALAQAQSDRDLAALNLERSTLRAPVDGIITNFELRPGKYVSAGS
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHCCHHHHEEEEEECCCCEEECCC
GVAALVDTGSYYVAGYFEETKLPRIAPGDRVKISLMGSDAVLSGRVRSIDAAIEDRERSD
CEEEEEECCCEEEEEEECCCCCCCCCCCCEEEEEEECCCCEECCCHHHHHHHHHHCCCCC
GSSLIANVTPTFSWVRLAQRVPVRIALDPVPEGTRLVAGRTATVEVLPGTASGTAQADAR
CCEEEEECCCHHHHHHHHHHCCEEEEECCCCCCCEEEECCCEEEEEECCCCCCCCCCCCC
GEAPTLTR
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA